MetaboList - August 2015

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Muñoz Pinedo, Cristina

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Sep 1, 2015, 9:00:40 AM9/1/15

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Regards,

Cristina

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Cancer metabolism

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Metabolic Rewiring by Oncogenic BRAF V600E Links Ketogenesis Pathway to BRAF-MEK1 Signaling

Hee-Bum Kang, Jun Fan, Ruiting Lin, Shannon Elf, Quanjiang Ji, Liang Zhao, Lingtao Jin, Jae Ho Seo, Changliang Shan, Jack L. Arbiser, Cynthia Cohen, Daniel Brat, Henry M. Miziorko, Eunhee Kim, Omar Abdel-Wahab, Taha Merghoub, Stefan Fröhling, Claudia Scholl, Pablo Tamayo, David A. Barbie, Lu Zhou, Brian P. Pollack, Kevin Fisher, Ragini R. Kudchadkar, David H. Lawson, Gabriel Sica, Michael Rossi, Sagar Lonial, Hanna J. Khoury, Fadlo R. Khuri, Benjamin H. Lee, Titus J. Boggon, Chuan He, Sumin Kang, Jing Chen

http://www.cell.com/molecular-cell/abstract/S1097-2765(15)00438-4

Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors

Anneleen Daemen, David Peterson, Nisebita Sahu, Ron McCord, Xiangnan Du, Bonnie Liu, Katarzyna Kowanetz, Rebecca Hong, John Moffat, Min Gao, Aaron Boudreau, Rana Mroue, Laura Corson, Thomas O’Brien, Jing Qing, Deepak Sampath, Mark Merchant, Robert Yauch, Gerard Manning, Jeffrey Settleman, Georgia Hatzivassiliou, and Marie Evangelista

http://www.pnas.org/content/112/32/E4410.abstract.html?etoc

The Plasma Membrane Calcium Pump in Pancreatic Cancer Cells Exhibiting the Warburg Effect Relies on Glycolytic ATP

Andrew David James, Waseema Patel, Zohra Butt, Magretta Adiamah, Raga Dakhel, Ayse Latif, Carolina Uggenti, Eileithyia Swanton, Hiromi Imamura, Ajith Kumar Siriwardena, and Jason Irving Edward Bruce

http://www.jbc.org/content/early/2015/08/20/jbc.M115.668707.abstrac

IDH1 Mutation Induces Reprogramming of Pyruvate Metabolism

Jose L. Izquierdo-Garcia, Pavithra Viswanath, Pia Eriksson, Larry Cai, Marina Radoul, Myriam M. Chaumeil, Michael Blough, H. Artee Luchman, Samuel Weiss, J. Gregory Cairncross, Joanna J. Phillips, Russell O. Pieper, and Sabrina M. Ronen

http://cancerres.aacrjournals.org/content/75/15/2999.abstract?etoc

PARP14 promotes the Warburg effect in hepatocellular carcinoma by inhibiting JNK1-dependent PKM2 phosphorylation and activation

Valeria Iansante, Pui Man Choy, Sze Wai Fung, Ying Liu, Jian-Guo Chai, Julian Dyson, Alberto Del Rio, Clive D’Santos, Roger Williams, Shilpa Chokshi, Robert A Anders, Concetta Bubici and Salvatore Papa

http://www.nature.com/ncomms/2015/150810/ncomms8882/full/ncomms8882.html

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Metabolic stress / antimetabolics

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ERK2 Mediates Metabolic Stress Response to Regulate Cell Fate

Sejeong Shin, Gwen R. Buel, Laura Wolgamott, David R. Plas, John M. Asara, John Blenis, Sang-Oh Yoon

http://www.cell.com/molecular-cell/abstract/S1097-2765(15)00492-X

Transcriptional regulation of Annexin A2 promotes starvation-induced autophagy

Kevin Moreau, Ghita Ghislat, Warren Hochfeld, Maurizio Renna, Eszter Zavodszky, Gautam Runwal, Claudia Puri, Shirley Lee, Farah Siddiqi, Fiona M. Menzies, Brinda Ravikumar and David C. Rubinsztein

http://www.nature.com/ncomms/2015/150820/ncomms9045/full/ncomms9045.html

Therapeutic Targeting of the Warburg Effect in Pancreatic Cancer Relies on an Absence of p53 Function

N.V. Rajeshkumar, Prasanta Dutta, Shinichi Yabuuchi, Roeland F. de Wilde,Gary V. Martinez, Anne Le, Jurre J. Kamphorst, Joshua D. Rabinowitz, Sanjay K. Jain, Manuel Hidalgo, Chi V. Dang, Robert J. Gillies, and Anirban Maitra

http://cancerres.aacrjournals.org/content/75/16/3355.abstract?etoc

The presence of wild type p53 in hematological cancers improves the efficacy of combinational therapy targeting metabolism

Nerea Allende-Vega, Ewelina Krzywinska, Stefania Orecchioni, Nuria Lopez-Royuela, Francesca Reggiani, Giovanna Talarico, Jean-François Rossi, Rodrigue Rossignol, Yosr Hicheri, Guillaume Cartro, Francesco Bertolini, Martin Villalba

http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=4653

Diacylglycerol Metabolism and Signaling Is a Driving Force Underlying FASN Inhibitor Sensitivity in Cancer Cells

Daniel I. Benjamin, Daniel S. Li, Wallace Lowe, Timothy Heuer, George Kemble, and Daniel K. Nomura

http://pubs.acs.org/doi/abs/10.1021/acschembio.5b00240

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HIFs and hypoxia, oxidative stress

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Hypoxia Induces Production of L-2-Hydroxyglutarate

Andrew M. Intlekofer, Raymond G. Dematteo, Sriram Venneti, Lydia W.S. Finley, Chao Lu, Alexander R. Judkins, Ariën S. Rustenburg, Patrick B. Grinaway, John D. Chodera, Justin R. Cross, Craig B. Thompson

http://www.cell.com/cell-metabolism/abstract/S1550-4131(15)00290-9

Hypoxia-Mediated Increases in l-2-hydroxyglutarate Coordinate the Metabolic Response to Reductive Stress

William M. Oldham, Clary B. Clish, Yi Yang, Joseph Loscalzo

http://www.cell.com/cell-metabolism/abstract/S1550-4131(15)00288-0

Structural integration in hypoxia-inducible factors

Dalei Wu, Nalini Potluri, Jingping Lu, Youngchang Kim & Fraydoon Rastinejad

http://www.nature.com/nature/journal/v524/n7565/full/nature14883.html

Mitochondrial Proteostatic Collapse Leads to Hypoxic Injury

Daniel M. Kaufman, C. Michael Crowder

http://www.cell.com/current-biology/abstract/S0960-9822(15)00789-7

The Cancer Cell Oxygen Sensor PHD2 Promotes Metastasis via Activation of Cancer-Associated Fibroblasts

Anna Kuchnio, Stijn Moens, Ulrike Bruning, Karol Kuchnio, Bert Cruys, Bernard Thienpont, Michaël Broux, Andreea Alexandra Ungureanu, Rodrigo Leite de Oliveira, Françoise Bruyère, Henar Cuervo, Ann Manderveld, An Carton, Juan Ramon Hernandez-Fernaud, Sara Zanivan, Carmen Bartic, Jean-Michel Foidart, Agnes Noel, Stefan Vinckier, Diether Lambrechts, Mieke Dewerchin, Massimiliano Mazzone, Peter Carmeliet

http://www.cell.com/cell-reports/abstract/S2211-1247(15)00750-0

Acute Activation of Oxidative Pentose Phosphate Pathway as First-Line Response to Oxidative Stress in Human Skin Cells

Andreas Kuehne, Hila Emmert, Joern Soehle, Marc Winnefeld, Frank Fischer, Horst Wenck, Stefan Gallinat, Lara Terstegen, Ralph Lucius, Janosch Hildebrand, Nicola Zamboni

http://www.cell.com/molecular-cell/abstract/S1097-2765(15)00456-6

Tumor hypoxia induces nuclear paraspeckle formation through HIF-2α dependent transcriptional activation of NEAT1 leading to cancer cell survival

H Choudhry, A Albukhari, M Morotti, S Haider, D Moralli, J Smythies, J Schödel, C M Green, C Camps, F Buffa, P Ratcliffe, J Ragoussis, A L Harris and D R Mole

http://www.nature.com/onc/journal/v34/n34/abs/onc2014378a.html

Knockout of Vdac1 activates hypoxia-inducible factor through reactive oxygen species generation and induces tumor growth by promoting metabolic reprogramming and inflammation

Brahimi-Horn M, Giuliano S, Saland E, Lacas-Gervais S, Sheiko T, Pelletier J, Bourget I, Bost F, Feral C, Boulter E, Tauc M, Ivan M, Garmy-Susini B, Popa A, Mari B, Sarry J, Craigen W, Pouyssegur J, Mazure N

http://www.cancerandmetabolism.com/content/3/1/8/abstract

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AMPK

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A Critical SUMO1 Modification of LKB1 Regulates AMPK Activity during Energy Stress

Joan Ritho, Stefan T. Arold, Edward T.H. Yeh

http://www.cell.com/cell-reports/abstract/S2211-1247(15)00728-7

Myristoylation confers noncanonical AMPK functions in autophagy selectivity and mitochondrial surveillance

Jiyong Liang, Zhi-Xiang Xu, Zhiyong Ding, Yiling Lu, Qinghua Yu, Kaitlin D. Werle, Ge Zhou, Yun-Yong Park, Guang Peng, Michael J. Gambello and Gordon B. Mills

http://www.nature.com/ncomms/2015/150814/ncomms8926/full/ncomms8926.html

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mTOR

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Amino Acid Activation of mTORC1 by a PB1-Domain-Driven Kinase Complex Cascade

Juan F. Linares, Angeles Duran, Miguel Reina-Campos, Pedro Aza-Blanc, Alex Campos, Jorge Moscat, Maria T. Diaz-Meco

http://www.cell.com/cell-reports/abstract/S2211-1247(15)00823-2

Brain Expressed X-Linked 2 Is Pivotal for Hyperactive mTOR-Mediated Tumorigenesis

Zhongdong Hu, Ying Wang, Fuqiang Huang, Rongrong Chen, Chunjia Li, Fang Wang, June Goto, David J. Kwiatkowski, Joanna Wdzieczak-Bakala, Pengfei Tu, Jianmiao Liu, Xiaojun Zha and Hongbing Zhang

http://m.jbc.org/content/early/2015/08/20/jbc.M115.665208.abstract?papetoc

Diacylglycerol kinase-ζ regulates mTORC1 and lipogenic metabolism in cancer cells through SREBP-1

P Torres-Ayuso, M Tello-Lafoz, I Mérida and A Ávila-Flores

http://www.nature.com/oncsis/journal/v4/n8/abs/oncsis201522a.html

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Miscellaneous

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Lactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector Functions

Robert Haas, Joanne Smith, Vidalba Rocher-Ros, Suchita Nadkarni, Trinidad Montero-Melendez, Fulvio D’Acquisto, Elliot J. Bland, Michele Bombardieri, Costantino Pitzalis, Mauro Perretti, Federica M. Marelli-Berg, Claudio Mauro

http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1002202

PTEN mediates Notch-dependent stalk cell arrest in angiogénesis

Helena Serra, Iñigo Chivite, Ana Angulo-Urarte, Adriana Soler, James D. Sutherland, Amaia Arruabarrena-Aristorena, Anan Ragab, Radiance Lim, Marcos Malumbres, Marcus Fruttiger, Michael Potente, Manuel Serrano, Àngels Fabra, Francesc Viñals, Oriol Casanovas, Pier Paolo Pandolfi, Anna Bigas, Arkaitz Carracedo, Holger Gerhardt and Mariona Graupera

http://www.nature.com/ncomms/2015/150731/ncomms8935/full/ncomms8935.html

Manganese superoxide dismutase deficiency triggers mitochondrial uncoupling and the Warburg effect

Y Xu, S Miriyala, F Fang, V Bakthavatchalu, T Noel, D M Schell, C Wang, W H St Clair and D K St Clair

http://www.nature.com/onc/journal/v34/n32/abs/onc2014355a.html

Monitoring Mitochondrial Pyruvate Carrier Activity in Real Time Using a BRET-Based Biosensor: Investigation of the Warburg Effect

Vincent Compan, Sandra Pierredon, Benoît Vanderperre, Petra Krznar, Ibtissam Marchiq, Nicola Zamboni, Jacques Pouyssegur, Jean-Claude Martinou

http://www.cell.com/molecular-cell/abstract/S1097-2765(15)00529-8

The amino acid sensor GCN2 inhibits inflammatory responses to apoptotic cells promoting tolerance and suppressing systemic autoimmunity

Buvana Ravishankar, Haiyun Liu, Rahul Shinde, Kapil Chaudhary, Wei Xiao, Jillian Bradley, Marianne Koritzinsky, Michael P. Madaio, and Tracy L. McGaha

http://www.pnas.org/content/112/34/10774.abstract.html?etoc

Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation

Yuhui Jiang, Xu Qian, Jianfeng Shen, Yugang Wang, Xinjian Li, Rui Liu, Yan Xia, Qianming Chen, Guang Peng, Shiaw-Yih Lin & Zhimin Lu

http://www.nature.com/ncb/journal/v17/n9/full/ncb3209.html

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Reviews / Comments

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Glutaminolysis and autophagy in cancer

Victor H Villar, Faten Merhi, Mojgan Djavaheri-Mergny & Raúl V Durán

http://www.tandfonline.com/doi/abs/10.1080/15548627.2015.1053680#.Vd7vP3HtlBc

Autophagy at the crossroads of catabolism and anabolism

Jasvinder Kaur & Jayanta Debnath