MetaboList - March 2015

[Muñoz Pinedo, Cristina]

Regards,

Cristina

 

 

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Cancer Metabolism

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Metabolic Reprogramming of Cancer-Associated Fibroblasts by IDH3α Downregulation

Daoxiang Zhang, Yongbin Wang, Zhimin Shi, Jingyi Liu, Pan Sun, Xiaodan Hou, Jian Zhang, Shimin Zhao, Binhua P. Zhou, Jun Mi

http://www.cell.com/cell-reports/abstract/S2211-1247(15)00133-3

 

Mutant IDH is sufficient to initiate enchondromatosis in mice 

Makoto Hirata, Masato Sasaki, Rob A. Cairns, Satoshi Inoue, Vijitha Puviindran, Wanda Y. Li, Bryan E. Snow, Lisa D. Jones, Qingxia Wei, Shingo Sato, Yuning J. Tang, Puviindran Nadesan, Jason Rockel, Heather Whetstone, Raymond Poon, Angela Weng, Stefan Gross, Kimberly Straley, Camelia Gliser, Yingxia Xu, Jay Wunder, Tak W. Mak, and Benjamin A. Alman

http://www.pnas.org/content/112/9/2829.abstract.html?etoc

 

Delivery-Corrected Imaging of Fluorescently-Labeled Glucose Reveals Distinct Metabolic Phenotypes in Murine Breast Cancer

Amy E. Frees, Narasimhan Rajaram, Samuel S. McCachren, Andrew N. Fontanella, Mark W. Dewhirst, Nimmi Ramanujam

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0115529

 

Switching of Pyruvate Kinase Isoform L to M2 Promotes Metabolic Reprogramming in Hepatocarcinogenesis

Carmen Chak-Lui Wong, Sandy Leung-Kuen Au, Aki Pui-Wah Tse, Iris Ming-Jing Xu, Robin Kit-Ho Lai, David Kung-Chun Chiu, Larry Lai Wei, Dorothy Ngo-Yin Fan, Felice Ho-Ching Tsang, Regina Cheuk-Lam Lo, Chun-Ming Wong, Irene Oi-Lin Ng

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0115036

 

Metabolic Phenotypes in Pancreatic Cancer

Min Yu, Quanbo Zhou, Yu Zhou, Zhiqiang Fu, Langping Tan, Xiao Ye, Bing Zeng, Wenchao Gao, Jiajia Zhou, Yimin Liu, Zhihua Li, Ye Lin, Qing Lin, Rufu Chen

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0115153

 

Differential Expression of Lipid Metabolism-Related Proteins in Different Breast Cancer Subtypes

Sewha Kim, YuKyung Lee, Ja Seung Koo

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0119473

 

AML cells have low spare reserve capacity in their respiratory chain that renders them susceptible to oxidative metabolic stress

Shrivani Sriskanthadevan, Danny V. Jeyaraju, Timothy E. Chung, Swayam Prabha, Wei Xu, Marko Skrtic, Bozhena Jhas, Rose Hurren, Marcela Gronda, Xiaoming Wang, Yulia Jitkova, Mahadeo A. Sukhai, Feng-Hsu Lin, Neil Maclean, Rob Laister, Carolyn A. Goard, Peter J. Mullen, Stephanie Xie, Linda Z. Penn, Ian M. Rogers, John E. Dick, Mark D. Minden, and Aaron D. Schimmer

http://bloodjournal.org/content/125/13/2120.abstract?etoc

 

The anticancer gene ORCTL3 targets stearoyl-CoA desaturase-1 for tumour-specific apoptosis

G AbuAli, W Chaisaklert, E Stelloo, E Pazarentzos, M-S Hwang, D Qize, S V Harding, A Al-Rubaish, A J Alzahrani, A Al-Ali, T A B Sanders, E O Aboagye and S Grimm

http://www.nature.com/onc/journal/v34/n13/abs/onc201493a.html

 

Myc and Ras oncogenes engage different energy metabolism programs and evoke distinct patterns of oxidative and DNA replication stress.

Maya-Mendoza A, Ostrakova J, Kosar M, Hall A, Duskova P, Mistrik M, Merchut-Maya JM, Hodny Z, Bartkova J, Christensen C, Bartek J

http://www.moloncol.org/article/S1574-7891(14)00266-X/abstract

 

Large-scale profiling of metabolic dysregulation in ovarian cancer.

Ke C, Hou Y, Zhang H, Fan L, Ge T, Guo B, Zhang F, Yang K, Wang J, Lou G, Li K

http://onlinelibrary.wiley.com/doi/10.1002/ijc.29010/abstract

 

 

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Crosstalk cell death / metabolism

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Effect of Polyunsaturated Fatty Acids and Their Metabolites on Bleomycin-Induced Cytotoxic Action on Human Neuroblastoma Cells In Vitro

Sailaja Polavarapu, Arul M. Mani, Naveen K. V. Gundala, Anasuya D. Hari, Siresha Bathina, Undurti N. Das

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0114766

 

Phospho-BAD BH3 Mimicry Protects β Cells and Restores Functional β Cell Mass in Diabetes

Sanda Ljubicic, Klaudia Polak, Accalia Fu, Jessica Wiwczar, Benjamin Szlyk, Yigang Chang, Juan C. Alvarez-Perez, Gregory H. Bird, Loren D. Walensky, Adolfo Garcia-Ocaña, Nika N. Danial

http://www.cell.com/cell-reports/abstract/S2211-1247(14)01123-1

 

Inhibition of Stat3 suppresses caspase-3 and the ubiquitin-proteasome system leading to preservation of muscle mass in cancer cachexia

Kleiton Augusto Santos Silva, Jiangling Dong, Yanjun Dong, Yanlan Dong, Nestor Schor, David J. Tweardy, Liping Zhang, and William E. Mitch

http://www.jbc.org/content/early/2015/03/18/jbc.M115.641514.abstract

 

 

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Starvation

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Fatty Acid Trafficking in Starved Cells: Regulation by Lipid Droplet Lipolysis, Autophagy, and Mitochondrial Fusion Dynamics

Angelika S. Rambold, Sarah Cohen, Jennifer Lippincott-Schwartz

http://www.cell.com/developmental-cell/abstract/S1534-5807(15)00072-6

 

Up-regulation of lysosomal TRPML1 channels is essential for lysosomal adaptation to nutrient starvation

Wuyang Wang, Qiong Gao, Meimei Yang, Xiaoli Zhang, Lu Yu, Maria Lawas, Xinran Li, Marthe Bryant-Genevier, Noel T. Southall, Juan Marugan, Marc Ferrer, and Haoxing Xu

http://www.pnas.org/content/112/11/E1373.abstract.html?etoc

 

Starvation Promotes REV1 SUMOylation and p53-Dependent Sensitization of Melanoma and Breast Cancer Cells

Hong Seok Shim, Min Wei, Sebastian Brandhorst, and Valter D. Longo

http://cancerres.aacrjournals.org/content/75/6/1056.abstract?etoc

 

Skp2-Dependent Ubiquitination and Activation of LKB1 Is Essential for Cancer Cell Survival under Energy Stress

Szu-Wei Lee, Chien-Feng Li, Guoxiang Jin, Zhen Cai, Fei Han, Chia-Hsin Chan, Wei-Lei Yang, Bin-Kui Li, Abdol Hossein Rezaeian, Hong-Yu Li, Hsuan-Ying Huang, Hui-Kuan Lin

http://www.cell.com/molecular-cell/abstract/S1097-2765(15)00016-7

 

 

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AMPK / mTOR

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Dynamic Visualization of mTORC1 Activity in Living Cells

Xin Zhou, Terri L. Clister, Pamela R. Lowry, Marcus M. Seldin, G. William Wong, Jin Zhang

http://www.cell.com/cell-reports/abstract/S2211-1247(15)00177-1

 

AMPK modulates Hippo pathway activity to regulate energy homeostasis  

Wenqi Wang, Zhen-Dong Xiao, Xu Li, Kathryn E. Aziz, Boyi Gan, Randy L. Johnson & Junjie Chen

http://www.nature.com/ncb/journal/v17/n4/full/ncb3113.html?WT.ec_id=NCB-201504

 

Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway  

Jung-Soon Mo, Zhipeng Meng, Young Chul Kim, Hyun Woo Park, Carsten Gram Hansen, Soohyun Kim, Dae-Sik Lim & Kun-Liang Guan

http://www.nature.com/ncb/journal/v17/n4/full/ncb3111.html?WT.ec_id=NCB-201504

 

NFκB up-regulation of glucose transporter 3 is essential for hyperactive mammalian target of rapamycin-induced aerobic glycolysis and tumor growth

Xiaojun Zha,Zhongdong Hu,Shuang Ji1,Fuquan Jin,Keguo Jiang,Chunjia Li,Pan Zhao,Zhenzhen Tu,Xianguo Chen,

Lijun Di,Haisheng Zhou,Hongbing Zhang

http://www.cancerletters.info/article/S0304-3835%2815%2900017-8/abstract

 

Stabilization of LKB1 and Akt by neddylation regulates energy metabolism in liver cancer.

Barbier-Torres L1, Delgado TC1, García-Rodríguez JL1, Zubiete-Franco I1, Fernández-Ramos D1, Buqué X2, Cano A3, Gutiérrez-de Juan V1, Fernández-Domínguez I1, Lopitz-Otsoa F1, Fernández-Tussy P1, Boix L4,5, Bruix J4,5, Villa E6, Castro A3, Lu SC7, Aspichueta P2, Xirodimas D8, Varela-Rey M1, Mato JM1, Beraza N1, Martínez-Chantar ML1.

http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=3191

 

 

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Anti-metabolic drugs

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Apoptotic Efficacy of Etomoxir in Human Acute Myeloid Leukemia Cells. Cooperation with Arsenic Trioxide and Glycolytic Inhibitors, and Regulation by Oxidative Stress and Protein Kinase Activities

María Cristina Estañ, Eva Calviño, Susana Calvo, Beatriz Guillén-Guío, María del Carmen Boyano-Adánez, Elena de Blas, Eduardo Rial, Patricio Aller

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0115250

 

Glycolytic Switch in Response to Betulinic Acid in Non-Cancer Cells

Elke H. Heiss, Matthias P. Kramer, Atanas G. Atanasov, Hortenzia Beres, Daniel Schachner, Verena M. Dirsch

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0115683

 

 

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Hypoxia

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Increased metabolites of 5-lipoxygenase from hypoxic ovarian cancer cells promote tumor-associated macrophage infiltration

Z Wen, H Liu, M Li, B Li, W Gao, Q Shao, B Fan, F Zhao, Q Wang, Q Xie, Y Yang, J Yu and X Qu

http://www.nature.com/onc/journal/v34/n10/abs/onc201485a.html

 

SIRT2 regulates tumour hypoxia response by promoting HIF-1α hydroxylation

K-S Seo, J-H Park, J-Y Heo, K Jing, J Han, K-N Min, C Kim, G Y Koh, K Lim, G-Y Kang, J Uee Lee, Y-H Yim, M Shong, T-H Kwak and G R Kweon

http://www.nature.com/onc/journal/v34/n11/abs/onc201476a.html?WT.ec_id=ONC-201503

 

c-Myc-mediated repression of miR-15-16 in hypoxia is induced by increased HIF-2α and promotes tumor angiogenesis and metastasis by upregulating FGF2

G Xue, H-L Yan, Y Zhang, L-Q Hao, X-T Zhu, Q Mei and S-H Sun

http://www.nature.com/onc/journal/v34/n11/abs/onc201482a.html?WT.ec_id=ONC-201503

 

 

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Miscellaneous

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Tetracyclines Disturb Mitochondrial Function across Eukaryotic Models: A Call for Caution in Biomedical Research

Norman Moullan, Laurent Mouchiroud, Xu Wang, Dongryeol Ryu, Evan G. Williams, Adrienne Mottis, Virginija Jovaisaite, Michael V. Frochaux, Pedro M. Quiros, Bart Deplancke, Riekelt H. Houtkooper, Johan Auwerx

http://www.cell.com/cell-reports/abstract/S2211-1247(15)00180-1

 

Regulation of Glutamine Carrier Proteins by RNF5 Determines Breast Cancer Response to ER Stress-Inducing Chemotherapies

Young Joo Jeon, Sihem Khelifa, Boris Ratnikov, David A. Scott, Yongmei Feng, Fabio Parisi, Chelsea Ruller, Eric Lau, Hyungsoo Kim, Laurence M. Brill, Tingting Jiang, David L. Rimm, Robert D. Cardiff, Gordon B. Mills, Jeffrey W. Smith, Andrei L. Osterman, Yuval Kluger, Ze’ev A. Ronai

http://www.cell.com/cancer-cell/abstract/S1535-6108(15)00056-2

 

Brief Report: Maintenance of mouse hematopoietic stem cells ex vivo by reprogramming cellular metabolism

Xia Liu, Hong Zheng, Wen-Mei Yu, Todd M. Cooper, Kevin D. Bunting, and Cheng-Kui Qu

http://bloodjournal.org/content/125/10/1562.abstract?etoc

 

Metabolomics Evaluation of Serum Markers for Cachexia and Their Intra-Day Variation in Patients with Advanced Pancreatic Cancer

Yutaka Fujiwara, Takashi Kobayashi, Naoko Chayahara, Yoshinori Imamura, Masanori Toyoda, Naomi Kiyota, Toru Mukohara, Shin Nishiumi, Takeshi Azuma, Masaru Yoshida, Hironobu Minami

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0113259

 

Role of 2-[18F] Fluoro-2-Deoxy-D-Glucose-Positron Emission Tomography/Computed Tomography in the Post-Therapy Surveillance of Breast Cancer

Hong-Tai Chang, Chin Hu, Yu-Li Chiu, Nan-Jing Peng, Ren-Shyan Liu

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0115127

 

 

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Reviews

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Metabolic pathways promoting cancer cell survival and growth  

Lindsey K. Boroughs and Ralph J. DeBerardinis

http://www.nature.com/ncb/journal/v17/n4/full/ncb3124.html

 

Nutrient-Sensing Mechanisms across Evolution

Lynne Chantranupong, Rachel L. Wolfson, David M. Sabatini

http://www.cell.com/cell/abstract/S0092-8674(15)00242-1

 

Regulation of mitochondrial nutrient and energy metabolism by BCL-2 family proteins

Alfredo Giménez-Cassina, Nika N. Danial

http://www.cell.com/trends/endocrinology-metabolism/abstract/S1043-2760(15)00027-2

 

Molecular drivers of cellular metabolic reprogramming in melanoma

Cecilie Abildgaard, Per Guldberg

http://www.cell.com/trends/molecular-medicine/abstract/S1471-4914(14)00224-X

 

T cell metabolic fitness in antitumor immunity.

Siska PJ, Rathmell JC.

http://www.cell.com/trends/immunology/abstract/S1471-4906(15)00038-1

 

PI3K at the crossroads of tumor angiogenesis signaling pathways

Adriana Soler, Ana Angulo-Urarte & Mariona Graupera

http://www.tandfonline.com/doi/abs/10.4161/23723556.2014.975624?ai=1gumh&ui=79l0u&af=T

 

Molecular mechanisms of mTOR regulation by stress

Alexander Martin Heberle, Mirja Tamara Prentzell, Karen van Eunen, Barbara Marleen Bakker, Sushma Nagaraja Grellscheid & Kathrin Thedieck

http://www.tandfonline.com/doi/abs/10.4161/23723548.2014.970489?ai=1gumh&ui=79l0u&af=T

 

Current Opinion in Cell Biology special issue

http://www.sciencedirect.com/science/journal/09550674/33/supp/C

Editorial overview: Cell regulation: Cell biology, fueling a renaissance in metabolism   

Jodi Nunnari, Johan Auwerx

 

Including:

- AMPK: positive and negative regulation, and its role in whole-body energy homeostasis  

D Grahame Hardie

- ROS-dependent signal transduction  

Colleen R Reczek, Navdeep S Chandel

- Hexosamine pathway and (ER) protein quality control  

Martin S Denzel, Adam Antebi

- Cell cycle regulation of mitochondrial function  

Isabel C Lopez-Mejia, Lluis Fajas

- Molecular basis for the regulation of the nuclear receptor LRH-1  

Sokrates Stein, Kristina Schoonjans

- Mitochondrial pyruvate import and its effects on homeostasis  

Benoit Vanderperre, Tom Bender, Edmund RS Kunji, Jean-Claude Martinou

- Metabolic control via the mitochondrial protein import machinery  

Magdalena Opalinska, Chris Meisinger

- PPARs and ERRs: molecular mediators of mitochondrial metabolism

Weiwei Fan, Ronald Evans

- mTOR signaling in cellular and organismal energetics  

Verena Albert, Michael N Hall

- Lipid-dependent regulation of the unfolded protein response  

Romain Volmer, David Ron

- The mitochondrial unfolded protein response — synchronizing genomes  

Virginija Jovaisaite, Johan Auwerx

- Membrane contact sites, gateways for lipid homeostasis  

Sujoy Lahiri, Alexandre Toulmay, William A Prinz

- Epigenetic modulation of metabolic decisions  

Anita Ost, John Andrew Pospisilik

- PINK1/Parkin-mediated mitophagy in mammalian cells  

Akinori Eiyama, Koji Okamoto

- Endocrine aspects of organelle stress — cell non-autonomous signaling of mitochondria and the ER  

Robert Schinzel, Andrew Dillin

- Mitochondrial division and fusion in metabolism  

Madhuparna Roy, P Hemachandra Reddy, Miho Iijima, Hiromi Sesaki

- The life cycle of lipid droplets

Hayaa F Hashemi, Joel M Goodman

- Acetyl-CoA and the regulation of metabolism: mechanisms and consequences  

Lei Shi, Benjamin P Tu 

 

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Comments

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Eat this, not that! How selective autophagy helps cancer cells survive

Robin Mathew & Eileen White

http://www.tandfonline.com/doi/abs/10.4161/23723556.2014.975638?ai=1gumh&ui=79l0u&af=T

   

The GLU that Holds Cancer Together: Targeting GLUtamine Transporters in Breast Cancer

Michael A. Moses, Len Neckers 

http://www.cell.com/cancer-cell/abstract/S1535-6108(15)00060-4

 

IDH1/2 Mutations and BCL-2 Dependence: An Unexpected Chink in AML’s Armour

Elodie Pronier, Ross L. Levine

http://www.cell.com/cancer-cell/abstract/S1535-6108(15)00063-X

 

Autophagy: Starvation Relieves Transcriptional Repression of ATG Genes

Rodney J. Devenish, Mark Prescott

http://www.cell.com/current-biology/abstract/S0960-9822(15)00077-9

 

WWOX loss activates aerobic glycolysis

Muhannad Abu-Remaileh, Victoria L Seewaldt & Rami I Aqeilane965640

http://www.tandfonline.com/doi/abs/10.4161/23723548.2014.965640

 

Harnessing the nuclear receptor PPARγ to inhibit the growth of lung adenocarcinoma by rewiring metabolic circuitries

Paul Yenerall & Ralf Kittler

http://www.tandfonline.com/doi/abs/10.4161/23723556.2014.980660?ai=1gumh&ui=79l0u&af=T

 

Energy stress tames the Hippo pathway  

Iswar K. Hariharan

http://www.nature.com/ncb/journal/v17/n4/full/ncb3141.html?WT.ec_id=NCB-201504

 

Lipid metabolism: Fatty acids on the move

http://www.nature.com/nrm/journal/v16/n4/full/nrm3972.html

 

BCL2 Is Synthetic Lethal to IDH1/2 Mutations in AML

http://cancerdiscovery.aacrjournals.org/content/5/3/223.1.abstract?etoc

 

MONDOA Is Required for MYC-Driven Metabolic Changes

http://cancerdiscovery.aacrjournals.org/content/5/3/226.2.abstract?etoc

 

Acetyl-CoA Synthetase 2 Confers a Growth Advantage under Metabolic Stress

http://cancerdiscovery.aacrjournals.org/content/5/3/OF10.abstract?etoc

 

Extracellular Metabolism Drives Tumor Cell Survival at Metastatic Sites

http://cancerdiscovery.aacrjournals.org/content/5/3/OF11.abstract?etoc

 

 

 

 

Cristina Muñoz-Pinedo Cell Death Regulation Group IDIBELL - Hospital Duran i Reynals 3a planta Gran Via de l'Hospitalet, 199 08908 L'Hospitalet de Llobregat Barcelona – Spain   phone +34 93 260 7130 cmu...@idibell.cat    www.apoptosis.es www.cancer-metabolism.org idibell.cat/modul/cell-death-regulation/en   Avís legal - Aviso legal - Legal notice