Metabolist - April 2016

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Muñoz Pinedo, Cristina

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May 2, 2016, 12:46:59 PM5/2/16

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Regards,

Cristina

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Cancer metabolism

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Reductive carboxylation supports redox homeostasis during anchorage-independent growth

Lei Jiang, Alexander A. Shestov, Pamela Swain, Chendong Yang, Seth J. Parker, Qiong A. Wang, Lance S. Terada, Nicholas D. Adams, Michael T. McCabe, Beth Pietrak, Stan Schmidt, Christian M. Metallo, Brian P. Dranka, Benjamin Schwartz & Ralph J. DeBerardinis

http://www.nature.com/nature/journal/v532/n7598/full/nature17393.html

Glutathione biosynthesis is a metabolic vulnerability in PI(3)K/Akt-driven breast cancer

Evan C. Lien, Costas A. Lyssiotis, Ashish Juvekar, Hai Hu, John M. Asara, Lewis C. Cantley, Alex Toker

http://www.nature.com/ncb/journal/v18/n5/full/ncb3341.html

Epithelial mesenchymal transition induces aberrant glycosylation through hexosamine biosynthetic pathway activation

Miguel C. Lucena, Patricia Carvalho-Cruz, Joana L. Donadio, Isadora A. Oliveira, Rafaela M. de Queiroz, Monica M. Marinho-Carvalho, Iron F. de Paula, Katia C. Gondim, Mark E. McComb, Catherine E. Costello, Stephen A. Whelan, Adriane R. Todeschini and Wagner B. Dias

http://www.jbc.org/content/early/2016/04/18/jbc.M116.729236.abstract

ERRα-Regulated Lactate Metabolism Contributes to Resistance to Targeted Therapies in Breast Cancer

Sunghee Park, Ching-Yi Chang, Rachid Safi, Xiaojing Liu, Robert Baldi, Jeff S. Jasper, Grace R. Anderson, Tingyu Liu, Jeffrey C. Rathmell, Mark W. Dewhirst, Kris C. Wood, Jason W. Locasale, Donald P. McDonnell

http://www.cell.com/cell-reports/abstract/S2211-1247(16)30282-0

mTORC2 controls cancer cell survival by modulating gluconeogenesis

MW Khan, D Biswas, M Ghosh, S Mandloi, S Chakrabarti & P Chakrabarti

http://www.nature.com/articles/cddiscovery201516

A Balanced Tissue Composition Reveals New Metabolic and Gene Expression Markers in Prostate Cancer

May-Britt Tessem, Helena Bertilsson, Anders Angelsen, Tone F. Bathen, Finn Drabløs, Morten Beck Rye

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0153727

MTAP Deletions in Cancer Create Vulnerability to Targeting of the MAT2A/PRMT5/RIOK1 Axis

Katya Marjon, Michael J. Cameron, Phong Quang, Michelle F. Clasquin, Everton Mandley, Kaiko Kunii, Michael McVay, Sung Choe, Andrew Kernytsky, Stefan Gross, Zenon Konteatis, Joshua Murtie, Michelle L. Blake, Jeremy Travins, Marion Dorsch, Scott A. Biller, Kevin M. Marks

http://www.cell.com/cell-reports/fulltext/S2211-1247(16)30299-6

Distinct Metabolic Signature of Human Bladder Cancer Cells Carrying an Impaired Fanconi Anemia Tumor-Suppressor Signaling Pathway

Jayabal Panneerselvam, Guoxiang Xie, Raymond Che, Mingming Su, Jun Zhang, Wei Jia, and Peiwen Fei

http://pubs.acs.org/doi/abs/10.1021/acs.jproteome.6b00076

PBRM1 Regulates the Expression of Genes Involved in Metabolism and Cell Adhesion in Renal Clear Cell Carcinoma

Basudev Chowdhury, Elizabeth G. Porter, Jane C. Stewart, Christina R. Ferreira, Matthew J. Schipma, Emily C. Dykhuizen

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0153718

Isocitrate dehydrogenase 1 mutations prime the all-trans retinoic acid myeloid differentiation pathway in acute myeloid leukemia

Héléna Boutzen, Estelle Saland, Clément Larrue, Fabienne de Toni, Lara Gales, Florence A. Castelli, Mathilde Cathebas, Sonia Zaghdoudi, Lucille Stuani, Tony Kaoma, Romain Riscal, Guangli Yang, Pierre Hirsch, Marion David, Véronique De Mas-Mansat, Eric Delabesse, Laurent Vallar, François Delhommeau, Isabelle Jouanin, Ouathek Ouerfelli, Laurent Le Cam, Laetitia K. Linares, Christophe Junot, Jean-Charles Portais, François Vergez, Christian Récher, and Jean-Emmanuel Sarry

http://jem.rupress.org/content/213/4/483?etoc

Enantiomer-specific and paracrine leukemogenicity of mutant IDH metabolite 2-hydroxyglutarate

A Chaturved1, M M A Cruz1, N Jyotsana1, A Sharma1, R Goparaju1, A Schwarzer2, K Görlich1, R Schottmann1, E A Struys3, E E Jansen, C Rohde4, C Müller-Tidow4, R Geffers5, G Göhring6, A Ganser1, F Thol1 and M Heuser

http://www.nature.com/leu/journal/vaop/naam/abs/leu201671a.html

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Glycolysis and glycolytic enzymes

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mTORC1-Dependent Metabolic Reprogramming Underlies Escape from Glycolysis Addiction in Cancer Cells

Raju V. Pusapati, Anneleen Daemen, Catherine Wilson, Wendy Sandoval, Min Gao, Benjamin Haley, Andreas R. Baudy, Georgia Hatzivassiliou, Marie Evangelista, Jeff Settleman

http://www.cell.com/cancer-cell/abstract/S1535-6108(16)30052-6

Focal adhesion kinase-promoted tumor glucose metabolism is associated with a shift of mitochondrial respiration to glycolysis

J Zhang, Q Gao, Y Zhou, U Dier, N Hempel and S N Hochwald

http://www.nature.com/onc/journal/v35/n15/abs/onc2015256a.html

Immunoregulatory Protein B7-H3 Reprograms Glucose Metabolism in Cancer Cells by ROS-Mediated Stabilization of HIF1α

Sangbin Lim, Hao Liu, Luciana Madeira da Silva, Ritu Arora, Zixing Liu, Joshua B. Phillips, David C. Schmitt, Tung Vu, Steven McClellan, Yifeng Lin, Wensheng Lin, Gary A. Piazza, Oystein Fodstad, and Ming Tan

http://cancerres.aacrjournals.org/content/76/8/2231.abstract?etoc

SH2 domain-containing phosphatase 1 regulates pyruvate kinase M2 in hepatocellular carcinoma

Wei-Tien Tai, Man-Hsin Hung, Pei-Yi Chu, Yao-Li Chen, Li-Ju Chen, Ming-Hsien Tsai, Min-Husan Chen, Chung-Wai Shiau, Yin-Pin Boo, and Kuen- Feng Chen

http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=7923

Modulation of PKM alternative splicing by PTBP1 promotes gemcitabine resistance in pancreatic cancer cells

S Calabretta, P Bielli, I Passacantilli, E Pilozzi, V Fendrich, G Capurso, G Delle Fave and C Sette

http://www.nature.com/onc/journal/v35/n16/abs/onc2015270a.html

PARP Inhibition Suppresses Growth of EGFR-Mutant Cancers by Targeting Nuclear PKM2

Nan Li, Lin Feng, Hui Liu, Jiadong Wang, Moses Kasembeli, My Kim Tran, David J. Tweardy, Steven Hsesheng Lin, Junjie Chen

http://www.cell.com/cell-reports/abstract/S2211-1247(16)30359-X

Mechanism of inhibition of human glucose transporter GLUT1 is conserved between cytochalasin B and phenylalanine amides

Khyati Kapoor, Janet S. Finer-Moore, Bjørn P. Pedersen, Laura Caboni, Andrew Waight, Roman C. Hillig, Peter Bringmann, Iring Heisler, Thomas Müller, Holger Siebeneicher, and Robert M. Stroud

http://www.pnas.org/content/113/17/4711.abstract.html?etoc

GAPDH (glyceraldehyde-3-phosphate dehydrogenase) Protein-Protein Interaction Inhibitor Reveals a Non-Catalytic Role for GAPDH Oligomerization in Cell Death

Nir Qvit, Amit U. Joshi, Anna D. Cunningham, Julio C.B. Ferreira, and Daria Mochly-Rosen

http://www.jbc.org/content/early/2016/04/27/jbc.M115.711630.abstract

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Glutamine and other amino acids

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The oncogenic transcription factor c-Jun regulates glutaminase expression and sensitizes cells to glutaminase-targeted therapy

Michael J. Lukey, Kai Su Greene, Jon W. Erickson, Kristin F. Wilson and Richard A. Cerione

http://www.nature.com/ncomms/2016/160418/ncomms11321/full/ncomms11321.html

Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor

AuthorsAbigail S. Krall, Shili Xu, Thomas G. Graeber, Daniel Braas, Heather R. Christofk

http://www.nature.com/ncomms/2016/160429/ncomms11457/full/ncomms11457.html

The Ephrin-A1/EPHA2 Signaling Axis Regulates Glutamine Metabolism in HER2-Positive Breast Cancer

Victoria M. Youngblood, Laura C. Kim, Deanna N. Edwards, Yoonha Hwang, Pranav R. Santapuram, Steven M. Stirdivant, Pengcheng Lu, Fei Ye, Dana M.Brantley-Sieders, and Jin Chen

http://cancerres.aacrjournals.org/content/76/7/1825.abstract?etoc

Deletion of Amino Acid Transporter ASCT2 (SLC1A5) Reveals an Essential Role for Transporters SNAT1 (SLC38A1) and SNAT2 (SLC38A2) to Sustain Glutaminolysis in Cancer Cells

Angelika Bröer, Farid Rahimi, and Stefan Bröer

http://www.jbc.org/content/early/2016/04/26/jbc.M115.700534.abstract

RhoC is a Potent Regulator of Glutamine Metabolism and N-acetylaspartate Production in Inflammatory Breast Cancer Cells

Michelle L. Wynn, Joel A. Yates, Charles R. Evans, Lauren Van Wassenhove, Zhi Fen Wu, Sydney Bridges, Liwei Bao, Chelsea Fournier, Sepideh Ashrafzadeh, Matthew J. Merrins, Leslie S. Satin, Santiago Schnell, Charles F. Burant, and Sofia D. Merajver

http://www.jbc.org/content/early/2016/04/25/jbc.M115.703959.abstract

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Lipids and cancer

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Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer

Roman Camarda, Alicia Y Zhou, Rebecca A Kohnz, Sanjeev Balakrishnan, Celine Mahieu, Brittany Anderton, Henok Eyob, Shingo Kajimura, Aaron Tward, Gregor Krings, Daniel K Nomura & Andrei Goga

http://www.nature.com/nm/journal/v22/n4/full/nm.4055.html

Cyclin E Associates with the Lipogenic Enzyme ATP-Citrate Lyase to Enable Malignant Growth of Breast Cancer Cells

Kimberly S. Lucenay, Iman Doostan, Cansu Karakas, Tuyen Bui, Zhiyong Ding, Gordon B. Mills, Kelly K. Hunt, and Khandan Keyomarsi

http://cancerres.aacrjournals.org/content/76/8/2406.abstract?etoc

Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments

Peck B, Schug Z, Zhang Q, Dankworth B, Jones D, Smethurst E, Patel R, Mason S, Jiang M, Saunders R, Howell M, Mitter R, Spencer-Dene B, Stamp G, McGarry L, James D, Shanks E, Aboagye E, Critchlow S, Leung H, Harris A, Wakelam M, Gottlieb E, Schulze A

http://www.cancerandmetabolism.com/content/4/1/6/abstract

FoxA and LIPG endothelial lipase control the uptake of extracellular lipids for breast cancer growth

Felipe Slebe, Federico Rojo, Maria Vinaixa, Mar García-Rocha, Giorgia Testoni, Marc Guiu, Evarist Planet, Sara Samino, Enrique J. Arenas, Antoni Beltran, Ana Rovira, Ana Lluch, Xavier Salvatella, Oscar Yanes, Joan Albanell, Joan J. Guinovart and Roger R. Gomis

http://www.nature.com/ncomms/2016/160405/ncomms11199/full/ncomms11199.html

Tumor-Induced Hyperlipidemia Contributes to Tumor Growth

Jianfeng Huang, Lena Li, Jihong Lian, Silvia Schauer, Paul W. Vesely, Dagmar Kratky, Gerald Hoefler, Richard Lehner

http://www.cell.com/cell-reports/fulltext/S2211-1247(16)30261-3

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Mitochondria, nucleotides

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Mitochondrial DNA Replication Defects Disturb Cellular dNTP Pools and Remodel One-Carbon Metabolism

Joni Nikkanen, Saara Forsström, Liliya Euro, Ilse Paetau, Rebecca A. Kohnz, Liya Wang, Dmitri Chilov, Jenni Viinamäki, Anne Roivainen, Päivi Marjamäki, Heidi Liljenbäck, Sofia Ahola, Jana Buzkova, Mügen Terzioglu, Nahid A. Khan, Sini Pirnes-Karhu, Anders Paetau, Tuula Lönnqvist, Antti Sajantila, Pirjo Isohanni, Henna Tyynismaa, Daniel K. Nomura, Brendan J. Battersby, Vidya Velagapudi, Christopher J. Carroll, Anu Suomalainen

http://www.cell.com/cell-metabolism/fulltext/S1550-4131(16)30012-2

Mitochondrial DNA plasticity is an essential inducer of tumorigenesis

W T Y Lee, J E Cain, A Cuddihy, J Johnson, A Dickinson, K-Y Yeung, B Kumar, T G Johns, D N Watkins, A Spencer & J C St John

http://www.nature.com/articles/cddiscovery201616

Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma

Justin L. Tan, Rachel D. Fogley, Ryan A. Flynn, Julien Ablain, Song Yang, Violaine Saint-André, Zi Peng Fan, Brian T. Do, Alvaro C. Laga, Koh Fujinaga, Cristina Santoriello, Celeste B. Greer, Yoon Jung Kim, John G. Clohessy, Anne Bothmer, Nicole Pandell, Serine Avagyan, John E. Brogie, Ellen van Rooijen, Elliott J. Hagedorn, Ng Shyh-Chang, Richard M. White, David H. Price, Pier Paolo Pandolfi, B. Matija Peterlin, Yi Zhou, Tae Hoon Kim, John M. Asara, Howard Y. Chang, Richard A. Young, Leonard I. Zon

http://www.cell.com/molecular-cell/fulltext/S1097-2765(16)00223-9

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Drugs

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BIRC5/Survivin as a target for glycolysis inhibition in high-stage neuroblastoma

J Hagenbuchner, U Kiechl-Kohlendorfer, P Obexer and M J Ausserlechner

http://www.nature.com/onc/journal/v35/n16/abs/onc2015264a.html

A novel agent exerts antitumor activity in breast cancer cells by targeting mitochondrial complex II

Liang Wang, Xiaojing Zhang, Guozhen Cui, Judy Yuet-Wa Chan, Li Wang, Chuwen Li, Luchen Shan, Changjiang Xu, Qingwen Zhang, Yuqiang Wang, Lijun Di, Simon Ming-Yuen Lee

http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B0%5D=8410&path%5B1%5D=24966#.VxXTUq-Dkuo.facebook

Combined Treatment of MCF-7 Cells with AICAR and Methotrexate, Arrests Cell Cycle and Reverses Warburg Metabolism through AMP-Activated Protein Kinase (AMPK) and FOXO1

Tamás Fodor, Magdolna Szántó, Omar Abdul-Rahman, Lilla Nagy, Ádám Dér, Borbála Kiss, Peter Bai

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0150232

Metformin Decouples Phospholipid Metabolism in Breast Cancer Cells

Tim A. D. Smith, Su M. Phyu

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0151179

Metformin Pharmacokinetics in Mouse Tumors: Implications for Human Therapy

Ryan J.O. Dowling, Sonya Lam, Christian Bassi, Samar Mouaaz, Ahmed Aman, Taira Kiyota, Rima Al-awar, Pamela J. Goodwin, Vuk Stambolic

http://www.cell.com/cell-metabolism/abstract/S1550-4131(16)30109-7

Are Metformin Doses Used in Murine Cancer Models Clinically Relevant?

Navdeep S. Chandel, Dania Avizonis, Colleen R. Reczek, Samuel E. Weinberg, Stephan Menz, Roland Neuhaus, Sven Christian, Andrea Haegebarth, Carolyn Algire, Michael Pollak

http://www.cell.com/cell-metabolism/fulltext/S1550-4131(16)30113-9

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Starvation

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Protein Kinase A Activation Promotes Cancer Cell Resistance to Glucose Starvation and Anoikis

Roberta Palorini, Giuseppina Votta, Yuri Pirola, Humberto De Vitto, Sara De Palma, Cristina Airoldi, Michele Vasso, Francesca Ricciardiello, Pietro Paolo Lombardi, Claudia Cirulli, Raffaella Rizzi, Francesco Nicotra, Karsten Hiller, Cecilia Gelfi, Lilia Alberghina, Ferdinando Chiaradonna

http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1005931

Cystine Deprivation Triggers Programmed Necrosis in VHL-Deficient Renal Cell Carcinomas

Xiaohu Tang, Jianli Wu, Chien-Kuang Ding, Min Lu, Melissa M. Keenan, Chao-Chieh Lin, Chih-An Lin, Charles C. Wang, Daniel George, David S. Hsu, and Jen-Tsan Chi

http://cancerres.aacrjournals.org/content/76/7/1892.abstract?etoc

c-MYC responds to glucose deprivation in a cell-type-dependent manner

S Wu, X Yin, X Fang, J Zheng, L Li, X Liu & L Chu

http://www.nature.com/articles/cddiscovery201557

Regulation of Pyruvate Kinase M Switch towards PKM1 by LKB1-AMPK Axis Tolerates Hypoglycemic Stress in Cancer Cells

Prakasam Gopinath, Rajnish Kumar Singh, Mohammad Askandar Iqbal, Ashu Bhan Tiku, and Rameshwar N. K. Bamezai

http://www.jbc.org/content/early/2016/04/26/jbc.M116.729079.abstract

Lipid droplet–mediated ER homeostasis regulates autophagy and cell survival during starvation

Ariadna P. Velázquez, Takashi Tatsuta, Ruben Ghillebert, Ingmar Drescher, and Martin Graef

http://jcb.rupress.org/content/212/6/621.abstract

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AMPK / mTOR

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AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival

Rigel J. Kishton, Carson E. Barnes, Amanda G. Nichols, Sivan Cohen, Valerie A. Gerriets, Peter J. Siska, Andrew N. Macintyre, Pankuri Goraksha-Hicks, Aguirre A. de Cubas, Tingyu Liu, Marc O. Warmoes, E. Dale Abel, Allen Eng Juh Yeoh, Timothy R. Gershon, W. Kimryn Rathmell, Kristy L. Richards, Jason W. Locasale, Jeffrey C. Rathmell

http://www.cell.com/cell-metabolism/abstract/S1550-4131(16)30111-5

Rapamycin requires AMPK activity and p27 expression for promoting autophagy-dependent Tsc2-null cell survival

Tania Campos, Javiera Ziehe, Francisco Fuentes-Villalobos, Orlando Riquelme, Daniela Peña, Rodrigo Troncoso, Sergio Lavandero, Violeta Morin, Roxana Pincheira, Ariel F. Castro

http://www.sciencedirect.com/science/article/pii/S0167488916300623

The Prognostic Value of Decreased LKB1 in Solid Tumors: A Meta-Analysis

Jian Xiao, Yong Zou, Xi Chen, Ying Gao, Mingxuan Xie, Xiaoxiao Lu, Wei Li, Bixiu He, Shuya He, Shaojin You, Qiong Chen

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0152674

Caspase-mediated cleavage of raptor participates in the inactivation of mTORC1 during cell death

R Martin, C Desponds, R O Eren, M Quadroni, M Thome & N Fasel

http://www.nature.com/articles/cddiscovery201624

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Hypoxia

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Hypoxia regulates global membrane protein endocytosis through caveolin-1 in cancer cells

E. Bourseau-Guilmain, J. A. Menard, E. Lindqvist, V. Indira Chandran, H. C. Christianson, M. Cerezo Magaña, J. Lidfeldt, G. Marko-Varga, C. Welinder, M. Belting

http://www.nature.com/ncomms/2016/160420/ncomms11371/full/ncomms11371.html

Glycerol-3-phosphate acyltransferase-1 upregulation by O-GlcNAcylation of Sp1 protects against hypoxia-induced mouse embryonic stem cell apoptosis via mTOR activation

H J Lee, J M Ryu, Y H Jung, K H Lee, D I Kim and H J Han

http://www.nature.com/cddis/journal/v7/n3/abs/cddis2015410a.html

HIF-1α regulates the interaction of chronic lymphocytic leukemia cells with the tumor microenvironment

Roberta Valsecchi, Nadia Coltella, Daniela Belloni, Manfredi Ponente, Elisa ten Hacken, Cristina Scielzo, Lydia Scarfò, Maria Teresa Sabrina Bertilaccio, Paola Brambilla, Elisa Lenti, Filippo Martinelli Boneschi, Andrea Brendolan, Elisabetta Ferrero, Marina Ferrarini, Paolo Ghia, Giovanni Tonon, Maurilio Ponzoni, Federico Caligaris-Cappio, and Rosa Bernardi

http://bloodjournal.org/content/127/16/1987.abstract?etoc

Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m6A-demethylation of NANOG mRNA

Chuanzhao Zhang, Debangshu Samanta, Haiquan Lu, John W. Bullen, Huimin Zhang, Ivan Chen, Xiaoshun He, and Gregg L. Semenza

http://www.pnas.org/content/113/14/E2047.abstract.html?etoc

Prolyl Hydroxylase 3 Attenuates MCL-1–Mediated ATP Production to Suppress the Metastatic Potential of Colorectal Cancer Cells

Praveenkumar Radhakrishnan, Nadine Ruh, Jonathan M. Harnoss, Judit Kiss, Martin Mollenhauer, Anna-Lena Scherr, Lisa K. Platzer, Thomas Schmidt, Klaus Podar, Joseph T. Opferman, Juergen Weitz, Henning Schulze-Bergkamen, Bruno C. Koehler, Alexis Ulrich, and Martin Schneider

http://cancerres.aacrjournals.org/content/76/8/2219.abstract?etoc

Hypoxic Signaling and the Cellular Redox Tumor Environment Determine Sensitivity to MTH1 Inhibition

Lars Bräutigam, Linda Pudelko, Ann-Sofie Jemth, Helge Gad, Mohit Narwal, Robert Gustafsson, Stella Karsten, Jordi Carreras Puigvert, Evert Homan, Carsten Berndt, Ulrika Warpman Berglund, Pål Stenmark, and Thomas Helleday

http://cancerres.aacrjournals.org/content/76/8/2366.abstract?etoc

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Prognosis / diagnostics / methods

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Pre-diagnosis blood glucose and prognosis in women with breast cancer

Monzavi-Karbassi B, Gentry R, Kaur V, Siegel E, Jousheghany F, Medarametla S, Fuhrman B, Safar A, Hutchins L, Kieber-Emmons T

http://www.cancerandmetabolism.com/content/4/1/7/abstract

Bridging the gap between non-targeted stable isotope labeling and metabolic flux analysis

Weindl D, Cordes T, Battello N, Sapcariu S, Dong X, Wegner A, Hiller K

http://www.cancerandmetabolism.com/content/4/1/10/abstract

Determining Maximum Glycolytic Capacity Using Extracellular Flux Measurements

Shona A. Mookerjee, David G. Nicholls, Martin D. Brand

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0152016

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Miscellaneous

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Metabolic maintenance of cell asymmetry following division in activated T lymphocytes

Katherine C. Verbist, Cliff S. Guy, Sandra Milasta, Swantje Liedmann, Marcin M. Kamiński, Ruoning Wang & Douglas R. Green

http://www.nature.com/nature/journal/v532/n7599/full/nature17442.html

The Mitochondrial Respiratory Chain Is Required for Organismal Adaptation to Hypoxia

Robert B. Hamanaka, Samuel E. Weinberg, Colleen R. Reczek, Navdeep S. Chandel

http://www.cell.com/cell-reports/fulltext/S2211-1247(16)30300-X

Transcription factor ATF4 directs basal and stress-induced gene expression in the unfolded protein response and cholesterol metabolism inthe liver

Michael E. Fusakio, Jeffrey A. Willy, Yongping Wang, Emily T. Mirek, Rana J. T. Al Baghdadi, Christopher M. Adams, Tracy G. Anthony, and Ronald C. Wek

http://www.molbiolcell.org/content/27/9/1536.abstract?etoc

Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism

Yuefeng Tang, Martina Wallace, Joan Sanchez-Gurmaches, Wen-Yu Hsiao, Huawei Li, Peter L. Lee, Santiago Vernia, Christian M. Metallo & David A. Guertin

http://www.nature.com/ncomms/2016/160421/ncomms11365/full/ncomms11365.html

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Reviews

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Intermediates of Metabolism: From Bystanders to Signalling Molecules

Robert Haas, Danilo Cucchi, Joanne Smith, Valentina Pucino, Claire Elizabeth Macdougall, Claudio Mauro

http://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(16)00026-8

Changing perspective on oncometabolites: from metabolic signature of cancer to tumorigenic and immunosuppressive agents

Mauro Corrado, Luca Scorrano and Silvia Campello

http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[0]=8727&path[1]=26258

The Role of Cholesterol in Cancer

Omer F. Kuzu, Mohammad A. Noory, and Gavin P. Robertson

http://cancerres.aacrjournals.org/content/76/8/2063.abstract?etoc

Amino Acid Sensing by mTORC1: Intracellular Transporters Mark the Spot

Deborah C.I. Goberdhan, Clive Wilson, Adrian L. Harris

http://www.cell.com/cell-metabolism/abstract/S1550-4131(16)30116-4

A lysosome-centered view of nutrient homeostasis

Vinod K. Mony, Shawna Benjamin & Eyleen J. O'Rourke

http://www.tandfonline.com/doi/full/10.1080/15548627.2016.1147671

Chronic Myeloid Leukemia and Hepatoblastoma: Two Cancer Models to Link Metabolism to Stem Cells

Maria Grazia Cipolleschi, Ilaria Marzi, Elisabetta Rovida and Persio Dello Sbarba

http://journal.frontiersin.org/article/10.3389/fonc.2016.00095/full

Metformin may function as anti-cancer agent via targeting cancer stem cells: the potential biological significance of tumor-associated miRNAs in breast and pancreatic cancers

Bin Bao, Asfar S. Azmi, Shadan Ali, Feras Zaiem, Fazlul H. Sarkar

http://atm.amegroups.com/article/view/3965/4955

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Comments

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Glycoholics Anonymous: Cancer Sobers Up with mTORC1

Vivian Fu, Toshiro Moroishi, Kun-Liang Guan

http://www.cell.com/cancer-cell/fulltext/S1535-6108(16)30099-X

mTORC1 signaling activates NRF1 to increase cellular proteasome levels.

Zhang Y, Manning BD.

http://www.tandfonline.com/doi/abs/10.1080/15384101.2015.1044188?journalCode=kccy20

Mutant KRAS Copy-Number Gain Drives Metabolic Reprogramming