MetaboList - June 2016

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Muñoz Pinedo, Cristina

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Jul 13, 2016, 2:03:31 PM7/13/16

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Regards,

Cristina

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Hypoxia/HIFs, angiogenesis

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Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine

Kimberly J. Briggs, Peppi Koivunen, Shugeng Cao, Keriann M. Backus, Benjamin A. Olenchock, Hetalben Patel, Qing Zhang, Sabina Signoretti, Gary J. Gerfen, Andrea L. Richardson, Agnieszka K. Witkiewicz, Benjamin F. Cravatt, Jon Clardy, William G. Kaelin

http://www.cell.com/cell/fulltext/S0092-8674(16)30593-1

Targeting Tumor Mitochondrial Metabolism Overcomes Resistance to Antiangiogenics

Paloma Navarro, Maria J. Bueno, Ivana Zagorac, Tamara Mondejar, Jesus Sanchez, Silvana Mourón, Javier Muñoz, Gonzalo Gómez-López, Veronica Jimenez-Renard, Francisca Mulero, Navdeep S. Chandel, Miguel Quintela-Fandino

http://www.cell.com/cell-reports/fulltext/S2211-1247(16)30650-7

Disrupting Hypoxia-Induced Bicarbonate Transport Acidifies Tumor Cells and Suppresses Tumor Growth

Alan McIntyre, Alzbeta Hulikova, Ioanna Ledaki, Cameron Snell, Dean Singleton, Graham Steers, Peter Seden, Dylan Jones, Esther Bridges, Simon Wigfield, Ji-Liang Li, Angela Russell, Pawel Swietach, and Adrian L. Harris

http://cancerres.aacrjournals.org/content/76/13/3744.abstract?etoc

A novel pVHL-independent but NEMO-driven pathway in renal cancer promotes HIF stabilization

A M Nowicka, I Häuselmann, L Borsig, S Bolduan, M Schindler, P Schraml, M Heikenwalder and H Moch

http://www.nature.com/onc/journal/v35/n24/abs/onc2015400a.html

Sprouty2 Regulates Hypoxia Inducible Factor-α (HIFα) Protein Levels and Transcription of HIFα - Responsive Genes

Kristin C. Hicks and Tarun B. Patel

http://www.jbc.org/content/early/2016/06/08/jbc.M116.714139.abstract

Exogenous pyruvate facilitates cancer cell adaptation to hypoxia by serving as an oxygen surrogate

Chengqian Yin, Dan He, Shuyang Chen, Xiaoling Tan, Nianli Sang

http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[0]=10301&

Genomic alterations underlie a pan-cancer metabolic shift associated with tumour hypoxia

Syed Haider, Alan McIntyre, Ruud G. P. M. van Stiphout, Laura M. Winchester, Simon Wigfield, Adrian L. Harris and Francesca M. Buffa

http://genomebiology.biomedcentral.com/articles/10.1186/s13059-016-0999-8

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Glycolytic enzymes

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A key role for transketolase-like 1 in tumor metabolic reprogramming

Santiago Diaz-Moralli, Esther Aguilar1, Silvia Marin, Johannes F. Coy, Mieke Dewerchin, Maciek R. Antoniewicz, Oscar Meca-Cortés, Leen Notebaert, Bart Ghesquière, Guy Eelen, Timothy M. Thomson, Peter Carmeliet, Marta Cascante

http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[0]=10429

Cytosolic PKM2 stabilizes mutant EGFR protein expression through regulating HSP90–EGFR association

Y-C Yang, T-Y Cheng, S-M Huang, C-Y Su, P-W Yang, J-M Lee, C-K Chen, M Hsiao, K-T Hua and M-L Kuo

http://www.nature.com/onc/journal/v35/n26/abs/onc2015397a.html

SIRT2-Mediated Deacetylation and Tetramerization of Pyruvate Kinase Directs Glycolysis and Tumor Growth

Seong-Hoon Park, Ozkan Ozden, Guoxiang Liu, Ha Yong Song, Yueming Zhu, Yufan Yan, Xianghui Zou, Hong-Jun Kang, Haiyan Jiang, Daniel R. Principe, Yong-Il Cha, Meejeon Roh, Athanassios Vassilopoulos, and David Gius

http://cancerres.aacrjournals.org/content/76/13/3802.abstract?etoc

miR-200b is a key regulator of tumor progression and metabolism targeting lactate dehydrogenase A in human malignant glioma

Su Hu1, Qian Jiang, Dongdong Luo1, Lei Zhao3, Xin Fu2, Yuqin Chen2, Xue Song4, Lihua Li1, Hailin Zhao1, Yingfang He1, Biao Peng

http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[0]=10301&

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Glutamine

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LRH-1-dependent programming of mitochondrial glutamine processing drives liver cancer

Pan Xu, Maaike H. Oosterveer, Sokrates Stein, Hadrien Demagny, Dongryeol Ryu, Norman Moullan, Xu Wang, Emine Can, Nicola Zamboni, Arnaud Comment, Johan Auwerx, and Kristina S choonjans

http://genesdev.cshlp.org/content/30/11/1255.abstract?etoc

ASCT2/SLC1A5 controls glutamine uptake and tumour growth in triple-negative basal-like breast cancer

M van Geldermalsen, Q Wang, R Nagarajah, A D Marshall, A Thoeng, D Gao, W Ritchie, Y Feng, C G Bailey, N Deng, K Harvey, J M Beith, C I Selinger, S A O'Toole, J E J Rasko and J Holst

http://www.nature.com/onc/journal/v35/n24/abs/onc2015381a.html

Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer

Yujun Hao, Yardena Samuels, Qingling Li, Dawid Krokowski, Bo-Jhih Guan, Chao Wang, Zhicheng Jin, Bohan Dong, Bo Cao, Xiujing Feng, Min Xiang, Claire Xu, Stephen Fink, Neal J. Meropol, Yan Xu, Ronald A. Conlon, Sanford Markowitz, Kenneth W. Kinzler, Victor E. Velculescu, Henri Brunengraber, Joseph E. Willis, Thomas LaFramboise, Maria Hatzoglou, Guo-Fang Zhang, Bert Vogelstein, Zhenghe Wang

http://www.nature.com/ncomms/2016/160620/ncomms11971/full/ncomms11971.html

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Serine, mitochondria

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Chromatin-Bound MDM2 Regulates Serine Metabolism and Redox Homeostasis Independently of p53

Romain Riscal, Emilie Schrepfer, Giuseppe Arena, Madi Y. Cissé, Floriant Bellvert, Maud Heuillet, Florian Rambow, Eric Bonneil, Frédérique Sabourdy, Charles Vincent, Imade Ait-Arsa, Thierry Levade, Pierre Thibaut, Jean-Christophe Marine, Jean-Charles Portais, Jean-Emmanuel Sarry, Laurent Le Cam, Laetitia K. Linares

http://www.cell.com/molecular-cell/abstract/S1097-2765(16)30109-5

Mitochondrial dysfunction remodels one-carbon metabolism in human cells

Xiaoyan Robert Bao, Shao-En Ong, Olga Goldberger, Jun Peng, Rohit Sharma, Dawn A Thompson, Scott B Vafai, Andrew G Cox, Eizo Marutani, Fumito Ichinose, Wolfram Goessling, Aviv Regev, Steven A Carr, Clary B Clish and Vamsi K Mootha

https://elifesciences.org/content/5/e10575

Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the Mitochondrial Folate Pathway

Gregory S. Ducker, Li Chen, Raphael J. Morscher, Jonathan M. Ghergurovich, Mark Esposito, Xin Teng, Yibin Kang, Joshua D. Rabinowitz

http://www.cell.com/cell-metabolism/fulltext/S1550-4131(16)30168-1

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Starvation

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Nutrient shortage triggers the hexosamine biosynthetic pathway via the GCN2-ATF4 signalling pathway

Cédric Chaveroux, Carmen Sarcinelli, Virginie Barbet, Sofiane Belfeki, Audrey Barthelaix, Carole Ferraro-Peyret, Serge Lebecque, Toufic Renno, Alain Bruhat, Pierre Fafournoux & Serge N. Manié

http://dx.doi.org/10.1038/srep27278

GCN2 contributes to mTORC1 inhibition by leucine deprivation through an ATF4 independent mechanism

Julien Averous, Sarah Lambert-Langlais, Florent Mesclon, Valérie Carraro, Laurent Parry, Céline Jousse, Alain Bruhat, Anne-Catherine Maurin, Philippe Pierre, Christopher G. Proud & Pierre Fafournoux

http://www.nature.com/articles/srep27698

AMPK and PKA interaction in the regulation of survival of liver cancer cells subjected to glucose starvation

Anabela C. Ferretti, Facundo M. Tonucci, Florencia Hidalg1, Evangelina Almada, Maria C. Larocca, Cristián Favre

http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=7404&pubmed-linkout=1

NAMPT suppresses glucose deprivation-induced oxidative stress by increasing NADPH levels in breast cancer

S M Hong, C W Park, S W Kim, Y J Nam, J H Yu, J H Shin, C H Yun, S-H Im, K-T Kim, Y C Sung and K Y Choi

http://www.nature.com/onc/journal/v35/n27/abs/onc2015415a.html

Metabolic reprogramming of glioblastoma cells by L-asparaginase sensitizes for apoptosis in vitro and in vivo

Georg Karpel-Massler, Doruntina Ramani, Chang Shu, Marc-Eric Halatsch, Mike-Andrew Westhoff, Jeffrey N. Bruce, Peter Canoll, and Markus D. Siegelin

http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5b%5d=9257

AMPK–SKP2–CARM1 signalling cascade in transcriptional regulation of autophagy

Hi-Jai R. Shin, Hyunkyung Kim, Sungryong Oh, Jun-Gi Lee, Minjung Kee, Hyun-Jeong Ko, Mi-Na Kweon, Kyoung-Jae Won, Sung Hee Baek

http://www.nature.com/nature/journal/v534/n7608/full/nature18014.html

PPAR-delta promotes survival of breast cancer cells in harsh metabolic conditions

X Wang, G Wang, Y Shi, L Sun, R Gorczynski, Y-J Li, Z Xu and D E Spaner

http://www.nature.com/oncsis/journal/v5/n6/abs/oncsis201641a.html

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AMPK / mTOR

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AMPK Facilitates Nuclear Accumulation of Nrf2 by Phosphorylating at Serine 550

Min Sung Joo, Won Dong Kim, Ki Young Lee, Ji Hyun Kim, Ja Hyun Koo, and Sang Geon Kim

http://mcb.asm.org/content/36/14/1931.abstract?etoc

Translation control during prolonged mTORC1 inhibition mediated by 4E-BP3

Yoshinori Tsukumo, Tommy Alain, Bruno D. Fonseca, Robert Nadon and Nahum Sonenberg

http://dx.doi.org/10.1038/ncomms11776

Proteomic analysis reveals GIT1 as a novel mTOR complex component critical for mediating astrocyte survival

Laura J. Smithson and David H. Gutmann

http://genesdev.cshlp.org/content/30/12/1383.abstract?etoc

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Anti-metabolic drugs

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Targeting One Carbon Metabolism with an Antimetabolite Disrupts Pyrimidine Homeostasis and Induces Nucleotide Overflow

Zheng Ser, Xia Gao, Christelle Johnson, Mahya Mehrmohamadi, Xiaojing Liu, Siqi Li, Jason W. Locasale

http://www.cell.com/cell-reports/fulltext/S2211-1247(16)30618-0

Mitochondria-Targeted Analogues of Metformin Exhibit Enhanced Antiproliferative and Radiosensitizing Effects in Pancreatic Cancer Cells

Gang Cheng, Jacek Zielonka, Olivier Ouari, Marcos Lopez, Donna McAllister, Kathleen Boyle, Christy S. Barrios, James J. Weber, Bryon D. Johnson, Micael Hardy, Michael B. Dwinell, and Balaraman Kalyanaraman

http://cancerres.aacrjournals.org/content/76/13/3904.abstract?etoc

Metformin combined with sodium dichloroacetate promotes B leukemic cell death by suppressing anti-apoptotic protein Mcl-1

Rebecca Voltan, Erika Rimondi, Elisabetta Melloni, Paola Gilli, Valerio Bertolasi, Fabio Casciano, Gian Matteo Rigolin, Giorgio Zauli, Paola Secchiero

http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=7879&pubmed-linkout=1

Metabolic targeting of oncogene MYC by selective activation of the proton-coupled monocarboxylate family of transporters

L Gan, R Xiu, P Ren, M Yue, H Su, G Guo, D Xiao, J Yu, H Jiang, H Liu, G Hu and G Qing

http://www.nature.com/onc/journal/v35/n23/abs/onc2015360a.html

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Colorectal cancer

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Oncogenic KRAS and BRAF drive metabolic reprogramming in colorectal cancer

Josiah E. Hutton, Xiaojing Wang, Lisa J. Zimmerman, Robbert J.C. Slebos, Irina A. Trenary, Jamey D. Young, Ming Li and Daniel C. Liebler

http://m.mcponline.org/content/early/2016/06/23/mcp.M116.058925.short

PAT4 levels control amino-acid sensitivity of rapamycin-resistant mTORC1 from the Golgi and affect clinical outcome in colorectal cancer

S-J Fan, C Snell, H Turley, J-L Li, R McCormick, S M W Perera, S Heublein, S Kazi, A Azad, C Wilson, A L Harris and D C I Goberdhan

http://www.nature.com/onc/journal/v35/n23/abs/onc2015363a.html

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Miscellaneous

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A Supplemented High-Fat Low-Carbohydrate Diet for the Treatment of Glioblastoma

Regina T. Martuscello, Vinata Vedam-Mai, David J. McCarthy, Michael E. Schmoll, Musa A. Jundi, Christopher D. Louviere, Benjamin G. Griffith, Colby L. Skinner, Oleg Suslov,Loic P. Deleyrolle, Brent A. Reynolds

http://clincancerres.aacrjournals.org/content/22/10/2482.long

Fast exchange fluxes around the pyruvate node: a leaky cell model to explain the gain and loss of unlabelled and labelled metabolites in a tracer experiment

Quek L, Liu M, Joshi S, Turner N

http://www.cancerandmetabolism.com/content/4/1/13/abstract

Excessive fatty acid oxidation induces muscle atrophy in cancer cachexia

Tomoya Fukawa, Benjamin Chua Yan-Jiang, Jason Chua Min-Wen, Elwin Tan Jun-Hao, Dan Huang et al.

http://www.nature.com/nm/journal/v22/n6/full/nm.4093.html

p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming

Tetsuya Saito, Yoshinobu Ichimura, Keiko Taguchi, Takafumi Suzuki, Tsunehiro Mizushima, Kenji Takagi, Yuki Hirose, Masayuki Nagahashi, Tetsuro Iso, Toshiaki Fukutomi, Maki Ohishi, Keiko Endo, Takefumi Uemura, Yasumasa Nishito, Shujiro Okuda, Miki Obata, Tsuguka Kouno, Riyo Imamura, Yukio Tada, Rika Obata et al.

http://www.nature.com/ncomms/2016/160627/ncomms12030/full/ncomms12030.html

Isocitrate Dehydrogenase Mutations Confer Dasatinib Hypersensitivity and SRC Dependence in Intrahepatic Cholangiocarcinoma

Supriya K. Saha, John D. Gordan, Benjamin P. Kleinstiver, Phuong Vu, Mortada S. Najem, Jia-Chi Yeo, Lei Shi, Yasutaka Kato, Rebecca S. Levin, James T. Webber, Leah J. Damon, Regina K. Egan, Patricia Greninger, Ultan McDermott, Mathew J. Garnett, Roger L. Jenkins, Kimberly M. Rieger-Christ, Travis B. Sullivan, Aram F. Hezel, Andrew S. Liss, Yusuke Mizukami, Lipika Goyal, Cristina R. Ferrone, Andrew X. Zhu, J. Keith Joung, Kevan M. Shokat, Cyril H. Benes, and Nabeel Bardeesy

http://cancerdiscovery.aacrjournals.org/content/6/7/727.abstract?etoc

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Reviews

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Sestrin regulation of TORC1: Is Sestrin a leucine sensor?

Jun Hee Lee , Uhn-Soo Cho, Michael Karin

http://stke.sciencemag.org/content/9/431/re5

Metabolomics: beyond biomarkers and towards mechanisms

Caroline H. Johnson, Julijana Ivanisevic & Gary Siuzdak

http://www.nature.com/nrm/journal/v17/n7/abs/nrm.2016.25.html?lang=en

Regulatory principles in metabolism–then and now

Rui Curi, Philip Newsholme, Gabriel Nasri Marzuca-Nassr, Hilton Kenji Takahashi, Sandro Massao Hirabara, Vinicius Cruzat, Mauricio Krause, Paulo Ivo Homem de Bittencourt Jr

http://www.biochemj.org/content/473/13/1845

ROS homeostasis and metabolism: a dangerous liason in cancer cells

E Panieri and M M Santoro

http://www.nature.com/cddis/journal/v7/n6/abs/cddis2016105a.html

Metabolism in cancer metastasis

Georg F. Weber

http://onlinelibrary.wiley.com/doi/10.1002/ijc.29839/abstract

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Comments / other

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Proliferating Cells Conserve Nitrogen to Support Growth

Ralph J. DeBerardinis