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Tramadol 

Known by the brands Ultram and ConZip, Tramadol is a medication used to help manage moderate to severe pain.

It falls under the category of narcotics and is available only with a prescription.

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Summary: Researchers discovered that certain neurons not only replay past experiences but also anticipate future events during sleep.

US Brand Name

  1. ConZip
  2. FusePaq Synapryn
  3. Qdolo
  4. Rybix ODT
  5. Ryzolt
  6. Ultram
  7. Ultram ER

Descriptions

Tramadol is used to relieve moderate to moderately severe pain, including pain after surgery. It is also used to treat pain severe enough to require opioid treatment and when other pain medicines did not work well enough or cannot be tolerated. The extended-release capsules or tablets are used for chronic ongoing pain.

Tramadol belongs to the group of medicines called opioid analgesics. It acts in the central nervous system (CNS) to relieve pain.

When tramadol is used for a long time, it may become habit-forming, causing mental or physical dependence. However, people who have continuing pain should not let the fear of dependence keep them from using narcotics to relieve their pain. Mental dependence (addiction) is not likely to occur when narcotics are used for this purpose. Physical dependence may lead to withdrawal side effects if treatment is stopped suddenly. However, severe withdrawal side effects can usually be prevented by gradually reducing the dose over a period of time before treatment is stopped completely.

This medicine is available only under a restricted distribution program called the Opioid Analgesic REMS (Risk Evaluation and Mitigation Strategy) program.

This product is available in the following dosage forms:

  • Capsule, Extended Release
  • Solution
  • Tablet
  • Tablet, Extended Release, 24 HR
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By studying rats’ hippocampal activity, they found that neurons stabilize spatial representations and prepare for future tasks. This groundbreaking study reveals the role of sleep in neuroplasticity and memory consolidation.

Key Facts:

  1. Neurons in the hippocampus anticipate future experiences during sleep.
  2. Sharp wave ripples in the brain aid in memory consolidation and spatial representation.
  3. The study uses advanced machine learning to track neuron activity and predict behavior.

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