RV: MetaboList - October 2014

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Muñoz Pinedo, Cristina

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Oct 31, 2014, 3:05:07 PM10/31/14

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Regards,

Cristina

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Cancer metabolism

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PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis

Valerie S. LeBleu, Joyce T. O’Connell, Karina N. Gonzalez Herrera, Harriet Wikman, Klaus Pantel, Marcia C. Haigis, Fernanda Machado de Carvalho, Aline Damascena, Ludmilla Thome Domingos Chinen, Rafael M. Rocha, John M. Asara & Raghu Kalluri

http://www.nature.com/ncb/journal/v16/n10/full/ncb3039.html?WT.ec_id=NCB-201410

The SIRT1/HIF2α Axis Drives Reductive Glutamine Metabolism under Chronic Acidosis and Alters Tumor Response to Therapy

Cyril Corbet, Nihed Draoui, Florence Polet, Adan Pinto, Xavier Drozak, Olivier Riant, and Olivier Feron

http://cancerres.aacrjournals.org/content/74/19/5507.abstract?etoc

p73 regulates serine biosynthesis in cancer

I Amelio, E K Markert, A Rufini, A V Antonov, B S Sayan, P Tucci, M Agostini, T C Mineo, A J Levine and G Melino

http://www.nature.com/onc/journal/v33/n42/abs/onc2013456a.html?WT.ec_id=ONC-201410

Lin28/let-7 axis regulates aerobic glycolysis and cancer progression via PDK1

Xiaoyu Ma, Chenchen Li, Linchong Sun, De Huang, Tingting Li, Xiaoping He, Gongwei Wu, Zheng Yang, Xiuying Zhong, Libing Song, Ping Gao and Huafeng Zhang

http://www.nature.com/ncomms/2014/141010/ncomms6212/full/ncomms6212.html?WT.ec_id=NCOMMS-20141015

Metabolic Vulnerabilities in Endometrial Cancer

Frances L. Byrne, Ivan K.H. Poon, Susan C. Modesitt, Jose L. Tomsig, Jenny D.Y. Chow, Marin E. Healy, William D. Baker, Kristen A. Atkins, Johnathan M. Lancaster, Douglas C. Marchion, Kelle H. Moley, Kodi S. Ravichandran, Jill K. Slack-Davis, and Kyle L. Hoehn

http://cancerres.aacrjournals.org/content/74/20/5832.abstract?etoc

Colorectal Cancer Detection Using Targeted Serum Metabolic Profiling

Jiangjiang Zhu, Danijel Djukovic, Lingli Deng, Haiwei Gu, Farhan Himmati, E. Gabriela Chiorean, and Daniel Raftery

http://pubs.acs.org/doi/abs/10.1021/pr500494u

Glioma Cells with the IDH1 Mutation Modulate Metabolic Fractional Flux through Pyruvate Carboxylase

Jose L. Izquierdo-Garcia, Larry M. Cai, Myriam M. Chaumeil, Pia Eriksson, Aaron E. Robinson, Russell O. Pieper, Joanna J. Phillips, Sabrina M. Ronen

http://www.plosone.org/article/info:doi/10.1371/journal.pone.0108289

Ovarian tumor-initiating cells display a flexible metabolism

Angela S. Anderson, Paul C. Roberts, Madlyn I. Frisard, Matthew W. Hulver

http://www.sciencedirect.com/science/article/pii/S0014482714003668

Role of pyruvate kinase M2 in transcriptional regulation leading to epithelial–mesenchymal transition

Atsushi Hamabe, Masamitsu Konno, Nobuhiro Tanuma, Hiroshi Shima, Kenta Tsunekuni, Koichi Kawamoto, Naohiro Nishida, Jun Koseki, Koshi Mimori, Noriko Gotoh, Hirofumi Yamamoto, Yuichiro Doki, Masaki Mori, and Hideshi Ishii

http://www.pnas.org/content/111/43/15526.abstract.html?etoc

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Anti-metabolic drugs

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Inhibition of Cancer Cell Proliferation by PPARγ Is Mediated by a Metabolic Switch that Increases Reactive Oxygen Species Levels

Nishi Srivastava, Rahul K. Kollipara, Dinesh K. Singh, Jessica Sudderth, Zeping Hu, Hien Nguyen, Shan Wang, Caroline G. Humphries, Ryan Carstens, Kenneth E. Huffman, Ralph J. DeBerardinis, Ralf Kittler

http://www.cell.com/cell-metabolism/abstract/S1550-4131(14)00369-6?elsca1=etoc&elsca2=email&elsca3=1550-4131_20141007_20_4_&elsca4=Cell%20Press

Enhanced Antitumor Immunity Contributes to the Radio-Sensitization of Ehrlich Ascites Tumor by the Glycolytic Inhibitor 2-Deoxy-D-Glucose in Mice

Abdullah Farooque, Niharika Singh, Jawahar Singh Adhikari, Farhat Afrin, Bilikere Srinivasa Rao Dwarakanath

http://www.plosone.org/article/info:doi/10.1371/journal.pone.0108131

Depletion of the central metabolite NAD leads to oncosis mediated cell death

Christopher Del Nagro, Yang Xiao, Linda Rangell, Mike Reichelt, and Thomas O'Brien

http://www.jbc.org/content/early/2014/10/29/jbc.M114.580159.abstract

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Starvation

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Asparagine Plays a Critical Role in Regulating Cellular Adaptation to Glutamine Depletion

Ji Zhang, Jing Fan, Sriram Venneti, Justin R. Cross, Toshimitsu Takagi, Bhavneet Bhinder, Hakim Djaballah, Masayuki Kanai, Emily H. Cheng, Alexander R. Judkins, Bruce Pawel, Julie Baggs, Sara Cherry, Joshua D. Rabinowitz, Craig B. Thompson

http://www.cell.com/molecular-cell/abstract/S1097-2765(14)00673-X

The Sestrins Interact with GATOR2 to Negatively Regulate the Amino-Acid-Sensing Pathway Upstream of mTORC1

Lynne Chantranupong, Rachel L. Wolfson, Jose M. Orozco, Robert A. Saxton, Sonia M. Scaria, Liron Bar-Peled, Eric Spooner, Marta Isasa, Steven P. Gygi, David M. Sabatini

http://www.cell.com/cell-reports/abstract/S2211-1247(14)00782-7?elsca1=etoc&elsca2=email&elsca3=2211-1247_20141009_9_1_&elsca4=Cell%20Press

Rapid Glucose Depletion Immobilizes Active Myosin V on Stabilized Actin Cables

Li Xu, Anthony Bretscher

http://www.cell.com/current-biology/abstract/S0960-9822(14)01137-3?elsca1=etoc&elsca2=email&elsca3=0960-9822_20141020_24_20_&elsca4=Cell%20Press

Let-7 Coordinately Suppresses Components of the Amino Acid Sensing Pathway to Repress mTORC1 and Induce Autophagy

Amy N. Dubinsky, Somasish Ghosh Dastidar, Cynthia L. Hsu, Rabaab Zahra, Stevan N. Djakovic, Sonia Duarte, Christine C. Esau, Brian Spencer, Travis D. Ashe, Kimberlee M. Fischer, Deidre A. MacKenna, Bryce L. Sopher, Eliezer Masliah, Terry Gaasterland, B. Nelson Chau, Luis Pereira de Almeida, Bradley E. Morrison, Albert R. La Spada

http://www.cell.com/cell-metabolism/abstract/S1550-4131(14)00398-2

SKN-1 and Nrf2 couples proline catabolism with lipid metabolism during nutrient deprivation

Shanshan Pang, Dana A. Lynn, Jacqueline Y. Lo, Jennifer Paek and Sean P. Curran

http://www.nature.com/ncomms/2014/141006/ncomms6048/full/ncomms6048.html?WT.ec_id=NCOMMS-20141008

An endocytosis pathway initiated through neuropilin-1 and regulated by nutrient availability

Hong-Bo Pang, Gary B. Braun, Tomas Friman, Pedro Aza-Blanc, Manuel E. Ruidiaz, Kazuki N. Sugahara, Tambet Teesalu and Erkki Ruoslahti

http://www.nature.com/ncomms/2014/141003/ncomms5904/full/ncomms5904.html?WT.ec_id=NCOMMS-20141008

Molecular Basis for the Ribosome Functioning as an L-Tryptophan Sensor

Lukas Bischoff, Otto Berninghausen, Roland Beckmann

http://www.cell.com/cell-reports/abstract/S2211-1247(14)00779-7

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AMPK / mTOR

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The mTORC1/S6K1 Pathway Regulates Glutamine Metabolism through the eIF4B-Dependent Control of c-Myc Translation

Alfredo Csibi, Gina Lee, Sang-Oh Yoon, Haoxuan Tong, Didem Ilter, Ilaria Elia, Sarah-Maria Fendt, Thomas M. Roberts, John Blenis

http://www.sciencedirect.com/science/article/pii/S0960982214009853

Regulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex

Ning Liang, Chi Zhang, Patricia Dill, Ganna Panasyuk, Delphine Pion, Vonda Koka, Morgan Gallazzini, Eric N. Olson, Hilaire Lam, Elizabeth P. Henske, Zheng Dong, Udayan Apte, Nicolas Pallet, Randy L. Johnson, Fabiola Terzi, David J. Kwiatkowski, Jean-Yves Scoazec, Guido Martignoni, and Mario Pende

http://jem.rupress.org/content/211/11/2249?etoc

Energy Stress Regulates Hippo-YAP Signaling Involving AMPK-Mediated Regulation of Angiomotin-like 1 Protein

Michael DeRan, Jiayi Yang, Che-Hung Shen, Eric C. Peters, Julien Fitamant, Puiyee Chan, Mindy Hsieh, Shunying Zhu, John M. Asara, Bin Zheng, Nabeel Bardeesy, Jun Liu, Xu Wu

http://www.cell.com/cell-reports/abstract/S2211-1247(14)00819-5?elsca1=etoc&elsca2=email&elsca3=2211-1247_20141023_9_2_&elsca4=Cell%20Press

AMP-activated protein kinase mediates the antioxidant effects of resveratrol through regulation of the transcription factor FoxO1

Hee Yun, Seolhui Park, Min-Jung Kim, Woo Kyeom Yang, Dong Uk Im, Ki Ryeol Yang, Jongki Hong, Wonchae Choe, Insug Kang, Sung Soo Kim and Joohun Ha

http://onlinelibrary.wiley.com/doi/10.1111/febs.12949/abstract?campaign=woletoc

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Hypoxia, HIF-1

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Fatty Acid Uptake and Lipid Storage Induced by HIF-1α Contribute to Cell Growth and Survival after Hypoxia-Reoxygenation

Karim Bensaad, Elena Favaro, Caroline A. Lewis, Barrie Peck, Simon Lord, Jennifer M. Collins, Katherine E. Pinnick, Simon Wigfield, Francesca M. Buffa, Ji-Liang Li, Qifeng Zhang, Michael J.O. Wakelam, Fredrik Karpe, Almut Schulze, Adrian L. Harris

http://www.cell.com/cell-reports/abstract/S2211-1247(14)00732-3?elsca1=etoc&elsca2=email&elsca3=2211-1247_20141009_9_1_&elsca4=Cell%20Press

Tumor suppressor WWOX regulates glucose metabolism via HIF1α modulation

M Abu-Remaileh and R I Aqeilan

http://www.nature.com/cdd/journal/v21/n11/abs/cdd201495a.html?WT.ec_id=CDD-201411

Phosphorylation-dependent mitochondrial translocation of MAP4 is an early step in hypoxia-induced apoptosis in cardiomyocytes

J Hu, Z Chu, J Han, Q Zhang, D Zhang, Y Dang, J Ren, H C Chan, J Zhang and Y Huang

http://www.nature.com/cddis/journal/v5/n9/abs/cddis2014369a.html?WT.ec_id=CDDIS-201409

Investigating the contribution of the active site environment to the slow reaction of hypoxia-inducible factor prolyl hydroxylase domain 2 with oxygen

Hanna Tarhonskaya, Rasheduzzaman Chowdhury, Ivanhoe K. H. Leung, Nikita D. Loik, James S. O. McCullagh, Timothy D. W. Claridge, Christopher J. Schofield and Emily Flashman

http://www.biochemj.org/bj/463/bj4630363.htm

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Miscellaneous

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Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase

Ruzica Bago, Nazma Malik, Michael J. Munson, Alan R. Prescott, Paul Davies, Eeva Sommer, Natalia Shpiro, Richard Ward, Darren Cross, Ian G. Ganley and Dario R. Alessi

http://www.biochemj.org/bj/463/bj4630413.htm

Gluconeogenesis in cancer: Door wide open

Katharina Leithner, Andelko Hrzenjak, and Horst Olschewski

http://www.pnas.org/content/111/42/E4394.full

Reply to Leithner et al.: Focus on phopshoenolpyruvate carboxykinase (PEPCK): A target of the p53-SIRT6-FoxO1 axis

Zhiming Li and Wei-Guo Zhu

http://www.pnas.org/content/111/42/E4395.full

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Reviews

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Angiogenesis revisited – role and therapeutic potential of targeting endothelial metabolism

Peter Stapor, Xingwu Wang, Jermaine Goveia, Stijn Moens, and Peter Carmeliet