MetaboList - February 2016

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Muñoz Pinedo, Cristina

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Mar 4, 2016, 2:18:51 PM3/4/16
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Cristina

 

 

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Nucleotide metabolism

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mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle

Issam Ben-Sahra, Gerta Hoxhaj, Stéphane J. H. Ricoult, John M. Asara, Brendan D. Manning

http://science.sciencemag.org/content/351/6274/728

 

Spatial colocalization and functional link of purinosomes with mitochondria

Jarrod B. French, Sara A. Jones, Huayun Deng, Anthony M. Pedley, Doory Kim, Chung Yu Chan, Haibei Hu, Raymond J. Pugh, Hong Zhao, Youxin Zhang, Tony Jun Huang, Ye Fang, Xiaowei Zhuang, Stephen J. Benkovic

http://science.sciencemag.org/content/351/6274/733

 

The PGC-1α/ERRα Axis Represses One-Carbon Metabolism and Promotes Sensitivity to Anti-folate Therapy in Breast Cancer

Étienne Audet-Walsh, David J. Papadopoli, Simon-Pierre Gravel, Tracey Yee, Gaëlle Bridon, Maxime Caron, Guillaume Bourque, Vincent Giguère, Julie St-Pierre

http://www.cell.com/cell-reports/abstract/S2211-1247(15)01542-9

 

The Interplay between Myc and CTP Synthase in Drosophila

Gabriel N. Aughey, Stuart J. Grice, Ji-Long Liu

http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1005867

 

 

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Cancer metabolism

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Metabolic Heterogeneity in Human Lung Tumors

Christopher T. Hensley, Brandon Faubert, Qing Yuan, Naama Lev-Cohain, Eunsook Jin, Jiyeon Kim, Lei Jiang, Bookyung Ko, Rachael Skelton, Laurin Loudat, Michelle Wodzak, Claire Klimko, Elizabeth McMillan, Yasmeen Butt, Min Ni, Dwight Oliver, Jose Torrealba, Craig R. Malloy, Kemp Kernstine, Robert E. Lenkinski, Ralph J. DeBerardinis

http://www.cell.com/cell/abstract/S0092-8674(15)01698-0

 

Tumour-specific proline vulnerability uncovered by differential ribosome codon reading

Fabricio Loayza-Puch, Koos Rooijers, Levi C. M. Buil, Jelle Zijlstra, Joachim F. Oude Vrielink, Rui Lopes, Alejandro Pineiro Ugalde, Pieter van Breugel, Ingrid Hofland, Jelle Wesseling, Olaf van Tellingen, Axel Bex & Reuven Agami

http://www.nature.com/nature/journal/v530/n7591/full/nature16982.html

 

Transketolase counteracts oxidative stress to drive cancer development  

Iris Ming-Jing Xu, Robin Kit-Ho Lai, Shu-Hai Lin, Aki Pui-Wah Tse, David Kung-Chun Chiu, Hui-Yu Koh, Cheuk-Ting Law, Chun-Ming Wong, Zongwei Cai, Carmen Chak-Lui Wong, and Irene Oi-Lin Ng

http://www.pnas.org/content/113/6/E725.abstract.html?etoc

 

Lipid and metabolite profiles of human brain tumors by desorption electrospray ionization-MS  

Alan K. Jarmusch, Valentina Pirro, Zane Baird, Eyas M. Hattab, Aaron A. Cohen-Gadol, and R. Graham Cooks

http://www.pnas.org/content/113/6/1486.abstract.html?etoc

 

Accumulated Metabolites of Hydroxybutyric Acid Serve as Diagnostic and Prognostic Biomarkers of Ovarian High-Grade Serous Carcinomas

Mika Hilvo, Ines de Santiago, Peddinti Gopalacharyulu, Wolfgang D. Schmitt, Jan Budczies, Marc Kuhberg, Manfred Dietel, Tero Aittokallio, Florian Markowetz, Carsten Denkert, Jalid Sehouli, Christian Frezza, Silvia Darb-Esfahani, and Elena Ioana Braicu

http://cancerres.aacrjournals.org/content/76/4/796.abstract?etoc

 

Diet-induced alteration of fatty acid synthase in prostate cancer progression

M Huang, A Koizumi, S Narita, T Inoue, N Tsuchiya, H Nakanishi, K Numakura, H Tsuruta, M Saito, S Satoh, H Nanjo, T Sasaki and T Habuchi

http://www.nature.com/oncsis/journal/v5/n2/abs/oncsis201542a.html

 

 

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Metabolic reprogramming

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Metabolic Reprogramming of Pancreatic Cancer Mediated by CDK4/6 Inhibition Elicits Unique Vulnerabilities

Jorge Franco, Uthra Balaji, Elizaveta Freinkman, Agnieszka K. Witkiewicz, Erik S. Knudsen

http://www.cell.com/cell-reports/abstract/S2211-1247(15)01550-8

 

Allele-Specific Reprogramming of Cancer Metabolism by the Long Non-coding RNA CCAT2

Roxana S. Redis, Luz E. Vela, Weiqin Lu, Juliana Ferreira de Oliveira, Cristina Ivan, Cristian Rodriguez-Aguayo, Douglas Adamoski, Barbara Pasculli, Ayumu Taguchi, Yunyun Chen, Agustin F. Fernandez, Luis Valledor, Katrien Van Roosbroeck, Samuel Chang, Maitri Shah, Garrett Kinnebrew, Leng Han, Yaser Atlasi, Lawrence H. Cheung, Gilbert Y. Huang, Paloma Monroig, Marc S. Ramirez, Tina Catela Ivkovic, Long Van, Hui Ling, Roberta Gafà, Sanja Kapitanovic, Giovanni Lanza, James A. Bankson, Peng Huang, Stephen Y. Lai, Robert C. Bast, Michael G. Rosenblum, Milan Radovich, Mircea Ivan, Geoffrey Bartholomeusz, Han Liang, Mario F. Fraga, William R. Widger, Samir Hanash, Ioana Berindan-Neagoe, Gabriel Lopez-Berestein, Andre L.B. Ambrosio, Sandra M. Gomes Dias, George A. Calin

http://www.cell.com/molecular-cell/abstract/S1097-2765(16)00016-2

 

Glutaminase 2 is a novel negative regulator of small GTPase Rac1 and mediates p53 function in suppressing metastasis

Cen Zhang, Juan Liu, Yuhan Zhao, Xuetian Yue, Yu Zhu, Xiaolong Wang, Hao Wu, Felix Blanco, Shaohua Li, Gyan Bhanot, Bruce G Haffty, Wenwei Hu and Zhaohui Feng

http://elifesciences.org/content/5/e10727v2/abstract2

 

Idh1 mutations contribute to the development of T-cell malignancies in genetically engineered mice  

Zhenyue Hao, Rob A. Cairns, Satoshi Inoue, Wanda Y. Li, Yi Sheng, François Lemonnier, Andrew Wakeham, Bryan E. Snow, Carmen Dominguez-Brauer, Jing Ye, Dana M. Larsen, Kimberly S. Straley, Erica R. Tobin, Rohini Narayanaswamy, Philippe Gaulard, and Tak W. Mak

http://www.pnas.org/content/113/5/1387.abstract.html?etoc

 

 

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Nutrient sensing

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Deubiquitination and Activation of AMPK by USP10

Min Deng, Xu Yang, Bo Qin, Tongzheng Liu, Haoxing Zhang, Wei Guo, Seung Baek Lee, Jung Jin Kim, Jian Yuan, Huadong Pei, Liewei Wang, Zhenkun Lou

http://www.cell.com/molecular-cell/abstract/S1097-2765(16)00011-3

 

A CREB-Sirt1-Hes1 Circuitry Mediates Neural Stem Cell Response to Glucose Availability

Salvatore Fusco, Lucia Leone, Saviana Antonella Barbati, Daniela Samengo, Roberto Piacentini, Giuseppe Maulucci, Gabriele Toietta, Matteo Spinelli, Michael McBurney, Giovambattista Pani, Claudio Grassi

http://www.cell.com/cell-reports/abstract/S2211-1247(15)01548-X

 

Hexokinase 2 is an intracellular glucose sensor of yeast cells that maintains the structure and activity of Mig1 repressor complex

Montserrat Vega, Alberto Riera, Alejandra Fernandez-Cid, Pilar Herrero, and Fernando Moreno

http://www.jbc.org/content/early/2016/02/10/jbc.M115.711408.abstract

 

Lysosomal recruitment of TSC2 is a universal response to cellular stress

Constantinos Demetriades, Monika Plescher and Aurelio A. Teleman

http://www.nature.com/ncomms/2016/160212/ncomms10662/full/ncomms10662.html

 

C/EBPγ Is a Critical Regulator of Cellular Stress Response Networks through Heterodimerization with ATF4

Christopher J. Huggins, Manasi K. Mayekar, Nancy Martin, Karen L. Saylor,Mesfin Gonit, Parthav Jailwala, Manjula Kasoji, Diana C. Haines, Octavio A. Quiñones, and Peter F. Johnson

http://mcb.asm.org/content/36/5/693.abstract?etoc

 

 

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mTOR and cancer

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Stabilization of p21 by mTORC1/4E-BP1 predicts clinical outcome of head and neck cancers

Susana Llanos, Juana M. García-Pedrero, Lucia Morgado-Palacin, Juan P. Rodrigo and Manuel Serrano

http://www.nature.com/ncomms/2016/160202/ncomms10438/full/ncomms10438.html

 

Inhibition of mTOR complex 2 induces GSK3/FBXW7-dependent degradation of sterol regulatory element-binding protein 1 (SREBP1) and suppresses lipogenesis in cancer cells

S Li, Y-T Oh, P Yue, F R Khuri and S-Y Sun

http://www.nature.com/onc/journal/v35/n5/abs/onc2015123a.html

 

Mesenchymal Tumorigenesis Driven by TSC2 Haploinsufficiency Requires HMGA2 and Is Independent of mTOR Pathway Activation

Jeanine D'Armiento, Takayuki Shiomi, Sarah Marks, Patrick Geraghty, Devipriya Sankarasharma, and Kiran Chada

http://cancerres.aacrjournals.org/content/76/4/844.abstract?etoc

 

Secreted IGFBP5 mediates mTORC1-dependent feedback inhibition of IGF-1 signalling

Ming Ding, Richard K. Bruick & Yonghao Yu

http://www.nature.com/ncb/journal/v18/n3/full/ncb3311.html

 

 

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Hypoxia / HIFs

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Systemic Reprogramming of Translation Efficiencies on Oxygen Stimulus

J.J. David Ho, Miling Wang, Timothy E. Audas, Deukwoo Kwon, Steven K. Carlsson, Sara Timpano, Sonia L. Evagelou, Shaun Brothers, Mark L. Gonzalgo, Jonathan R. Krieger, Steven Chen, James Uniacke, Stephen Lee

http://www.cell.com/cell-reports/abstract/S2211-1247(16)00057-7

 

Epigenetic re-expression of HIF-2α suppresses soft tissue sarcoma growth

Michael S. Nakazawa, T. S. Karin Eisinger-Mathason, Navid Sadri, Joshua D. Ochocki, Terence P. F. Gade, Ruchi K. Amin and M. Celeste Simon 

http://www.nature.com/ncomms/2016/160203/ncomms10539/full/ncomms10539.html

 

Mutant versions of von Hippel-Lindau (VHL) can protect HIF1α from SART1-mediated degradation in clear-cell renal cell carcinoma

Á Ordóñez-Navadijo, E Fuertes-Yebra, B Acosta-Iborra, E Balsa, A Elorza, J Aragonés and M O Landazuri

http://www.nature.com/onc/journal/v35/n5/abs/onc2015113a.html

 

HIF-1α Promotes Glutamine-Mediated Redox Homeostasis and Glycogen-Dependent Bioenergetics to Support Postimplantation Bone Cell Survival

Steve Stegen, Nick van Gastel, Guy Eelen, Bart Ghesquière, Flora D’Anna, Bernard Thienpont, Jermaine Goveia, Sophie Torrekens, Riet Van Looveren, Frank P. Luyten, Patrick H. Maxwell, Ben Wielockx, Diether Lambrechts, Sarah-Maria Fendt, Peter Carmeliet, Geert Carmeliet

http://www.cell.com/cell-metabolism/abstract/S1550-4131(16)00036-X

 

Hypoxia-Induced Epithelial-to-Mesenchymal Transition in Hepatocellular Carcinoma Induces an Immunosuppressive Tumor Microenvironment to Promote Metastasis

Long-Yun Ye, Wei Chen, Xue-Li Bai, Xing-Yuan Xu, Qi Zhang, Xue-Feng Xia, Xu Sun, Guo-Gang Li, Qi-Da Hu, Qi-Han Fu, and Ting-Bo Liang

http://cancerres.aacrjournals.org/content/76/4/818.abstract?etoc

 

 

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Ischemia

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A Unifying Mechanism for Mitochondrial Superoxide Production during Ischemia-Reperfusion Injury

Edward T. Chouchani, Victoria R. Pell, Andrew M. James, Lorraine M. Work, Kourosh Saeb-Parsy, Christian Frezza, Thomas Krieg, Michael P. Murphy

http://www.cell.com/cell-metabolism/abstract/S1550-4131(15)00624-5

 

Deletion or Inhibition of the Oxygen Sensor PHD1 Protects against Ischemic Stroke via Reprogramming of Neuronal Metabolism

Annelies Quaegebeur, Inmaculada Segura, Roberta Schmieder, Dries Verdegem, Ilaria Decimo, Francesco Bifari, Tom Dresselaers, Guy Eelen, Debapriva Ghosh, Shawn M. Davidson, Sandra Schoors, Dorien Broekaert, Bert Cruys, Kristof Govaerts, Carla De Legher, Ann Bouché, Luc Schoonjans, Matt S. Ramer, Gene Hung, Goele Bossaert, Don W. Cleveland, Uwe Himmelreich, Thomas Voets, Robin Lemmens, C. Frank Bennett, Wim Robberecht, Katrien De Bock, Mieke Dewerchin, Bart Ghesquière, Sarah-Maria Fendt, Peter Carmeliet

http://www.cell.com/cell-metabolism/abstract/S1550-4131(15)00622-1

 

CaMKII is a RIP3 substrate mediating ischemia- and oxidative stress-induced myocardial necroptosis  

Ting Zhang, Yan Zhang, Mingyao Cui, Li Jin, Yimei Wang

http://www.nature.com/nm/journal/v22/n2/full/nm.4017.html

 

 

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Drugs and mechanisms

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MCT1 Modulates Cancer Cell Pyruvate Export and Growth of Tumors that Co-express MCT1 and MCT4

Candice Sun Hong, Nicholas A. Graham, Wen Gu, Carolina Espindola Camacho, Vei Mah, Erin L. Maresh, Mohammed Alavi, Lora Bagryanova, Pascal A.L. Krotee, Brian K. Gardner, Iman Saramipoor Behbahan, Steve Horvath, David Chia, Ingo K. Mellinghoff, Sara A. Hurvitz, Steven M. Dubinett, Susan E. Critchlow, Siavash K. Kurdistani, Lee Goodglick, Daniel Braas, Thomas G. Graeber, Heather R. Christofk

http://www.cell.com/cell-reports/abstract/S2211-1247(16)30035-3

 

Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers

Edouard Mullarky, Natasha C. Lucki, Reza Beheshti Zavareh, Justin L. Anglin, Ana P. Gomes, Brandon N. Nicolay, Jenny C. Y. Wong, Stefan Christen, Hidenori Takahashi, Pradeep K. Singh, John Blenis, J. David Warren, Sarah-Maria Fendt, John M. Asara, Gina M. DeNicola, Costas A. Lyssiotis, Luke L. Lairson, and Lewis C. Cantley

http://www.pnas.org/content/113/7/1778.abstract.html?etoc

 

Discovery of tumor-specific irreversible inhibitors of stearoyl CoA desaturase

Panayotis C Theodoropoulos, Stephen S Gonzales, Sarah E Winterton, Carlos Rodriguez-Navas, John S McKnight, Lorraine K Morlock, Jordan M Hanson, Bethany Cross, Amy E Owen, Yingli Duan, Jose R Moreno, Andrew Lemoff, Hamid Mirzaei, Bruce A Posner, Noelle S Williams, Joseph M Ready & Deepak Nijhawan

http://www.nature.com/nchembio/journal/vaop/ncurrent/full/nchembio.2016.html

 

 

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Methods

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Oxygen-Enhanced MRI Accurately Identifies, Quantifies, and Maps Tumor Hypoxia in Preclinical Cancer Models

James P.B. O'Connor, Jessica K.R. Boult, Yann Jamin, Muhammad Babur, Katherine G. Finegan, Kaye J. Williams, Ross A. Little, Alan Jackson, Geoff J.M. Parker, Andrew R. Reynolds, John C. Waterton, and Simon P. Robinson

http://cancerres.aacrjournals.org/content/76/4/787.abstract?etoc

 

A Method for Multiplexed Measurement of Mitochondrial Pyruvate Carrier Activity

Lawrence R. Gray, Adam J. Rauckhorst, and Eric B. Taylor

http://www.jbc.org/content/early/2016/01/28/jbc.M115.711663.abstract

 

Impact of Freezing Delay Time on Tissue Samples for Metabolomic Studies

Tonje H. Haukaas, Siver A. Moestue, Riyas Vettukattil, Beathe Sitter, Santosh Lamichhane, Remedios Segura, Guro F. Giskeødegård, and Tone F. Bathen

http://journal.frontiersin.org/article/10.3389/fonc.2016.00017/full

 

 

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Miscellaneous

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Proinflammatory signal suppresses proliferation and shifts macrophage metabolism from Myc-dependent to HIF1α-dependent  

Lingling Liu, Yun Lu, Jennifer Martinez, Yujing Bi, Gaojian Lian, Tingting Wang, Sandra Milasta, Jian Wang, Mao Yang, Guangwei Liu, Douglas R. Green, and Ruoning Wang

http://www.pnas.org/content/113/6/1564.abstract.html?etoc

 

Regulation of glucose metabolism by p62/SQSTM1 through HIF1α

Ke Chen, Jin Zeng, Haibing Xiao, Chunhua Huang, Junhui Hu, Weimin Yao, Gan Yu, Wei Xiao, Hua Xu, and Zhangqun Ye

http://jcs.biologists.org/content/129/4/817.abstract?etoc

 

Expression of Concern: Sirtuin-3 deacetylation of cyclophilin D induces dissociation of hexokinase II from the mitochondria. Nataly Shulga, Robin Wilson-Smith, John G. Pastorino. J Cell Sci doi: 10.1242/jcs.061846

Michael Way

http://jcs.biologists.org/content/129/4/868?etoc

 

Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis

Brian J. DeBosch, Monique R. Heitmeier, Allyson L. Mayer, Cassandra B. Higgins, Jan R. Crowley, Thomas E. Kraft, Maggie Chi, Elizabeth P. Newberry, Zhouji Chen, Brian N. Finck, Nicholas O. Davidson, Kevin E. Yarasheski, Paul W. Hruz, and Kelle H. Moley

http://stke.sciencemag.org/content/9/416/ra21.abstract

 

SIRT6 deacetylates PKM2 to suppress its nuclear localization and oncogenic functions

Abhishek Bhardwaj and Sanjeev Das

http://www.pnas.org/content/113/5/E538.abstract.html?etoc

 

 

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Reviews

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AMPK: An Energy-Sensing Pathway with Multiple Inputs and Outputs

D. Grahame Hardie, Bethany E. Schaffer, Anne Brunet

http://www.cell.com/trends/cell-biology/abstract/S0962-8924(15)00215-9

 

Mitochondrial Dynamics and Metabolic Regulation

Timothy Wai, Thomas Langer

http://www.cell.com/trends/endocrinology-metabolism/abstract/S1043-2760(15)00236-2

 

Energy disruptors: rising stars in anticancer therapy?

F Bost, A-G Decoux-Poullot, J F Tanti and S Clavel

http://www.nature.com/oncsis/journal/v5/n1/full/oncsis201546a.html

 

T Cells and Cancer: How Metabolism Shapes Immunity

Barbara Molon, Bianca Calì and Antonella Viola

http://journal.frontiersin.org/article/10.3389/fimmu.2016.00020/full

 

Integration of omics: more than the sum of its parts

Buescher  J, Driggers  EM

http://www.cancerandmetabolism.com/content/4/1/4/abstract

 

Fat, Calories, and Cancer

Yves A. DeClerck

http://cancerres.aacrjournals.org/content/76/3/509?etoc

 

A Retrospective: On Clinical Studies with 5-Fluorouracil

V. Craig Jordan

http://cancerres.aacrjournals.org/content/76/4/767?etoc

 

Oxygen-Enhanced MRI Is a Major Advance in Tumor Hypoxia Imaging

Mark W. Dewhirst and Samuel R. Birer

http://cancerres.aacrjournals.org/content/76/4/769?etoc

 

Potential of Induced Metabolic Bioluminescence Imaging to Uncover Metabolic Effects of Antiangiogenic Therapy in Tumors

Stefano Indraccolo and Wolfgang Mueller-Klieser

http://journal.frontiersin.org/article/10.3389/fonc.2016.00015/full

 

Understanding cachexia as a cancer metabolism syndrome

P E Porporato

http://www.nature.com/oncsis/journal/v5/n2/abs/oncsis20163a.html

 

 

-------------------

Comments

-------------------

 

(TORC)ing up purine biosynthesis

Eric H. Ma and Russell G. Jones

http://science.sciencemag.org/content/351/6274/670

 

Bringing IDH into the Fold

Gelareh Zadeh, Kenneth Aldape

http://www.cell.com/cancer-cell/abstract/S1535-6108(16)30004-6?

 

An expanded role for mTORC1 in autophagy  

Young-Mi Kim, Ji-Man Park, Douglas Grunwald & Do-Hyung Kim

http://www.tandfonline.com/doi/full/10.1080/23723556.2015.1010958

 

Influence of metabolic stress on translation of p53 isoforms

Debjit Khan, Samit Chattopadhyay & Saumitra Das

http://www.tandfonline.com/doi/full/10.1080/23723556.2015.1039689

 

Metabolic rewiring in cancer-associated fibroblasts provides a niche for oncogenesis and metastatic dissemination  

Jingyi Liu, Jun Mi & Binhua P. Zhou

http://www.tandfonline.com/doi/full/10.1080/23723556.2015.1056331

 

AMPK-dependent phosphorylation of lipid droplet protein PLIN2 triggers its degradation by CMA

Susmita Kaushik & Ana Maria Cuervo

http://www.tandfonline.com/doi/full/10.1080/15548627.2015.1124226

 

Cell biology: Form follows function for mitochondria

Chunxin Wang & Richard Youle

http://www.nature.com/nature/journal/v530/n7590/full/530288a.html

 

Mystery solved: Trehalose kickstarts autophagy by blocking glucose transport

Pablo Mardones, David C. Rubinsztein, and Claudio Hetz

http://stke.sciencemag.org/content/9/416/fs2.abstract

 

p62 regulates glucose metabolism through HIF1α

http://jcs.biologists.org/content/129/4/e0403?etoc

 

Cancer biology: Metabolism varies within tumours

http://www.nature.com/nature/journal/v530/n7590/full/530257c.html

 

Releasing aldolase from the cytoskeleton

http://stke.sciencemag.org/content/9/413/ec21.abstract

 

IDH1-Mutant Cancers Are Susceptible to NAD^+ Depletion

http://cancerdiscovery.aacrjournals.org/content/6/2/117.1.abstract?etoc

 

Hypoxia Promotes Cancer Stem Cells via ID2-Dependent VHL Inactivation

http://cancerdiscovery.aacrjournals.org/content/6/2/120.1.abstract?etoc

 

 

 

 

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Cristina Muñoz-Pinedo

Cell Death Regulation Group

IDIBELL - Hospital Duran i Reynals 3a planta

Gran Via de l'Hospitalet, 199

08908 L'Hospitalet de Llobregat

Barcelona – Spain

 

phone +34 93 260 7130

cmu...@idibell.cat    www.apoptosis.es

www.cancer-metabolism.org

idibell.cat/modul/cell-death-regulation/en

 

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