The answer is yes, some of the tests will fail if you don't have a
dataset, which can be found here:
And you have not set (tacky I know), the environment variable
SON_TRACE_DATASETS to point to the root of it.
I've updated the install doc on dev and the master to reflect this.
https://github.com/benedictpaten/cactus/blob/development/doc/INSTALL.txt
As to if cactus is ready for whole genomes, I think I'd have to say no.
We're trying really hard to make it so, I hope within a couple of
months we will have solved the remaining scaling problems,
Benedict
http://dl.dropbox.com/u/156669/datasets.tar.bz2