MetaboList - October 2015
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Muñoz Pinedo, Cristina
Nov 8, 2015, 5:12:10 PM11/8/15
to cancerme...@googlegroups.com
Regards,
Cristina
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Cancer metabolism
----------------------------------
MYC/PGC-1α Balance Determines the Metabolic Phenotype and Plasticity of Pancreatic Cancer Stem Cells
Patricia Sancho, Emma Burgos-Ramos, Alejandra Tavera, Tony Bou Kheir, Petra Jagust, Matthieu Schoenhals, David Barneda, Katherine Sellers, Ramon Campos-Olivas, Osvaldo Graña, Catarina R. Viera, Mariia Yuneva, Bruno Sainz, Christopher Heeschen
http://www.cell.com/cell-metabolism/abstract/S1550-4131(15)00406-4
Mitochondrial Phosphoenolpyruvate Carboxykinase Regulates Metabolic Adaptation and Enables Glucose-Independent Tumor Growth
Emma E. Vincent, Alexey Sergushichev, Takla Griss, Marie-Claude Gingras, Bozena Samborska, Thierry Ntimbane, Paula P. Coelho, Julianna Blagih, Thomas C. Raissi, Luc Choinière, Gaëlle Bridon, Ekaterina Loginicheva, Breanna R. Flynn, Elaine C. Thomas, Jeremy M. Tavaré, Daina Avizonis, Arnim Pause, Douglas J.E. Elder, Maxim N. Artyomov, Russell G. Jones
http://www.cell.com/molecular-cell/abstract/S1097-2765(15)00659-0
PDK1-Dependent Metabolic Reprogramming Dictates Metastatic Potential in Breast Cancer
Fanny Dupuy, Sébastien Tabariès, Sylvia Andrzejewski, Zhifeng Dong, Julianna Blagih, Matthew G. Annis, Atilla Omeroglu, Dongxia Gao, Samuel Leung, Eitan Amir, Mark Clemons, Adriana Aguilar-Mahecha, Mark Basik, Emma E. Vincent, Julie St.-Pierre, Russell G. Jones, Peter M. Siegel
http://www.cell.com/cell-metabolism/abstract/S1550-4131(15)00398-8
Unsaturated Fatty Acids Stimulate Tumor Growth through Stabilization of β-Catenin
Hyeonwoo Kim, Carlos Rodriguez-Navas, Rahul K. Kollipara, Payal Kapur, Ivan Pedrosa, James Brugarolas, Ralf Kittler, Jin Ye
http://www.cell.com/cell-reports/abstract/S2211-1247(15)01021-9
Non-canonical Hedgehog/AMPK-Mediated Control of Polyamine Metabolism Supports Neuronal and Medulloblastoma Cell Growth
Davide D’Amico, Laura Antonucci, Laura Di Magno, Sonia Coni, Giulia Sdruscia, Alberto Macone, Evelina Miele, Paola Infante, Lucia Di Marcotullio, Enrico De Smaele, Elisabetta Ferretti, Laura Ciapponi, Felice Giangaspero, John R. Yates, Enzo Agostinelli, Beatrice Cardinali, Isabella Screpanti, Alberto Gulino, Gianluca Canettieri
http://www.cell.com/developmental-cell/abstract/S1534-5807(15)00588-2
Metabolic reprogramming induces resistance to anti-NOTCH1 therapies in T cell acute lymphoblastic leukemia
Daniel Herranz, Alberto Ambesi-Impiombato, Jessica Sudderth, Marta Sánchez-Martín, Laura Belver, Valeria Tosello, Luyao Xu, Agnieszka A Wendorff, Mireia Castillo, J Erika Haydu, Javier Márquez, José M Matés, Andrew L Kung, Stephen Rayport, Carlos Cordon-Cardo, Ralph J DeBerardinis & Adolfo A Ferrando
http://www.nature.com/nm/journal/v21/n10/full/nm.3955.html
p53 regulates the mevalonate pathway in human glioblastoma multiforme
C Laezza, A D'Alessandro, L Di Croce, P Picardi, E Ciaglia, S Pisanti, A M Malfitano, M Comegna, R Faraonio, P Gazzerro and M Bifulco
http://www.nature.com/cddis/journal/v6/n10/abs/cddis2015279a.html
Functional genomic screening reveals asparagine dependence as a metabolic vulnerability in sarcoma
Simone Hettmer, Anna C Schinzel, Daria Tchessalova, Michaela Schneider, Christina L. Parker, Roderick Bronson, Nigel G.J. Richards, William Hahn and Amy J Wagers
http://elifesciences.org/content/early/2015/10/24/eLife.09436
Expression of Lipid Metabolism-Related Proteins in Metastatic Breast Cancer
Yoon Yang Jung, Hye Min Kim, Ja Seung Koo
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0137204
-----------------------------------
Anti-metabolic drugs
-----------------------------------
Treatment with a Small Molecule Mutant IDH1 Inhibitor Suppresses Tumorigenic Activity and Decreases Production of the Oncometabolite 2-Hydroxyglutarate in Human Chondrosarcoma Cells
Luyuan Li, Ana C. Paz, Breelyn A. Wilky, Britt Johnson, Karina Galoian, Andrew Rosenberg, Guozhi Hu, Gabriel Tinoco, Olaf Bodamer, Jonathan C. Trent
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0133813
Antileukemic Activity of 2-Deoxy-D-Glucose through Inhibition of N-Linked Glycosylation in Acute Myeloid Leukemia with FLT3-ITD or c-KIT Mutations
Clément Larrue, Estelle Saland, François Vergez, Nizar Serhan, Eric Delabesse, Véronique Mansat-De Mas, Marie-Anne Hospital, Jérôme Tamburini, Stéphane Manenti, Jean Emmanuel Sarry, and Christian Récher
http://mct.aacrjournals.org/content/14/10/2364.long
Identification of P450 Oxidoreductase as a Major Determinant of Sensitivity to Hypoxia-Activated Prodrugs
Francis W. Hunter, Richard J. Young, Zvi Shalev, Ravi N. Vellanki, JingliWang, Yongchuan Gu, Naveen Joshi, Sreevalsan Sreebhavan, Ilan Weinreb, David P. Goldstein, Jason Moffat, Troy Ketela, Kevin R. Brown, Marianne Koritzinsky, Benjamin Solomon, Danny Rischin, William R. Wilson, and Bradly G. Wouters
http://cancerres.aacrjournals.org/content/75/19/4211.abstract?etoc
Targeting glutamine metabolism sensitizes pancreatic cancer to PARP-driven metabolic catastrophe induced by ß-lapachone
Chakrabarti G, Moore Z, Luo X, Ilcheva M, Ali A, Padanad M, Zhou Y, Xie Y, Burma S, Scaglioni P, Cantley L, DeBerardinis R, Kimmelman A, Lyssiotis C, Boothman D
http://www.cancerandmetabolism.com/content/3/1/12/abstract
2-Deoxyglucose induces the expression of thioredoxin interacting protein (TXNIP) by increasing O-GlcNAcylation - Implications for targeting the Warburg effect in cancer cells
Hong, SY; Hagen, T
http://www.sciencedirect.com/science/article/pii/S0006291X15304885
Targeting mitochondrial complex I using BAY 87-2243 reduces melanoma tumor growth
Schöckel L, Glasauer A, Basit F, Bitschar K, Truong H, Erdmann G, Algire C, Hägebarth A, Willems P, Kopitz C, Koopman W, Héroult M
http://www.cancerandmetabolism.com/content/3/1/11/abstract
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AMPK
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AMPK Protects Leukemia-Initiating Cells in Myeloid Leukemias from Metabolic Stress in the Bone Marrow
Yusuke Saito, Richard H. Chapple, Angelique Lin, Ayumi Kitano, Daisuke Nakada
http://www.cell.com/cell-stem-cell/abstract/S1934-5909%2815%2900374-4#.Vg1tDbu2M_o.facebook
Snf1/AMPK promotes the formation of Kog1/Raptor-bodies to increase the activation threshold of TORC1 in budding yeast
James E Hughes Hallett, Xiangxia Luo and Andrew P Capaldi
http://elifesciences.org/content/early/2015/10/06/eLife.09181
AMPK inhibits MTDH expression via GSK3β and SIRT1 activation: potential role in triple negative breast cancer cell proliferation
Paradesi Naidu Gollavilli, Anantha Koteswararao Kanugula, Rajeswari Koyyada, Santosh Karnewar, Praveen Kumar Neeli and Srigiridhar Kotamraju
http://onlinelibrary.wiley.com/doi/10.1111/febs.13391/abstract?campaign=woletoc
AMPK Promotes Aberrant PGC1β Expression To Support Human Colon Tumor Cell Survival
Kurt W. Fisher, Binita Das, Hyun Seok Kim, Beth K. Clymer, Drew Gehring, Deandra R. Smith, Diane L. Costanzo-Garvey, Mario R. Fernandez, Michael G. Brattain, David L. Kelly, John MacMillan, Michael A. White, and Robert E. Lewis
http://mcb.asm.org/content/35/22/3866.abstract?etoc
------------------
Hypoxia
------------------
Suppressors of superoxide production from mitochondrial complex III
Adam L Orr, Leonardo Vargas, Carolina N Turk, Janine E Baaten, Jason T Matzen, Victoria J Dardov, Stephen J Attle, Jing Li, Douglas C Quackenbush, Renata L S Goncalves, Irina V Perevoshchikova, H Michael Petrassi, Shelly L Meeusen, Edward K Ainscow & Martin D Brand
http://www.nature.com/nchembio/journal/vaop/ncurrent/full/nchembio.1910.html
The Apoptotic Effect of HIF-1α Inhibition Combined with Glucose plus Insulin Treatment on Gastric Cancer under Hypoxic Conditions
Tomokazu Tanaka, Yoshihiko Kitajima, Shuusuke Miyake, Kazuyoshi Yanagihara, Hiromitsu Hara, Aki Nishijima-Matsunobu, Koichi Baba, Masaaki Shida, Kota Wakiyama, Jun Nakamura, Hirokazu Noshiro
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0137257
Carbonic Anhydrase Activity Monitored In Vivo by Hyperpolarized ^13C-Magnetic Resonance Spectroscopy Demonstrates Its Importance for pH Regulation in Tumors
Ferdia A. Gallagher, Helen Sladen, Mikko I. Kettunen, Eva M. Serrao, Tiago B. Rodrigues, Alan Wright, Andrew B. Gill, Sarah McGuire, Thomas C.Booth, Joan Boren, Alan McIntyre, Jodi L. Miller, Shen-Han Lee, Davina Honess, Sam E. Day, De-En Hu, William J. Howat, Adrian L. Harris, and Kevin M. Brindle
http://cancerres.aacrjournals.org/content/75/19/4109.abstract?etoc
ACLY and ACC1 Regulate Hypoxia-Induced Apoptosis by Modulating ETV4 via α-ketoglutarate
Melissa M. Keenan, Beiyu Liu, Xiaohu Tang, Jianli Wu, Derek Cyr, Robert D. Stevens, Olga Ilkayeva, Zhiqing Huang, Laura A. Tollini, Susan K. Murphy, Joseph Lucas, Deborah M. Muoio, So Young Kim, Jen-Tsan Chi
http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1005599
----------------------------------------
Nutrient sensing, ischemia
----------------------------------------
Amino Acids Stimulate TORC1 through Lst4-Lst7, a GTPase-Activating Protein Complex for the Rag Family GTPase Gtr2
Marie-Pierre Péli-Gulli, Alessandro Sardu, Nicolas Panchaud, Serena Raucci, Claudio De Virgilio
http://www.cell.com/cell-reports/abstract/S2211-1247(15)00956-0
Muscle wasting in fasting requires activation of NF-κB and inhibition of AKT/mTOR by the protein acetylase, GCN5
Donghoon Lee and Alfred L. Goldberg
http://www.jbc.org/content/early/2015/10/29/jbc.M115.685164.abstract
TRIB3 enhances cell viability during glucose deprivation in HEK293-derived cells by upregulating IGFBP2, a novel nutrient deficiency survival factor
Tiit Örda, b, Daima Örda, Priit Adlerc, Jaak Viloc, Tõnis Örd
http://www.sciencedirect.com/science/article/pii/S0167488915001962
Glucose Starvation in Cardiomyocytes Enhances Exosome Secretion and Promotes Angiogenesis in Endothelial Cells
Nahuel A. Garcia, Imelda Ontoria-Oviedo, Hernán González-King, Antonio Diez-Juan, Pilar Sepúlveda
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0138849
The rate of glycolysis quantitatively mediates specific histone acetylation sites
Cluntun A, Huang H, Dai L, Liu X, Zhao Y, Locasale J
http://www.cancerandmetabolism.com/content/3/1/10/abstract
------------------------
Miscellaneous
------------------------
Real-time metabolome profiling of the metabolic switch between starvation and growth
Hannes Link, Tobias Fuhrer, Luca Gerosa, Nicola Zamboni & Uwe Sauer
http://www.nature.com/nmeth/journal/v12/n11/full/nmeth.3584.html
PET imaging of tumor glycolysis downstream of hexokinase through noninvasive measurement of pyruvate kinase M2
Timothy H. Witney, Michelle L. James, Bin Shen1, Edwin Chang1, Christoph Pohling1, Natasha Arksey1, Aileen Hoehne1,‡, Adam Shuhendler1, Jun-Hyung Park1, Deepika Bodapati1, Judith Weber1, Gayatri Gowrishankar1, Jianghong Rao1, Frederick T. Chin1 and Sanjiv Sam Gambhir
http://stm.sciencemag.org/content/7/310/310ra169.abstract
Direct link between metabolic regulation and the heat-shock response through the transcriptional regulator PGC-1α
Neri Minsky and Robert G. Roeder
http://www.pnas.org/content/112/42/E5669.abstract.html?etoc
Subcellular Distribution of NAD+ between Cytosol and Mitochondria Determines the Metabolic Profile of Human Cells
Magali R. VanLinden, Christian Dölle, Ina K. N. Pettersen, Veronika A. Kulikova, Marc Niere, Gennaro Agrimi, Sissel E. Dyrstad, Ferdinando Palmieri, Andrey A. Nikiforov, Karl Johan Tronstad, and Mathias Ziegler
http://www.jbc.org/content/early/2015/10/02/jbc.M115.654129.abstract
Novel p53-dependent anticancer strategy by targeting iron signaling and BNIP3L-induced mitophagy
Nastasia Wilfinger, Shane Austin, Barbara Scheiber-Mojdekhar, Walter Berger, Siegfried Reipert, Monika Praschberger, Jakob Paur, Robert Trondl, Bernhard K. Keppler, Christoph C. Zielinski, Karin Nowikovsky
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5b%5d=6233&pubmed-linkout=1
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Reviews
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MYC, Metabolism, and Cancer
Zachary E. Stine, Zandra E. Walton, Brian J. Altman, Annie L. Hsieh, and Chi V. Dang
http://cancerdiscovery.aacrjournals.org/content/5/10/1024.abstract?etoc
Uncovering metabolism in rhabdomyosarcoma
Eugenio Monti & Alessandro Fanzani
http://www.tandfonline.com/doi/abs/10.1080/15384101.2015.1071746?journalCode=kccy20
C-labeled biochemical probes for the study of cancer metabolism with dynamic nuclear polarization-enhanced magnetic resonance imaging
Salamanca-Cardona L, Keshari K
http://www.cancerandmetabolism.com/content/3/1/9/abstract
Metabolic reprogramming of the tumour microenvironment
Yazhi Xing, Shimin Zhao, Binhua P. Zhou and Jun Mi
http://onlinelibrary.wiley.com/doi/10.1111/febs.13402/abstract
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Previews
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Differences in Metabolic Programming Define the Site of Breast Cancer Cell Metastasis
Heike Döppler, Peter Storz
http://www.cell.com/cell-metabolism/abstract/S1550-4131(15)00479-9
Sugar? No Thank You, Just a Deep Breath of Oxygen for Cancer Stem Cells
Andrea Viale, Giulio F. Draetta
http://www.cell.com/cell-metabolism/abstract/S1550-4131(15)00477-5
A Polyamine Twist on Hedgehog Signaling
Xuesong Zhao, Rosalind A. Segal
http://www.cell.com/developmental-cell/abstract/S1534-5807(15)00625-5
Hypoxia-recruited angiogenic neutrophils
Eric L. Campbell
http://bloodjournal.org/content/126/17/1972?etoc
Targeting leukemia’s “fatty tooth”
Ismael Samudio and Marina Konopleva
http://bloodjournal.org/content/126/16/1874?etoc
The TRIB3-SQSTM1 interaction mediates metabolic stress-promoted tumorigenesis and progression via suppressing autophagic and proteasomal degradation
Fang Hua, Ke Li, Jiao-Jiao Yu & Zhuo-Wei Hu
http://www.tandfonline.com/doi/full/10.1080/15548627.2015.1084458
Metabolic competition between tumors and T cells
http://stke.sciencemag.org/content/8/397/ec281.abstract?utm_campaign=email-sig-toc
Cristina
----------------------------------
Cancer metabolism
----------------------------------
MYC/PGC-1α Balance Determines the Metabolic Phenotype and Plasticity of Pancreatic Cancer Stem Cells
Patricia Sancho, Emma Burgos-Ramos, Alejandra Tavera, Tony Bou Kheir, Petra Jagust, Matthieu Schoenhals, David Barneda, Katherine Sellers, Ramon Campos-Olivas, Osvaldo Graña, Catarina R. Viera, Mariia Yuneva, Bruno Sainz, Christopher Heeschen
http://www.cell.com/cell-metabolism/abstract/S1550-4131(15)00406-4
Mitochondrial Phosphoenolpyruvate Carboxykinase Regulates Metabolic Adaptation and Enables Glucose-Independent Tumor Growth
Emma E. Vincent, Alexey Sergushichev, Takla Griss, Marie-Claude Gingras, Bozena Samborska, Thierry Ntimbane, Paula P. Coelho, Julianna Blagih, Thomas C. Raissi, Luc Choinière, Gaëlle Bridon, Ekaterina Loginicheva, Breanna R. Flynn, Elaine C. Thomas, Jeremy M. Tavaré, Daina Avizonis, Arnim Pause, Douglas J.E. Elder, Maxim N. Artyomov, Russell G. Jones
http://www.cell.com/molecular-cell/abstract/S1097-2765(15)00659-0
PDK1-Dependent Metabolic Reprogramming Dictates Metastatic Potential in Breast Cancer
Fanny Dupuy, Sébastien Tabariès, Sylvia Andrzejewski, Zhifeng Dong, Julianna Blagih, Matthew G. Annis, Atilla Omeroglu, Dongxia Gao, Samuel Leung, Eitan Amir, Mark Clemons, Adriana Aguilar-Mahecha, Mark Basik, Emma E. Vincent, Julie St.-Pierre, Russell G. Jones, Peter M. Siegel
http://www.cell.com/cell-metabolism/abstract/S1550-4131(15)00398-8
Unsaturated Fatty Acids Stimulate Tumor Growth through Stabilization of β-Catenin
Hyeonwoo Kim, Carlos Rodriguez-Navas, Rahul K. Kollipara, Payal Kapur, Ivan Pedrosa, James Brugarolas, Ralf Kittler, Jin Ye
http://www.cell.com/cell-reports/abstract/S2211-1247(15)01021-9
Non-canonical Hedgehog/AMPK-Mediated Control of Polyamine Metabolism Supports Neuronal and Medulloblastoma Cell Growth
Davide D’Amico, Laura Antonucci, Laura Di Magno, Sonia Coni, Giulia Sdruscia, Alberto Macone, Evelina Miele, Paola Infante, Lucia Di Marcotullio, Enrico De Smaele, Elisabetta Ferretti, Laura Ciapponi, Felice Giangaspero, John R. Yates, Enzo Agostinelli, Beatrice Cardinali, Isabella Screpanti, Alberto Gulino, Gianluca Canettieri
http://www.cell.com/developmental-cell/abstract/S1534-5807(15)00588-2
Metabolic reprogramming induces resistance to anti-NOTCH1 therapies in T cell acute lymphoblastic leukemia
Daniel Herranz, Alberto Ambesi-Impiombato, Jessica Sudderth, Marta Sánchez-Martín, Laura Belver, Valeria Tosello, Luyao Xu, Agnieszka A Wendorff, Mireia Castillo, J Erika Haydu, Javier Márquez, José M Matés, Andrew L Kung, Stephen Rayport, Carlos Cordon-Cardo, Ralph J DeBerardinis & Adolfo A Ferrando
http://www.nature.com/nm/journal/v21/n10/full/nm.3955.html
p53 regulates the mevalonate pathway in human glioblastoma multiforme
C Laezza, A D'Alessandro, L Di Croce, P Picardi, E Ciaglia, S Pisanti, A M Malfitano, M Comegna, R Faraonio, P Gazzerro and M Bifulco
http://www.nature.com/cddis/journal/v6/n10/abs/cddis2015279a.html
Functional genomic screening reveals asparagine dependence as a metabolic vulnerability in sarcoma
Simone Hettmer, Anna C Schinzel, Daria Tchessalova, Michaela Schneider, Christina L. Parker, Roderick Bronson, Nigel G.J. Richards, William Hahn and Amy J Wagers
http://elifesciences.org/content/early/2015/10/24/eLife.09436
Expression of Lipid Metabolism-Related Proteins in Metastatic Breast Cancer
Yoon Yang Jung, Hye Min Kim, Ja Seung Koo
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0137204
-----------------------------------
Anti-metabolic drugs
-----------------------------------
Treatment with a Small Molecule Mutant IDH1 Inhibitor Suppresses Tumorigenic Activity and Decreases Production of the Oncometabolite 2-Hydroxyglutarate in Human Chondrosarcoma Cells
Luyuan Li, Ana C. Paz, Breelyn A. Wilky, Britt Johnson, Karina Galoian, Andrew Rosenberg, Guozhi Hu, Gabriel Tinoco, Olaf Bodamer, Jonathan C. Trent
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0133813
Antileukemic Activity of 2-Deoxy-D-Glucose through Inhibition of N-Linked Glycosylation in Acute Myeloid Leukemia with FLT3-ITD or c-KIT Mutations
Clément Larrue, Estelle Saland, François Vergez, Nizar Serhan, Eric Delabesse, Véronique Mansat-De Mas, Marie-Anne Hospital, Jérôme Tamburini, Stéphane Manenti, Jean Emmanuel Sarry, and Christian Récher
http://mct.aacrjournals.org/content/14/10/2364.long
Identification of P450 Oxidoreductase as a Major Determinant of Sensitivity to Hypoxia-Activated Prodrugs
Francis W. Hunter, Richard J. Young, Zvi Shalev, Ravi N. Vellanki, JingliWang, Yongchuan Gu, Naveen Joshi, Sreevalsan Sreebhavan, Ilan Weinreb, David P. Goldstein, Jason Moffat, Troy Ketela, Kevin R. Brown, Marianne Koritzinsky, Benjamin Solomon, Danny Rischin, William R. Wilson, and Bradly G. Wouters
http://cancerres.aacrjournals.org/content/75/19/4211.abstract?etoc
Targeting glutamine metabolism sensitizes pancreatic cancer to PARP-driven metabolic catastrophe induced by ß-lapachone
Chakrabarti G, Moore Z, Luo X, Ilcheva M, Ali A, Padanad M, Zhou Y, Xie Y, Burma S, Scaglioni P, Cantley L, DeBerardinis R, Kimmelman A, Lyssiotis C, Boothman D
http://www.cancerandmetabolism.com/content/3/1/12/abstract
2-Deoxyglucose induces the expression of thioredoxin interacting protein (TXNIP) by increasing O-GlcNAcylation - Implications for targeting the Warburg effect in cancer cells
Hong, SY; Hagen, T
http://www.sciencedirect.com/science/article/pii/S0006291X15304885
Targeting mitochondrial complex I using BAY 87-2243 reduces melanoma tumor growth
Schöckel L, Glasauer A, Basit F, Bitschar K, Truong H, Erdmann G, Algire C, Hägebarth A, Willems P, Kopitz C, Koopman W, Héroult M
http://www.cancerandmetabolism.com/content/3/1/11/abstract
------------------
AMPK
------------------
AMPK Protects Leukemia-Initiating Cells in Myeloid Leukemias from Metabolic Stress in the Bone Marrow
Yusuke Saito, Richard H. Chapple, Angelique Lin, Ayumi Kitano, Daisuke Nakada
http://www.cell.com/cell-stem-cell/abstract/S1934-5909%2815%2900374-4#.Vg1tDbu2M_o.facebook
Snf1/AMPK promotes the formation of Kog1/Raptor-bodies to increase the activation threshold of TORC1 in budding yeast
James E Hughes Hallett, Xiangxia Luo and Andrew P Capaldi
http://elifesciences.org/content/early/2015/10/06/eLife.09181
AMPK inhibits MTDH expression via GSK3β and SIRT1 activation: potential role in triple negative breast cancer cell proliferation
Paradesi Naidu Gollavilli, Anantha Koteswararao Kanugula, Rajeswari Koyyada, Santosh Karnewar, Praveen Kumar Neeli and Srigiridhar Kotamraju
http://onlinelibrary.wiley.com/doi/10.1111/febs.13391/abstract?campaign=woletoc
AMPK Promotes Aberrant PGC1β Expression To Support Human Colon Tumor Cell Survival
Kurt W. Fisher, Binita Das, Hyun Seok Kim, Beth K. Clymer, Drew Gehring, Deandra R. Smith, Diane L. Costanzo-Garvey, Mario R. Fernandez, Michael G. Brattain, David L. Kelly, John MacMillan, Michael A. White, and Robert E. Lewis
http://mcb.asm.org/content/35/22/3866.abstract?etoc
------------------
Hypoxia
------------------
Suppressors of superoxide production from mitochondrial complex III
Adam L Orr, Leonardo Vargas, Carolina N Turk, Janine E Baaten, Jason T Matzen, Victoria J Dardov, Stephen J Attle, Jing Li, Douglas C Quackenbush, Renata L S Goncalves, Irina V Perevoshchikova, H Michael Petrassi, Shelly L Meeusen, Edward K Ainscow & Martin D Brand
http://www.nature.com/nchembio/journal/vaop/ncurrent/full/nchembio.1910.html
The Apoptotic Effect of HIF-1α Inhibition Combined with Glucose plus Insulin Treatment on Gastric Cancer under Hypoxic Conditions
Tomokazu Tanaka, Yoshihiko Kitajima, Shuusuke Miyake, Kazuyoshi Yanagihara, Hiromitsu Hara, Aki Nishijima-Matsunobu, Koichi Baba, Masaaki Shida, Kota Wakiyama, Jun Nakamura, Hirokazu Noshiro
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0137257
Carbonic Anhydrase Activity Monitored In Vivo by Hyperpolarized ^13C-Magnetic Resonance Spectroscopy Demonstrates Its Importance for pH Regulation in Tumors
Ferdia A. Gallagher, Helen Sladen, Mikko I. Kettunen, Eva M. Serrao, Tiago B. Rodrigues, Alan Wright, Andrew B. Gill, Sarah McGuire, Thomas C.Booth, Joan Boren, Alan McIntyre, Jodi L. Miller, Shen-Han Lee, Davina Honess, Sam E. Day, De-En Hu, William J. Howat, Adrian L. Harris, and Kevin M. Brindle
http://cancerres.aacrjournals.org/content/75/19/4109.abstract?etoc
ACLY and ACC1 Regulate Hypoxia-Induced Apoptosis by Modulating ETV4 via α-ketoglutarate
Melissa M. Keenan, Beiyu Liu, Xiaohu Tang, Jianli Wu, Derek Cyr, Robert D. Stevens, Olga Ilkayeva, Zhiqing Huang, Laura A. Tollini, Susan K. Murphy, Joseph Lucas, Deborah M. Muoio, So Young Kim, Jen-Tsan Chi
http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1005599
----------------------------------------
Nutrient sensing, ischemia
----------------------------------------
Amino Acids Stimulate TORC1 through Lst4-Lst7, a GTPase-Activating Protein Complex for the Rag Family GTPase Gtr2
Marie-Pierre Péli-Gulli, Alessandro Sardu, Nicolas Panchaud, Serena Raucci, Claudio De Virgilio
http://www.cell.com/cell-reports/abstract/S2211-1247(15)00956-0
Muscle wasting in fasting requires activation of NF-κB and inhibition of AKT/mTOR by the protein acetylase, GCN5
Donghoon Lee and Alfred L. Goldberg
http://www.jbc.org/content/early/2015/10/29/jbc.M115.685164.abstract
TRIB3 enhances cell viability during glucose deprivation in HEK293-derived cells by upregulating IGFBP2, a novel nutrient deficiency survival factor
Tiit Örda, b, Daima Örda, Priit Adlerc, Jaak Viloc, Tõnis Örd
http://www.sciencedirect.com/science/article/pii/S0167488915001962
Glucose Starvation in Cardiomyocytes Enhances Exosome Secretion and Promotes Angiogenesis in Endothelial Cells
Nahuel A. Garcia, Imelda Ontoria-Oviedo, Hernán González-King, Antonio Diez-Juan, Pilar Sepúlveda
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0138849
The rate of glycolysis quantitatively mediates specific histone acetylation sites
Cluntun A, Huang H, Dai L, Liu X, Zhao Y, Locasale J
http://www.cancerandmetabolism.com/content/3/1/10/abstract
------------------------
Miscellaneous
------------------------
Real-time metabolome profiling of the metabolic switch between starvation and growth
Hannes Link, Tobias Fuhrer, Luca Gerosa, Nicola Zamboni & Uwe Sauer
http://www.nature.com/nmeth/journal/v12/n11/full/nmeth.3584.html
PET imaging of tumor glycolysis downstream of hexokinase through noninvasive measurement of pyruvate kinase M2
Timothy H. Witney, Michelle L. James, Bin Shen1, Edwin Chang1, Christoph Pohling1, Natasha Arksey1, Aileen Hoehne1,‡, Adam Shuhendler1, Jun-Hyung Park1, Deepika Bodapati1, Judith Weber1, Gayatri Gowrishankar1, Jianghong Rao1, Frederick T. Chin1 and Sanjiv Sam Gambhir
http://stm.sciencemag.org/content/7/310/310ra169.abstract
Direct link between metabolic regulation and the heat-shock response through the transcriptional regulator PGC-1α
Neri Minsky and Robert G. Roeder
http://www.pnas.org/content/112/42/E5669.abstract.html?etoc
Subcellular Distribution of NAD+ between Cytosol and Mitochondria Determines the Metabolic Profile of Human Cells
Magali R. VanLinden, Christian Dölle, Ina K. N. Pettersen, Veronika A. Kulikova, Marc Niere, Gennaro Agrimi, Sissel E. Dyrstad, Ferdinando Palmieri, Andrey A. Nikiforov, Karl Johan Tronstad, and Mathias Ziegler
http://www.jbc.org/content/early/2015/10/02/jbc.M115.654129.abstract
Novel p53-dependent anticancer strategy by targeting iron signaling and BNIP3L-induced mitophagy
Nastasia Wilfinger, Shane Austin, Barbara Scheiber-Mojdekhar, Walter Berger, Siegfried Reipert, Monika Praschberger, Jakob Paur, Robert Trondl, Bernhard K. Keppler, Christoph C. Zielinski, Karin Nowikovsky
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5b%5d=6233&pubmed-linkout=1
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Reviews
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MYC, Metabolism, and Cancer
Zachary E. Stine, Zandra E. Walton, Brian J. Altman, Annie L. Hsieh, and Chi V. Dang
http://cancerdiscovery.aacrjournals.org/content/5/10/1024.abstract?etoc
Uncovering metabolism in rhabdomyosarcoma
Eugenio Monti & Alessandro Fanzani
http://www.tandfonline.com/doi/abs/10.1080/15384101.2015.1071746?journalCode=kccy20
C-labeled biochemical probes for the study of cancer metabolism with dynamic nuclear polarization-enhanced magnetic resonance imaging
Salamanca-Cardona L, Keshari K
http://www.cancerandmetabolism.com/content/3/1/9/abstract
Metabolic reprogramming of the tumour microenvironment
Yazhi Xing, Shimin Zhao, Binhua P. Zhou and Jun Mi
http://onlinelibrary.wiley.com/doi/10.1111/febs.13402/abstract
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Previews
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Differences in Metabolic Programming Define the Site of Breast Cancer Cell Metastasis
Heike Döppler, Peter Storz
http://www.cell.com/cell-metabolism/abstract/S1550-4131(15)00479-9
Sugar? No Thank You, Just a Deep Breath of Oxygen for Cancer Stem Cells
Andrea Viale, Giulio F. Draetta
http://www.cell.com/cell-metabolism/abstract/S1550-4131(15)00477-5
A Polyamine Twist on Hedgehog Signaling
Xuesong Zhao, Rosalind A. Segal
http://www.cell.com/developmental-cell/abstract/S1534-5807(15)00625-5
Hypoxia-recruited angiogenic neutrophils
Eric L. Campbell
http://bloodjournal.org/content/126/17/1972?etoc
Targeting leukemia’s “fatty tooth”
Ismael Samudio and Marina Konopleva
http://bloodjournal.org/content/126/16/1874?etoc
The TRIB3-SQSTM1 interaction mediates metabolic stress-promoted tumorigenesis and progression via suppressing autophagic and proteasomal degradation
Fang Hua, Ke Li, Jiao-Jiao Yu & Zhuo-Wei Hu
http://www.tandfonline.com/doi/full/10.1080/15548627.2015.1084458
Metabolic competition between tumors and T cells
http://stke.sciencemag.org/content/8/397/ec281.abstract?utm_campaign=email-sig-toc
--
Cristina Muñoz Pinedo
Cell Death Regulation Group
IDIBELL (Bellvitge Biomedical Research Institute)
tel +34 93 260 7130 - fax +34 93 260 7426
http://www.idibell.cat/modul/regulacio-de-la-mort-cellular/EN
http://www.cancer-metabolism.org
Mailing address:
Cristina Muñoz-Pinedo
Fundació IDIBELL
Hospital Duran i Reynals 3ª planta
Gran Vía de L'Hospitalet 199
L'Hospitalet (Barcelona)
08908 España
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