MetaboList - September 2015

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Muñoz Pinedo, Cristina

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Oct 2, 2015, 7:16:59 PM10/2/15

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Regards,

Cristina

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Cancer Metabolism

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Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses

Ping-Chih Ho, Jessica Dauz Bihuniak, Andrew N. Macintyre, Matthew Staron, Xiaojing Liu, Robert Amezquita, Yao-Chen Tsui, Guoliang Cui, Goran Micevic, Jose C. Perales, Steven H. Kleinstein, E. Dale Abel, Karl L. Insogna, Stefan Feske, Jason W. Locasale, Marcus W. Bosenberg, Jeffrey C. Rathmell, Susan M. Kaech

http://www.cell.com/cell/abstract/S0092-8674(15)01025-9

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

Chih-Hao Chang, Jing Qiu, David O’Sullivan, Michael D. Buck, Takuro Noguchi, Jonathan D. Curtis, Qiongyu Chen, Mariel Gindin, Matthew M. Gubin, Gerritje J.W. van der Windt, Elena Tonc, Robert D. Schreiber, Edward J. Pearce, Erika L. Pearce

http://www.cell.com/cell/abstract/S0092-8674(15)01029-6

Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis

Simone Cardaci, Liang Zheng, Gillian MacKay, Niels J. F. van den Broek, Elaine D. MacKenzie, Colin Nixon, David Stevenson, Sergey Tumanov, Vinay Bulusu, Jurre J. Kamphorst, Alexei Vazquez, Stewart Fleming, Francesca Schiavi, Gabriela Kalna, Karen Blyth, Douglas Strathdee & Eyal Gottlieb

http://www.nature.com/ncb/journal/v17/n10/full/ncb3233.html

Lack of Evidence for PKM2 Protein Kinase Activity

Aaron M. Hosios, Brian P. Fiske, Dan Y. Gui, Matthew G. Vander Heiden

http://www.cell.com/molecular-cell/abstract/S1097-2765(15)00571-7

TPD52 expression increases neutral lipid storage within cultured cells

Alvin Kamili, Nuruliza Roslan, Sarah Frost, Laurence C. Cantrill, Dongwei Wang, Austin Della-Franca, Robert K. Bright, Guy E. Groblewski, Beate K. Straub, Andrew J. Hoy, Yuyan Chen, and Jennifer A. Byrne

http://jcs.biologists.org/content/128/17/3223.abstract?etoc

O-GlcNAcylation of G6PD promotes the pentose phosphate pathway and tumor growth

Xiongjian Rao, Xiaotao Duan, Weimin Mao, Xuexia Li, Zhonghua Li, Qian Li, Zhiguo Zheng, Haimiao Xu, Min Chen, Peng G. Wang, Yingjie Wang, Binghui Shen and Wen Yi

http://www.nature.com/ncomms/2015/150924/ncomms9468/full/ncomms9468.html

2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling

Xudong Fu, Randall M. Chin, Laurent Vergnes, Heejun Hwang, Gang Deng, Yanpeng Xing, Melody Y. Pai, Sichen Li, Lisa Ta, Farbod Fazlollahi, Chuo Chen, Robert M. Prins, Michael A. Teitell, David A. Nathanson, Albert Lai, Kym F. Faull, Meisheng Jiang, Steven G. Clarke, Timothy F. Cloughesy, Thomas G. Graeber, Daniel Braas, Heather R. Christofk, Michael E. Jung, Karen Reue, Jing Huang

http://www.cell.com/cell-metabolism/abstract/S1550-4131(15)00276-4

p110α Hot Spot Mutations E545K and H1047R Exert Metabolic Reprogramming Independently of p110α Kinase Activity

Aditi Chaudhari, Daniel Krumlinde, Annika Lundqvist, Levent M. Akyürek, Sashidhar Bandaru, Kristina Skålén, Marcus Ståhlman, Jan Borén, Yvonne Wettergren, Katarina Ejeskär, and Victoria Rotter Sopasakis

http://mcb.asm.org/content/35/19/3258.abstract?etoc

p63 supports aerobic respiration through hexokinase II

Guiditta Viticchiè, Massimiliano Agostini, Anna Maria Lena, Mara Mancini, Huiqing Zhou, Lello Zolla, David Dinsdale, Gaelle Saintigny, Gerry Melino, and Eleonora Candi

http://www.pnas.org/content/112/37/11577.abstract.html?etoc

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Anti-metabolic drugs

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Synthetic dosage lethality in the human metabolic network is highly predictive of tumor growth and cancer patient survival

Wout Megchelenbrink, Rotem Katzir, Xiaowen Lu, Eytan Ruppin, and Richard A. Notebaart

http://www.pnas.org/content/112/39/12217.abstract.html?etoc

The bifunctional autophagic flux by 2-deoxyglucose to control survival or growth of prostate cancer cells

Jeong Yong Jeon, Seung Won Kim, Ki Cheong Park and Mijin Yun

http://www.biomedcentral.com/1471-2407/15/623

Mcl-1 downregulation leads to the heightened sensitivity exhibited by BCR-ABL positive ALL to induction of energy and ER-stress

Guy J. Leclerc, Joanna DeSalvo, Jianfeng Du1, Ningguo Gao, Gilles M. Leclerc, Mark A. Lehrman, Theodore J. Lampidis, Julio C. Barredo

http://www.lrjournal.com/article/S0145-2126(15)30360-X/abstract

Targeting glutaminolysis has antileukemic activity in acute myeloid leukemia and synergizes with BCL-2 inhibition

Nathalie Jacque, Anne Marie Ronchetti, Clément Larrue, Godelieve Meunier,Rudy Birsen, Lise Willems, Estelle Saland, Justine Decroocq, Thiago Trovati Maciel, Mireille Lambert, Laury Poulain, Marie Anne Hospital, Pierre Sujobert, Laure Joseph, Nicolas Chapuis, Catherine Lacombe, Ivan Cruz Moura, Susan Demo, Jean Emmanuel Sarry, Christian Recher, Patrick Mayeux, Jérôme Tamburini, and Didier Bouscary

http://bloodjournal.org/content/126/11/1346.abstract?etoc

Novel actions of 2-deoxy-D-glucose: protection against Shiga toxins and changes in cellular lipids

Simona Kavaliauskiene, Tore Skotland, Tuulia Sylvänne, Helena Simolin, Tove Irene Klokk, Maria Lyngaas Torgersen, Anne Berit Dyve Lingelem, Roger Simm, Kim Ekroos, Kirsten Sandvig

http://www.biochemj.org/content/470/1/23.long

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Starvation, mTOR

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Amino Acid Availability Modulates Vacuolar H+-ATPase Assembly

Laura A. Stransky and Michael Forgac

http://www.jbc.org/content/early/2015/09/16/jbc.M115.659128.abstract

Regulation of autophagy by coordinated action of mTORC1 and protein phosphatase 2A

Pui-Mun Wong, Yan Feng, Junru Wang, Rong Shi and Xuejun Jiang

http://www.nature.com/ncomms/2015/150827/ncomms9048/full/ncomms9048.html

DRAM-3 modulates autophagy and promotes cell survival in the absence of glucose

M Mrschtik, J O'Prey, L Y Lao, J S Long, F Beaumatin, D Strachan, M O'Prey, J Skommer and K M Ryan

http://www.nature.com/cdd/journal/v22/n10/abs/cdd201526a.html

Disruption of the Rag-Ragulator Complex by c17orf59 Inhibits mTORC1

Lawrence D. Schweitzer, William C. Comb, Liron Bar-Peled, David M. Sabatini

http://www.cell.com/cell-reports/abstract/S2211-1247(15)00830-X

Starvation-Dependent Regulation of Golgi Quality Control Links the TOR Signaling and Vacuolar Protein Sorting Pathways

Niv Dobzinski, Silvia G. Chuartzman, Rachel Kama, Maya Schuldiner, Jeffrey E. Gerst

http://www.cell.com/cell-reports/abstract/S2211-1247(15)00897-9

Endogenous Sterol Metabolites Regulate Growth of EGFR/KRAS-Dependent Tumors via LXR

Linara Gabitova, Diana Restifo, Andrey Gorin, Kunal Manocha, Elizabeth Handorf, Dong-Hua Yang, Kathy Q. Cai, Andres J. Klein-Szanto, David Cunningham, Lisa E. Kratz, Gail E. Herman, Erica A. Golemis, Igor Astsaturov

http://www.cell.com/cell-reports/abstract/S2211-1247(15)00894-3

SREBP maintains lipid biosynthesis and viability of cancer cells under lipid- and oxygen-deprived conditions and defines a gene signature associated with poor survival in glioblastoma multiforme

C A Lewis, C Brault, B Peck, K Bensaad, B Griffiths, R Mitter, P Chakravarty, P East, B Dankworth, D Alibhai, A L Harris and A Schulze

http://www.nature.com/onc/journal/v34/n40/abs/onc2014439a.html

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Hypoxia

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Tumor-Promoting Effects of Myeloid-Derived Suppressor Cells Are Potentiated by Hypoxia-Induced Expression of miR-210

Muhammad Zaeem Noman, Bassam Janji, Shijun Hu, Joseph C. Wu, Fabio Martelli, Vincenzo Bronte, and Salem Chouaib

http://cancerres.aacrjournals.org/content/75/18/3771.abstract?etoc

Hypoxia Drives Breast Tumor Malignancy through a TET–TNFα–p38–MAPK Signaling Axis

Min-Zu Wu, Su-Feng Chen, Shin Nieh, Christopher Benner, Luo-Ping Ger, Chia-Ing Jan, Li Ma, Chien-Hung Chen, Tomoaki Hishida, Hong-Tai Chang, Yaoh-Shiang Lin, Nuria Montserrat, Pedro Gascon, Ignacio Sancho-Martinez,and Juan Carlos Izpisua Belmonte

http://cancerres.aacrjournals.org/content/75/18/3912.abstract?etoc

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Miscellaneous

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Mitochondrial uncoupling links lipid catabolism to Akt inhibition and resistance to tumorigenesis

Sara M. Nowinski, Ashley Solmonson, Joyce E. Rundhaug, Okkyung Rho, Jiyoon Cho, Cory U. Lago, Christopher L. Riley, Sunhee Lee, Shohei Kohno, Christine K. Dao, Takeshi Nikawa, Shawn B. Bratton, Casey W. Wright, Susan M. Fischer, John DiGiovanni and Edward M. Mills

http://www.nature.com/ncomms/2015/150827/ncomms9137/full/ncomms9137.html

Insulin and mTOR Pathway Regulate HDAC3-Mediated Deacetylation and Activation of PGK1

Shiwen Wang, Bowen Jiang, Tengfei Zhang, Lixia Liu, Yi Wang, Yiping Wang, Xiufei Chen, Huaipeng Lin, Lisha Zhou, Yukun Xia, Leilei Chen, Chen Yang, Yue Xiong, Dan Ye, Kun-Liang Guan

http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1002243

Lower glycolysis carries a higher flux than any biochemically possible alternative

Steven J. Court, Bartlomiej Waclaw and Rosalind J. Allen

http://www.nature.com/ncomms/2015/150929/ncomms9427/full/ncomms9427.html

Structure and mechanism of the mammalian fructose transporter GLUT5

Norimichi Nomura, Grégory Verdon, Hae Joo Kang, Tatsuro Shimamura, Yayoi Nomura, Yo Sonoda, Saba Abdul Hussien, Aziz Abdul Qureshi, Mathieu Coincon, Yumi Sato, Hitomi Abe, Yoshiko Nakada-Nakura, Tomoya Hino, Takatoshi Arakawa, Osamu Kusano-Arai, Hiroko Iwanari, Takeshi Murata, Takuya Kobayashi, Takao Hamakubo, Michihiro Kasahara, So Iwata & David Drew

http://www.nature.com/nature/journal/vaop/ncurrent/full/nature14909.html

PKA Phosphorylates the ATPase Inhibitory Factor 1 and Inactivates Its Capacity to Bind and Inhibit the Mitochondrial H+-ATP Synthase

Javier García-Bermúdez, María Sánchez-Aragó, Beatriz Soldevilla, Araceli del Arco, Cristina Nuevo-Tapioles, José M. Cuezva

http://www.cell.com/cell-reports/abstract/S2211-1247(15)00949-3

AMPK and PFKFB3 mediate glycolysis and survival in response to mitophagy during mitotic arrest

Elena Doménech, Carolina Maestre, Lorena Esteban-Martínez, David Partida, Rosa Pascual, Gonzalo Fernández-Miranda, Esther Seco, Ramón Campos-Olivas, Manuel Pérez, Diego Megias, Katherine Allen, Miguel López, Asish K. Saha, Guillermo Velasco, Eduardo Rial, Raúl Méndez, Patricia Boya, María Salazar-Roa & Marcos Malumbres

http://www.nature.com/ncb/journal/v17/n10/full/ncb3231.html

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Reviews

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The double trouble of metabolic diseases: the diabetes–cancer link

Slavica Tudzarova and Mahasin A. Osman

http://www.molbiolcell.org/content/26/18/3129.abstract?etoc

Tumors and Mitochondrial Respiration: A Neglected Connection

Andrea Viale, Denise Corti, and Giulio F. Draetta

http://cancerres.aacrjournals.org/content/75/18/3687.abstract?etoc

Metabolic Reprogramming of Immune Cells in Cancer Progression

Subhra K. Biswas