Muñoz Pinedo, Cristina
Regards,
Cristina
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Cancer Metabolism
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Structures of human phosphofructokinase-1 and atomic basis of cancer-associated mutations
Bradley A. Webb, Farhad Forouhar, Fu-En Szu, Jayaraman Seetharaman, Liang Tong & Diane L. Barber
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature14405.html
Aerobic glycolysis tunes YAP/TAZ transcriptional activity
Elena Enzo, Giulia Santinon, Arianna Pocaterra, Mariaceleste Aragona, Silvia Bresolin, Mattia Forcato, Daniela Grifoni, Annalisa Pession, Francesca Zanconato, Giulia Guzzo, Silvio Bicciato, and Sirio Dupont
http://EMBOJ.embopress.org/content/34/10/1349?etoc
MYC oncogene overexpression drives renal cell carcinoma in a mouse model through glutamine metabolism
Emelyn H. Shroff, Livia S. Eberlin, Vanessa M. Dang, Arvin M. Gouw, Meital Gabay, Stacey J. Adam, David I. Bellovin, Phuoc T. Tran, William M. Philbrick, Adolfo Garcia-Ocana, Stephanie C. Casey, Yulin Li, Chi V. Dang, Richard N. Zare, and Dean W. Felsher
http://www.pnas.org/content/112/21/6539.abstract.html?etoc
ATM Couples Replication Stress and Metabolic Reprogramming during Cellular Senescence
Katherine M. Aird, Andrew J. Worth, Nathaniel W. Snyder, Joyce V. Lee, Sharanya Sivanand, Qin Liu, Ian A. Blair, Kathryn E. Wellen, Rugang Zhang
http://www.cell.com/cell-reports/abstract/S2211-1247(15)00389-7
Brief Report: Stromal cell–mediated glycolytic switch in CLL cells involves Notch-c-Myc signaling
Regina Jitschin, Martina Braun, Mirjeta Qorraj, Domenica Saul, Katarina Le Blanc, Thorsten Zenz, and Dimitrios Mougiakakos
http://bloodjournal.org/content/125/22/3432.abstract?etoc
IDH2 and NPM1 Mutations Cooperate to Activate Hoxa9/Meis1 and Hypoxia Pathways in Acute Myeloid Leukemia
Yoko Ogawara, Takuo Katsumoto, Yukiko Aikawa, Yutaka Shima, Yuki Kagiyama, Tomoyoshi Soga, Hironori Matsunaga, Takahiko Seki, Kazushi Araki, and Issay Kitabayashi
http://cancerres.aacrjournals.org/content/75/10/2005.abstract?etoc
Metabolic Signature Identifies Novel Targets for Drug Resistance in Multiple Myeloma
Patricia Maiso, Daisy Huynh, Michele Moschetta, Antonio Sacco, Yosra Aljawai, Yuji Mishima, John M. Asara, Aldo M. Roccaro, Alec C. Kimmelman,and Irene M. Ghobrial
http://cancerres.aacrjournals.org/content/75/10/2071.abstract?etoc
Blocking anaplerotic entry of glutamine into the TCA cycle sensitizes K-Ras mutant cancer cells to cytotoxic drugs
M Saqcena, S Mukhopadhyay, C Hosny, A Alhamed, A Chatterjee and D A Foster
http://www.nature.com/onc/journal/v34/n20/abs/onc2014207a.html
Polymorphism in one-carbon metabolism pathway affects survival of gastric cancer patients: Large and comprehensive study
Zhao T, Gu D, Xu Z, Huo X, Shen L, Wang C, Tang Y, Wu P, He J, Gong W, He ML, Chen J
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=3259
cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions
Linchong Sun, Libing Song, Qianfen Wan, Gongwei Wu, Xinghua Li, Yinghui Wang, Jin Wang, Zhaoji Liu, Xiuying Zhong, Xiaoping He, Shengqi Shen, Xin Pan, Ailing Li, Yulan Wang, Ping Gao, Huiru Tang and Huafeng Zhang
http://www.nature.com/cr/journal/v25/n4/full/cr201533a.html
MACC1 supports human gastric cancer growth under metabolic stress by enhancing the Warburg effect
L Lin, H Huang, W Liao, H Ma, J Liu, L Wang, N Huang, Y Liao and W Liao
http://www.nature.com/onc/journal/v34/n21/abs/onc2014204a.html?WT.ec_id=ONC-201505
Analyses of the Transcriptome and Metabolome Demonstrate That HIF1α Mediates Altered Tumor Metabolism in Clear Cell Renal Cell Carcinoma
Denise R. Minton, Leiping Fu, Qiuying Chen, Brian D. Robinson, Steven S. Gross, David M. Nanus, Lorraine J. Gudas
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0120649
Comprehensive Analysis of Glycolytic Enzymes as Therapeutic Targets in the Treatment of Glioblastoma
Morgane Sanzey, Siti Aminah Abdul Rahim, Anais Oudin, Anne Dirkse, Tony Kaoma, Laurent Vallar, Christel Herold-Mende, Rolf Bjerkvig, Anna Golebiewska, Simone P. Niclou
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0123544
Signaling through the Phosphatidylinositol 3-Kinase (PI3K)/ Mammalian Target of Rapamycin (mTOR) Axis is Responsible for Aerobic Glycolysis mediated by Glucose Transporter in Epidermal Growth Factor Receptor (EGFR)-mutated Lung Adenocarcinoma
Hideki Makinoshima, Masahiro Takita, Koichi Saruwatari, Shigeki Umemura, Yuuki Obata, Genichiro Ishii, Shingo Matsumoto, Eri Sugiyama, Atsushi Ochiai, Ryo Abe, Koichi Goto, Hiroyasu Esumi, and Katsuya Tsuchihara
http://www.jbc.org/content/early/2015/05/28/jbc.M115.660498.abstract
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AMPK
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AMP-activated protein kinase is dispensable for maintaining ATP levels and for survival following inhibition of glycolysis, but promotes tumour engraftment of ras-transformed fibroblasts
Joffrey Pelletier, Danièle Roux, Benoit Viollet, Nathalie M. Mazure, and Jacques Pouysségur
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=3738
Glucose-Based Regulation of miR-451/AMPK Signaling Depends on the OCT1 Transcription Factor
Khairul I. Ansari, Daisuke Ogawa, Arun K. Rooj, Sean E. Lawler, Anna M. Krichevsky, Mark D. Johnson, E. Antonio Chiocca, Agnieszka Bronisz, Jakub Godlewski
http://www.cell.com/cell-reports/abstract/S2211-1247(15)00391-5
5′-AMP-activated protein kinase alpha regulates stress granule biogenesis
Hicham Mahboubi, Ramla Barise, Ursula Stochaj
http://www.sciencedirect.com/science/article/pii/S0167488915001160
Enhanced amino acid utilization sustains growth of cells lacking Snf1/AMPK
[yeast]
Raffaele Nicastro, Farida Tripodi, Cinzia Guzzi, Veronica Reghellin, Sakda Khoomrung, Claudia Capusoni, Concetta Compagno, Cristina Airoldi, Jens Nielsen, Lilia Alberghina, Paola Coccetti
http://www.sciencedirect.com/science/article/pii/S0167488915001159
Protein kinase Snf1 is involved in the proper regulation of the unfolded protein response in Saccharomyces cerevisiae
Jofre Ferrer Dalmau, Francisca Randez Gil, Maribel Marquina, José A. Prieto and Antonio Casamayor
http://www.biochemj.org/bj/468/bj4680033.htm
Polarized activities of AMPK and BRSK in primary hippocampal neurons
Vedangi Sample, Santosh Ramamurthy, Kirill Gorshkov, Gabriele V. Ronnett, and Jin Zhang
http://www.molbiolcell.org/content/26/10/1935.abstract?etoc
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Anti-metabolic drugs, starvation
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Dose-dependent Effect of 2-Deoxy-D-Glucose on Glycoprotein Mannosylation in Cancer Cells
Ahadova, A; Gebert, J; Doeberitz, MV; Kopitz, J; Kloor, M
http://onlinelibrary.wiley.com/doi/10.1002/iub.1364/abstract
Fasting induces anti-Warburg effect that increases respiration but reduces ATP-synthesis to promote apoptosis in colon cancer models
Giovanna Bianchi, Roberto Martella, Silvia Ravera, Cecilia Marini, Selene Capitanio, Annamaria Orengo, Laura Emionite, Chiara Lavarello, Adriana Amaro, Andrea Petretto, Ulrich Pfeffer, Gianmario Sambuceti, Vito Pistoia, Lizzia Raffaghello, and Valter D. Longo
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=3688
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Hypoxia
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The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase
Thomas R. Cox, Robin M. H. Rumney, Erwin M. Schoof, Lara Perryman, Anette M. Høye, Ankita Agrawal, Demelza Bird, Norain Ab Latif, Hamish Forrest, Holly R. Evans, Iain D. Huggins, Georgina Lang, Rune Linding, Alison Gartland & Janine T. Erler
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature14492.html
EFNA3 long noncoding RNAs induced by hypoxia promote metastatic dissemination
L Gómez-Maldonado, M Tiana, O Roche, A Prado-Cabrero, L Jensen, A Fernandez-Barral, I Guijarro-Muñoz, E Favaro, G Moreno-Bueno, L Sanz, J Aragones, A Harris, O Volpert, B Jimenez and L del Peso
http://www.nature.com/onc/journal/v34/n20/abs/onc2014200a.html
Snail is a Direct Target of HIF1α in Hypoxia-induced Endothelial to Mesenchymal Transition of Human Coronary Endothelial Cells
Xingbo Xu, Xiaoying Tan, Bjoern Tampe, Elisa Sanchez, Michael Zeisberg, and Elisabeth M. Zeisberg
http://www.jbc.org/content/early/2015/05/13/jbc.M115.636944.abstract
Autophagy mediates HIF2α degradation and suppresses renal tumorigenesis
X-D Liu, J Yao, D N Tripathi, Z Ding, Y Xu, M Sun, J Zhang, S Bai, P German, A Hoang, L Zhou, D Jonasch, X Zhang, C J Conti, E Efstathiou, N M Tannir, N T Eissa, G B Mills, C L Walker and E Jonasch
http://www.nature.com/onc/journal/v34/n19/abs/onc2014199a.html
Hypoxia drives transient site-specific copy gain and drug-resistant gene expression
Joshua C. Black, Elnaz Atabakhsh, Jaegil Kim, Kelly M. Biette, Capucine Van Rechem, Brendon Ladd, Paul d. Burrowes, Carlos Donado, Hamid Mattoo, Benjamin P. Kleinstiver, Bing Song, Grasiella Andriani, J. Keith Joung, Othon Iliopoulos, Cristina Montagna, Shiv Pillai, Gad Getz, and JohnathanR. Whetstine
http://genesdev.cshlp.org/content/29/10/1018.abstract?etoc
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Methods
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SoNar, a Highly Responsive NAD+/NADH Sensor, Allows High-Throughput Metabolic Screening of Anti-tumor Agents
Yuzheng Zhao, Qingxun Hu, Feixiong Cheng, Ni Su, Aoxue Wang, Yejun Zou, Hanyang Hu, Xianjun Chen, Hai-Meng Zhou, Xinzhi Huang, Kai Yang, Qian Zhu, Xue Wang, Jing Yi, Linyong Zhu, Xuhong Qian, Lixin Chen, Yun Tang, Joseph Loscalzo, Yi Yang
http://www.cell.com/cell-metabolism/abstract/S1550-4131(15)00164-3
Spatially Resolved Metabolic Phenotyping of Breast Cancer by Desorption Electrospray Ionization Mass Spectrometry
Sabine Guenther, Laura J. Muirhead, Abigail V.M. Speller, Ottmar Golf, Nicole Strittmatter, Rathi Ramakrishnan, Robert D. Goldin, Emrys Jones, Kirill Veselkov, Jeremy Nicholson, Ara Darzi, and Zoltan Takats
http://cancerres.aacrjournals.org/content/75/9/1828.abstract?etoc
MS-DIAL: data-independent MS/MS deconvolution for comprehensive metabolome analysis
Hiroshi Tsugawa, Tomas Cajka, Tobias Kind, Yan Ma, Brendan Higgins, Kazutaka Ikeda, Mitsuhiro Kanazawa, Jean VanderGheynst, Oliver Fiehn & Masanori Arita
http://www.nature.com/nmeth/journal/v12/n6/full/nmeth.3393.html
New method to assess mitophagy flux by flow cytometry
Marta Mauro-Lizcano, Lorena Esteban-Martínez, Esther Seco, Ana Serrano-Puebla, Lucia Garcia-Ledo, Cláudia Figueiredo-Pereira, Helena L A Vieira & Patricia Boya
http://www.tandfonline.com/doi/abs/10.1080/15548627.2015.1034403?ai=1gmor&ui=79l0u&af=T
Quantification of folate metabolism using transient metabolic flux analysis
Tedeschi PM, Johnson-Farley N, Lin H, Shelton LM, Ooga T, Mackay G, Van Den Broek N, Bertino JR, Vazquez A
http://www.cancerandmetabolism.com/content/3/1/6/abstract
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Miscellaneous
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Rod-Derived Cone Viability Factor Promotes Cone Survival by Stimulating Aerobic Glycolysis
Najate Aït-Ali, Ram Fridlich, Géraldine Millet-Puel, Emmanuelle Clérin, François Delalande, Céline Jaillard, Frédéric Blond, Ludivine Perrocheau, Sacha Reichman, Leah C. Byrne, Anne Olivier-Bandini, Jacques Bellalou, Emmanuel Moyse, Frédéric Bouillaud, Xavier Nicol, Deniz Dalkara, Alain van Dorsselaer, José-Alain Sahel, Thierry Léveillard
http://www.cell.com/cell/abstract/S0092-8674(15)00310-4
IL-7-Induced Glycerol Transport and TAG Synthesis Promotes Memory CD8+ T Cell Longevity
Guoliang Cui, Matthew M. Staron, Simon M. Gray, Ping-Chih Ho, Robert A. Amezquita, Jingxia Wu, Susan M. Kaech
http://www.cell.com/cell/abstract/S0092-8674(15)00308-6
Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis
Susmita Kaushik and Ana Maria Cuervo
http://www.nature.com/ncb/journal/v17/n6/full/ncb3166.html?WT.ec_id=NCB-201506
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Reviews
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Amino Acid Transporters in Cancer and Their Relevance to “Glutamine Addiction”: Novel Targets for the Design of a New Class of Anticancer Drugs
Yangzom D. Bhutia, Ellappan Babu, Sabarish Ramachandran, and Vadivel Ganapathy
http://cancerres.aacrjournals.org/content/75/9/1782.abstract?etoc
Role of tumor hypoxia in acquisition of resistance to microtubule-stabilizing drugs
Viswanath Das, Jana Stepankova, Marian Hajduch, John H. Miller
http://www.sciencedirect.com/science/article/pii/S0304419X1500013X
Targeting the 5'-AMP-activated protein kinase and related metabolic pathways for the treatment of prostate cancer.
Popovics P, Frigo DE, Schally AV, Rick FG
http://informahealthcare.com/doi/abs/10.1517/14728222.2015.1005603
Defining the Metabolome: Size, Flux, and Regulation
Nicola Zamboni, Alan Saghatelian, Gary J. Patti
http://www.cell.com/molecular-cell/abstract/S1097-2765(15)00303-2
Pyruvate kinase M2 at a glance
Weiwei Yang and Zhimin Lu
http://jcs.biologists.org/content/128/9/1655.abstract?etoc
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Comments
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Tumor Metabolism: MAGE-A Proteins Help TRIM Turn Over AMPK
Reuben J. Shaw
http://www.cell.com/current-biology/abstract/S0960-9822(15)00334-6
Paving the way for therapeutic prevention of tumor metastasis with agents targeting mitochondrial superoxide
Paolo E Porporato & Pierre Sonveaux
http://www.tandfonline.com/doi/abs/10.4161/23723548.2014.968043?ai=1gumh&ui=79l0u&af=T
Endothelial cells and cancer cells: metabolic partners in crime?
Zecchin A, Borgers G, Carmeliet P:
http://www.ncbi.nlm.nih.gov/pubmed/?term=25767953%5Buid%5D
Targeting the Warburg effect for leukemia therapy: Magnitude matters
Ying-Hua Wang & David T Scadden
http://www.tandfonline.com/doi/abs/10.4161/23723556.2014.981988?ai=1gumh&ui=79l0u&af=T
Chronic lymphocytic leukemia and the Warburg effect
Carol Moreno
http://bloodjournal.org/content/125/22/3368?etoc
Nutrient stress revamps cancer cell metabolism
Moscat J, Richardson A, Diaz-Meco MT.
http://www.nature.com/cr/journal/v25/n5/full/cr201538a.html#close
Metabolic signals in the hypoxic response
http://stke.sciencemag.org/content/8/375/ec116.abstract?utm_campaign=email-sig-toc&utm_src=email
Improving PET Evaluation of Brain Tumors
http://cancerdiscovery.aacrjournals.org/content/5/5/458.2.abstract?etoc
How inhibition of TORC1 stimulates gene expression
http://stke.sciencemag.org/content/8/376/ec124.abstract
--
Great upcoming meetings in Europe this autumn:
- Cancer and Metabolism conference, 2015
http://www.abcam.com/events/cancer-and-metabolism-conference-2015
Chaired by Eyal Gottlieb, Karen Vousden and Christian Frezza
- Metabolism in Cancer and Stromal Cells
http://www.vibconferences.be/event/metabolism-in-cancer-and-stromal-cells
Organizing Committee: Peter Carmeliet, Sarah-Maria Fendt, Matt Vander Heiden, Ralph Deberardinis
Cristina Muñoz-Pinedo Cell Death Regulation Group IDIBELL - Hospital Duran i Reynals 3a planta Gran Via de l'Hospitalet, 199 08908 L'Hospitalet de Llobregat Barcelona – Spain
phone +34 93 260 7130 cmu...@idibell.cat www.apoptosis.es idibell.cat/modul/cell-death-regulation/en
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