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Joaquim Machado

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Oct 22, 2013, 3:16:50 PM10/22/13
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O iPAD vai se desmaterializando ! Eh o que se espera de uma membrana porosa de interface entre teleporters.

--
Joaquim A. Machado
MINDWINGS&LEBLON: Arquitetura da Biodiversidade
Estudos, Projetos e Negociações
Campinas - SP - Brasil
T - 55 - 19 - 8830 - 3600

Joaquim Machado

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Oct 27, 2013, 7:36:18 PM10/27/13
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Por que o iPad pode dominar o mundo da computação

Há dois caminhos possíveis para a divisão de tablets da Apple AAPL -1.12% Inc.: o chamado Cenário Maravilhoso e o Cenário Super-Extra-Maravilhoso-Com-Chantilly.

No primeiro, a linha de iPads da Apple continua a ganhar muito mais dinheiro do que os tablets rivais e provavelmente continua a ser a mais vendida da categoria. Mas, com a concorrência cada vez mais acirrada de dispositivos de baixo preço, o iPad pode lentamente entregar seu domínio e acabar escorregando para talvez 25% ou menos do mercado de tablets. Isso não seria desastroso para a Apple. Neste cenário, o iPad estaria no mesmo lugar que seu irmão mais velho, o iPhone, com os ganhos espetaculares de uma participação de mercado regular. Em outras palavras, incrível.

No segundo cenário, o iPad vira a mesa. Como fez a divisão de iPods, os tablets da Apple manteriam uma liderança imbatível de longo prazo tanto em lucros como em participação de mercado. É claro que você vai ver um monte de rivais disputando o segundo lugar, mas esse será um espetáculo à parte. Para a indústria de PCs, este cenário é um pesadelo.

Se você acredita que os tablets estão se tornando o principal aparelho de computação do nosso tempo, tanto em casa como no trabalho, então o domínio de mercado da Apple estabeleceria uma rentabilidade colossal e estável. O iPad tornaria a Apple o equivalente de uma combinação da Microsoft Inc., MSFT +5.96% Intel Inc. e Dell Inc. DELL -0.07% no negócio de computadores do futuro.

Na terça-feira, a Apple lançou uma série de novos iPads. Qual dos dois caminhos é o mais provável, se considerarmos os novos modelos?

Vou violar tudo que aprendi nas aulas que tive na Pundit University e fazer uma previsão firme: acho que os novos iPads da Apple vão ajudar a levá-la para o segundo cenário, o super-extra-com-chantilly. Com o iPad, a Apple está entrando com força total — e é provável que vença.

Eu sei que você está cético. A participação de mercado do iPad está caindo ultimamente e, no terceiro trimestre, a Apple registrou a primeira queda em vendas comparadas com o mesmo período do ano anterior. No início desta semana, defendi que a divisão da Motorola, do Google Inc., GOOG -1.01% era uma tentativa de longo prazo para acabar com os lucros da Apple com smartphones.

Agora, depois de anos lançando produtos considerados ruins, o Google e outros concorrentes também estão fazendo tablets bons e baratos — então será que o iPad não é tão vulnerável quanto o iPhone?

Mas na coletiva de imprensa da Apple na terça-feira, o diretor-presidente Tim Cook falou sobre dois números que devem dar dor de cabeça aos rivais.

O primeiro número é US$ 299. Esse é o novo preço do iPad mini nos Estados Unidos, US$ 40 a menos do que o mesmo modelo vendido no ano passado e o menor preço já cobrado por um iPad. Assim como na divisão de reprodutores de música, a Apple não pretende vender o produto mais barato do mercado. Mas ao oferecer bastante diversidade de preço na sua linha e adicionar um número suficiente de recursos novos anualmente, ela vai continuar a ampliar sua acessibilidade, enquanto continua a gerar lucro.

Lembre-se que com os aparelhos de música digital essa estratégia funcionou perfeitamente: uma década após seu lançamento, o iPod ainda domina 78% do mercado. Estou apostando que a história se repitirá com os tablets. Quando você considera o software de produtividade gratuito que a Apple está adicionando a todos os iPads, seus preços são baixos o suficiente para dar ao tablet uma vantagem sobre seus rivais mais baratos.

O segundo número de Tim Cook é: 64%. Essa é a parcela de aparelhos da Apple que está usando o iOS 7 — a mudança mais radical de seu sistema operacional móvel desde que o iPhone chegou ao mercado, em 2007 — apenas algumas semanas depois de seu lançamento. A rápida adesão ressalta uma das principais vantagens do iPad: trata-se de uma plataforma unificada, enquanto os outros tablets estão sozinhos.

É verdade que alguns tablets rivais oferecem melhores especificações e preços mais baixos — o Nexus 7, do Google, custa US$ 229 nos EUA, é fino, leve, rápido e tem uma tela fantasticamente nítida —, mas todos sofrem com problema fatal que limita seu apelo. Os rivais da Apple não possuem muitos aplicativos otimizados para tablets. Enquanto isso, o iPad conseguiu atrair mais de 400.000 aplicativos que são projetados para o tamanho de sua tela.

Há uma razão muito simples: quando os programadores desenvolvem aplicativos para o iPad, eles funcionam em todos os modelos, do iPad que custa US$ 299 nos EUA aos que custam mais do que US$ 800.

Os rivais da Apple não podem reivindicar nenhuma semelhança a esse tipo de uniformidade de modelos. O sistema operacional do Android, do Google, é perigosamente fragmentado. Os tablets de fabricantes diferentes e em tamanhos diferentes executam versões diferentes do Android, inclusive a versão completamente reformulada do Kindle Fire, da Amazon.com AMZN +9.39% . Isso aumenta o tempo e o custo para desenvolver aplicativos para o sistema, o que torna o Android um problema para implantações empresariais de grande escala.

Os céticos podem dizer que a fragmentação atinge também os smartphones do Android e, mesmo assim, o sistema operacional do Google conseguiu superar a fatia de mercado do iPhone. Mas os tablets são diferentes. As pessoas encaram os tablets mais como PCs do que como telefones — eles servem para tarefas simples de computação e, por causa disso, são muito mais dependentes de uma grande biblioteca de apps.

Um telefone sem aplicativos ainda é mais ou menos útil. Você ainda pode fazer ligações e enviar mensagens. Mas um tablet sem aplicativos decentes o suficiente? É decididamente um aparelho de segunda linha: você vai perder os jogos mais novos, os aplicativos sociais mais recentes, tudo o que é novidade. Lembre-se que oTwitter Inc. só lançou um aplicativo para tablets Android este mês, mas o aplicativo para o iPad existe há muito tempo.

E aqui está a pegadinha que ilustra todo o problema de participação de mercado do Android: por enquanto, o app do Twitter está disponível apenas em tablets Samsung Electronics Inc. 005930.SE 0.00% Se você tem o Nexus 7 ou qualquer outro tablet do Android, você terá que lidar com a versão deturpada do aplicativo do Twitter para o smartphone.

A uniformidade do iPad é especialmente importante para sua aplicação no ambiente de negócios. A Apple está posicionando o tablet como substituto para computadores numa variedade de tarefas comerciais — nos balcões de atendimento ao cliente, nas recepções de restaurantes, em bancos, escolas, cabines de avião, praticamente em todos os lugares que alguém precisaria de um computador, mas não quer lidar com um PC. Nessas implementações de grande escala, a plataforma de desenvolvimento única e confiável do iPad é fundamental para a manter baixos os custos de manutenção e desenvolvimento.

Esta vantagem é reforçada por ela mesma: quanto mais as pessoas compram o iPad, mais programadores são atraídos, fortalecendo a plataforma e conquistando mais usuários. Em termos econômicos, essa dinâmica, na qual o aumento de vendas melhora o produto, elevando ainda mais as vendas, é conhecida como efeito de rede.

Você também pode chamá-la de o segredo do sucesso do Windows, que agora está alimentando a hegemonia da Apple pós-PC.







Joaquim A.  Machado
MINDWINGS & LEBLON
Science, Politics and Art
iPhone +55-19-8830-3600
Campinas - SP  Brazil








Joaquim Machado

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Oct 28, 2013, 12:23:13 PM10/28/13
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DEPT. OF AGRICULTURE

FIRE-EATERS

The search for the hottest chili.

BY LAUREN COLLINSNOVEMBER 4, 2013

New varieties of “superhots” provide near-death experiences in a bowl of guacamole. Photograph by Grant Cornett.
New varieties of “superhots” provide near-death experiences in a bowl of guacamole. Photograph by Grant Cornett.

In mid-December of 2011, Brady Bennett went out drinking at Adobe Gila’s at the Greene, a Mexican restaurant in Dayton, Ohio. After two beers, the bartender offered him a free shot. Bennett chose Patrón tequila with apple schnapps. Soon, he recalled, his throat began to swell. He struggled to breathe, and his nose, mouth, and lungs “felt as though they were on fire.” He called for an ambulance, moaning, and was taken to the hospital. A year later, Bennett filed a lawsuit against Adobe Gila’s, claiming that the bartender had spiked his drink with extract of the bhut jolokia, or ghost chili. (Adobe Gila’s denies the allegations.) “It wasn’t as if they gave him a little Tabasco,” Jeff McQuiston, Bennett’s lawyer, told the Dayton Daily News. “This stuff is lethal.” The bhut jolokia is a hundred and fifty times hotter than a jalapeño. Gastromasochists have likened it to molten lava, burning needles, and “the tip of my tongue being branded by a fine point of heated steel.” Yet, at more than a million Scoville heat units—the Scoville scale, developed by the pharmacist Wilbur Scoville in 1912, measures the pungency of foods—the bhut jolokia is at least 462,400 SHU short of being the world’s hottest chili pepper.

“Chili pepper” is a confusing term, another of Christopher Columbus’s deathless misnomers. (Columbus and his men classified the spicy plant they had heard being referred to in Hispaniola as aji—farther north, in Mexico, it was known by the Nahuatl word chilli—as a relative of black pepper.) Chilis belong toCapsicum, a genus of the nightshade family. Horticulturists consider them fruits, and grocers stock them near the limes and cilantro. Most chilis contain capsaicin, an alkaloid compound that binds to pain receptors on the tongue, producing a sensation of burning. Sweet banana peppers are usually neutral. Pepperoncini (approximately 300 SHU) produce just a flicker of heat, while cayennes (40,000) are to Scotch bonnets (200,000) as matches are to blowtorches. Capsaicin is meant to deter predators, but for humans it can be too little of a bad thing. Because capsaicin causes the body to release endorphins, acting as a sort of neural fire hose, many people experience chilis as the ideal fulcrum of pain and pleasure.

In recent years, “superhots”—chilis that score above 500,000 on the Scoville scale—have consumed the attention of chiliheads, who debate grow lights on Facebook (“You can overwinter with a few well-placed T-8s”), swap seeds in flat-rate boxes (Australian customs is their nemesis), and show up in droves at fiery-foods events (wares range from Kiss My Bhut hot sauce to Vanilla Heat coffee creamer). Chilis, in general, are beautiful. There is a reason no one makes Christmas lights in the shape of rutabagas. Superhots come in the brightest colors and the craziest shapes. Their names, evoking travel and conquest—Armageddon, Borg 9, Naga Morich, Brain Strain—sound as though they were made up by the evil twins of the people who brand body lotions. Trinidad 7-Pots are so called because it’s said that one of them is enough to season seven pots of stew.

Like computers, superhots are evolving at a rate that embarrasses the phenomena of just a few years ago. In 1992, Jane and Michael Stern observed, in this magazine, that five thousand Scoville units “would be considered very hot by most people, but even that is piddling compared with the blistering fury of the habanero pepper, which can reach three hundred thousand.” (The Scoville test originally measured how many drops of sugar water it would take to dilute the heat of a chili; pungency is now determined more reliably by high-performance liquid chromatography, whose results can still be reported in Scoville units.) From 1994 to 2007, the Red Savina—a scarlet, heart-shaped pod rating 570,000 SHU—held the Guinness World Record for hottest chili pepper. Then the bhut jolokia, the existence of which had been whispered about for years among chiliheads, as though it were a vegetable Loch Ness monster, surfaced on the international scene. In 2000, R. K. R. Singh, a scientist at a Ministry of Defense research laboratory in Assam, India, where the bhut jolokia is widely grown, submitted some samples for analysis. The test results, which indicated that it was significantly more powerful than the Red Savina, made their way to Paul Bosland, a professor of horticulture and former sauerkraut expert who, for the past twenty-two years, has run the Chile Pepper Institute, at New Mexico State University. Bosland was skeptical of the Indian scientists’ numbers, but he managed to obtain some bhut jolokia seeds, which he grew into plants. In January of 2007, he filed with Guinness, which awarded the C.P.I.’s bhut jolokia (1,001,300 SHU) the new world record.

In February of 2011, Guinness confirmed that the Infinity chili, grown in Lincolnshire, England, by a former R.A.F. security guard, had surpassed the bhut jolokia by more than sixty-five thousand SHU. Only two weeks later, a Cumbrian farmer named Gerald Fowler introduced the Naga Viper. At 1,382,118 SHU, it was, Fowler said, “hot enough to strip paint.” He told reporters, “We’re absolutely, absolutely chuffed. Everyone complains about the weather and rain here in Cumbria, but we think it helped us breed the hottest chili.” He posed for the Daily Mail wearing a sombrero.

Chiliheads are mostly American, British, and Australian guys. (There is also a valiant Scandinavian contingent.) Chili growing is to gardening as grilling is to cooking, allowing men to enter, and dominate, a domestic sphere without sacrificing their bluster. “I can’t remember eating anything spicy before the parrot came along,” Fowler, a big man with a brushy mustache, told me, in July. The chili world is full of garrulous, confiding, erratic narrators who say things like “before the parrot came along.” In Fowler’s case, the parrot belonged to his father’s brother. “Uncle Jim wanted another parrot, and his wife said, ‘Nope, you’ve got a parrot, and that’s it.’ So he made up this story that my dad wanted a parrot, and next time he visited us he brought one.” The parrot, named Murphy, came with a chili plant. (Birds can’t taste capsaicin.) Fowler quit fishing and started growing habaneros in his bedroom. Soon, he had left his job as a Web designer and founded the Chili Pepper Company, through which he sells seeds, sauces, powders, and products such as Kiss the Devil, a mouth spray made with chili-infused alcohol. “You can have just a little bit before you go to the gym, to get your endorphins up,” Fowler told me.

Chilis have become an attractive business. According to a report by IBISWorld, a market-research firm, hot-sauce production is one of America’s ten fastest-growing industries, along with solar-panel manufacturing and online eyeglass sales. Last year, the Los Angeles hot-sauce company Huy Fong Foods sold more than sixty million dollars’ worth of sriracha. (Americans bought so much sriracha in 2007 that there was a three-month national shortage.) Chilis are the male equivalent of cupcakes, tempting entrepreneurial amateurs with dreams of a more flavorful life. Gerald Fowler said, “In the last five years, you find somebody’s been made redundant, he likes chili, he’ll set up a chili business.” The month after the Naga Viper got the Guinness record, Fowler made an extra forty thousand dollars.

At the moment, there is no definitive claimant to the title of world’s hottest pepper. Lacking a central authority, the chili community finds itself embroiled in a three-way schism. In June of 2011, a group of Australian growers captured the Guinness record with the Trinidad Scorpion Butch T (1,463,700 SHU). Less than a year later, Bosland’s Chile Pepper Institute issued a press release: “When it comes to bringing the heat, there’s a new king of the hill.” Bosland claimed that a C.P.I. chili called the Trinidad Moruga Scorpion had exceeded two million Scoville units.

Then, in August of last year, Ed Currie, of the PuckerButt Pepper Company, of Fort Mill, South Carolina, unveiled a new contender. Currie announced, “The PuckerButt Pepper Company has raised the bar for hot pepper heat intensity by producing an amazing hot pepper, the Smokin’ Ed’s Carolina Reaper, which surpasses the current world record holder, the Butch T Trinidad Scorpion.” The Carolina Reaper’s recommended uses, according to PuckerButt’s Web site, included hot sauces, salsa, and “settling old scores.” Steven Leckart wrote inMaxim that eating one was “like being face-fucked by Satan.”

Currie’s announcement divided opinion among chiliheads, a fractious lot. His associates—battling trolls (and baiting them, too)—made their allegiances known. Joe (Pepper Joe) Arditi, who runs a seed company in Myrtle Beach and is one of four venders licensed to sell Currie’s chili, wrote in his online catalogue, “Do we need a new World’s Hottest? I think so. We have the Super Bowl, World Series, Grammy, and Oscar awards for new champs every year.” (Pepper Joe, who was offering Carolina Reaper seeds at ten dollars a pack, vowed to enforce “a strict 3-pack max” per customer.) He declared the Carolina Reaper “now the reigning King.”

On GardenWeb.com, a commenter wrote of Pepper Joe:


He has disrespected Guinness and the creator of thecurrent world record holder by putting ed’s pepper at #1 without substantiation, abusing the Guinness name for personal gain. That is misrepresentation and theft.
But he knows, there is one born every minute. My two cents? Don’t be the one born in the next minute! . . . Welcome to the circus.

Eating, more than breathing or sleeping, lends itself to competition. There are bake-offs, wing wars, contests to see who can eat the most hot dogs, bratwurst, Twinkies, tamales, cannoli, apple pies, buffalo wings, ribs, oysters, pastrami, sweet corn, deep-fried asparagus, ice cream, pancakes, pepperoni rolls, and boiled eggs. Superhots are the most accessible of thrills—fugu straight from the garden. For the culinary extremist, or exhibitionist, they provide an outlet for impulses that might have compelled his adolescent self to drink a concoction or try to swallow a teaspoonful of cinnamon. (A recent study found a positive correlation between chili-eating and “sensation-seeking” behavior.) As a leisure activity, superhots offer some of the pleasures of mild drugs and extreme sports without requiring one to break the law or work out. They are near-death experiences in a bowl of guacamole.

Chief among the chilihead’s occupational hazards is getting burnt up. In layman’s terms, this means eating a chili that causes one to experience profuse sweating, redness, nausea, ear-popping, abdominal cramps, vomiting, or all of the above. Getting burnt up can happen by accident (underestimation, misidentification) or on purpose (dares, pranks, curry). At the Engine Inn, a pub a short walk from Gerald Fowler’s house in Cumbria, I sampled the Naga Viper Curry, “made with officially the world’s hottest chili pepper and served with pilau rice, mango chutney and a giant poppadum.” “Tastes like heaven, Burns like hell,” a chalkboard read. “594 curries sold, 397 finished.” Though the waitress had warned, “We do it almost inedible,” I made 398. Never has a runny nose been so enjoyable.

Chilis are believed to have health benefits. Four show jumpers were disqualified from the 2008 Olympics for having treated their horses with creams containing capsaicin, which can act as a stimulant. Traffic cops in China hand out chilis to keep drivers alert. In 2008, when Katie Couric asked Hillary Clinton how she kept her stamina up on the campaign trail, she replied, “I eat a lot of hot peppers.” But, according to Paul Rozin, of the University of Pennsylvania, who studies the psychology of taste, the salutary effects of chilis aren’t substantial enough to account for their appeal to humans, the only mammals that eat them. With his theory of “benign masochism,” Rozin frames the allure of chilis as an emotional phenomenon. He writes, “We may come to enjoy our body’s negative responses to situations when we realize that there is no, or minimal, actual danger. In the case of the roller coaster, our body is scared, and sympathetically activated, but we know we are safe. Similarly for our crying in sad movies, and the burn we feel with chili pepper.” Chilis, in other words, are slasher flicks we can eat, bite-size Cyclones.

Ted Barrus, a custodian from Hammond, Oregon, has made a second career as Ted the Fire-Breathing Idiot, a friendly jackass and “chili reviewer.” Barrus started rating chilis because he liked the attention. “I still don’t really eat spicy food except when I’m doing reviews,” he said. “A typical meal for me is a regular old American meal—a burger and fries. Very rarely do I eat salad. You know, I’m a fat guy. I like fat-guy food.”

Barrus consumes whatever people send him, from raspberry-chipotle fudge to ranch-dressing soda. Armed with a jar of peanut butter and gallons of milk (casein, a protein in dairy products, can alleviate the effects of capsaicin), he regularly sets himself such stunts as eating twenty-one of the world’s hottest peppers: seven bhut jolokia, five Trinidad Scorpion Butch Ts, four Douglah 7-Pots, three Trinidad Moruga Scorpions, two Jonah 7-Pots. (He made it through eleven of them.) Last June, he and a friend decided to try the Carolina Reaper.

In the video that Barrus posted on YouTube (41,960 views), the camera homes in on a pair of pods, positioned starkly on a tabletop as though they were hand grenades seized by sheriffs’ deputies in a weapons bust.

“It looks like something from ‘The Simpsons’ or some horror movie,” Barrus says. “It’s very, very heavy and dense.”

Each of the two, Barrus and his sidekick, stuffs a whole chili into his mouth and begins to chew.

“It’s the most immediate tongue burn I’ve ever had,” Barrus says. “It’s immediately frying my tongue.”

A few seconds go by.

“Wow. My gums are on fire.”

“Urrgh, the gut burn is intense!”

“That was hell, boy. Hell in my mouth.”

When I asked Barrus, over the phone, what he thought was the world’s hottest chili, he replied, “I always say, ‘Guinness says the Butch T, New Mexico says the Trinidad Moruga Scorpion, and Ed Currie says the Carolina Reaper.’ ” He continued, “It’s very complicated. It’s not cut-and-dried.”

The chili industry is rife with conflicts of interest—Currie, for instance, recently flew Barrus to a convention—but Barrus insisted that he was a reliable gauge of heat. “I go by my own burn,” he said.

According to Barrus, “most chiliheads feel you have to respect Guinness,” even though its authority is less than absolute. Guinness doesn’t perform tests itself; it just certifies results that conform to its requirements. In Barrus’s opinion, growers have reason to be secretive about their methods. He said, “The problem is that you have so many people who test who are affiliated with venders. Some people who create these crosses are afraid venders are going to get the seeds, grow them out, rename it, and call it their own cross.”

He was unconvinced by the claims of the Chile Pepper Institute, saying, “You know, I’ve eaten Moruga Scorpions that were no hotter than a habanero.” As for the Carolina Reaper, he acknowledged that Currie’s association with Pepper Joe, who had a reputation for slick salesmanship, had “hurt his credibility.” (Pepper Joe, for his part, said, “I’m a marketer—that’s my DNA.” He added, “We positively have the data. We took a new pepper and in fourteen months made it a household recognizable name, and to me that’s just short of astonishing.”) Barrus said, “Ed partnered up with him for the release of the Carolina Reaper. So some people look at Ed like, how much can you trust Ed Currie?”

Several weeks later, I was in South Carolina, standing in the middle of a field with Ed Currie. Currie had picked me up at my hotel in a GMC van. I had immediately started coughing—chili fumes. Currie rolled down a window.

Currie has a beard and an excitable yet downbeat manner. He was dressed in jean shorts, a T-shirt that said “Tree Hugger: I Will Cling to the Old Rugged Cross,” and a gold-and-silver Tag Heuer watch. He surveyed his plants, which were shoulder-high and stretched in lush rows back to a spring-fed pond. “Less talking, more working!” he yelled to some bare-chested workers who were picking pods under the sun. He turned to me and said, “I don’t really care much for the spotlight, but God’s doing it, and I’ve just got to keep on going.”

Being a North Carolina native, I asked Currie if he was from the area. He explained that he had grown up in West Bloomfield, Michigan, where his father was the chief financial officer of a division of the John Hancock insurance company. Currie continued, “I went to the University of Michigan, and I got kicked out. Before that I was at Eastern Michigan. I never went to one class—I just took the tests, which I could do because I’m a genius. My family had a history of heart disease and cancer, and all this time I’m studying how not to die, never quite correlating that the amount of drinking and drugs I was doing might lead to premature death. I was just reading, looking at places where they had low incidences of illness.” Currie developed a theory that spicy food might be good for you. “In 1982, I went to a Vietnamese restaurant in Orchard Lake, Michigan, and I said, ‘I want to eat hot chilis. What’s the hottest you’ve got?’ And they said, ‘No, no, no,’ and I said, ‘Yes, yes, yes.’ ” He smiled. “I got high as crap!”

Currie started making hot sauces. “When you’re bored, you’re bored,” he said. He went to seven different schools and eventually graduated from Central Michigan. Meanwhile, he was drinking and doing drugs. He got a D.W.I., lost his driver’s license, went to jail, got married and divorced. By 1999, he said, “I had five different liquor stores delivering to my house. I was a big fat sloppy drunk pig, and I decided I wanted to die. It was winter, and I left the door open—snow was coming in the house—and then an angel came in and said, ‘You’ve got to get to the hospital.’ ” Currie waved a forearm in front of me and rolled up his sleeve. “See? Goosebumps.”

We got into the van. Currie, who has been clean for fourteen years, worked in the trust department at Wells Fargo until January, when he turned full time to chilis. He fielded a flurry of calls on his iPhone as we drove to his house. Eventually, we parked next to a modest white A-frame with an extravagantly landscaped garden: palm trees, cattails, a seven-foot-tall cosmos. “Look, palms are only supposed to bloom in the springtime,” Currie said. “I get them to bloom all year long.” He added, “I know about nutrients, I know about plant reproductive cycles—I grew pot in Michigan in the middle of wintertime!”

There was something strange about the street Currie lived on: while the front yards on the block, except for Currie’s, were largely barren, many of the back yards appeared to be as lush as tropical jungles. Currie, it turned out, had turned the neighborhood into an extended chili farm. “I might or might not have about thirty-five yards that I lease out for the summer every year,” he said. “It’s all camouflaged,” he continued, slipping behind a house to check up on a test plot. “No one knows where it is. People have come into my yard and tried to steal stuff.”

Currie first suspected that he had a very hot chili on his hands in 2002, when he crossed a habanero (he got the seeds, he says, from a former co-worker who was from St. Vincent) with a Pakistani Naga (these came from a Michigan friend—“a Pakistani prince” whom he used to babysit, and whom he says he can’t say more about “because of his job”). Horticultural protocol requires that a new chili self-pollinate for five to eight generations before it can be considered stable and, therefore, a distinct variety. Currie says he grew his plant to five generations and then took it to nearby Winthrop University for tests. In 2010, Cliff Calloway, a chemistry professor at Winthrop, certified that the chili, which was then called the HP22B, averaged a heat of 1,474,000 SHU. The next year, the report somehow came to the attention of the local media. “It went viral,” Currie said. “People were trashing me on every forum. Ted Barrus called and said, ‘You’ve got to get on here and defend yourself.’ Apparently, I didn’t ask the pepper gods if it was all right for me to be cross-breeding chilis.”

In June of 2011, Currie wrote to Guinness:


Hello, my name is Ed Currie and I own the PuckerButt Pepper Company. We have been testing a pepper I hybrided at Winthrop University for the last several years and have a pepper that’s weighted average over the years is 1,474,000 scoville. I have attached a chart one of the grad students used for her part of the project. I actually have a pepper that is closer to two million consistently, but I am waiting on the results from this year and making sure the seed is consistent. How should I proceed and what data do I need to provide. . . . It would be great to have the US on the map for heat.
Thanks for your help.
 
Sincerely
Smokin Ed

Currie paid six hundred and fifty dollars to Guinness to “fast-track” the application, but, for one reason or another, the proceedings stalled. Guinness says that it has never received the proper paperwork from Currie. “We keep asking for documentation and he says he’ll send it, but we still haven’t got anything,” Sara Wilcox, a spokesperson for Guinness, told me. Currie argues that Guinness has failed to keep track of the documentation he’s sent—when the person he was originally dealing with left the company, in 2012, he was forced to start afresh—and that Guinness keeps changing the rules for the category.

“I don’t think they want to give the record to an American,” Currie said. “That’s just my personal opinion.”

Given the stalemate with Guinness, Currie decided late last year to declare the chili the world’s hottest on his own authority. First, he changed the HP22B’s name to the Carolina Reaper. “God brought a couple of guys into my life who used to work at Pepsi,” he told me. “They’re all about the corporate marketing thing.”

Currie’s critics question the long-term viability of the Carolina Reaper. Ted Barrus explained, “There’s a lot of controversy over Ed Currie’s chili because in Europe some people got the Reaper, they grew out the seeds, and their chilis don’t look like anybody else’s. They’re saying it’s no longer stable.” Currie acknowledged that some customers had got weird results, but the problem, he said, stemmed from a few contaminated seed packs. (Currie has recently furnished Guinness with a letter from a biology professor at Winthrop attesting that his plants are stable.) Besides, he said, the Carolina Reaper was, at this point, almost an anachronism, and he was persisting in trying to win recognition for it merely as a point of pride. “The Carolina Reaper’s the mildest of the peppers I’ve crossed,” he said, looking me in the eye. He had goosebumps again. “We have one hundred and sixty-two hotter ones yet to come.”

“F or over 1 year now, the Reaper has been so close to getting a record,” Jim Duffy wrote to me recently. “Do you think people in the Industry are tired of hearing about it almost getting it over and over again? Is it the ‘Boy Who Cried Wolf’ and now Industry people are just ignoring it?”

Duffy, of Refining Fire Chiles, in San Diego, is Ed Currie’s arch-frenemy and sometime business partner. They pray together on the phone every day, and tend to preface their criticisms of each other by saying, “He’s a good friend of mine, but . . .” (As hybrids go, the chili world would make an excellent setting for both a Will Ferrell movie and an adaptation of “Julius Caesar.” Among the pejoratives the chiliheads I spoke with used to describe each other were “clown,” “joke,” “Johnny-come-lately,” “whack job,” and “palooka.”) Duffy says that he’s not a record-chaser, but his beef with the Carolina Reaper may owe something to the fact that he gave Paul Bosland and the Chile Pepper Institute the seeds they used to grow the Trinidad Moruga Scorpion, which they proclaimed “the hottest pepper on the planet” in February of 2012. Duffy said of it, to the Associated Press, “Like Cabbage Patch dolls right before Christmas or Beanie Babies, it’s, like, the hot item.”

According to C.P.I. data, the Trinidad Moruga Scorpion averages only 1.2 million Scoville units, but its heat peaks at more than two million. To assert its primacy, its boosters have devised a novel argument: the chili record should be determined by maximum, rather than mean (the scariest wolf ever, rather than the scariest wolf most of the time). To some chiliheads, this constitutes a curious reversal of methodology—only six years ago, the C.P.I. claimed the Guinness World Record by citing the bhut jolokia’s mean heat.

“It drives me nuts!” Alex de Wit, an Australian grower who is part of the team that holds the current Guinness record for the Trinidad Scorpion Butch T, told me. “I think if you want a world record, you have to do it according to the rules.” De Wit e-mailed me later, “If they would beat me and did it exactly as supposed to do, well done and good on them. I am the first to applaud and clap my hands. . . . Anything else is just loose sand to my opinion, and not based upon facts but fiction.” De Wit was equally upset by Ed Currie’s claims about the Carolina Reaper: “I really do not have the time or energy for dicks (excusez le mot).” He closed his e-mail, “I wish you a spicy day.”

Jim Duffy dismissed such criticism. “Does a runner win a race on the average, or does he win it by being the fastest?” he said, when we spoke on the phone, his voice gaining Scovilles by the second. “Is any record won by the fastest, the hottest, the tallest, the biggest, or are records given for the average? Who cares about the average?” He concluded, “Every record in the history of man has been based on the high.”

Duffy and Bosland have yet to secure independent recognition for the Trinidad Moruga. I asked Duffy if the use of maximum numbers amounted to, as some chiliheads had complained, a misleading focus on outliers.

“Well, I’ll tell you, dear, you can come out here to San Diego, and you can walk in my field, and you can bite into a Reaper and you can bite into a Moruga, and we’ll see which one you walk away from,” he said. “My grower Daniel, he’s got Reapers in his dehydrator, and he eats them like potato chips.”

After we got off the phone, Duffy sent me an e-mail that contained a list of ten questions to ponder. The ninth suggested that some of his competitors might be using substances that artificially inflate the capsaicin content of their chilis. “There is no test out there that can detect the use of these nutrients in the pepper,” Duffy wrote. “Yes, Virginia! Peppers can be juiced!”

Butch T, of the Trinidad Scorpion Butch T, is Butch Taylor, a plumber in Baton Rouge, Louisiana. In 2005, Taylor got some Trinidad Scorpion seeds from a guy named Mark in New Jersey, who had got them from a local nursery. Taylor recalled, “When I grew them down here, they just grew unbelievable. I got three plants out of five seeds, and every plant I grew was dedicated to seeds. The first time I tasted it, I just thought, This is the hottest thing I’ve ever seen.”

Taylor kept growing the plants, selecting at each generation for the hottest specimens. He gave the seeds away to chiliheads all over the world, sticking a little label that said “Butch T” at the bottom of each packet, so that absent-minded recipients would be able to keep track of where they had come from. Besides that, he didn’t think much of it. “I didn’t have any money to pay for testing—I didn’t even know how to have them tested at the time,” he told me. “And since I was growing the seeds, not selling them, I couldn’t see the purpose of setting the record.” He learned that his namesake chili was the hottest chili in the world, according to Guinness, the day that the record was announced. The Australians who developed Taylor’s strain into a winner had named it after him. “It took me a while to get my head around it, because I’m a little more shy, unless I’ve been drinking or something,” he recalled. “I thought that was very decent of them.”

Butch Taylor is spoken of in reverent tones in the chili community. A human bhut jolokia, he doesn’t travel often to chili conventions, and his Web site is dormant. He can be a little hard to find, but, in recent years, he has maintained a steady presence on Facebook, advising fellow-enthusiasts on how to deal with fire ants or sharing observations about pod phenotypes. In January, he posted his “2013 (incomplete) grow list,” a document that included sixty-one types of chili and was pored over as though it were a Vatican encyclical. Christopher Phillips, another veteran chilihead, wrote, “Congratulations Butch. You have now officially set yourself up for 52,390 seed requests come harvest time? LOL. Nice list!!” Taylor likes blues piano and L.S.U. football. He misses the taste of glue on stamps. He even has his own groupie—a woman who sends him pictures of herself posing next to plants grown from his seeds.

A few years ago, Taylor and his wife, Shirley, whom he met when he was thirteen, were living in a farmhouse that they built with their own hands on some land that Taylor’s family has owned for years. The farm is about an hour north of Baton Rouge, in Wilkinson County, Mississippi. When the economic crisis hit, gas cost too much for them to make the commute every day, so they started spending the week in a travel trailer that they park in the driveway of their daughter’s house. On weekends, they drive out to the country.

One day in September, Butch and Shirley picked me up at the Baton Rouge airport. Taylor did not look exactly like the picture he had sent—it was of Brad Pitt—but he welcomed me warmly. His eyes are bright blue. He was wearing shorts and a blue polo shirt with white stripes. “Hush, baby!” Shirley, who has strawberry-blond hair and a deep, honeyed voice, said to their shih tzu, Laila Habanero, as I climbed into their truck. A chili-pepper ornament dangled from the rearview mirror.

A couple of hours later, Taylor was standing in the kitchen of the farmhouse, softening shallots in butter for a crawfish étouffée. “I’ve cooked since the time I could lift a skillet,” he said. Taylor had his first chili by accident. “I ate a tepín that I found growing in a flower bed when I was eleven,” he said. “It burnt me up.” As an adult, he started growing tomatoes; chilis followed. “This is based on an old recipe I came across in a preserving book from the eighteen-hundreds,” Taylor said, picking up a jar of pepper brandy that was sitting on the counter. Chilis take on a metaphysical dimension in Taylor’s telling. “I don’t find peppers,” he said. “Peppers find me.”

The following morning, Taylor put on his boots and went outside. Next door, his mother’s chickens were clucking in a pen. Hummingbirds darted past a pecan tree. Taylor unplugged a homemade electrical fence and stepped into his chili field. “This used to be a dog yard,” he said. “My stepfather ran the hounds at Angola State Penitentiary. He used to feed them deer carcasses. The grass grew so thick that you could barely run a motor over it, so I thought it would be a good place to put a garden.”

Taylor walked through rows of plants, gathering ripe pods in a wooden basket. His plants hadn’t done particularly well this season—they were smaller than usual, and their leaves were a sickly yellow. (He thought he had got a bad batch of fertilizer.) Still, even in early fall, they were yielding chilis galore: chilis in the shape of bugles; chilis that glowed like Chinese lanterns; chilis that, Taylor pointed out, resembled pit bulls’ teeth. When I asked him the big question, he hedged. “What I believe is the hottest pepper? I don’t know,” he said.

Still, he couldn’t resist a tiny dig. “This is a Trinidad Scorpion from Australia,” he said, fingering a bumpy bright-red pod. He handed it to me. “Notice a resemblance to Ed’s?”

Taylor allowed that chiliheads were a competitive bunch. “Of course, I have an unfair advantage,” he said, indicating the sun beating down overhead. “It’s kind of like bringing a Ferrari to a Volkswagen race.”

Taylor led me to a white outbuilding that serves as a dedicated hot-sauce kitchen: eight-gallon pots, nitrile gloves, face mask, radio, a de-seeding stool embellished, like a hot rod, with flames. Every year, he makes a few sauces, which he sells mostly to his plumbing buddies. “I’ve been trying to convince myself that I have to sell more stuff to pay for all the different stuff I want to do,” he said. “I just can’t get into it.” Taylor has a theory about the economics of chilis: like hemlines, they rise when times are tough. “The deal with the hot sauce is that nobody has the money to eat out, so they stay home and start cooking again. After a while, you think, Well, there’s got to be something different I can do with this.” The only problem, Taylor said, is that nobody ever buys a bottle of superhot sauce twice.

Eventually, we walked back to the house.

“How were they lookin’, baby?” Shirley asked.

“I’ve got a lot of peppers out there to pick this weekend,” Butch replied.

He had brought a Trinidad Scorpion Butch T in from the field. The pod had a bulbous cap and a tapering tail that recalled the stinger of a wasp. Its skin was pebbly, like the nose of a drinker. It looked as though it had been made of melted wax from the candles at an Italian restaurant.

Taylor took a knife and whittled off a flake no larger than a clove. I put it in my mouth and chewed. The capsaicin hit loud and fast, a cymbal clang of heat. My face flushed. My eyes glassed over and I started pacing the kitchen, as though I could walk off the burn. It took twenty minutes and a can of Dr Pepper to banish the sensation of having a sort of tinnitus of the mouth.

Before we came inside, Taylor had shown me his greenhouse, where he tends his most precious plants. A single bush dominated the small hut. Hanging from its branches were an assortment of pods, some of them deep red and some of them a faint green. The plant, which was not yet stable, was the third generation of an accidental cross of a 7-Pot Jonah and, most likely, a Trinidad Scorpion Butch T. Taylor was calling it the wal—the Wicked-Ass Little 7-Pot. He shook a branch, unleashing a swarm of flies, and picked a pod from the stem. “Just off the top of my head, the first one I tasted, I’d say two million Scovilles,” he said. “But it may just be a freak of nature. You get those now and then.” 


Joaquim Machado

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Are We Too Close to Making Gattaca a Reality?

By Ferris Jabr | October 28, 2013 |  


baby

(Credit: Katie Tegtmeyer, Flickr)

Sometime in the not-too-distant future, Marie and Antonio Freeman step into a doctor’s office to design their next child.

“Your extracted eggs, Marie, have been fertilized with Antonio’s sperm,” the doctor says. “After screening we’re left with, as you see, two healthy boys and two very healthy girls.”

A monitor displays what looks like soap bubbles that bumped into each other on a green background.

“Naturally, no critical predispositions to any of the major heritable diseases,” the doctor says. “All that remains is to select the most compatible candidate. We might as well start with gender—have you given it any thought?”

“We would want Vincent to have a brother, you know, to play with,” Marie says, referring to her first child.

Acknowledging this, the doctor continues: “You have specified hazel eyes, dark hair and fair skin. I have taken the liberty of eradicating any potentially prejudicial conditions: premature baldness, myopia, alcoholism and addictive susceptibility, propensity for violence and obesity—”

“We didn’t want—I mean, diseases, yes,” Marie interrupts.

“Right, we were wondering if it’s good to leave a few things to chance,” Antonio says.

“You want to give your child the best possible start,” the doctor replies. “Believe me, we have enough imperfection built-in already. Your child doesn’t need any additional burdens. And keep in mind, this child is still you, simply the best of you. You could conceive naturally a thousand times and never get such a result.”

The Freemans are characters in the science fiction film Gattaca, which explores liberal eugenics as an unintended consequence of certain technologies meant to assist human reproduction. Although Antonio and Marie do not exist outside the movie’s imaginary universe, their real-life counterparts could be walking among us sooner than we think—and, in a sense, they already are.

When Gattaca premiered in 1997, doctors had been using laboratory techniques to help women and men overcome infertility for more than a decade. In 1978, Louise Brown of the U.K. became the world’s first “test tube baby”—the first person conceived through in vitro fertilization (IVF), a procedure in which sperm and eggs are combined in the lab to create several viable embryos that are subsequently implanted in a woman’s womb. The first IVF clinic opened in the U.S. in 1980. Today, hundreds of fertility clinics in the country offer IVF and more than one percent of children born in the U.S. are conceived this way.

In the years surrounding Gattaca’s release, doctors were also talking about how to responsibly use another, more controversial technique to help people have children: preimplantation genetic diagnosis (PGD). In this procedure, clinicians vacuum up one of eight cells in a three-day-old embryo created through IVF and analyze the DNA within to find genes associated with debilitating and potentially fatal diseases. Sometimes, doctors wait two more days, when the embryo has become what is known as a blastocyst—a mostly hollow ball of around 100 cells—and collect between 5 and 20 cells for DNA analysis. In most cases, this extraction does not significantly disturb the embryo’s development. PGD can identify embryos that will almost certainly develop disorders caused by a mutation in a single gene, such as cystic fibrosis, sickle cell disease, Tay-Sachs and Huntington’s, as well as disorders that result from an extra chromosome, such as Down syndrome. From its earliest days, PGD has been principally intended for people who have a high risk of conceiving a child with a particular disorder, because it runs in the family or because they happen to harbor a certain genetic mutation.

Couples have also created one child through IVF-PGD in order to save another. At least 30 fertility clinics in the U.S. will help parents conceive a “savior sibling”—a child whose umblical cord blood can be harvested as a source of stem cells to treat leukemia, Fanconi anemia or another terrible illness in his or her older sibling. An infusion of stem cells donated by a relative whose immune cells are genetically similar to those of the sick child has a much better chance of succeeding than cells from a stranger. Siblings inherit their immune system genes from the same parents, so they are sometimes an almost exact immunological match—something doctors at fertility clinics can determine by looking at an embryo’s DNA.

Nominally, clinics agree to help parents in this way only if the couple had always intended to have several children. But some parents in this situation undoubtedly alter their original family plan out of desperation. So what happens if the treatment fails? How will the inevitable disappointment change the way parents feel about their second child? And how does learning that one’s entire existence hinges on saving someone else’s life warp the psychological development of a child or young adult? In Jodi Picoult’s 2004 novel My Sister’s Keeper, thirteen-year-old savior sibling Anna sues her parents for medical emancipation when they ask her to donate a kidney to her older sister Kate, who has leukemia.

Preventing and treating diseases are not the only reasons people have turned to pre-implantation genetic diagnosis. PGD also makes it possible for parents to predetermine characteristics of a child to suit their personal preferences. In a few cases, people have used PGD to guarantee that a child will have what many others would consider a disability, such as dwarfism or deafness. In the early 2000s, lesbian couple Sharon Duchesneau and Candy McCullough—both deaf from birth—visited one sperm bank after another searching for a donor who was also congenitally deaf. All the banks declined their request or said they did not take sperm from deaf men, but the couple got what they were looking for from a family friend. Their son, Gauvin McCullough, was born in November 2001; he is mostly deaf but has some hearing in one ear. Deafness, the couple argued, is not a medical condition or defect—it is an identity, a culture. Many doctors and ethicists disagreed, berating Duchesneau and McCullough for deliberately depriving a child of one of his primary senses.

Much more commonly, hopeful parents in the past decade have been paying upwards of $18,000 to choose the sex of their child. Sometimes the purpose of such sex selection is avoiding a disease caused by a mutation on the X chromosome: girls are much less likely to have these illnesses because they have two X chromosomes, so one typical copy of the relevant gene can compensate for its mutated counterpart. Like Marie and Antonio Freeman in Gattaca, however, many couples simply want a boy or a girl. Perhaps they have had three boys in a row and long for a girl. Or maybe their culture values sons far more than daughters. Although the U.K., Canada and many other countries have prohibited non-medical sex selection through PGD, the practice is legal in the U.S. The official policy of the American Society of Reproductive Medicine is as follows: “Whereas preimplantation sex selection is appropriate to avoid the birth of children with genetic disorders, it is not acceptable when used solely for nonmedical reasons.” Yet in a 2006 survey of 186 U.S. fertility clinics, 58 allowed parents to choose sex as a matter of preference. And that was seven years ago. More recent statistics are scarce, but fertility experts confirm that sex selection is more prevalent now than ever.

“A lot of U.S. clinics offer non-medical sex selection,” says Jeffrey Steinberg, director of The Fertility Institutes, which has branches in Los Angeles, New York and Guadalajara, Mexico. “We do it every single day. We did three this morning.”

In 2009 Steinberg announced that he would soon give parents the option to choose their child’s skin color, hair color and eye color in addition to sex. He based this claim on studies in which scientists at deCode Genetics in Iceland suggested they could identify the skin, hair and eye color of a Scandinavian by looking at his or her DNA. “It’s time for everyone to pull their heads out of the sand,” Steinbergproclaimed to the BBC at the time. Many fertility specialists were outraged. Mark Hughes, a pioneer of pre-implantation genetic diagnosis, told the San Diego Union-Tribune that the whole idea was absurd and the Wall Street Journal quoted him as saying that “no legitimate lab would get into it and, if they did, they’d be ostracized.” Likewise, Kari Stefansson, chief executive of deCode, did not mince words with the WSJ:  “I vehemently oppose the use of these discoveries for tailor-making children,” he said. Fertility Institutes even received a call from the Vatican urging its staff to think more carefully. Seifert withdrew his proposal.

But that does not mean he and other likeminded clinicians and entrepreneurs have forgotten about the possibility of parents molding their children before birth. “I’m still very much in favor of using genetics for all it can offer us,” Steinberg says, “but I learned a lesson: you really have to take things very, very slowly, because science is scary to a lot of people.” Most recently, a minor furor erupted over a patent awarded to the personal genomics company 23andMe. The patent in question, issued on September 24th, describes a method of “gamete donor selection based on genetic calculations.” 23andMe would first sequence the DNA of a man or woman who wants a baby as well as the DNA of several potential sperm or egg donors. Then, the company would calculate which pairing of hopeful parent and donor would most likely result in a child with various traits.

Illustrations in the patent depict drop down menus with choices like: “I prefer a child with Low Risk of Colorectal Cancer; “High Probability of Green Eyes;” “100% Likely Sprinter;” and “Longest Expected Life Span” or “Least Expected Life Cost of Health Care.” All the choices are presented as probabilities because, in most cases, the technique 23andMe describes could not guarantee that a child will or will not have a certain trait. Their calculations would be based on an analysis of two adults’ genomes using DNA derived from blood or saliva, which does reflect the genes inside those adults’ sperm and eggs. Every adult cell in the human body has two copies of every gene in that person’s genome; in contrast, sperm and eggs have only one copy of each gene and which copy is assigned to which gamete is randomly determined. Consequently, every gamete ends up with a unique set of genes. Scientists have no way of sequencing the DNA inside an individual sperm or egg without destroying it.

“When we originally introduced the tool and filed the patent there was some thinking the feature could have applications for fertility clinics. But we’ve never pursued the idea, and have no plans to do so,” 23andMe spokeswoman Catherine Afarian said in a prepared statement. Nevertheless, doctors using PGD can already—or will soon be able to—accomplish at least some of what 23andMe proposes and give parents a few of the choices the Freemans made about their second son.

Since Steinberg’s contentious proposal in 2009, researchers have developed a much clearer understanding of the various genes responsible for the pigments in our bodies. Forensic geneticist Manfred Kayser of Erasmus MC and his colleagues have published many studies in which they have accurately identified people’s eye andhair color by looking at their DNA. Their tests cannot recognize every possible shade, but they are specific enough to distinguish between brown, blue and mottled brown-blue eyes, as well as brown, black, blonde and red hair. Such studies are intended to help solve crimes, but clinicians at fertility clinics could easily adapt the strategies for PGD. Based on ongoing research, Manfred thinks he and other scientists will soon be able to confidently identify skin color by looking at someone’s genes as well. In the more distant future, he adds, researchers will probably learn enough to deduce the texture of a person’s hair, the shape of his or her face, and the person’s height.

Today, genetic analysis can also reveal the likelihood of various quirks of human biology that some people find fascinating and others might consider trivial. Take, for example, the probability that someone will experience “Asian glow.” The ALDH2 gene codes for an enzyme named aldehyde dehydrogenase that converts a toxic byproduct of alcohol metabolism into a benign acid. People with only one or no working copies of the gene feel nauseated and flush red when they drink alcohol.Around 50 percent of East Asians have underactive aldehyde dehydrogenases.Earwax consistency is also relatively easy to predict with a genetic test because it is controlled by a single gene: one version of the gene produces sticky amber ear wax; the other makes dry, gray, flaky earwax. A single gene also largely determines one’s ability to taste certain bitter compounds commonly found in Brussels sprouts, coffee, cabbage and other foods.

These examples of relatively straightforward relationships between genes and traits are exceptions to the daunting complexity of human genetics. Most characteristics of the human body—even seemingly simple ones like earlobe attachment, dimples and hair whorls—have stumped researchers with far more convoluted genetics than they anticipated. That’s why confidently reporting eye and hair color based on DNA is a relatively recent accomplishment. In high school, you may have learned that eye color is a simple Mendelian trait in which one or two dominant copies of a gene produces brown eyes whereas two recessive versions result in blue eyes. In fact,more than a dozen genes likely interact to determine the hue of your iris. So, when it comes to something as multi-faceted as intelligence or personality, we may never have a particularly useful predictive genetic test. For the foreseeable future, then, any possibility of designer babies may be limited to rather basic—though, to many parents, important—human features: essentially, the shape and color of a child’s face and body.

IVF presents another set of barriers to tailor-making children through PGD. After all, PGD does not entail actively engineering DNA inside an embryo to fit parents’ specifications; rather, parents select what they consider the most desirable genetic package from a group of successfully fertilized embryos. And clinicians can only fertilize as many eggs as they collect from a woman’s ovaries Currently, IVF retrieves between 8 and 15 eggs on average—enough to provide parents with quite a few options, but not a large enough number to ensure that any one embryo will have more than a handful of desired traits.

As scientists continue to examine the human genome from every angle, however, they will undoubtedly uncover new genetic associations that—if they cannot promise a particular feature—will at least divulge a probability. 23andMe claims that, by sequencing your DNA, it can tell you something interesting about 60 “traits,” many of which are physical characteristics or talents of some kind. As that type of knowledge continues to surface, some people will not be able to resist it, even when it rests only on a few preliminary studies. A clinic could take advantage of these insights to discreetly give couples the option of choosing more than just the sex of their child through PGD, framing it as a way to tip the scales, to—as the doctor inGattaca says—give one’s child “the best possible start.” One couple would tell another. Some parents—especially the wealthy—may begin to believe they have a choice between leaving their child’s future completely to chance and helping that child in at least some small way. When Gattaca appeared in theaters in 1997, much of what the film depicted was not yet possible. Now, some of it is. What separates our society from a proto-Gattaca today is not so much scientific understanding or technology as people’s attitudes towards that technology—a much more delicate membrane.

“Unfettered development of PGD applications is providing parents and fertility specialists an increasing and unprecedented level of control over the genetic make-up of their children,” wrote Tania Simoncelli, Assistant Director for Forensic Sciences within the White House Office of Science and Technology Policy, in 2003. “Indeed, if ever there was a case for a ‘slippery slope,’ this is it. Advances in PGD, together with cloning and genetic engineering, are tending towards a new era of eugenics. Unlike the state-sponsored eugenics of the Nazi era, this new eugenics is an individual, market-based eugenics, where children are increasingly regarded as made-to order consumer products.”

An era of market-based eugenics would exterminate any lingering notions of meritocracy. Perseverance, adaptability, and self-improvement would become subordinate to to what people would see as innate talent and near certain prosperity preordained by one’s genes. Despite laws meant to prevent genetic discrimination, the world of Gattaca is a highly stratified one with two distinct classes: the valids—who have the right genes, the most prestigious jobs and the highest quality of life—and the in-valids, who were conceived in the typical fashion and are relegated to menial work and relative poverty. Eugenics also risks creating a genetically homogenous population that is far more vulnerable to disease and freak deleterious mutations than a diverse one.

But that could never happen this side of the silver screen, right?

“The demand is up,” Steinberg says. “People are liberalizing. You will see PGD done on almost every embryo in the future.”

About the Author: Ferris Jabr is an associate editor focusing on neuroscience and psychology. Follow on Twitter @ferrisjabr.

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Should Your Product Connect To The Internet Of Things?

SMART DESIGN'S GORDON HUI OUTLINES THREE ESSENTIAL QUESTIONS TO ASK BEFORE YOU CONNECT YOUR "DUMB" PRODUCT TO THE CLOUD.

Thanks to widespread Internet adoption and over 10 billion connected devices around the world, companies today are more excited than ever about the Internet of Things. Add in the hype about Google Glass and the Nest Thermostat, and nearly every business, including those from traditionally low-tech industries, wants to get on the cloud, track a group of devices, and gather data. The question, however, is not if a device can be connected, but why the company is connecting a previously “dumb” product to the cloud. Or stated differently, if a company invests in making my toaster talk to my lawnmower, is that really a good business decision and why?

Companies that are successfully adapting and innovating Internet of Things platforms are focused on identifying meaningful opportunities, not just technologies. These opportunities bridge a practical understanding of what embedded computing could potentially do with a clear hypothesis about what will change the game for a large consumer segment or cross-section of industries.

CREATING MEANINGFUL CONNECTED PRODUCTS


To create successful, connected device-based businesses, senior leaders should be prepared to answer three questions that I call the Internet of Why:

1. Why does connecting to the cloud create greater value for the user?

Although the cost of sensors and RFID tags continue to decrease, connecting a previously “dumb” device to the cloud often requires investments in new capabilities and features that must be maintained over time, resulting in a more premium product. The higher price point can be justified only if adding connectivity truly addresses previously unmet customer needs or opportunities.

For Philips Hue, an Internet-enabled lightbulb set, understanding why consumers would want connected lighting was the first major step to building a great platform. In the early phases of the project, the Hue product team identified hundreds of use case scenarios, which were repeatedly explored and tested until four consumer value propositions--ambience creation, security, biological benefits, and gentle reminders--were identified. These value propositions, not the technology itself, established the direction for product development efforts.

2. Why are the connected features on your product roadmap integral to the core experience?

When connecting a product to the Web, it can be tempting to build the most ideal user experience that fulfills both the grandest ambitions of discriminating customers and the perfectionist inclinations of the product team. However, creating the ideal takes time and money, and assumptions about perfection will change based on customer feedback. Taking a Lean Startup approach, with an emphasis on just the features that need to be deployed, encourages a more focused first-generation product and faster speed to market.

The team behind the famous Pebble watch, which debuted as a Kickstarter campaign, allowed for prototyping and a limited run of the first-generation device. After demonstrating the value of the core experience, the Pebble team added meaningful features, like waterproofing and an updated SDK, based on actual feedback from users about what they would pay for.

3. Why does connecting to the cloud enhance your business model?

Connecting products offers the potential to fundamentally shift the revenue and cost dynamics of any business, but embedding connectivity also introduces greater monetization complexity. Whereas an unconnected product might have one revenue stream, a Web-enabled product can leverage multiple revenue streams spanning a variety of B2B and B2C customers. The potential for new services--both free and paid--and unique possibilities associated with new data streams makes alignment on a business model even more difficult.

Progressive Insurance’s Snapshot program is an example of how dramatically the Internet of Things can transform a traditional business model. In exchange for inserting a telematics device into the car’s diagnostic port, Progressive will provide a discounted policy rate based on how an insured motorist actually drives, including how hard he or she brakes and the time of day the car is used. By offering this type of usage-based insurance, Progressive is better able to match insurance premiums to the actual risk profile of individual policyholders, resulting in significantly higher per-policy profitability and improved pricing for safe drivers.

TECHNOLOGY ALONE IS NOT THE ANSWER


In the age of connected devices, access to technology is no longer a barrier to entry; open-source hardware tools such as Arduino and Raspberry Pi can be purchased for under $35, while software and Web services from Amazon are available for pennies per terabyte. Instead, the challenge is to bridge the technology to a larger context and understand why connecting to the cloud creates greater value for the user, product experience, and business model. Companies that are actively addressing this contextual challenge, as opposed to focusing on technology and hype, are having the most success and enabling true differentiation in the connected-products space.

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Scientific American

Study Linking Genetically Modified Corn to Rat Tumors Is Retracted

Publisher withdraws paper despite authors' objections, citing weak evidence

By Barbara Casassus and Nature magazine  | Friday, November 29, 2013 | 46



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Bowing to scientists' near-universal scorn, the journal Food and Chemical Toxicology today fulfilled its threat to retract a controversial paper claiming that a genetically modified (GM) maize causes serious disease in rats, after the authors refused to withdraw it.

The paper, from a research group led by Gilles-Eric Séralini, a molecular biologist at the University of Caen, France, and published in 2012,  showed “no evidence of fraud or intentional misrepresentation of the data,” said a statement from Elsevier, which publishes the journal. But the small number and type of animals used in the study mean that “no definitive conclusions can be reached.” The known high incidence of tumors in the Sprague–Dawley strain of rat ”cannot be excluded as the cause of the higher mortality and incidence observed in the treated groups,” it added.

Today’s move came as no surprise. Earlier this month, the journal’s editor-in-chief Wallace Hayes threatened retraction if Séralini refused to withdraw the paper. Hayes announced the retraction at a press conference in Brussels this morning. Séralini and his team stand by their results, and allege that the retraction derives from the journal's editorial appointment of biologist Richard Goodman, who previously worked for biotechnology giant Monsanto for seven years.

Goodman however denies any involvement in the decision to retract the paper. "Food and Chemical Toxicology asked me to become an associate editor in January 2013 because of my extensive experience in the area, and after I complained about the Séralini study,” he says. “I am paid a small honorarium for handling manuscripts about biotechnology on a part-time basis, after hours. But I did not review the data in the Séralini study, nor did I have anything to do with the determination that the paper should be withdrawn from or retained by the journal. “The magazine reviewed our paper more than any other,” says co-author and physician Joël Spiroux de Vendômois, who is also president of the Paris-based Committee for Research and Independent Information on Genetic Engineering (CRIIGEN), which collaborated in the study. The retraction is “a public-health scandal," he says.

The study found that rats fed for two years with Monsanto’s glyphosate-resistant NK603 maize (corn) developed many more tumors and died earlier than controls. It also found that the rats developed tumors when glyphosate (Roundup), the herbicide used with GM maize, was added to their drinking water. (See "Rat study sparks GM furore").

At the November 28 press conference, Corinne Lepage, a Member of the European Parliament and former French environment minister, said that Séralini’s paper asked “good questions about the long-term toxicity of GMOs [GM organisms] and the Roundup herbicide.” Retraction of the paper “will not make these questions disappear," added Lepage, who is also a co-founder of CRIIGEN.

Alleged conflicts of interest are at the center of the latest round of controversy. Lepage called for the resignation of  Anne Glover, who was appointed chief scientific adviser to the European Commission two years ago and whom Lepage says is an advocate of GMOs. Since then, Lepage noted, the commission has proposed, for the first time since 1996, to authorize cultivation of GM maize in Europe. Conflicts of interest with the European Food Safety Authority (EFSA) in Parma, Italy, which is responsible for assessing the risks of GMOs, “remain numerous,” she added.

The paper’s retraction was the latest in a series of setbacks for Séralini and his group. The publication of his team's study was greeted by a storm of protest from scientists, and both the EFSA and Germany’s Federal Institute for Risk Assessment In Berlin slammed the paper for providing inadequate data to support its conclusions.

This article is reproduced with permission from the magazine Nature. The article was first published on November 28, 2013.

Joaquim A.  Machado
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Scientific American

Mushrooms Create Their Own Breeze

Mushrooms can make a slight spore-dispersing breeze to spread their genetic material even if the air is calm. Katherine Harmon reports

 | Monday, November 25, 2013 | 1

60-Second Science

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Mushrooms must scatter their spores to make little mushrooms. And we've long assumed that they rely on a friendly breeze for spore spreading. But a new study shows that mushrooms can create their own spore-casting wind.

Fluid mechanics researchers trained high-speed video cameras on common Shiitake and oyster mushrooms. The scientists discovered that the mushroom spores floated off even when the air was calm. They enlisted mathematical models to solve the mystery.

Turns out that before the spore dispersal, the mushrooms released water vapor. This moisture cooled the air around the 'shroom, causing a convective dynamic that got the air moving. Just this faint fungal breeze was enough to carry the spores away from the parent. The findings were presented at the Annual Meeting of the American Physical Society's Division of Fluid Dynamics in Pittsburgh. [Emilie Dressaire, et al., " Control of Fluidic Environments by Mushrooms "]

This discovery suggests that mushrooms aren't simply in a race to produce the most spores. Evolution also engineered a good way to spread them.

—Katherine Harmon

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Bizarre Fire Ants Create Rafts to Survive Frequent Floods

Certain species in Brazil grab hold of one another to form a living collective that can float for weeks


TechMediaNetwork



An ant raft stays on top of the water surface even when it is hardly pressed by a branch -- showing water repellency and buoyancy.Image: Nathon Mlot

What behaves like a solid and a liquid and is red all over? Rafts of fire ants, according to new research that describes the unusual physical nature of these structures for the first time.

Solenopsis invicta, a common species of fire ant, originates from the rainforests of Brazil, where heavy precipitation can cause flooding to occur up to twice daily. In order to stick together as a colony during these deluges, the fire ants hook their legs and mouths together to create a living, breathing waterproof material that floats for hours, or even weeks, if necessary, until floods subside.

These so-called fire-ant rafts contain nearly 200 bodies per square inch (6.5 square centimeters); they can grow to be as large as garbage bin lids in the case of large colonies, but more typically, they grow to the size of small plates. The ants are wired to assemble themselves quickly in response to an emergency, and can organize thousands of bodies in less than two minutes, according to study researcher David Hu at the Georgia Institute of Technology, who has studied these rafts for the past several years and describes them as a living fabric. 

"They are all acting together, and there are so many of them, that they are really becoming a single material," Hu told LiveScience.

Hu and his team have now conducted the first-ever experiments to calculate the physical characteristics of these rafts, in an effort to inform materials scientists interested in creating similar structures for robotics and potentially construction as well.

With a tool called a rheometer — which measures a material's resistance to motionand is used to check the viscosity of consumer products such as shampoo and chocolate — the team measured and compared the physical characteristics of clumps of living and dead fire ants.

They found that living fire ants within a raft constantly rearranged themselves in response to forces, such as the nudge of a stick in the lab or a drop of rain in nature, and that this rearrangement allows the rafts to bounce back elastically, like rubber, when a force is removed.

"No matter what you do, they are always constantly rearranging their bodies to respond to stresses," Hu said. "Where someone pushes on them, they initially act like a solid, but if you leave the plate, there they will also flow and respond. There are very few materials that act like that."

This responsiveness allows the fire ants to deal with obstacles they may face while floating around the rainforest floor, such as small rocks or bursts of waves in a puddle, Hu said.

The team found that dead fire ants, on the other hand, behaved like solids only and were immediately discarded from rafts, because they jeopardize the integrity of the superorganism, Hu said.

By coming up with a set of equations that describes the movement of these rafts, Hu believes his team's work will inform ongoing efforts to create small, self-arranging robots that could be deployed in tight spaces to make hard-to-reach-measurements, or even self-healing building materials that could emerge from within a broken bridge, for example, and fill in crevices to prevent further damage.

The team will present their findings today (Nov. 26) at the annual meeting of the American Physical Society Division of Fluid Dynamics in Pittsburgh.

Follow Laura Poppick on TwitterOriginal article on LiveScience.

Copyright 2013 LiveScience, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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The Big Sleep.docx

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DECEMBER 3, 2013

DEATHWATCH

POSTED BY MARK O'CONNELL

DEATH-APP-290.jpg.jpeg

At the time of this writing, there are sixteen thousand two hundred and seventy-seven days remaining in my life. I know this because an app I have installed on my phone tells me so. I downloaded it about a week ago, back when I still had sixteen thousand two hundred and eighty-four days left to live, a number that strikes me in retrospect as an embarrassment of riches, days-wise. By the time you read this, I will have even fewer days left to live. Depending on the turnaround time for this piece, I could be down to a number as low as sixteen thousand two hundred and seventy. I’m running out of days here, is what the app is telling me, in its bluntly literal way.

This little contrivance is called Days of Life, and it’s as chillingly simple and straightforward as its name suggests. Here’s how it works: you punch in your date of birth, your gender, and the country you live in, and then it estimates your life expectancy based on these variables. I happen to be male and Irish and so, by the reckoning of the app, I will live for seventy-nine years. (If I happened to reside in either of the two options above or below Ireland on the scrolling list of countries in the settings—Iraq or Israel—I’d be looking at sixty-five and eighty years, respectively.) It won’t take any further particulars into consideration; it doesn’t care whether I’m a smoker, what my B.M.I. or my income is, whether anyone in my immediate family has died from cancer. No: I’m a thirty-four-year-old Irishman, and so I’ve got sixteen thousand two hundred and seventy-seven days left to live.

Actually, it’s more like sixteen thousand two hundred and seventy-six and three-quarters now because, what with one distraction or another, it’s taken me an absurdly long time to get the preceding two paragraphs written. (How did this happen? Where did the time go, and why did I allow it to get away? Did I really need to answer those e-mails, read those tweets, make and drink those cups of coffee?) And this is essentially the point of the app. It’s supposed to make you think like this—to terrify you into productivity, turning mortal dread into a procrastination preventative.

At the top of the screen, there’s a digital-clock-style display that informs you how many days you’ve got left. This is grim enough, of course, but what’s really unsettling is the circular pie chart that takes up the bottom half of the screen. When you fire up the app, this circle is entirely filled with little green dots; but then, in a sickening, clockwise sweep, these dots begin to turn orange, until the proportion of your life that has already passed—gone, finished, irredeemably over—is represented in contrast to the only slightly larger proportion that remains. And, suddenly, you’re looking at your life in pie-chart form: a handy infographic of personal transience, an illustration of how close you’re getting to being dead. It’s the Quantified Self in its most reductive form.

And it doesn’t really matter that the thing could never be accurate. Because what you’re looking at, you realize, is something like a best-case scenario: this is how much time you have left provided you don’t get a terminal disease in your mid-thirties, or die in a car crash at forty-eight, or suffer a fatal stroke in your late fifties, or choke on the ham-and-Emmental sandwich you plan to hastily consume this very lunchtime. You’d be doing quite well, you realize, to have sixteen thousand two hundred and seventy-seven days left. And if it’s not that precise number of days, it’s some other number, exact and unknown; either way, the number is finite, and decreases in size with every breath you draw. “Nothing more terrible, nothing more true,” as Larkin put it in “Aubade,” terribly and truthfully. For older users, Days of Life’s help section provides the following piece of consumer assistance: “IMPORTANT: In case your settings determines that you should already be dead, the app adds 10 more years to your life expectancy.” This, you feel, is customer service of a rare and unnerving excellence.

The app has a couple of optional extras. You can get it to send you daily notifications, and you can have it post your details automatically to Facebook or Twitter: a frictionless sharing of your own proximity to the void. But in terms of its basic functionality, Days of Life is, as I say, an extremely simple app. The principle is the same as that of Web sites like the Death Clock, where you enter a few relevant particulars—date of birth, B.M.I., general outlook, units of alcohol per week, and so forth—in exchange for the estimated date of your death. Which is to say that it makes explicit the information that is already covertly contained in the rhythmical ticking of your wristwatch’s second hand or the blinking digits of your bedside alarm clock at 3:45 A.M. on a sleepless night: you’re only headed in one direction, friend, and you’re getting there one second at a time. (“Unresting death, a whole day nearer now”—Larkin again, declining to sugar the pill.)

There are, for me, two major sources of fascination with this app. The first is the way in which its visual design recalls the experience of playing a video game, where your character’s vitality is represented by a system of symbols at the bottom of the screen—a decreasing lineup of little hearts, say, or a pulsing red level to warn of perilously dwindling life force. Days of Life’s orange and green pie chart makes a similarly stark statement, but instead of encouraging you to run around looking for a turkey leg to devour or a vial of magic potion to knock back, its intention is to make you consider your own mortality and to want, as a result, to spend your remaining time as wisely as possible. What that means these days, of course, is “productivity.”

And this is the other thing I find most fascinating and disturbing about the app: the brutally frank way in which it encapsulates a particularly fraught aspect of our relationship to technology. When I look at that little pie chart of my remaining days, I see my life represented as a kind of product, a consumer good with a timeline of built-in obsolescence. The imperative is to get as much use-value out of yourself as you can, while you can. (When you click on “About” in the app, you read this: “Many entrepreneurs have achieved success after recognizing that life is short and every minute counts. Use this app every day for motivation and to set short and long term goals.”)

I waste a lot of time agonizing over the amount of time I waste; I am preoccupied to the point of obsession with my various failures to achieve self-optimization, with the idea that I have too little time, and I am producing too little with it. (One of the ironies of being a writer—or working in any kind of creative area, I suppose—is the tendency to conceive of yourself in oddly dehumanizing ways: as “productive” or “unproductive,” as laboring toward some kind of Stakhanovite ideal of efficiency and yield.) At a rate of about once per second, my word processor’s cursor blinks at the end of the last word typed. If I look at it for long enough, I begin to imagine it ticking (“Write! … Write! … Write!”) as it counts down the remaining time—before a deadline, before I have to leave my desk to pick up my son from child care. Before I’m dead.

Days of Life is one of those technologies that seems to incidentally satirize our relationship with technology more broadly. It sits in the “Productivity” folder on my iPhone’s home screen, along with my calendar and a to-do list app called Remember the Milk, but it would be as appropriately housed in a folder called “Existential Terror.” So much of what we value in technology is its promise to upgrade the hardware of our lives, to make us more useful to ourselves—more productive, more profitable, more effective. Days of Life functions like a reductio ad absurdum of the logic of personal productivity. The pie chart becomes a special way of being afraid: an image of the self as a micro-economy of numbered days.

Mark O’Connell is Slate’s books columnist, and a staff writer for The Millions. You can follow him on Twitter @mrkocnnll.

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3D Hubs

3D Hubs Releases December Trend Report

Michael Molitch-Hou BY MICHAEL MOLITCH-HOU ON  · 3D PRINTERSINDUSTRY NEWS ADD COMMENT

Connecting 3D printer owners across the world gives 3D Hubs access to key statistics relying on their users as sample of the larger picture.  In November, the company released their second trend report, which suggested that Open Source RepRaps, Ultimakers, and MakerBots were among the most used 3D printers in their pool. Earlier today, the self-defined “world’s largest collaborative production platform for 3D printer owners and makers” released its December trend report, outlining how the different brands are trending.

3D Hubs trend report december 2013 trending printers

According to 3D Hubs, their research can detail “hot printers in the market right now.” Due to the commercial release of the Ultimaker 2 and the shipment of the Form1 SL printer, there is a significant increase in activity from those two machines.  3D Hubs also argues that MakerBot is gaining traction with the Replicator 2 and Replicator 2X and that “with this growth rate the Replicator is posed to overtake the Ultimaker as the most popular printer on the platform soon.”            The company, based in Europe, has a European slant, but that may change soon with the “unlocking” of a number of US cities since the opening of their offices in New York.  Still, 3D printers users show a bias towards their native machines, with the Replicator 2 more popular in North America and Ultimaker more popular in Europe.

Simultaneously more interesting and less interesting, is the distribution of colors and materials being printed through 3D printers.  The point that should be gleaned from the color distribution chart is that more colors are being increasingly offered as 3D printing becomes more popular. The colors most often used are the ol’ red, white, and blue, but the entire color spectrum is quite diverse and includes glow-in-the-dark filament, as well.  ABS and PLA are divided in terms of use, but nylon, wood, and flexible PLA is starting to be taken advantage of, too.  Again, what I think this alludes to is the increased diversity of materials out on the market.

The report offers a bit of insight into trends in 3D printing from a sample of about 2,000 users, about 2% of the total 3D printer users according to 3D Hubs.  That sample size, I think, is pretty significant and is drawn from a wide number of countries, but it may be slightly skewed demographically.  For the 3D Hubs trend report to become a truly useful statistical analysis, and not just a potentially useful marketing ploy, it would be beneficial to see things income, gender, race, and, even, political affiliation.  Is 3D Hubs made up of a bunch of middle class white dudes? Or is it a diverse community?  What are their favorite movies? Who are their favorite historical figures? God, I hope it’s not Mussolini. That guy was awful!














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RISK ASSESSMENT SECURITY & HACKTIVISM

Flying hacker contraption hunts other drones, turns them into zombies

Ever wanted your own botnet of flying drones? SkyJack can help.

by Dan Goodin - Dec 3 2013, 8:49pm BRST

Serial hacker Samy Kamkar has released all the hardware and software specifications that hobbyists need to build an aerial drone that seeks out other drones in the air, hacks them, and turns them into a conscripted army of unmanned vehicles under the attacker's control.

Dubbed SkyJack, the contraption uses a radio-controlled Parrot AR.Drone quadcopter carrying a Raspberry Pi circuit board, a small battery, and two wireless transmitters. The devices run a combination of custom software and off-the-shelf applications that seek out wireless signals of nearby Parrot drones, hijack the wireless connections used to control them, and commandeer the victims' flight-control and camera systems. SkyJack will also run on land-based Linux devices and hack drones within radio range. At least 500,000 Parrot drones have been sold since the model was introduced in 2010.

Kamkar is the creator of the infamous Samy worm, a complex piece of JavaScript that knocked MySpace out of commission in 2005 when the exploit added more than one million MySpace friends to Kamkar's account. Kamkar was later convicted for the stunt. He has since devoted his skills to legal hacks, including development of the "evercookie," a highly persistent browser cookie with troubling privacy implications. He has also researched location data stored by Android devices.

SkyJack made its debut the same week that Amazon unveiled plans to use drones to deliver packages to customers' homes or businesses.

"How fun would it be to take over drones, carrying Amazon packages... or take over any other drones and make them my little zombie drones," Kamkar asked rhetorically in a blog post published Monday. "Awesome."

SkyJack: autonomous drone hacking.

SkyJack works by monitoring the media access control (MAC) addresses of all Wi-Fi devices within radio range. When it finds a MAC address belonging to a block of addresses used by Parrot AR.Drone vehicles, SkyJack uses the open-source Aircrack-ng app for Wi-Fi hacking to issue a command that disconnects the vehicle from the iOS or Android device currently being used to control and monitor it. Operators of the flying hacker drone are then able to use their own smart device to control the altitude, speed, and direction of the hijacked drone and to view its live video feeds.

At the moment, SkyJack is engineered to target a small range of drones. That's because it's programmed to take over drones only if their MACs fall inside an address block reserved by Parrot AR.Drone vehicles. If the MAC falls outside that range, SkyJack takes no action at all. But the software is built in a way to easily target other types of drones that have communication systems that are similar to Parrot. That means a much broader range of devices may be susceptible to radio-controlled hijacking if they fail to adequately secure their connections.

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NATURE BIOTECHNOLOGY | NEWS



Monsanto buys Climate Corporation for $1.1 billion

Nature Biotechnology
 
31,
 
1064
 
 
doi:10.1038/nbt1213-1064a
Published online
 

St. Louis–based Monsanto in October announced plans to acquire the Climate Corp. of San Francisco, a company that describes itself as using “machine learning to predict the weather and other essential elements for agribusiness.” It provides farmers with specialized weather forecasting as well as a variety of insurance products.










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A Chimp’s Day in Court: Inside the Historic Demand for Nonhuman Rights


Tommy, the 26-year-old chimpanzee plaintiff of the Nonhuman Rights Project’s first lawsuit, in his cage in Gloversville, New York. Image: Pennebaker Hegedus Films


On the morning of December 2, a lawyer named Steve Wise and three other members of the Nonhuman Rights Project walked up the steps of the Fulton County Courthouse in Johnstown, New York and into the annals of history.

In Wise’s hands was a lawsuit demanding something unprecedented in American law: formal recognition that a 26-year-old chimpanzee named Tommy, kept alone in a cage in a local warehouse, is a person, possessing a legal right to bodily liberty previously reserved for humans.

One day later, Wise delivered a similar lawsuit in Niagara Falls, on behalf of Kiko, a chimpanzee living in the home of a couple who purchased him 20 years ago from an Ohio ice cream parlor. Two days after that, Wise filed suit on Long Island, claiming freedom for Hercules and Leo, two chimps used in locomotion studies at Stony Brook University and owned by the New Iberia Research Center, a facility infamous for the abuse of its animals.

What Wise and the members of his Nonhuman Rights Project assert is both simple and radical: that personhood — the legal prerequisite for having rights of any sort at all — should no more be based on species classification than it is on skin color. Instead, the lawsuits argue that personhood derives from cognitive and emotional qualities that chimpanzees, like humans, possess in abundance.


Tommy and Kiko and Hercules and Leo are not humans, acknowledges Wise, deserving full human rights. They shouldn’t have a right to vote, or to enter a restaurant or a public school. But they and every other captive chimpanzee are enough like us to have a right not to be owned and imprisoned against their will. If it’s not realistic to release them into a wild they’ve never known, they might be sent to chimpanzee sanctuaries, free to live with a modicum of the liberty they deserve. Not because we’ve deigned to be nice to them, but because it’s their right.

Whether a judge will agree remains to be seen, and most legal scholars, even those who support the case, think it’s unlikely. Never in the history of western law have ideals of liberty and equality been formally applied to an animal other than Homo sapiens. Judges don’t like being radical. The lawsuit also raises what many consider an unacceptably impractical possibility: personhood demands filed on behalf of not only chimpanzees, but animals used in research and on farms, or living in our landscapes.


'If you have the cognitive capacity to live life as you choose, you should be able to do that. Your species is completely irrelevant.'
Legal implications aside, however, the argument for chimpanzee personhood draws on decades of scientific research on humanity’s closest living relative. And where the argument turns from law to science, the Nonhuman Rights Project’s claims are backed with affidavits filed by nine of the world’s leading primate researchers, describing in exhaustive detail the scientific evidence for regarding Tommy, Kiko, Hercules and Leo as extraordinarily complex, self-aware and autonomous creatures comparable in many ways to ourselves.

Such information has previously been applied to questions of welfare, to cage sizes and research justifications, but not to fundamental legal questions of personhood. Yet this is where the science points, and though many people dismiss these claims as quixotic and impractical, Wise and his compatriots are following scientific fact to an arguably logical legal conclusion.

It’s still entirely possible that the lawsuits will be dismissed without Wise opening his mouth in a New York courtroom. But it’s also possible that a judge will at least agree to hear their case. If and when that happens, a chimpanzee will finally have his day in court. “It doesn’t matter if you’re a human or a chimp,” said Wise. “If you have the cognitive capacity to live life as you choose, you should be able to do that. Your species is completely, completely irrelevant.”

Aristotle’s Animate Windshields

The lawsuit is the culmination of a legal strategy seeded three decades ago, when Wise was practicing animal protection — or, as he prefers to say, animal slave — law in Massachusetts. He litigated hundreds of cases, ranging from the unusual mistreatment of dogs and cats to more unusual lawsuits: attempts to stop deer hunts, the transfer of a dolphin from the New England Aquarium into sonar research with the U.S. Navy.

Sometimes, as when an especially egregious abuse violated local animal cruelty statutes, Wise would win. But often his lawsuits were dismissed by judges who argued that Wise couldn’t sue on behalf of animals he or his clients didn’t personally own. In legal terms, they lacked standing: the ability to show how humans would suffer from the mistreatment of an animal.

It might sound illogical that an animal’s suffering could be legally irrelevant unless it directly affects a human, but “these are the kinds of gymnastics that animal protection lawyers have to go through,” said Wise during a September talk at George Washington University. “Nonhuman animals are legal things, and they have always been legal things. That means they’re essentially invisible to our civil law.”

Cruelty laws aside, some animal protections do exist, such as those for endangered species. Yet even those reflect the value society places on populations and species units. They say nothing about the personhood of an individual animal. And though individuality might be acknowledged in, say, requirements that research chimpanzees be given toys to play with, they reflect token generosities rather than any acknowledgement of an animal’s essential personhood.

“The example I give is that I can take a baseball bat, and smash the window of your car, and I’ll be charged with something,” said Wise during the talk. “But the car or the windshield doesn’t have legal rights. It’s not a person. Essentially, a non-human animal is a kind of animate windshield. If I’m cruel to her, I can go to jail, but the non-human animal is a complete bystander to this. She doesn’t have any rights.”

Wise furthered the analogy with references to animals as legally equivalent to tables and chairs — language that, to anyone who knows a cat or dog, or really has any experience with animals whatsoever, will sound strange: animals are self-evidently not these things. Yet as Wise argues inDrawing the Line, a 2002 book in which he articulated the legal and scientific framework of the lawsuits, western law’s view of animals has been shaped by an intellectual tradition that might charitably be called ignorance, from Aristotle’s proclamation that, just as slaves were made to serve their masters, so animals were made to serve humans, on through René Descartes’ characterization of animals as clockwork automata.

Whether this intellectual history is directly responsible for modern law’s treatment of animals is a matter of debate for legal historians. The fact remains, though, that Tommy — whom Wise visited personally in October, under the guise of being curious about a herd of holiday-rental reindeer also kept at a trailer dealership run by Tommy’s owner, and found alone in a newspaper-lined cement cage in a dank, cavernous warehouse with nothing to occupy his attention but a small color television — might as well be a windshield.

“There is no question this court would release Tommy if he were a human being,” read the documents. “There can be equally no doubt that Tommy is imprisoned for a single reason: despite his capacities for autonomy, self-determination, self-awareness, and dozens of other allied and connected extraordinarily complex cognitive abilities, he is a chimpanzee.”



Loulis, who learned to use sign language from his adopted mother Washoe, the first chimpanzee taught to sign.Image: Mary Lee Jensvold/Friends of Washoe



The Mind of a Chimpanzee

Making a factual case for those capacities are the affidavits filed by the nine scientists, whose expertise spans not only primatology but psychology, neuroscience, animal behavior, anthropology, cognition and learning theory. The scientists are not themselves members of the Nonhuman Rights Project, and the affidavits don’t talk about law, only science. Gathered together, they amount to more than 200 pages of text and reference, reviewing hundreds of studies — not just their own, but from hundreds of other researchers — on dozens of cognitive, neurological and behavioral traits [see sidebar for a complete list].

Lawsuits aside, the affidavits are a veritable textbook of contemporary and historical chimpanzee research, and if conveying their full detail requires more space than a journalistic article affords, a few themes stand out. At a purely neurological level, chimpanzees share many of the same features — enlarged frontal lobes, asymmetry between left- and right-brain functions, specialized cell types in specific brain regions — associated with high-level cognition in humans.

Mary Lee Jensvold, an experimental psychologist and former director of the Chimpanzee and Human Communication Institute, who worked for 27 years with chimps taught sign language, describes the conceptual richness of their communicative abilities, which include symbolic thought, perspective-taking and references to past and future events, and the parallel manner in which these develop in both human and chimpanzee infants. These are evidence, say she and others, of deep cognitive similarities.


A Cognitive Recipe for Personhood

"The affidavits submitted in support of this Petition, summarized below, demonstrate that chimpanzees possess those complex cognitive abilities sufficient for common law personhood and the right to bodily liberty, as a matter of liberty, equality or both. Their most significant cognitive ability is "autonomy," which the other cognitive abilities support. These included, but are not limited to, the possession of an autobiographical self, episodic memory, self-determination, self-consciousness, self-knowing, self-agency, referential and intentional communication, empathy, a working memory, language, metacognition, numerosity, and material, social and symbolic culture, their ability to plan, engage in mental time travel, intentional action, sequential learning, mediational learning, mental state modeling, visual perspective-taking, cross-modal perception, their ability to understand cause-and-effect, the experiences of others, to imagine, imitate, engage in deferred imitation, emulate, to innovate and to make and use tools."

Similar parallels can be seen in brain development, writes Primatologist Tetsuro Matsuzawa of Kyoto University, current president of the International Primatological Society. He also discusses their highly sophisticated numerical and sequencing abilities, which have been the subject of public fascination: chimps out-calculating human children, and even college students! These math skills, explains Matsuzawa, indicate the sophistication of memory systems considered central to planning and making decisions, rather than acting on instinct or automatic, stimulus-response conditioning.

Another series of well-known findings involve tool-making and cultural traditions, both of which were once thought to be uniquely human capacities. William McGrew, an evolutionary primatologist at the University of Cambridge, describes how chimpanzees learn from one another to make complex tools that resemble those used by Stone Age humans and even some surviving aboriginal groups. “The foraging kits of some chimpanzee populations, such as in western Tanzania, are indistinguishable in complexity from the tool kits of some of the simplest material cultures of humans, such as Tasmanian aborigines,” McGrew writes.

Different methods of tool manufacture and use are considered hallmarks of distinct chimpanzee cultures, of which more than 40 exist in Africa. Cultures are also distinguished by social traditions: McGrew recounts how the famed primatologist Jane Goodall, who sits on the Nonhuman Rights Project’s Board of Directors, documented males of group she studies performing slow, rhythmic dances at the beginning of rain seasons. It’s not unreasonable, Goodall says, to think these might be rain dances.

Whether that’s so is speculation, but the cognitive faculties underlying culture are not. In chimpanzees as in humans, writes McGrew, social learning requires emulation, imitation, and an ability to explain, all of which signify a sense of self. That’s hardly not unique in the animal kingdom — even a cockroach likely has self-awareness — but there’s reason to think that a chimpanzee’s self-awareness is comparable to our own. Not only can chimpanzees only can recognize themselves in mirrors, which is considered a sign of sophisticated self-awareness; they also recognize photographs of themselves as youngsters.

Perhaps crucially, they’re capable of “mental time travel,” said Matthias Osvath, a cognitive zoologist Sweden’s University of Lund. Known for his research on Santino, a chimpanzee who makes elaborate plans to throw stones at zoo visitors, Osvath describes mental time travel as the ability to imagine oneself in the past and future, as well as the present. This capacity underlies an essential aspect of human experience, Osvath said: we engage in some form of it whenever our own thoughts stray from the immediate moment, and when we make plans.

It’s this ability that produces the autobiographical, first-person sense we have of our own lives, and it could very well mean that Tommy is both aware of the misery of his situation and can contemplate a future of never-ending captivity. If so, that would not in itself be the grounds for the Nonhuman Rights Project’s personhood claim: rather, it would be a facet of what the various capacities of chimpanzees, from complex memory and self-awareness to imagination and mental time travel, signify: autonomy.

As best as we can tell, Tommy and Kiko and Hercules and Leo don’t live their lives according to a predetermined program. They can go to sleep at night thinking of what they might do the next day, then wake up and do it — or not. They live consciously, with full awareness and exercised choice.

This assertion, that the cognitive qualities enumerated amount to autonomy, is arguably a judgement that drifts away from established fact and towards a philosophical argument about the nature of autonomy. But as psychologist James King of the University of Arizona, former editor of the Journal of Comparative Psychologynotes in his affidavit, autonomy isn’t even something we can directly observe even in humans.

Rather, we judge it by behavior, and “evidence for autonomous behavior in humans is not seriously disputed,” writes King. “In chimpanzees, the behavioral evidence for autonomy is not seriously disputed.” And if we can’t measure autonomy the way we can, say, gravity, it’s the simplest explanation for what we can observe in chimpanzees.


'One of the chimps signed, "Key. Out.'"'
A few decades ago, before most of this research was conducted, when editors at the journal Nature castigated Jane Goodall for referring to chimpanzees with gender-specific pronouns, such claims would have been deeply controversial. After all, noted Osvath, science too had to free itself from the intellectual legacy of Aristotle and animals-as-machines. But the essential outlines are widely accepted.

To be sure, said Brian Hare, a Duke University evolutionary anthropologist who has studied cognition in chimpanzees and dogs, individual pieces of the cited research might still be debated, but over fine points of similarity and difference. “If you’re talking about it in a quick way, all those statements are accurate, but in each of those categories where chimpanzees might be similar to us, there’s different types of equivalence,” Hare said.

In other words, a chimpanzee has an autobiographical sense of self, but does he spend as much time as we do contemplating its future? Does he experience autonomy the way we do? That we don’t know for sure, but the Nonhuman Rights Project argument isn’t for one-to-one equivalence, but rather substantive similarity. Indeed, that’s essentially the judgment passed by an Institute of Medicine committee convened in 2011 to advise the National Institutes of Health on its use of chimpanzees in research: they’re just too much like humans to use in harmful experiments unless there’s an overwhelming, human life-saving reason to do so.

To all this, one might raise the question: Could a chimpanzee ask to be free? In the wild, where chimpanzees are known to communicate using abstract, symbolic gestures, that might indeed be possible, but Mary Lee Jensvold recalled a more germane story, involving chimpanzees trained to us sign language by Roger Fouts, the Chimpanzee and Human Communication Institute’s founder, early in his career, when Fouts was still at the University of Oklahoma’s Institute for Primate Studies.

The chimps were sold to the Laboratory for Experimental Medicine and Surgery in Primates in New York. Years later, one of Fouts’ collaborators, Gonzaga University comparative psychologist Mark Bodamer, visited the laboratory. “He met the signing chimps,” said Jensvold. “The chimps were signing. One of the technicians said, ‘They’re always doing that.’ And one of the chimps signed, ‘Key. Out.’”



From left to right: Natalie Prosin, Elizabeth Stein, Steve Wise and Monica Miller. Image: Brandon Keim/Wired



Does a Person Need to Be Human?

If the Nonhuman Rights Project’s story were a movie, it would cut now to a montage of hotel conference rooms, take-out cartons and ever-growing piles of paper strewn around the project’s principals. There’s Wise, of course, his hair grayer and face more lined than in the dust-jacket photos of his books; Elizabeth Stein, Wise’s intellectual sparring partner, who left financial law to defend animals; Monica Miller, a recent law school graduate who handles their legal database-dives and archive-searches; executive director Natalie Prosin, who does a little of everything; and, appearing via Skype on a laptop, Lori Marino, the Emory University neuroscientist who first showed that dolphins could recognize themselves in mirrors.

Over the past two years, with volunteer help from dozens of animal law students and lawyers, the group analyzed the laws of all 50 states, plumbing the arcana of 19th-century slave cases and legal guardianship precedents, posing for each some 60 fine-print questions designed to identify the most legally hospitable state for their lawsuit. Earlier this year they picked New York, where courts have historically been generous in their willingness to hear personhood claims, and decided to bring suit on behalf of every chimp they could find.

Two of these, named Merlin and Reba, kept in a cage at a zoo in the upstate town of Catskills, died before the case was ready. Merlin was the second to die, three months after Reba, from complications resulting from an abscessed tooth. According to the Nonhuman Rights Project, he spent the last several weeks of his life punching himself in the face. A third chimpanzee, a 28-year-old named Charlie, “The Karate Chimp, who was owned by the same couple who own Kiko, died in early November. The couple, Carmen and Christi Presti, run a self-described primate sanctuary previously known as Monkey Business; they’d purchased Charlie as a 15-month-old, later teaching him karate and displaying him on TV shows including America’s Funniest Home Videos and How I Met Your Mother.

The Christis did not respond to requests to be interviewed, nor did Tommy’s owner, Patrick Lavery, or Stony Brook University, where Hercules and Leo are used in anatomist Susan Larson’s research on primate locomotion. Both are owned by the New Iberia Research Center, to which a third Stony Brook chimpanzee, named Carter, was returned last August. A chimpanzee named Carter is also mentioned in a 2007 Humane Society undercover investigation at NIRC, which has been accused of illegally breeding chimps.

The HSUS allegations described several hundred NIRC chimpanzees living in barren, windowless concrete rooms, with literally nothing to do, sometimes in isolation and at other times packed into cages. Infants were routinely taken from their mothers shortly after birth; in the wild, they’d have nursed for five years, and remained with their mothers for several years after that. At NIRC, juveniles often displayed the compulsive rocking typical of abandoned human children. “Danielle gave birth to son Carter on 9/1/06,” read the report. “Carter was taken from his mother so she could be bred again.”

New Iberia was ultimately fined a pittance of $18,000 for violating the Animal Welfare Act. This sort of treatment, and the institution of chimpanzee ownership that supports it, isn’t just wrong, contends Wise. It violates their rights. To make that argument, he’s appealing to common law, a body of jurisprudence distinct from Constitutional law — Wise doesn’t argue, and has openly criticized the notion, that the 13th Amendment should apply to non-humans — and from statutory law, which is passed by legislatures. Common law is where everything else gets settled, and at least historically, it’s where judges have the latitude to make and interpret law in keeping with changing social standards and scientific knowledge.

Personal injuries fall under the auspices common law. So do rights to privacy and inter-family disputes. It was also in a common-law court where a slave’s personhood was legally recognized for the first time. That case, Somerset v. Steuart, took place in England in 1772, and is the subject of a book by Wise, Though the Heavens May Fall, in which he details the legal arguments that convinced one of history’s most influential jurists, Lord Mansfield, himself a slave-owner, that a runaway slave named James Somerset was a person with a right to be free.


'He’s called the law into question on its fundamental values of dignity, equality and autonomy.'
That case and its arguments, including the legal strategy of filing a writ of habeas corpus, an ancient legal principle — it translates from Latin as, “show the body” — used to challenge unlawful imprisonment, was formative for Wise. It guides the Nonhuman Rights Project’s lawsuits, which ask for writs of habeas corpus on behalf of the chimpanzees, and is among the dozens of cases and legal theories cited in their court documents.

These run from Somerset v. Steuart and The Collected Works of Abraham Lincoln to tomes of Roman civil law and Lemmon v. People, an 1852 case in which the New York Supreme Court allowed a dock worker to file habeas corpus writs on behalf of eight slaves held on a boat in New York harbor. That precedent, hopes Wise, will convince a judge that the Nonhuman Rights Project can represent the chimpanzees. They also quote John Chipman Gray, an influential late-19th and early-20th century legal scholar, who said that “personhood as a legal concept arises not from the humanity of the subject but from the ascriptions of rights and duties to the subject.”

That is, in a formal nutshell, the essence of the Nonhuman Rights Project’s argument: a person — an entity capable of possessing legal rights — does not need to be human. To a certain extent this has already been demonstrated by the legal personhood afforded to corporations and ships, but those are still human institutions. Wise is calling for personhood based purely on principle.

“Legal person has never been a synonym for ‘human being,’” reads the lawsuit. “A free being such as Tommy, who possesses autonomy, self-determination, self-awareness, and the ability to choose how to live his life, must be recognized as a common law ‘person.’” The rights to which Tommy is entailed, they stress, don’t include nearly all the rights given to humans — he’s not entitled to a free education or emergency health care — but by virtue of his autonomy, his capacity for self-determination, has a right not to be imprisoned.

This sort of right is technically known as a “dignity right,” and Erin Daly, a Widener University School of Law professor who has written extensively about dignity rights, called their proposed grounding in autonomy “a reasonable and interesting argument,” though unprecedented. “I don’t know of anything that says, ‘Anything with autonomy has dignity rights,’” she said — not because the idea has been rejected, but because nobody’s yet made that case so explicitly.

“As a legal culture, we do care about autonomy. It’s an important value in America, and more so in America than in other countries,” Daly said. “I think that makes sense to test whether nonhumans should be accorded dignity rights in some way.”

Should a judge feel uncomfortable with the idea that self-determination is an intrinsic basis for liberty, the lawsuit offers a related but subtly different argument, grounded instead in equality: the principle by which, if one person is similar to another, they are treated equally by the law. It’s on this principle that rights for blacks, other racial minorities, women and non-heterosexuals have been granted — and not because they were necessarily considered the full equals of existing rights-holders, but because they were equal enough.

Likewise, even humans whose cognitive capacities are well below those of chimpanzees — people with severe mental disabilities, infants whose brains won’t ever develop, adults with severe dementia — are granted some rights. They might be kept in institutions, or have certain decisions made for them, but they can’t be owned or experimented upon. That isn’t simply because they satisfy some arbitrary genetic standard, argues Wise, or qualify via legal loophole for the protections of fully abled humans. It’s because they have capacities of autonomy and selfhood, however limited, that we as a society value so deeply.

“We’ll go in front of a judge and say, “Whatever is the reason why a human being should have a right to bodily liberty, whatever trait they have, whatever characteristic they have, our chimpanzee has it too,” Wise said. “You can name whatever you want. Our chimp has it too.”

“The strength of Wise’s case is that he’s called the law into question on its fundamental values of dignity, equality and autonomy,” said Paul Waldau, who teaches animal law and ethics at Harvard Law School. “He’s saying, ‘If you will just accept these as the really beautiful foundations of our law, then I win.’ He’s using the real foundational arguments of the legal system to do this. And in a way it’s quite conservative: He’s saying, ‘The basic values are good — and watch how, if you extrapolate them carefully, they will take us: to legal rights for chimpanzees. That’s beautiful. It affirms the system, even as it asks the system to go beyond what it presently has done.”


Before the Court

Beautiful as the argument might be, however, can it succeed? Even among legal scholars who respect Wise’s arguments, and acknowledge changing human relationships to animals — widespread condemnations of cruelty, insistence on humanely-treated farm animals, the NIH’s historic rejection of most chimp experimentation, a fifteen-fold increase in academic animal law programs over the last two decades — it’s difficult to find one who thinks a judge will rule in the chimpanzees’ favor.

“I think Wise’s work as academic theory, as policy, as discussion, is second to none,” said Jonathan Lovvorn, a Georgetown University law professor and senior litigator at the Humane Society of the United States. “His work was transformative within the legal academic field. But I think that translating it at this stage into a legal strategy is just not feasible.”

The problem, said Lovvorn, is that chimpanzee personhood, however limited, is still too radical for most judges to consider. Though articulated in bedrock principles of liberty and equality, it’s still aboutan animal. It would represent a legal sea change; in the profession’s argot, it’s “too big an ask,” said Lovvorn. It’s true that common law has historically been flexible, a vehicle for judicial activism, he said, but that was far more true in the 18th and 19th century than it is now.

Other reservations that will almost certainly cross a judge’s mind were raised more than a decade agowhen Wise debated Richard Epstein, a legal scholar at New York University, and Richard Posner, a judge on the 7th U.S. Circuit Court of Appeals. “Chimpanzees and bonobos may be the obvious candidates,” said Epstein, but that could open the door to personhood claims on behalf of cattle or sheep or rats and mice used in human life-saving medical research. “It’s not clear how far exactly you want to run this,” he said.

To this, Wise would rejoin that the lawsuit is about the possibility of granting a single right to chimpanzees, and has nothing to do with sheep or rats — but it’s no secret that it represents what Wise has often described as his goal of breaking down the legal wall that now separates humans from all other animals. “Once we begin to punch through that wall,” said Wise, “all sorts of roads possibly open.”

Chimpanzees are now considered exceptional, but similar arguments could presently be made on behalf of other great apes, elephants and some cetaceans, which the Nonhuman Rights Project had also considered. Given that many scientists now recognize consciousness across the animal kingdom, autonomy may eventually prove to be an easily attainable standard for personhood.

One might argue that it’s only ethically and scientifically consistent to judge the personhood of each species empirically, as the Nonhuman Rights Project does with chimpanzees, and contemplate rights on a species-by-species basis. From a certain perspective, this is even exciting: if a non-human animals can be persons, then what sort of persons should they be? What rights should they have, or not? Might an entirely new class of rights possession, “animalhood,” be established? But excitement is not what most career- and reputation-minded judges seek.


'Once we begin to punch through that wall, all sorts of roads open.'
Moreover, as Posner noted, Wise is likely to encounter a deep-seated, almost primal objection that legal rights are simplyhuman rights, however arbitrary that may seem. And as Posner wrote in How Judges Think, judges often go with their gut. Of the many factors guiding their decisions, wrote Posner, what the law actually says is often the least important.

In the meantime, says Lovvorn, there’s a danger that the Nonhuman Rights Project’s efforts will distract from more practical, immediately realistic animal welfare reforms, such as improvements in farm animal treatment or reductions in biomedical experiments on animals. Opponents of such reforms, said Lovvorn, might seize upon chimpanzee personhood as an example of the radical changes that ostensibly modest reformers really want. “I can’t tell you how many times we hear people say, ‘We can’t give pigs or laying hens enough room to turn around and stretch their wings, because the end game here is personhood for animals and an end to their commercial use.’”

Brian Hare also struck a practical tone, noting that reforms already underway to protect chimpanzees, such as eliminating a federal loophole that grants endangered status to wild but not captive chimps, could accomplish some of the Nonhuman Rights Project’s goals while avoiding thorny questions of personhood. “I think it’s great that he’s asking the question and challenging the law,” said Hare, “but I’m not sure that this particular solution is necessary, or in the best interest of the chimpanzees themselves. I think they are fighting for rights when they should be fighting for welfare and conservation.”

William McGrew, however, expressed reservations about the limits of good intentions in the absence of enforceable rights. McGrew said he used to think that, “once humans knew of the apes’ qualities, people would extend their concern to their closest living relations.” Now, “being older and wiser, I see that was unrealistically idealistic. Just like minors and minorities amongst humans, chimpanzees need legal protection” — and that, McGrew said, should include recognized rights of life, liberty and the pursuit of happiness.

Relying on endangered species protections also raises the question of whether chimpanzees would remain protected if someday they’re not endangered. Would they deserve any less consideration then? Rights, argues Wise, are a matter of principle, not something to abandon when they seem inconvenient. Neither are they uncontroversial or unthreatening, at least not when they’re first granted. And even if courts rule against chimpanzee personhood — something that, Wise concedes, is quite possible — at the very least a judge might have the courage and integrity to hold the discussion openly, in light of scientific fact and legal principle.

That discussion could well begin in coming weeks, as judges consider the lawsuits now before them. They might dismiss the cases summarily, without a hearing; or, if one decides to issue the habeas corpus writ, then the chimpanzee’s owner will be ordered to appear in court and justify the animal’s detention. Wise hopes that, even if judges aren’t prepared to accept that a chimpanzee could have a right, they’ll be courageous and open-minded enough to listen to the arguments.

If the Nonhuman Rights Project loses, said Wise, they’ll appeal the decision; if they lose the appeal, they’ll review their arguments and try again, and again after that. Yet there’s at least a possibility, however slim, that a judge will rule in their favor, and make possible the lawsuit’s concluding request: That Tommy, who can’t be released to Africa, can be delivered from solitary confinement in a warehouse cage and taken to a sanctuary, “there to spend the rest of his life living like a chimpanzee, amongst chimpanzee friends, climbing, playing, socializing, feeling the sun, and seeing the sky.”

An aerial view of Save the Chimps, a sanctuary in Florida that could house the Nonhuman Rights Project’s chimpanzee plaintiffs. Image: savethechimps.org


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Data mining social media: Twitter's untapped potential

There's a lot of talk around data mining social media but not much action, according to Matthew Russell, author of Mining the Social Web, Second Edition, a guide to social data collection and analysis. The perceived difficulty of data mining is a main barrier for those interested in getting involved. It's a false barrier, said Russell, because mining Twitter with well-known programming languages -- Python, in particular -- doesn't require advanced developer or data scientist skills.

Twitter logo

Mining data in social media helps businesses gather crucial information. Once they know the basics of putting in API requests, analyzing sales trends or code and so on, they can use the insights to fuel innovation, according to Russell, CTO of cloud services provider, Digital Reasoning Systems Inc. This article presents his advice for developers who, in his words, want to get their hands dirty with data. 

Russell advocates using Python for first social data mining projects because its syntax is simple and its data structure is compatible with textual data. "Most social media properties are going to return data to you in JSON format," Russell explained. JSON (JavaScript Object Notation) is a flexible and intuitive text-based data format often used in Web environments in order to communicate both simple and complex data structures over a network. "Python's core data structures are so close to JSON that there's no real penalty for working with that data. It's very easy to make that request."

The ultimate data mining platform

Every social networking medium presents a value proposition for data mining, but Russell sees no better starting point than Twitter. The simplicity and asymmetric following model of this platform, together with the 232 million active monthly users, make it particularly suited for data mining. Russell likened the app to a busy public street. "You have a lot of chatter and amongst all that chatter there's a signal that can be teased out."

I think the simplicity of [Twitter, aggregated] with millions of active accounts, creates a lot of value.
Matthew Russell,
Digital Reasoning

From a developer perspective, Twitter is particularly suited for data mining because of three key attributes.

  • Twitters's API is well designed and easy to access.
  • Twitter data is in a convenient format for analysis.
  • Twitter's terms of use for the data are relatively liberal. It is generally accepted that tweets are public and accessible to anyone, hence the asymmetric following model that allows access to any account without request for approval.

"I think the simplicity of [Twitter, aggregated] with millions of active accounts, creates a lot of value," Russell said. This potential value is largely untapped, however, and Russell believes executives and developers are missing opportunities to uncover important social trends.

Beyond advertising

Twitter's data is almost exclusively used for reputation management, branding and sentiment analysis. In other words, it's advertising. "When you have 232 million active monthly accounts with a fairly high percentage of those active daily, that's where there are some other unique opportunities, as far as social research goes," Russell said.

He described Twitter as an interest graph, an online portrayal of an individual or group's interests. On a small scale, an interest graph serves to predict purchase behavior. On a larger scale, it can be used to analyze societal trends. "If you think of a following relationship as an 'interested in' relationship, which it really is, you have some pretty powerful data in aggregate," he said. When an interest graph operates on a massive scale, its potential for valuable insights begins to stretch beyond advertising. "There's already a body of data so you want to tap into that, not so much to result in an action like selling something, but really to understand what's going on in a market or in a niche area." An example is a hedge fund whose entire trading model was built on interest analysis of Twitter data, which they then used to make smarter investments.

The value of Twitter's API should not be underestimated, in Russell's opinion. The API acts as an entry point that can allow the Twitter platform to enable third-party innovation. "There are an awful lot of creative human beings out in the world who will probably have more good ideas than [Twitter] could ever come up with internally," he said. Twitter's API is an enormous and, as of yet, underused resource. "Anyone can harness that energy and tap into this third-party commodity in order to innovate, from a tiny little startup of one person with a good idea to a much larger corporate entity with dozens of software developers."

The potential of Twitter's self-organizing, ever-growing pool of data offers direct insight into trends and interests on both a personal and collective scale, but it has yet to fully capture the imagination of developers. And, in terms of the value that could come from data mining social media, Twitter is just the tip of the iceberg. Russell predicts and hopes that businesses will begin to treat ads as a means to an end, and that they will find the true value in innovating with social media data.

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Joaquim Machado

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Drone detects wheat disease progression

Texas A&M AgriLife   |   November 27, 2013
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Charlie Rush, Ph.D., hopes to use a unique method – helicopter drone – to track disease progression across wheat fields to eventually help producers make better irrigation decisions.

Rush, a Texas A&M AgriLife Research plant pathologist in Amarillo, has enlisted the help of Ian Johnson, a Montana State University-Bozeman graduate student who is using his work in the university’s Science and Natural History Filmmaking Program to help scientists conduct research.
Approximately 1.1 million acres of wheat in the High Plains are irrigated, Rush said, making wheat the second-largest user of irrigation water from the Ogallala Aquifer. In this same region, mite-vectored virus diseases are the predominant pathogenic constraint to sustainable wheat production each year.
The viruses causing these diseases are transmitted by the wheat curl mite, he said. Infected wheat plants not only have reduced grain and forage yields, but also greatly reduced root weight and water-use efficiency. Therefore, fertilizer and groundwater applied as irrigation to diseased wheat is largely wasted.
Rush’s team is using the helicopter to take remote images of a field study where they are trying to develop an economic threshold for irrigation of wheat infected with wheat streak and other mite-vectored diseases.
“The problem for farmers is that these diseases develop in gradients over time and they don’t know whether or not they should apply new pesticides or fertilizers or water,” he said. “Most of these practices are done in April, and that is when the disease is just starting to show up. They may know they have disease in the field, but they really don’t know how much damage it might cause.
“So what we are trying to do is be able to go in early in the season and look at the disease development at a particular time and then based on what it looks like, say in early April, be able to give them a prediction of what the crop will be at harvest time.”
To do that, Rush said his team has been going into the field using different types of remote imaging, such as the hand-held hyperspectral radiometer, to measure and quantify the severity of disease development in the field.
 wedge image can be made after the helicopter has made about six passes over the field. The images it captures were stitched together by Ian Johnson, a Montana State University-Bozeman graduate student, for a complete picture.
 
“Now the application and use of this helicopter drone is one more way of measuring the disease development,” he said. “The beautiful thing about this is instead of having to deal with handheld devices, you can come in and fly the entire field in a matter of five minutes and get a very, very high resolution. So we are excited about the possibilities this may provide for our project.”
Johnson said he will use the drone to make four or five flights during the growing season and then generate results that will help Rush. This Y6 helicopter, named for its Y shape and six propellers, is made by 3D Robotics and includes an autopilot.
“That allows us to preprogram flights and fly a grid. As it is flying the grid, it takes top-down photos,” Johnson said. “Once we collect the photos, we stitch them together and build a giant photo mosaic of each field we flew over. We are hoping to provide incremental photo coverage of the fields as the disease progresses through the fields.”
Johnson said using this technology for agricultural research provides a whole list of improvements to the previous services available. Many researchers have used satellite imagery before, but this provides resolution 100 to 1,000 times greater than the LandSat satellite imagery Rush and his team used in the past.
“That’s a huge improvement when you are looking at ground-coverage and trying to pick out diseased plants,” he said. “Another improvement is temporal resolution. We can fly this every day for a couple of weeks or every week for a whole season, whereas with satellite you have to wait two to three weeks for a pass and that is if you can get your slot. So this is a great improvement.”
Another thing, Johnson said, is the drone is currently using visible spectrum only – still photographs – because the project is focused on the yellow band of light, which easily captures the typical symptoms of wheat streak mosaic.
“But this is a modular system,” he said. “We could put near infrared, thermal, any array of multi-spectral sensors on here to capture whatever data it is the project demands.”
Rush said one of the things he is most excited about with this new technology is that although aerial images have been taken before and unmanned aircraft have been used to measure things, “they have never been used to our knowledge to manage irrigation applications, especially in diseased crops.
“This is something that is totally new,” he said. “Obviously, in the Texas Panhandle where water is such a precious resource, anything that we can do to reduce waste or farmers putting on irrigation water when it is not going to pay off for them is going to be a positive thing.”
Rush said he is confident that with the studies currently underway, this new technology will allow them to very quickly provide growers with the information they need to better manage their irrigation.

Joaquim Machado

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Tudo indica que "frontiers of science" vai  novamente aportar tools para a efetividade da visão holística da Agricultura Ecológica


Home > Newsroom > NewLeaf Symbiotics acquires Intuitive Genomics

NewLeaf Symbiotics acquires Intuitive Genomics

NewLeaf Symbiotics  |   December 9, 2013
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NewLeaf Symbiotics Inc. an agricultural biotech company, announced the acquisition of Intuitive Genomics Inc., a leader in the design and implementation of custom bioinformatics solutions.

The acquisition of Intuitive Genomics’ elite computational and bioinformatics capabilities compliments NewLeaf’s R&D and product pipeline and positions the rapidly growing company as a top player in the burgeoning biologicals category.

NewLeaf Symbiotics is researching and commercializing naturally beneficial plant bacteria for crop health and protection. The use of natural biologicals to control plant disease and increase crop yield is one of the most promising opportunities to address the rapidly expanding global agricultural productivity gap.

“This is a major step forward for NewLeaf. A deep genomics and bioinformatics capability will be key to unlocking the full potential of our Prescriptive Biologics platform, R&D breakthroughs and the positive field results we are demonstrating,” said NewLeaf CEO Tom Laurita. “The intellectual property potential created by this acquisition is substantial. And the ability to attract scientists of this caliber to our company is validation of NewLeaf’s strategic direction.”

Both companies are located at the BioResearch and Development Growth (BRDG) Park at theDonald Danforth Plant Science Center in St. Louis, Missouri.  Intuitive Genomics co-founders, James C. Carrington Ph.D., president of the Danforth Center will join the NewLeaf Science Advisory Board; Todd Mockler, Ph.D., associate member and Geraldine and Robert Virgil Distinguished Investigator at the Danforth Center will become vice-president of genomics at NewLeaf; and Doug Bryant, Ph.D., director, Bioinformatics Core at the Danforth Center will become vice-president of bioinformatics at NewLeaf.

“This is exactly the sort of collaboration the Danforth Plant Science Center seeks to foster.  Here you have two locally incubated companies, each of which is a leader in its field, working in close proximity and recognizing the value in joining forces,” Carrington remarked.

"We have been pushing the envelope in bioinformatics for the past several years and have concluded that there is tremendous potential in biologicals. This is clear when you consider the recent acquisitions by ag industry giants in this area, and the recent high impact studies on both human and plant microbiomes,” Mockler said. “We surveyed the environment and NewLeaf Symbiotics is the most exciting opportunity we have seen for Intuitive Genomics,” Bryant added. 

Joaquim Machado

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Local 3D Printers Doing Well Locally

Rachel Park BY RACHEL PARK ON  · 3D PRINTERS,EUROPEINDUSTRY INSIGHTS ADD COMMENT

I could go with the oft-used cliché of not enough hours in a day! Or how about too many articles in a day! Or too many 3D printers at a show! Take your pick on the reason for the tardiness of writing this article, which germinated while I was walking around the 3D printshow in London a few weeks back now ….

There is a clearly identifiable trend strengthening across the 3D printing industry, one I spotted early signs of as 3D printers emerged across regions, most notably South America earlier this year. At the other end of 2013, there is a proliferation of 3D printers coming from member states of Europe and it was plain to see at the 3D Printshow as they were paraded almost side by side.

Both the Sharebot and WASP have sprung up in Italy. Poland is home to Omni 3D, Spain is the country of origin of the Witbox, while I have already covered the BeetheFirst developed in Portugal.

The proliferation of extrusion-based “personal” 3D printers from all corners of the world is not that surprising considering the trajectory of the 3D printing industry. And each region is producing their own and will likely find most success within that region, while also harbouring global dreams.

The WitBox 3D printer, from established Spanish company BQ is already enjoying local success. The strategy is to reach a wider audience though, as evidenced by the company’s presence at both the 3D Printshow in London and at Euromold in Germany and they are also looking for distributors from further afield in the US.

Witbox 3D printerBQ’s seven year history has seen it diversify from multimedia devices into the development and sales of its Witbox 3D printer, which competes well with its peers, both in aesthetics and productivity.

The print chamber is enclosed (but not heated) and, interestingly, can be locked for safety, a consideration of the fact that this is ultimately a 3D printer to be found in homes. A nice touch, I thought, and pre-emptive. With a fairly standard (these days) print volume, accuracy of 50 microns can be achieved. The machine processes PLA material, again, one assumes for the home environment. The RRP of the WitBox is €1,600.

Omni3D (previously RapCraft) from Poland was also present at the 3D Printshow, with a range of 3D printers, based on the same platform, but catering for different applications and sizes. The team was so enthusiastic about what they are doing, great advocates for their nation and technical capabilities and keen to share their vision — dogs and all — with the world.

The company has a comprehensive portfolio of 3D printers, accessories and materials. 3D printer wise they offer the original RapCraft kits, as well as an assembled version (1.3). Further advancements have seen the development of the Factory 1.0 3D printer and the Architect 3D printer. All producing some nice, quite large in some cases, parts.

Architect 3D printer Omni3D

The WASP project was a part of the Italian contingent at the 3D Printshow, and an inspiration it was too. The project is a blend of commercialism, academia and altruistism. The brainchild of Massimo Moretti of CSP srl, though, the altruism is the driving force with the goal of 3D printing clay houses for people in developing nations.  The project has resulted in a range of 3D printers, all based on the Delta platform, of various sizes, but the most striking by far is the large scale version printing with clay. The smaller platforms, typically print with plastic filament.

Wasp 3D Printer

The plan is to go bigger though — for the houses. It turns out the WASP project is so called for a couple of reasons. Massimo’s original idea was formulated as a result of a mud dauber, a little wasp that built its nest using only wet ground, depositing it and consolidating it. From this, WASP became an acronym reflecting the ultimate goal —World’s Advanced Saving Project.  The commercial aspect of the project involves selling machines (with most notable success in Italy to date) to fund the dream of printing clay houses. All the people involved are fully invested and wholly driven to achieve this.

It was hardly surprising then that at the International 3D Printshow awards, the WASP project walked away with the accolade in the Green category — well deserved.

One of my key take aways from this particular show was local production finding success in their own regions. It’s a growing phenomenon and one likely to increase, particularly when USPs are as narrow as they are.


Joaquim Machado

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Scientific American

In a "Rainbow" Universe Time May Have No Beginning

If different wavelengths of light experience spacetime differently, the big bang may never have happened

By Clara Moskowitz  | Monday, December 9, 2013 | 43



Image: cherrychil/stock.xchng

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What if the universe had no beginning, and time stretched back infinitely without a big bang to start things off? That's one possible consequence of an idea called "rainbow gravity," so-named because it posits that gravity's effects on spacetime are felt differently by different wavelengths of light, aka different colors in the rainbow.

Rainbow gravity was first proposed 10 years ago as a possible step toward repairing the rifts between the theories of general relativity (covering the very big) and quantum mechanics (concerning the realm of the very small). The idea is not a complete theory for describing quantum effects on gravity, and is not widely accepted. Nevertheless, physicists have now applied the concept to the question of how the universe began, and found that if rainbow gravity is correct, spacetime may have a drastically different origin story than the widely accepted picture of the big bang.

According to Einstein's general relativity, massive objects warp spacetime so that anything traveling through it, including light, takes a curving path. Standard physics says this path shouldn't depend on the energy of the particles moving through spacetime, but in rainbow gravity, it does. "Particles with different energies will actually see different spacetimes, different gravitational fields," says Adel Awad of the Center for Theoretical Physics at Zewail City of Science and Technology in Egypt, who led the new research, published in October in theJournal of Cosmology and Astroparticle Physics. The color of light is determined by its frequency, and because different frequencies correspond to different energies, light particles (photons) of different colors would travel on slightly different paths though spacetime, according to their energy.

The effects would usually be tiny, so that we wouldn't notice the difference in most observations of stars, galaxies and other cosmic phenomena. But with extreme energies, in the case of particles emitted by stellar explosions called gamma-ray bursts, for instance, the change might be detectable. In such situations photons of different wavelengths released by the same gamma-ray burst would reach Earth at slightly different times, after traveling somewhat altered courses through billions of light-years of time and space. "So far we have no conclusive evidence that this is going on," says Giovanni Amelino-Camelia, a physicist at the Sapienza University of Rome who has researched the possibility of such signals. Modern observatories, however, are just now gaining the sensitivity needed to measure these effects, and should improve in coming years.

The extreme energies needed to bring out strong consequences from rainbow gravity, although rare now, were dominant in the dense early universe, and could mean things got started in a radically different fashion than we tend to think. Awad and his colleagues found two possible beginnings to the universe based on slightly different interpretations of the ramifications of rainbow gravity. In one scenario, if you retrace time backward, the universe gets denser and denser, approaching an infinite density but never quite reaching it. In the other picture the universe reaches an extremely high, but finite, density as you look back in time and then plateaus. In neither case is there a singularity—a point in time when the universe is infinitely dense—or in other words, a big bang. "This was, of course, an interesting result, because in most cosmological models, we have singularities," Awad says. The result suggests perhaps the universe had no beginning at all, and that time can be traced back infinitely far.

Whereas it is too soon to know if these scenarios might describe the truth, they are intriguing. "This paper and a few other papers show there could be a rightful place in cosmology for this idea [of rainbow gravity], which is encouraging to me," says Amelino-Camelia, who was not involved in the study, but has researched frameworks for pursuing a quantum theory of gravity. "In quantum gravity we are finding more and more examples where there is this feature which you may call rainbow gravity. It is something that is increasingly compelling."

Yet the concept has its critics. "It's a model that I do not believe has anything to do with reality," says Sabine Hossenfelder of the Nordic Institute for Theoretical Physics. This idea is not the only way to do away with the big bang singularity, she adds. "The problem isn't to remove the singularity, the problem is to modify general relativity in a consistent way, so that one still reproduces all its achievements and that of the Standard Model [of particle physics] in addition."

Lee Smolin of the Perimeter Institute for Theoretical Physics in Ontario, who first suggested the idea of rainbow gravity along with Joao Magueijo of Imperial College London, says that, in his mind, rainbow gravity has been subsumed in a larger idea called relative locality. According to relative locality, observers in different locations across spacetime will not agree on where events take place—in other words, location is relative. "Relative locality is a deeper way of understanding the same idea" as rainbow gravity, Smolin says. The new paper by Awad and his colleagues "is interesting," he adds, "but before really believing the result, I would want to redo it within the framework of relative locality. There are going to be problems with locality the way it's written that the authors might not be aware of."

In the coming years researchers hope to analyze gamma-ray bursts and other cosmic phenomena for signs of rainbow gravity effects. If they are found, it could mean the universe has a more "colorful" history than we knew.

Joaquim Machado

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Bolsista do Ciência sem Fronteiras é premiada em competição de engenharia de sistemas biológicos

Enquanto para muitas pessoas, o termo "Biologia sintética" é ainda desconhecido, a aluna do 4º ano do curso de Ciências Físicas e Biomoleculares do Instituto de Física de São Carlos (IFSC/USP), Monique Freitas, já recebe prêmios por sua pesquisa realizada nessa promissora área da Biologia.

Tudo começou em 2011, quando Monique se inscreveu no programa Ciência sem Fronteiras e foi selecionada para, no ano seguinte, ser estudante da Boston University (EUA) pelo período de um ano letivo.

Antes mesmo de embarcar para Boston, Monique já havia ouvido falar da International Genetically Engineered Machine (iGEM), competição internacional de engenharia de sistemas biológicos, que reúne equipes de estudantes de graduação e pós-graduação de diversos países do mundo para apresentar suas pesquisas.

Com o intuito de participar da iGEM e se interar melhor sobre os estudos relacionados à biologia sintética, já em Boston, durante as férias de verão estadunidenses, que duram cerca de três meses (entre junho e agosto), a estudante procurou um laboratório na própria universidade que tivesse pesquisas nessa área. "Entrei em contato com um professor e manifestei meu interesse em participar da competição, e foi quando ele me deu oportunidade de estagiar no laboratório de biologia sintética da Boston University. Isso foi, mais ou menos, em abril", relembra Monique.

Um mês depois, ela e mais um colega, o estadunidense Shawn Jin, formaram a equipe que participaria da iGEM, para desenvolver o projeto que, no futuro, seria um dos maiores destaques da competição.

A biologia sintética - Sendo considerada uma área recente de estudos, a biologia sintética tem como principal objetivo criar formas de vida artificiais a partir de elementos naturais. Na engenharia genética clássica, o procedimento padrão para criação de organismos que desempenhem novas funções ocorre da seguinte maneira: escolhe-se uma sequência de DNA já existente, por exemplo, a de uma bactéria. Uma parte do DNA da bactéria é retirada e substituída por uma parte de DNA de outro organismo. Nesse caso, a bactéria servirá de intermediária para produzir alguma substância.

A biologia sintética se utiliza dos mesmos procedimentos, mas vai um pouco além. Nesse caso, não serão "misturas" de DNAs de apenas dois organismos, mas partes de DNA de diversos organismos, unidas para originar um completamente novo e capaz de muitas tarefas, como, por exemplo, o desenvolvimento de novos métodos de detecção de antibióticos no leite, métodos alternativos, sustentáveis e mais baratos para o tingimento de jeans e ferramentas biológicas modernas para cura da tuberculose *.

A criação dos estudantes - Durante três meses, Monique e Shawn realizaram uma maratona de estudos para montar a pesquisa que apresentariam no iGEM. "Foi um período de estudos muito intenso e também de muito aprendizado. Durante minha iniciação científica no IFSC, eu havia trabalhado com nanotecnologia, sob a orientação do professor Valtencir Zucolotto, e nos EUA comecei a trabalhar com pesquisas relacionadas à biologia molecular, diferente daquilo que eu já estava mais familiarizada, portanto", conta a estudante.

A pesquisa dos estudantes teve como foco o desenvolvimento de ferramentas que possibilitem um rápido mapeamento dos três pilares básicos da pesquisa da biologia sintética: a criação de novas e diferentes sequências de DNA para construção de circuitos genéticos, a caracterização dos novos circuitos e, finalmente, a disponibilização das informações para outros pesquisadores da área. "Nosso trabalho mais intenso foi na primeira parte, que possibilitaria a otimização dos trabalhos realizados nessa área", explica.

Em mais detalhes, o que Monique e Shawn fizeram foi introduzir uma técnica, descrita em um paper alemão , conhecida como Clonagem modular. A técnica tem diversas vantagens quando comparada às usualmente utilizadas, como diminuir expressivamente o tempo para junção das partes de DNA de organismos diferentes.

O reconhecimento - Passados quatro meses após o início de seu estágio no laboratório de biologia sintética, chegou a hora da primeira fase da competição. Nessa fase, as apresentações orais e de pôsteres são feitas por região, e a equipe de Monique apresentou seu projeto na competição regional do Leste dos EUA. "Todos apresentam seus projetos e, posteriormente, são entregues medalhas de acordo com o desempenho de cada equipe, permitindo o avanço para segunda fase da competição, na qual equipes do mundo inteiro participam", conta Monique.

Foi na primeira fase, portanto, que o projeto de Monique obteve destaque, e a equipe da pesquisadora brasileira foi uma das que conquistou medalha de ouro na competição, deixando para trás equipes formadas por estudantes de instituições como Yale University e Johns Hopkins University. "Nosso intuito em participar da iGEM era muito mais para aprender do que para contribuir com algo, pois os jurados só selecionam trabalhos que consideram de importante visibilidade para toda comunidade. Foi uma grande surpresa, pois nosso time tinha muitas limitações, a começar pelo número de participantes. O time do MIT**, por exemplo, era formado por 20 estudantes", relembra Monique.

O ineditismo do trabalho de Monique aliado ao fato de a estudante ter criado uma metodologia universal para o mapeamento de trabalhos de biologia sintética foram os principais fatores que levaram à sua vitória na primeira fase do iGEM. "Uma das principais características da competição é a apresentação de projetos com forte aplicação. No entanto, dentro das limitações que tínhamos, e com uma equipe formada por apenas duas pessoas, decidimos não ousar demais em nosso projeto. Por isso ficamos tão surpresos com a repercussão que ele teve", conta. "Todos os trabalhos são muito bem desenvolvidos e a parte científica não é deixada de lado. Por exemplo, tivemos que deixar documentado na internet o 'passo a passo' de todo nosso trabalho e, inclusive, o nossocaderno de laboratório disponibilizado, para que a veracidade dos experimentos pudesse ser constatada ".

Depois de avançar para fase final do iGEM, realizada no MIT, Monique teve a oportunidade de conhecer pesquisas apresentadas por estudantes do mundo inteiro. Embora nessa etapa não tenha sido contemplada com prêmios, como na primeira fase, ela teve a oportunidade de conhecer trabalhos considerados por ela incríveis. "É surpreendente ver tanta gente na graduação ou na pós-graduação desenvolvendo coisas tão impactantes, tudo iniciativas dos próprios alunos, contando com o apoio de outros grupos de pesquisa. Todos se doam e se engajam muito", conta Monique.

O papel do IFSC - Monique afirma que a participação no iGEM foi importante por vários motivos e, entre eles, para que ela fosse capaz de entender a relevância de toda aprendizagem adquirida no IFSC e, além disso, ter a chance de receber um feedback de especialistas sobre o trabalho que ela desenvolveu. "Você volta com um novo olhar e com novas ideias para sua pesquisa. A troca de ideias com outras pessoas também é muito importante! Ter contato com novos projetos, ver como surgiram ideias, conhecer pessoas do mundo todo que fazem ciência, tudo isso é maravilhoso".

Monique também diz que, tanto na competição quanto no período de um ano letivo em que estudou na Boston University, todos os conhecimentos adquiridos previamente no IFSC foram essenciais para que ela tirasse o máximo proveito do intercâmbio. "Muitas vezes, ficamos muito presos às demandas do curso, e nos esquecemos de ver as partes boas, como as habilidades que desenvolvemos e o conhecimento tão abrangente que conseguimos adquirir aqui", conta. "Chegar lá e ver que você tem base para lidar com os novos desafios é algo muito bom, voltei ainda mais apaixonada pelo curso".

O futuro - Prestes a concluir sua graduação, Monique, desde agosto, é estagiária da empresaBraskem (Campinas-SP) na área de biologia sintética. Para ela, essa também está sendo uma grande chance de ter o contato com a parte aplicada do curso de Ciências Físicas e Biomoleculares.

No que se refere aos estudos no exterior, ela conta que já se inscreveu para pós-graduação em algumas universidades estadunidenses, mas afirma que, caso seja aceita em alguma delas, pretende voltar ao Brasil depois de finalizá-la, para trazer ao país os conhecimentos adquiridos. "No Brasil, a área de biologia sintética é ainda muito recente. Então, quero aprender bastante lá para poder trazer tudo para cá, no futuro. Se minha rápida experiência de alguns meses já foi capaz de me ensinar tanto, imagine em quatro anos, que é o período que dura a pós-graduação?".

Monique faz questão de prestar diversos agradecimentos aos docentes e funcionários do IFSC que a ajudaram durante todo processo de inscrição para o Ciência sem Fronteiras, desde a parte burocrática da documentação até as cartas de recomendação.

Para que outros alunos do Instituto se interem sobre o assunto (tanto sobre o intercâmbio quanto sobre a própria área de biologia sintética), Monique e estudantes de outras Unidades da USP realizarão um encontro no próximo dia 14 de dezembro para compartilhar experiências e conhecimentos sobre esses tópicos principais.

Ela conta que já existe um grupo de alunos no IFSC e da USP, em geral, articulando-se para participar da iGEM de 2014. Para os interessados em saber mais sobre o encontro e sobre a experiência de Monique, ela deixa seu contato: monique...@usp.br

Para assistir à apresentação de Monique para PUB-Boston

.

 
 
 
 
 

Texto: Assessoria de Comunicação do Instituto de Física de São Carlos/USP

Joaquim Machado

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Scientific American

The Universe Really Is a Hologram, According to New Simulations

A 10-dimensional theory of gravity makes the same predictions as standard quantum physics in fewer dimensions

By Ron Cowen and Nature magazine  | Wednesday, December 11, 2013 | 15



Image: Astronomy Picture of the Day

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A team of physicists has provided some of the clearest evidence yet that our universe could be just one big projection.

In 1997, theoretical physicist Juan Maldacena proposed that an audacious model of the Universe in which gravity arises from infinitesimally thin, vibrating strings could be reinterpreted in terms of well-established physics. The mathematically intricate world of strings, which exist in nine dimensions of space plus one of time, would be merely a hologram: the real action would play out in a simpler, flatter cosmos where there is no gravity.

Maldacena's idea thrilled physicists because it offered a way to put the popular but still unproven theory of strings on solid footing—and because it solved apparent inconsistencies between quantum physics and Einstein's theory of gravity. It provided physicists with a mathematical Rosetta stone, a “duality,” that allowed them to translate back and forth between the two languages, and solve problems in one model that seemed intractable in the other and vice versa. But although the validity of Maldacena's ideas has pretty much been taken for granted ever since, a rigorous proof has been elusive.

In two papers posted on the arXiv repository, Yoshifumi Hyakutake of Ibaraki University in Japan and his colleagues now provide, if not an actual proof, at least compelling evidence that Maldacena’s conjecture is true.

In one paper, Hyakutake computes the internal energy of a black hole, the position of its event horizon (the boundary between the black hole and the rest of the Universe), its entropy and other properties based on the predictions of string theory as well as the effects of so-called virtual particles that continuously pop into and out of existence. In the other3, he and his collaborators calculate the internal energy of the corresponding lower-dimensional cosmos with no gravity. The two computer calculations match.

“It seems to be a correct computation,” says Maldacena, who is now at the Institute for Advanced Study in Princeton, New Jersey and who did not contribute to the team's work.

Regime change

The findings “are an interesting way to test many ideas in quantum gravity and string theory,” Maldacena adds. The two papers, he notes, are the culmination of a series of articles contributed by the Japanese team over the past few years. “The whole sequence of papers is very nice because it tests the dual [nature of the universes] in regimes where there are no analytic tests.”

“They have numerically confirmed, perhaps for the first time, something we were fairly sure had to be true, but was still a conjecture — namely that the thermodynamics of certain black holes can be reproduced from a lower-dimensional universe,” says Leonard Susskind, a theoretical physicist at Stanford University in California who was among the first theoreticians to explore the idea of holographic universes.

Neither of the model universes explored by the Japanese team resembles our own, Maldacena notes. The cosmos with a black hole has ten dimensions, with eight of them forming an eight-dimensional sphere. The lower-dimensional, gravity-free one has but a single dimension, and its menagerie of quantum particles resembles a group of idealized springs, or harmonic oscillators, attached to one another.

Nevertheless, says Maldacena, the numerical proof that these two seemingly disparate worlds are actually identical gives hope that the gravitational properties of our universe can one day be explained by a simpler cosmos purely in terms of quantum theory.

This article is reproduced with permission from the magazine Nature. The article was first published on December 10, 2013.

Joaquim Machado

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Joaquim Machado

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Gut check: more than food required

December 13, 2013 - by Corey Allen

eric brown 770 nbt

“Probiotics are the best intervention we have to foster a healthier gut,” says UBC’s Eric Brown. Photo: Martin Dee

A simple new probiotic intervention may help babies fight off the harmful effects of malnutrition and preserve millions of lives

The future in the fight against global malnutrition may lie in the engineering of a healthy gut.

That’s how Eric Brown, a PhD candidate in microbiology and immunology at the University of British Columbia, sees it.

“Malnutrition can’t be solved with a change in diet alone, or by simply feeding a starving child nutritious food,” says Brown. “Infusing their guts with better strains of bacteria, coupled with a good diet, is what is needed.”

The long and short of the probiotics pitch: In the near future, with the advancements made in genetic technology, newborns in developing countries could soon ingest specific strains of bacteria capable of reversing underlying defects caused by malnutrition. The probiotics, specifically cultured in a lab for the individual child, would help foster a healthy gut, staving off malnutrition and preventing cognitive and gut defects.

It would be time-sensitive, though, with the microbe cocktail needing to be administered to children during the first few years of life when damage done to the gut is irreversible.

New approaches to addressing malnutrition cannot come fast enough as the condition affects millions of people worldwide. Recent figures by the United Nations Food and Agricultural Organization estimate one in eight people of the world’s 7.1 billion population are undernourished. People in areas most affected by malnutrition – sub-Saharan Africa, parts of Southeast Asia and India – die younger, experience stunted growth and become more prone to disease due to a weakened immune system.

The power of microbes

Previous research on gut microbes showed they are implicated in a host of conditions including asthma, diabetes and mental illness among others. Researchers at the University of Washington found that when the gut microbes from severely malnourished children in Malawi were transplanted into mice, the growth stunting carried over to mice even after they were fed a well-nourished diet. A remarkable study involving microbes took place at the University of Guelph, which saw a woman cured of Clostridium difficile, a bacterial infection that causes diarrhea, by inserting probiotic strains from someone else’s feces into her bowel.

“Microbes that live in our guts outnumber human cells by ten times,” says Brown. “They play a profound role in human health that we still do not fully understand.”

Despite the upsurge in research, probiotics aren’t new. In fact, humans have taken these gut microbes for thousands of years in fermented foods and yogurts without knowing it, says Brown. And because access to proper food and sanitation for the entire world is farther off than advances in microbiology, “probiotics are the best intervention we have to foster a healthier gut.”

Eric Brown

Eric Brown

Probiotics boost a body’s immune system, which allows for your gut to absorb the nutrients in the food we eat. But for a malnourished child, nutrients are hard to absorb. That’s because of environmental enteric dysfunction–or gut dysfunction– a process that takes effect following childbirth in regions with poor sanitation, if a baby does not receive enough probiotics to help stop it. It’s why mothers are encouraged to breastfeed, given the milk they have containsLactobacillus species– just one of countless bacteria vital to good health.

Much more to learn

So why is all the attention on gut microbes only happening now? The technology simply didn’t exist 10 years ago, says Brown. Researchers can now study the genetic sequences of all the microbes that live in the human gut utilizing a technique called metagenomics. DNA from the microbes is sent to a sequencer that can then identify all the genes and bacteria present.

With the development of new technology and an increase in funding from private organizations like the Bill and Melinda Gates Foundation, the use of probiotics in stopping malnutrition may not be that far off. Currently, Gregor Reid from the University of Western Ontario is teaching African mothers how to make their own probiotics. At UBC’s Michael Smith Laboratories, Brown is working under professor Brett Finlay to develop a model to learn more about the influence intestinal microbes have on malnourishment.

As for how Brown’s vision may come to pass, there’s still a lot to figure out, including its implementation and distribution, not to mention the cost. For instance, the delivery method of the engineered microbes remains unknown, but could come in something as simple as a pill.

“There’s a lot we still don’t know, but we do know probiotics have a beneficial effect on our gut health,” says Brown. “Twenty to 30 years from now, it may become normal for children to take certain probiotics when they’re young.”

Related: Alleviating suffering for millions

UBC Prof. Kishor Wasan’s lab, in conjunction with the Bill and Melinda Gates Foundation, the Canadian Institutes of Health Research (CIHR) and iCoTherapeutics have created a new oral formulation that is in clinical trials to treat leishmaniasis, a disease that afflicts 350 million people worldwide.

Joaquim Machado

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Scientific American

The Gut’s Microbiome Changes Rapidly with Diet

A new study finds that populations of bacteria in the gut are highly sensitive to the food we digest

By Rachel Feltman  | Saturday, December 14, 2013 | 3



Enterococcus faecalis is a commensal bacteria that lives in the human gut.Image: National Institute of Diabetes and Digestive and Kidney Diseases

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You are what you eat, and so are the bacteria that live in your gut.

Microbiologists have known for some time that different diets create different gut flora, but previous research has focused on mice instead of humans, leaving the actual relationship between our food and our stomach bacteria unclear. A new study, published Wednesday in Nature, indicates that these changes can happen incredibly fast in the human gut—within three or four days of a big shift in what you eat. “We found that the bacteria that lives in peoples’ guts is surprisingly responsive to change in diet,” Lawrence David, assistant professor at the Duke Institute for Genome Sciences and Policy and one of the study’s authors, says. “Within days we saw not just a variation in the abundance of different kinds of bacteria, but in the kinds of genes they were expressing.” (Scientific American is part of Nature Publishing Group.)

Eugene Chang, a professor of medicine at the University of Chicago who specializes in gastroenterology agrees that the speed is surprising. “One of the major points of this study was that in contrast to what we thought might take days, weeks or years began to happen within hours,” says Chang, who was not part of the study. They also observed changes in the amount of bile acid secreted into the stomach, and found that bacteria native to our food—microorganisms used to produce cheeses and cure meats—are surprisingly resilient, and colonize the gut along with species already in our microbiome.

But why do we care about which critters are helping us digest our food? “The incredible quickness of this shifting is interesting,” David says, “for at least two reasons:” The first is evolutionary. These rapid changes, he says, could have been very useful for ancient humans. For hunters and gatherers, diet could be altered quickly and with little transition—weeks of nuts and seeds might be broken up by a sudden influx of meat from a successful hunt—and the ability to rapidly change the microbiome would ensure maximum nutrient absorption from even the most unfamiliar foods.

For modern humans, the rapid shift could be less adaptive. The 10 participants in the study switched to either a plant- or animal-based diet, with the former avoiding animal products and the latter eating milk, cheese and meat. In the subjects eating animal products the researchers saw a significant uptick in Bilophila wadsworthia, a bacteria known to contribute to colitis, a variety of inflammatory bowel disease, in mice. But the link hasn’t been studied in humans, so David does not think that cheese-lovers are necessarily eating themselves sick. “We’re anticipating that people will try to draw conclusions about which diet is better from this,” David says, “and we want to address that it’s very difficult to come to any health-related judgment based on this study.” Without measurements of host health during the study, like inflammation in the gut or immune system responses, David says, such a connection is impossible to make.

Chang, who has worked on the connection between B. wadsworthia and colitis in mice, agrees that the new study does nothing to prove the same for humans. But he thinks there may be something there. “This study shows how sensitive the body is to dietary change,” he says. “For the lay public, it underscores the importance of diet in health and disease. People should pay more attention to what they eat. But it rests on scientists to recognize that dietary discipline has these varied effects, and to understand what each component does so we can design healthier diets.” Dramatic changes in our diet, he says, could very well be the cause of “Western disorders” such as inflammatory bowel disease and obesity. Still, David says, his study was not meant to change the way we eat.

Follow-up research could monitor host health to support a connection between certain bacteria and disease. Whereas the initial study was small, David says the research team is unlikely to repeat it with a larger group. The results were consistent from one individual to another, so although more participants would add statistical support, he doubts they would see a change in the bacterial activity. “I should also point out,” David says, “that it’s fairly difficult to get even 10 people that will radically change their diet and then track themselves so regularly.” Instead, he anticipates that future studies will explore how things like food preparation change which flora flourish in the gut.


Joaquim Machado

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THE WORLD IS YOUR BROWSER

How the “internet of things” will replace the web

By Christopher Mims @mims December 15, 2013
Coming soon: The age of smart-everything. Quirky
 
The second in a series.
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We’ve already written about why 2014 is really, finally the year that the “internet of things”—that effort to remotely control every object on earth—becomes visible in our everyday lives.
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But most of us don’t recognize just how far the internet of things will go, from souped-up gadgets that track our every move to a world that predicts our actions and emotions. In this way, the internet of things will become more central to society than the internet as we know it today. The web will survive, just as email survived the arrival of the web. But its role will be reduced to that of a language for displaying content on screens, which are likely to be more ubiquitous but less necessary. Here’s a closer look at the internet of things that’s already here, and where it’s headed.
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The internet of things will create a world of “invisible buttons”

Rooms that know when you’re present and how you’re feeling can illuminate themselves appropriatelyPhilips
The pioneer species of the internet of things is the smartphone. For example, every time we take a smartphone with us in a car, it beams information on our location and speed to Google. The result is real-time traffic information that can be used by everyone.
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That smartphones gather traffic data without their users ever being aware that they’re doing so shows how the internet of things replaces the internet-related actions we already know—click a button, navigate a webpage—with context. This awareness, especially as it relates to where we are in the physical world, what time of day it is, and whatever other data Google and other companies have about us, leads to what Amber Case, a researcher for mapping company Esri, calls “invisible buttons.” An invisible button is simply an area in space that is “clicked” when a person or object—in this case, a smartphone—moves into that physical space. It could be as small as a two-inch square on top of a conventional credit card reader, to enable payments, or as large as a room, which might want to know that you have entered or left so that it can turn on or off the lights. With Phillips’ Hue and countless other smart lights, this is already possible.
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If invisible buttons were just rigidly defined on-off switches, they wouldn’t be terribly useful. But because the actions they trigger can be modified by an infinitude of other variables, such as the time of day, our previous actions, the actions of others or what Google knows about our calendar, they quickly become a means to program our physical world.
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That we currently need a cell phone to act as a proximity sensor is just an artifact of where the technology is at present. The same can be accomplished with any number of other internet-connected sensors. GE and Quirky’s motion, sound, light, temperature and humidity sensor, called Spotter, is a good example. It’s even possible to determine proximity indirectly—for example, internet-connected smart energy systems can figure out you’re home the moment you switch on a light.
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Apple’s play for the internet of things

Apple stores can already pinpoint your location with unprecedented accuracy.AP Photo/Mark Lennihan
Apple seems keen on the idea of invisible buttons. While the company has been relatively quiet about the technology, it recently rolled out something called iBeacon, which allows any newer iPhone or Android phone to know its position in space with centimeter precision. You can think of iBeacon as a version of GPS that works indoors, and which is also more precise. This allows the developers using Apple’s technology to define “invisible buttons” of just about any dimensions.
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What do Apple and its consumers get from this innovation? Apple gets more access to its customers; its customer get more access to its stuff. Apple just rolled out iBeacon technology in its own retail stores
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Right now companies like Estimote are pitching to retailers the hardware “beacons” that broadcast the signal required to make iBeacon work. That Apple has made iBeacon open enough to work with third-party hardware providers like Estimote shows that Apple wants the standard to spread. Notably, the signals broadcast by any iBeacon-compatible radio (which broadcast signals known as Bluetooth Low Energy) can also be picked up by Android and Windows phones, which shows that Apple is trying to dominate a technology that could become ubiquitous across phones. This means invisible spatial buttons that could be so small that touching your smartphone, smartwatch or other equipped device to a surface will allow you to press that “button.” There’s nothing stopping this technology from be squeezed into something as small as a credit card, or being embedded in clothing or other discrete wearable devices like fitness sensors, wristwatches or even temporary tattoos.
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Anticipatory computing and the end of interfaces

The more we reveal to Google, the better our user experience will be.AP Photo/Paul Sakuma
Objects on our bodies (health monitors, smart glasses) and in our homes and businesses (smart thermostats, lights, appliances and security systems) can all be programmed to interact in complicated and unexpected ways once the internet knows that we’re present and what our intentions might be. For example, a smart home might know when you wake up based on the activity monitor on your wrist, and begin warming up the house, brewing a pot of coffee and switching off your security system. That’s the vision of companies like Smartthings, which is in the forefront of making the internet of things accessible to people other than techies and hobbyists.
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These pro-active actions are all part of what some call “anticipatory computing.” Invisible buttons and other contextual information about you will allow the internet to do more than facilitate your needs. It would actually anticipate them. Google Now is a good example of the potential of this technology. As long as you opt in, Google has access to every meaningful store of explicit data about yourself you create—email, contacts, calendars, social media—and plenty of implicit ones as well, like your web-browsing history. Adding location and other physical inputs to that data allows Google Now to do everything from sending youhyperlocal news items targeted to the precise neighborhood in which you live tooffering information about the television show you’re watching at that exact moment.
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So what’s required for more companies to tap into anticipatory computing? There are companies that specialize in “reality mining,” which refers to using data to track the remarkable predictability of our daily lives. This is a potential bonanza for marketers who want to target ads to particular times and places. Marketers are already starting to use this technology to target both online and real-world advertising (like billboards).
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Wearable computers will keep us connected at all times

The UP wristband is one of the first wearables that can trigger actions in other smart, connected objects.Jawbone
The next layer of the internet of things will require combining disparate streams of data “mined” from reality—everything from your location to the members of your social network. This is called sensor fusion, a task that is basic to all big data projects. Knowing where you are throughout the day won’t mean much, but add in data about who else is present and a computer algorithm can tell you how likely you are to get the flu. Finding the connections—in other words, meaning—in all this data is key to making it useful. “We have frictionless data gathering but we don’t have frictionless correlation,” Esri’s Case said at last year’s Le Web conference. “If you have to be a data scientist to do it, then it’s totally wrong.”
1

Mike Bell, head of the new devices group at Intel, says that the future of smart devices, “whether it’s a wearable [computer] or a next-generation tablet replacement, will have a real user interface, but it’s not necessarily visual.” Bell, whose primary interest is wearable computing, can’t talk about what Intel is currently working on, but I’d guess from our conversations that it’s more likely to look like a wristband fitness monitor than another cell phone.
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In other words, the internet of things will replace the internet, but not by giving us another way to explicitly tell computers what we want. Instead, by sensing our actions, the internet-connected devices around us will react automatically, and their representations in the cloud will be updated accordingly. In some ways, interacting with computers in the future could be more about telling them what not to do—at least until they’re smart enough to realize that we are modifying our daily routine.
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Sensing and responding to your needs, wants and emotions

There’s no need to post a status update about how you’re feeling when your smart gadgets already know.Good Night Lamp
If this all sounds like mind reading, that’s because in a way it is. Munjal Shah, entrepreneur in residence at Charles River Ventures, surveyed a thousand peopleabout what super powers they would acquire if they could. The most popular answer was “speak all languages,” but the number two answer might surprise you: the ability to comfort anyone. Shah had conducted the survey in order to determine what sort of businesses could be built to give people these abilities (the first one, universal translation, is at least plausible). Comforting a friend is, he concluded, exactly the sort of thing the internet of things would be good at. First, our connected devices will be able to monitor our state—inactivity could indicate sickness or depression. And maybe we’ve recently posted on social media about a tragedy that befell us. Text alerts are sent out to friends, asking them to reach out, and voila—in as much as mediated communication is any sort of comfort, no one need ever feel lonely again.
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Once our possessions can both sense and respond, and are directed for the most part by computers, the world becomes something like a living creature. “We believe the digital world and the physical world are merging, and that done correctly what this will do is create a virtual representation of all of our physical devices online,”said Jeff Hagins, chief technology officer of Smartthings. “What that will accomplish is that it will make the physical world programmable. When we change the digital representation, the physical world will change in response.” If your goal is to fuse your mind and body with the internet, this is good news. But if you were hoping that in the future, getting away from it all would be as simple as switching off your mobile phone, you’re in for a rude surprise.
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Read part one in this series: 2014 is the year of the internet of things—no, seriously, we mean it this time


Joaquim Machado

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Cover Image: January 2014 Scientific American MagazineSee Inside

Scientists Successfully Model a Living Cell with Software[Preview]

In creating the first complete computer model of an entire single-celled organism, biologists are forging a powerful new kind of tool for illuminating how life works


open blue computer cell illustration

Image: André Kutscherauer

In Brief

  • Computer models that can account for the function of every gene and molecule in a cell could revolutionize how we study, understand and design biological systems.
  • A comprehensive simulation of a common infectious bacterium was completed last year and, while still imperfect, is already generating new discoveries.
  • Scientists are now building models of more complex organisms. Their long-term goal is to simulate human cells and organs in comparable detail.

The crucial insight came to me as i leisurely rode my bike home from work. It was Valentine's Day, 2008. While I cruised along, my mind mulled over a problem that had been preoccupying me and others in my field for more than a decade. Was there some way to simulate life—including all the marvelous, mysterious and maddeningly complex biochemistry that makes it work—in software?


A working computer model of living cells, even if it were somewhat sketchy and not quite accurate, would be a fantastically useful tool. Research biologists could try out ideas for experiments before committing time and money to actually do them in the laboratory. Drug developers, for example, could accelerate their search for new antibiotics by homing in on molecules whose inhibition would most disrupt a bacterium. Bioengineers like myself could transplant and rewire the genes of virtual microorganisms to design modified strains having special traits—the ability to fluoresce when infected by a certain virus, say, or perhaps the power to extract hydrogen gas from petroleum—without the risks involved in altering real microbes. Eventually, if we can learn to make models sophisticated enough to simulate human cells, these tools could transform medical research by giving investigators a way to conduct studies that are currently impractical because many kinds of human cells cannot be cultured.



This article was originally published with the title Sim(u)2lating A + living Cell.


Joaquim Machado

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Welcome to WholeCellViz!

WholeCellViz is a web-based software program for visually analyzing whole-cell simulations.

WholeCellViz enables users to interactively analyze many aspects of cell physiology including:

  • Cell mass, volume, and shape,
  • Metabolite, RNA, and protein copy numbers,
  • Metabolic reaction fluxes,
  • Molecular machine statuses – DNA polymerase, RNA polymerase, ribosome, FtsZ ring, and the
  • Chromosome copy number, superhelicity, integrity, and DNA binding status.

Currently, WholeCellViz provides access to cached simulations of the Gram-positive bacterium Mycoplasma genitalium2. See theAdvanced usage section below for information about how to install WholeCellViz locally to use the software to run and analyze your own simulations and/or other high-throughput biological data, as well as how to add additional visualizations.

Features

WholeCellViz has several features for visually analyzing whole-cell simulations:

  • 14 structured visualizations encompassing a wide spectrum of cell physiology. These visualizations each provide tooltips and mouse clicks to enable users to obtain further information.
  • A time series plot tool to further explore model predictions.
  • layout editor which enables users to configure a grid of structured visualizations and time series plots, enabling users to simultaneously compare multiple model predictions side-by-side.
  • A layout history. Simply use your browser's backward/forward buttons to undo/redo layout changes.
  • A single animation timeline with play, pause, seek, speed, and repeat controls.
  • Data import in JSON format
  • Graphical export in SVG format
  • Data export in JSON format

WholeCellViz is freely available open-source and can be easily expanded for use with new whole-cell simulations and other high-throughput data. See the Advanced usage section below for information about how to install WholeCellViz locally to use the software to run and analyze your own simulations and/or other high-throughput biological data, as well as how to add additional visualizations.

Current limitations

The version of WholeCellViz at wholecellviz.stanford.edu is currently limited to cached simulations of the Gram-positive bacterium M. genitalium. Please install WholeCellViz locally on your own machine to use WholeCellViz to analyze other whole-cell simulation data and/or to add additional structured visualizations to WholeCellViz. See the Advanced usage section below for more information.

Getting started

No installation is necessary to use WholeCellViz. The only required software is a modern web browser. To use WholeCellViz simply:

  1. Click the "Start" menu button at the top-left to load the software
  2. Click the example visualization buttons at the top-right to load preconfigured visualization layouts
  3. Click the  icon at the bottom-right to open the layout editor and configure the visualization layout, and
  4. Use the play, pause, seek, speed, and repeat controls at the bottom to control the animation timeline.

See the tutorial ("Help" » "Tutorial" from the top-left menu) inside the software for additional help getting started.

Recommended browsers

We recommend using Chrome. WholeCellViz was developed and extensively tested using Chrome on Windows 7. See theimplementation section below for further information on browser compatibility.

Structured visualizations

WholeCellViz provides users 14 structured visualizations (below) to visually analyze whole-cell model simulations.

DNA replication, protein occupancy, methylation, & damage
This visualization displays the polymerization (blue), protein DNA binding (green), methylation (orange), and strand break (red) status of the M. genitalium chromosomes. Mother DNA is colored dark blue. Daughter DNA is colored light blue.
DNA replication, protein occupancy, methylation, & damage
This visualization displays the polymerization (blue), protein DNA binding (green), methylation (orange), and strand break (red) status of the M. genitalium chromosomes. Mother DNA is colored dark blue. Daughter DNA is colored light blue.
Mature RNA expression

This visualization displays the mature copy number of each RNA transcript over the cell cycle. Each colored rectangle represents an individual transcription unit. Mouse over each transcription unit to see its name and a brief description. Click each transcription unit to obtain a detailed description at WholeCellKB.

The copy number of each transcript has been normalized to its maximal expression over the cell cycle. High expression is colored yellow. Low expression is colored blue.

Metabolism
This visualization depicts the fluxes of several metabolic reactions (green indicates high flux, red indicates low flux) and the concentrations of several metabolites (node size).
Cell shape
This animation displays the predicted shape of M. genitalium over its life cycle.
Cell shape
This animation displays the predicted shape of M. genitalium over its life cycle.
FtsZ contractile ring
FtsZ proteins are believed to catalyze cell division by cyclically forming and contracting rings at the cell septum during cell division. This visualization displays the state of the FtsZ contractile rings during cytokinesis. Each thin line represents one FtsZ filament. Each thick line represents two parallel FtsZ filaments. Blue lines represent unbent filaments. Gray lines represent bent filaments.
DNA replication
This visualization is a space-time plot of the replication initiation (green) and replication machinery (blue).
Nascent protein monomer expression

This visualization displays the nascent copy number of each protein monomer over the cell cycle. Each colored rectangle represents an individual protein monomer. Mouse over each protein monomer to see its name and a brief description. Click each protein monomer to obtain a detailed description at WholeCellKB.

The copy number of each protein has been normalized to its maximal expression over the cell cycle. High expression is colored yellow. Low expression is colored blue.

Nascent RNA expression

This visualization displays the nascent copy number of each RNA transcript over the cell cycle. Each colored rectangle represents an individual transcription unit. Mouse over each transcription unit to see its name and a brief description. Click each transcription unit to obtain a detailed description at WholeCellKB.

The copy number of each transcript has been normalized to its maximal expression over the cell cycle. High expression is colored yellow. Low expression is colored blue.

Mature protein monomer expression

This visualization displays the mature copy number of each protein monomer over the cell cycle. Each colored rectangle represents an individual protein monomer. Mouse over each protein monomer to see its name and a brief description. Click each protein monomer to obtain a detailed description at WholeCellKB.

The copy number of each protein has been normalized to its maximal expression over the cell cycle. High expression is colored yellow. Low expression is colored blue.

Translation
This visualization depicts the length of the longest polypeptide of each protein-coding gene. Protein-coding genes with one active ribosome are colored blue. Genes with multiple active ribosomes are colored green.
Gene expression
This visualization displays the expression of every RNA and protein gene product. High expression is colored yellow; low expression is colored blue.
Replication initiation – oriC DnaA Boxes
29 DnaA molecules are believed to segregate the chromosome strands and thereby initiate DNA replication by cooperatively binding to five (R1-5) high affinity sites near the oriC. This visualization represents the DnaA occupancy of the R1-5 sites.

Basic usage

Installing and running

The only requirement for running WholeCellViz is a modern web browser (see recommended browsers). Otherwise, no installation is required. To start WholeCellViz click the "Start" button at the top-left of this page. Clicking the start button will open WholeCellViz already configured with grid of six structured visualizations.

Example views

The easiest way to start using WholeCellViz is to view the seven example visualization views (grids of related structured visualizations). Click the buttons at the top-right of the page to open each example view.

Configuring panels

To configure the displayed visualizations:

  1. Open the configuration editor by selecting "Edit" » "Panels" from the top-left menu.
  2. Select the desired grid size (number of rows and columns of panels, each of which can contain one structured visualization or one set of time series plots).
  3. Use the "Configure panel" select box to choose the panel you wish to configure.
  4. Use the "Simulation" select box to choose a simulation to plot.
  5. Use the "Series" text box to search the model predictions (e.g. type "ATP").
    1. Search results will displayed in the select box immediately below.
    2. Second, optionally use the "Series type" select box to search just a subset of the model predictions (e.g. only metabolites).
    3. Next, highlight the model prediction(s) you wish to plot in the results select box.
    4. Click the  icon to visualize the highlighted model prediction(s) in the selected panel.
    5. Finally, highlight rows in the table at the right-hand-side and click the  icon to remove model predictions from the panel.

Undo/redo configuration changes

WholeCellViz uses your browser's location history to track its configuration history. To undo a configuration change simply press your browser's back button. To redo a configuration change simply press your browser's forward button.

Expanding panels to fullscreen

Click the  icons at the top-right of the visualization panels to expand panels to the occupy the entire screen.

Viewing panel details

Click the  icon at the top-right of each visualization panel to open a help window containing a textual description of the panel's content.

Viewing/hiding labels

Click the  icon at the bottom-right of the screen to toggle on/off visualization labels (e.g. metabolite, gene, protein, reaction names).

Turning on/off tooltips, clicks

To turn on/off user interaction (tooltips and mouse clicks) with the structured visualizations: (1) open the configuration editor by selecting "Edit" » "User interaction" from the top-left menu and (2) toggle the select boxes.

Controling the timeline: play, pause, seek, speed, repeat

Click the controls in the bottom menu to play, pause, seek, speed up/down, and repeat animations. Click the  button to play animations. Click the  button to pause animations. Click the  button to open a slider to select the animation speed. Drag the progress bar thumb to seek the animation to a desired time point. Click the  icon to toggle animation looping on/off.

Importing data

To import data stored on another server other than WholeCellViz.stanford.edu, select "Edit" » "Data source" from the top-left menu and then enter the data source URL. The URL must point to another server running the WholeCellViz server software. See the installation instructions for more information.

Exporting graphics

To export the graphics currently plotted in WholeCellViz in SVG format select "Download" » "Graphics (SVG)" from the top-left menu. SVG is common vector graphics format which can be edited by popular vector graphics editors such as Illustrator andInkscape.

Exporting data

To export the data currently plotted in WholeCellViz in JSON format select "Download" » "Data (JSON)" from the top-left menu. JSON is a very popular data interchange format supported by most modern programming languages.

Advanced usage

Working with external data

By default WholeCellViz is configured to read cached whole-cell simulation data stored at wholecell.stanford.edu/sim. To change the data source URL: (1) from the top menu click "Edit" » "Data source" and (2) enter the desired data source URL. Note: this URL must point to a location where all of the server-side WholeCellViz software is installed. See Installing WholeCellViz locally section for further information.

Adding new visualizations

To add a new structured visualization to WholeCellViz: (1) install WholeCellViz locally on your own machine, (2) add a new subclass of the Visualization2D or Visualization3D classes to wholecellviz/js/WholeCellViz-visualizations.js, and (3) add a new entry to the WholeCellViz metadata MySQL database corresponding to the new visualization.

Installing WholeCellViz locally

The easiest way to run the WholeCellViz software locally is to download the Whole-cell virtual machine posted at SimTK. Installation and usage instructions are also posted at SimTK. The virtual machine is a virtual Mint Linux machine for use with the free VirtualBox software. The virtual machine includes WholeCellViz as well as the simulation software and WholeCellKB. The virtual machine can be used to run new whole-cell simulations, analyze new simulations using WholeCellViz, and add new structured visualizations to WholeCelLViz.

To install WholeCellViz on your own machine: (1) download the WholeCellViz source code from SimTK, and (2) follow the installation instructions posted in the Developer's Guide at SimTK.

Running simulations

See wholecell.stanford.edu for further information about installing and running the whole-cell simulation software.

Downloading WholeCellViz

The WholeCellViz source code and simulated data are freely available under the MIT license at SimTK.

MIT license

Copyright (c) 2013 Stanford University

Permission is hereby granted, free of charge, to any person obtaining a copy of this software and associated documentation files (the "Software"), to deal in the Software without restriction, including without limitation the rights to use, copy, modify, merge, publish, distribute, sublicense, and/or sell copies of the Software, and to permit persons to whom the Software is furnished to do so, subject to the following conditions:

The above copyright notice and this permission notice shall be included in all copies or substantial portions of the Software.

THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE SOFTWARE.

Citing WholeCellViz

Please use the following references to cite WholeCellViz:

  1. Lee R*, Karr JR*, Covert MW. WholeCellViz: Data Visualization for Whole-Cell Models. (In preparation).
  2. Karr JR et al. A Whole-Cell Computational Model Predicts Phenotype from Genotype. Cell 150 2, 389-401 (2012). Cell |PubMed | SimTK

Development Team

WholeCellViz was developed by a team of three researchers at Stanford University:


Implementation

WholeCellViz consists of a graphical user interface and storage server. The WholeCellViz user interface was implemented in javascript using jQueryflot, and three.js. The WholeCellViz server was implemented using PHP and MySQL. Simulations were stored on the server using JSON. The user interface and server communicated using JSON.

WholeCellViz was tested on several browsers including Chrome (v26.0.1410.64, Windows), Firefox (v20.0.1, Windows), Internet Explorer (10.0.9200.16540, Windows), and Opera (12.15, Windows). All browsers work well with two exceptions (1) Opera displays arcs differently from the other browsers, causing Opera to display the 2D cell shape animation incorrectly and (2) only Chrome supports the three.js library, and therefore only Chrome can display the 3D cell shape animation.

Questions & comments

Please contact us at whol...@lists.stanford.edu with any questions and/or comments about WholeCellViz.

Joaquim Machado

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Dec 19, 2013, 4:18:10 AM12/19/13
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Joaquim Machado

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A REPORTER AT LARGE

THE INTELLIGENT PLANT

Scientists debate a new way of understanding flora.

by Michael PollanDECEMBER 23, 2013

Plants have electrical and chemical signalling systems, may possess memory, and exhibit brainy behavior in the absence of brains.

Plants have electrical and chemical signalling systems, may possess memory, and exhibit brainy behavior in the absence of brains. Construction by Stephen Doyle.

In 1973, a book claiming that plants were sentient beings that feel emotions, prefer classical music to rock and roll, and can respond to the unspoken thoughts of humans hundreds of miles away landed on the New York Times best-seller list for nonfiction. “The Secret Life of Plants,” by Peter Tompkins and Christopher Bird, presented a beguiling mashup of legitimate plant science, quack experiments, and mystical nature worship that captured the public imagination at a time when New Age thinking was seeping into the mainstream. The most memorable passages described the experiments of a former C.I.A. polygraph expert named Cleve Backster, who, in 1966, on a whim, hooked up a galvanometer to the leaf of a dracaena, a houseplant that he kept in his office. To his astonishment, Backster found that simply by imagining the dracaena being set on fire he could make it rouse the needle of the polygraph machine, registering a surge of electrical activity suggesting that the plant felt stress. “Could the plant have been reading his mind?” the authors ask. “Backster felt like running into the street and shouting to the world, ‘Plants can think!’ ”
Backster and his collaborators went on to hook up polygraph machines to dozens of plants, including lettuces, onions, oranges, and bananas. He claimed that plants reacted to the thoughts (good or ill) of humans in close proximity and, in the case of humans familiar to them, over a great distance. In one experiment designed to test plant memory, Backster found that a plant that had witnessed the murder (by stomping) of another plant could pick out the killer from a lineup of six suspects, registering a surge of electrical activity when the murderer was brought before it. Backster’s plants also displayed a strong aversion to interspecies violence. Some had a stressful response when an egg was cracked in their presence, or when live shrimp were dropped into boiling water, an experiment that Backster wrote up for the International Journal of Parapsychology, in 1968.
In the ensuing years, several legitimate plant scientists tried to reproduce the “Backster effect” without success. Much of the science in “The Secret Life of Plants” has been discredited. But the book had made its mark on the culture. Americans began talking to their plants and playing Mozart for them, and no doubt many still do. This might seem harmless enough; there will probably always be a strain of romanticism running through our thinking about plants. (Luther Burbank and George Washington Carver both reputedly talked to, and listened to, the plants they did such brilliant work with.) But in the view of many plant scientists “The Secret Life of Plants” has done lasting damage to their field. According to Daniel Chamovitz, an Israeli biologist who is the author of the recent book “What a Plant Knows,” Tompkins and Bird “stymied important research on plant behavior as scientists became wary of any studies that hinted at parallels between animal senses and plant senses.” Others contend that “The Secret Life of Plants” led to “self-censorship” among researchers seeking to explore the “possible homologies between neurobiology and phytobiology”; that is, the possibility that plants are much more intelligent and much more like us than most people think—capable of cognition, communication, information processing, computation, learning, and memory.
The quotation about self-censorship appeared in a controversial 2006 article in Trends in Plant Science proposing a new field of inquiry that the authors, perhaps somewhat recklessly, elected to call “plant neurobiology.” The six authors—among them Eric D. Brenner, an American plant molecular biologist; Stefano Mancuso, an Italian plant physiologist; František Baluška, a Slovak cell biologist; and Elizabeth Van Volkenburgh, an American plant biologist—argued that the sophisticated behaviors observed in plants cannot at present be completely explained by familiar genetic and biochemical mechanisms. Plants are able to sense and optimally respond to so many environmental variables—light, water, gravity, temperature, soil structure, nutrients, toxins, microbes, herbivores, chemical signals from other plants—that there may exist some brainlike information-processing system to integrate the data and coördinate a plant’s behavioral response. The authors pointed out that electrical and chemical signalling systems have been identified in plants which are homologous to those found in the nervous systems of animals. They also noted that neurotransmitters such as serotonin, dopamine, and glutamate have been found in plants, though their role remains unclear.
Hence the need for plant neurobiology, a new field “aimed at understanding how plants perceive their circumstances and respond to environmental input in an integrated fashion.” The article argued that plants exhibit intelligence, defined by the authors as “an intrinsic ability to process information from both abiotic and biotic stimuli that allows optimal decisions about future activities in a given environment.” Shortly before the article’s publication, the Society for Plant Neurobiology held its first meeting, in Florence, in 2005. A new scientific journal, with the less tendentious title Plant Signaling & Behavior, appeared the following year.
Depending on whom you talk to in the plant sciences today, the field of plant neurobiology represents either a radical new paradigm in our understanding of life or a slide back down into the murky scientific waters last stirred up by “The Secret Life of Plants.” Its proponents believe that we must stop regarding plants as passive objects—the mute, immobile furniture of our world—and begin to treat them as protagonists in their own dramas, highly skilled in the ways of contending in nature. They would challenge contemporary biology’s reductive focus on cells and genes and return our attention to the organism and its behavior in the environment. It is only human arrogance, and the fact that the lives of plants unfold in what amounts to a much slower dimension of time, that keep us from appreciating their intelligence and consequent success. Plants dominate every terrestrial environment, composing ninety-nine per cent of the biomass on earth. By comparison, humans and all the other animals are, in the words of one plant neurobiologist, “just traces.”
Many plant scientists have pushed back hard against the nascent field, beginning with a tart, dismissive letter in response to the Brenner manifesto, signed by thirty-six prominent plant scientists (Alpi et al., in the literature) and published in Trends in Plant Science. “We begin by stating simply that there is no evidence for structures such as neurons, synapses or a brain in plants,” the authors wrote. No such claim had actually been made—the manifesto had spoken only of “homologous” structures—but the use of the word “neurobiology” in the absence of actual neurons was apparently more than many scientists could bear.
“Yes, plants have both short- and long-term electrical signalling, and they use some neurotransmitter-like chemicals as chemical signals,” Lincoln Taiz, an emeritus professor of plant physiology at U.C. Santa Cruz and one of the signers of the Alpi letter, told me. “But the mechanisms are quite different from those of true nervous systems.” Taiz says that the writings of the plant neurobiologists suffer from “over-interpretation of data, teleology, anthropomorphizing, philosophizing, and wild speculations.” He is confident that eventually the plant behaviors we can’t yet account for will be explained by the action of chemical or electrical pathways, without recourse to “animism.” Clifford Slayman, a professor of cellular and molecular physiology at Yale, who also signed the Alpi letter (and who helped discredit Tompkins and Bird), was even more blunt. “ ‘Plant intelligence’ is a foolish distraction, not a new paradigm,” he wrote in a recent e-mail. Slayman has referred to the Alpi letter as “the last serious confrontation between the scientific community and the nuthouse on these issues.” Scientists seldom use such language when talking about their colleagues to a journalist, but this issue generates strong feelings, perhaps because it smudges the sharp line separating the animal kingdom from the plant kingdom. The controversy is less about the remarkable discoveries of recent plant science than about how to interpret and name them: whether behaviors observed in plants which look very much like learning, memory, decision-making, and intelligence deserve to be called by those terms or whether those words should be reserved exclusively for creatures with brains.
No one I spoke to in the loose, interdisciplinary group of scientists working on plant intelligence claims that plants have telekinetic powers or feel emotions. Nor does anyone believe that we will locate a walnut-shaped organ somewhere in plants which processes sensory data and directs plant behavior. More likely, in the scientists’ view, intelligence in plants resembles that exhibited in insect colonies, where it is thought to be an emergent property of a great many mindless individuals organized in a network. Much of the research on plant intelligence has been inspired by the new science of networks, distributed computing, and swarm behavior, which has demonstrated some of the ways in which remarkably brainy behavior can emerge in the absence of actual brains.
“If you are a plant, having a brain is not an advantage,” Stefano Mancuso points out. Mancuso is perhaps the field’s most impassioned spokesman for the plant point of view. A slight, bearded Calabrian in his late forties, he comes across more like a humanities professor than like a scientist. When I visited him earlier this year at the International Laboratory of Plant Neurobiology, at the University of Florence, he told me that his conviction that humans grossly underestimate plants has its origins in a science-fiction story he remembers reading as a teen-ager. A race of aliens living in a radically sped-up dimension of time arrive on Earth and, unable to detect any movement in humans, come to the logical conclusion that we are “inert material” with which they may do as they please. The aliens proceed ruthlessly to exploit us. (Mancuso subsequently wrote to say that the story he recounted was actually a mangled recollection of an early “Star Trek” episode called “Wink of an Eye.”)
In Mancuso’s view, our “fetishization” of neurons, as well as our tendency to equate behavior with mobility, keeps us from appreciating what plants can do. For instance, since plants can’t run away and frequently get eaten, it serves them well not to have any irreplaceable organs. “A plant has a modular design, so it can lose up to ninety per cent of its body without being killed,” he said. “There’s nothing like that in the animal world. It creates a resilience.”
Indeed, many of the most impressive capabilities of plants can be traced to their unique existential predicament as beings rooted to the ground and therefore unable to pick up and move when they need something or when conditions turn unfavorable. The “sessile life style,” as plant biologists term it, calls for an extensive and nuanced understanding of one’s immediate environment, since the plant has to find everything it needs, and has to defend itself, while remaining fixed in place. A highly developed sensory apparatus is required to locate food and identify threats. Plants have evolved between fifteen and twenty distinct senses, including analogues of our five: smell and taste (they sense and respond to chemicals in the air or on their bodies); sight (they react differently to various wavelengths of light as well as to shadow); touch (a vine or a root “knows” when it encounters a solid object); and, it has been discovered, sound. In a recent experiment, Heidi Appel, a chemical ecologist at the University of Missouri, found that, when she played a recording of a caterpillar chomping a leaf for a plant that hadn’t been touched, the sound primed the plant’s genetic machinery to produce defense chemicals. Another experiment, done in Mancuso’s lab and not yet published, found that plant roots would seek out a buried pipe through which water was flowing even if the exterior of the pipe was dry, which suggested that plants somehow “hear” the sound of flowing water.
The sensory capabilities of plant roots fascinated Charles Darwin, who in his later years became increasingly passionate about plants; he and his son Francis performed scores of ingenious experiments on plants. Many involved the root, or radicle, of young plants, which the Darwins demonstrated could sense light, moisture, gravity, pressure, and several other environmental qualities, and then determine the optimal trajectory for the root’s growth. The last sentence of Darwin’s 1880 book, “The Power of Movement in Plants,” has assumed scriptural authority for some plant neurobiologists: “It is hardly an exaggeration to say that the tip of the radicle . . . having the power of directing the movements of the adjoining parts, acts like the brain of one of the lower animals; the brain being seated within the anterior end of the body, receiving impressions from the sense organs and directing the several movements.” Darwin was asking us to think of the plant as a kind of upside-down animal, with its main sensory organs and “brain” on the bottom, underground, and its sexual organs on top.
Scientists have since found that the tips of plant roots, in addition to sensing gravity, moisture, light, pressure, and hardness, can also sense volume, nitrogen, phosphorus, salt, various toxins, microbes, and chemical signals from neighboring plants. Roots about to encounter an impenetrable obstacle or a toxic substance change course before they make contact with it. Roots can tell whether nearby roots are self or other and, if other, kin or stranger. Normally, plants compete for root space with strangers, but, when researchers put four closely related Great Lakes sea-rocket plants (Cakile edentula) in the same pot, the plants restrained their usual competitive behaviors and shared resources.
Somehow, a plant gathers and integrates all this information about its environment, and then “decides”—some scientists deploy the quotation marks, indicating metaphor at work; others drop them—in precisely what direction to deploy its roots or its leaves. Once the definition of “behavior” expands to include such things as a shift in the trajectory of a root, a reallocation of resources, or the emission of a powerful chemical, plants begin to look like much more active agents, responding to environmental cues in ways more subtle or adaptive than the word “instinct” would suggest. “Plants perceive competitors and grow away from them,” Rick Karban, a plant ecologist at U.C. Davis, explained, when I asked him for an example of plant decision-making. “They are more leery of actual vegetation than they are of inanimate objects, and they respond to potential competitors before actually being shaded by them.” These are sophisticated behaviors, but, like most plant behaviors, to an animal they’re either invisible or really, really slow.
The sessile life style also helps account for plants’ extraordinary gift for biochemistry, which far exceeds that of animals and, arguably, of human chemists. (Many drugs, from aspirin to opiates, derive from compounds designed by plants.) Unable to run away, plants deploy a complex molecular vocabulary to signal distress, deter or poison enemies, and recruit animals to perform various services for them. A recent study in Science found that the caffeine produced by many plants may function not only as a defense chemical, as had previously been thought, but in some cases as a psychoactive drug in their nectar. The caffeine encourages bees to remember a particular plant and return to it, making them more faithful and effective pollinators.
One of the most productive areas of plant research in recent years has been plant signalling. Since the early nineteen-eighties, it has been known that when a plant’s leaves are infected or chewed by insects they emit volatile chemicals that signal other leaves to mount a defense. Sometimes this warning signal contains information about the identity of the insect, gleaned from the taste of its saliva. Depending on the plant and the attacker, the defense might involve altering the leaf’s flavor or texture, or producing toxins or other compounds that render the plant’s flesh less digestible to herbivores. When antelopes browse acacia trees, the leaves produce tannins that make them unappetizing and difficult to digest. When food is scarce and acacias are overbrowsed, it has been reported, the trees produce sufficient amounts of toxin to kill the animals.
Perhaps the cleverest instance of plant signalling involves two insect species, the first in the role of pest and the second as its exterminator. Several species, including corn and lima beans, emit a chemical distress call when attacked by caterpillars. Parasitic wasps some distance away lock in on that scent, follow it to the afflicted plant, and proceed to slowly destroy the caterpillars. Scientists call these insects “plant bodyguards.”
Plants speak in a chemical vocabulary we can’t directly perceive or comprehend. The first important discoveries in plant communication were made in the lab in the nineteen-eighties, by isolating plants and their chemical emissions in Plexiglas chambers, but Rick Karban, the U.C. Davis ecologist, and others have set themselves the messier task of studying how plants exchange chemical signals outdoors, in a natural setting. Recently, I visited Karban’s study plot at the University of California’s Sagehen Creek Field Station, a few miles outside Truckee. On a sun-flooded hillside high in the Sierras, he introduced me to the ninety-nine sagebrush plants—low, slow-growing gray-green shrubs marked with plastic flags—that he and his colleagues have kept under close surveillance for more than a decade.
Karban, a fifty-nine-year-old former New Yorker, is slender, with a thatch of white curls barely contained by a floppy hat. He has shown that when sagebrush leaves are clipped in the spring—simulating an insect attack that triggers the release of volatile chemicals—both the clipped plant and its unclipped neighbors suffer significantly less insect damage over the season. Karban believes that the plant is alerting all its leaves to the presence of a pest, but its neighbors pick up the signal, too, and gird themselves against attack. “We think the sagebrush are basically eavesdropping on one another,” Karban said. He found that the more closely related the plants the more likely they are to respond to the chemical signal, suggesting that plants may display a form of kin recognition. Helping out your relatives is a good way to improve the odds that your genes will survive.
The field work and data collection that go into making these discoveries are painstaking in the extreme. At the bottom of a meadow raked by the slanted light of late summer, two collaborators from Japan, Kaori Shiojiri and Satomi Ishizaki, worked in the shade of a small pine, squatting over branches of sagebrush that Karban had tagged and cut. Using clickers, they counted every trident-shaped leaf on every branch, and then counted and recorded every instance of leaf damage, one column for insect bites, another for disease. At the top of the meadow, another collaborator, James Blande, a chemical ecologist from England, tied plastic bags around sagebrush stems and inflated the bags with filtered air. After waiting twenty minutes for the leaves to emit their volatiles, he pumped the air through a metal cylinder containing an absorbent material that collected the chemical emissions. At the lab, a gas chromatograph-mass spectrometer would yield a list of the compounds collected—more than a hundred in all. Blande offered to let me put my nose in one of the bags; the air was powerfully aromatic, with a scent closer to aftershave than to perfume. Gazing across the meadow of sagebrush, I found it difficult to imagine the invisible chemical chatter, including the calls of distress, going on all around—or that these motionless plants were engaged in any kind of “behavior” at all.
Research on plant communication may someday benefit farmers and their crops. Plant-distress chemicals could be used to prime plant defenses, reducing the need for pesticides. Jack Schultz, a chemical ecologist at the University of Missouri, who did some of the pioneering work on plant signalling in the early nineteen-eighties, is helping to develop a mechanical “nose” that, attached to a tractor and driven through a field, could help farmers identify plants under insect attack, allowing them to spray pesticides only when and where they are needed.
Karban told me that, in the nineteen-eighties, people working on plant communication faced some of the same outrage that scientists working on plant intelligence (a term he cautiously accepts) do today. “This stuff has been enormously contentious,” he says, referring to the early days of research into plant communication, work that is now generally accepted. “It took me years to get some of these papers published. People would literally be screaming at one another at scientific meetings.” He added, “Plant scientists in general are incredibly conservative. We all think we want to hear novel ideas, but we don’t, not really.”
I first met Karban at a scientific meeting in Vancouver last July, when he presented a paper titled “Plant Communication and Kin Recognition in Sagebrush.” The meeting would have been the sixth gathering of the Society for Plant Neurobiology, if not for the fact that, under pressure from certain quarters of the scientific establishment, the group’s name had been changed four years earlier to the less provocative Society for Plant Signaling and Behavior. The plant biologist Elizabeth Van Volkenburgh, of the University of Washington, who was one of the founders of the society, told me that the name had been changed after a lively internal debate; she felt that jettisoning “neurobiology” was probably for the best. “I was told by someone at the National Science Foundation that the N.S.F. would never fund anything with the words ‘plant neurobiology’ in it. He said, and I quote, ‘ “Neuro” belongs to animals.’ ” (An N.S.F. spokesperson said that, while the society is not eligible for funding by the foundation’s neurobiology program, “the N.S.F. does not have a boycott of any sort against the society.”) Two of the society’s co-founders, Stefano Mancuso and František Baluška, argued strenuously against the name change, and continue to use the term “plant neurobiology” in their own work and in the names of their labs.
The meeting consisted of three days of PowerPoint presentations delivered in a large, modern lecture hall at the University of British Columbia before a hundred or so scientists. Most of the papers were highly technical presentations on plant signalling—the kind of incremental science that takes place comfortably within the confines of an established scientific paradigm, which plant signalling has become. But a handful of speakers presented work very much within the new paradigm of plant intelligence, and they elicited strong reactions.
The most controversial presentation was “Animal-Like Learning in Mimosa Pudica,” an unpublished paper by Monica Gagliano, a thirty-seven-year-old animal ecologist at the University of Western Australia who was working in Mancuso’s lab in Florence. Gagliano, who is tall, with long brown hair parted in the middle, based her experiment on a set of protocols commonly used to test learning in animals. She focussed on an elementary type of learning called “habituation,” in which an experimental subject is taught to ignore an irrelevant stimulus. “Habituation enables an organism to focus on the important information, while filtering out the rubbish,” Gagliano explained to the audience of plant scientists. How long does it take the animal to recognize that a stimulus is “rubbish,” and then how long will it remember what it has learned? Gagliano’s experimental question was bracing: Could the same thing be done with a plant?
Mimosa pudica, also called the “sensitive plant,” is that rare plant species with a behavior so speedy and visible that animals can observe it; the Venus flytrap is another. When the fernlike leaves of the mimosa are touched, they instantly fold up, presumably to frighten insects. The mimosa also collapses its leaves when the plant is dropped or jostled. Gagliano potted fifty-six mimosa plants and rigged a system to drop them from a height of fifteen centimetres every five seconds. Each “training session” involved sixty drops. She reported that some of the mimosas started to reopen their leaves after just four, five, or six drops, as if they had concluded that the stimulus could be safely ignored. “By the end, they were completely open,” Gagliano said to the audience. “They couldn’t care less anymore.”
Was it just fatigue? Apparently not: when the plants were shaken, they again closed up. “ ‘Oh, this is something new,’ ” Gagliano said, imagining these events from the plants’ point of view. “You see, you want to be attuned to something new coming in. Then we went back to the drops, and they didn’t respond.” Gagliano reported that she retested her plants after a week and found that they continued to disregard the drop stimulus, indicating that they “remembered” what they had learned. Even after twenty-eight days, the lesson had not been forgotten. She reminded her colleagues that, in similar experiments with bees, the insects forgot what they had learned after just forty-eight hours. Gagliano concluded by suggesting that “brains and neurons are a sophisticated solution but not a necessary requirement for learning,” and that there is “some unifying mechanism across living systems that can process information and learn.”
A lively exchange followed. Someone objected that dropping a plant was not a relevant trigger, since that doesn’t happen in nature. Gagliano pointed out that electric shock, an equally artificial trigger, is often used in animal-learning experiments. Another scientist suggested that perhaps her plants were not habituated, just tuckered out. She argued that twenty-eight days would be plenty of time to rebuild their energy reserves.
On my way out of the lecture hall, I bumped into Fred Sack, a prominent botanist at the University of British Columbia. I asked him what he thought of Gagliano’s presentation. “Bullshit,” he replied. He explained that the word “learning” implied a brain and should be reserved for animals: “Animals can exhibit learning, but plants evolve adaptations.” He was making a distinction between behavioral changes that occur within the lifetime of an organism and those which arise across generations. At lunch, I sat with a Russian scientist, who was equally dismissive. “It’s not learning,” he said. “So there’s nothing to discuss.”
Later that afternoon, Gagliano seemed both stung by some of the reactions to her presentation and defiant. Adaptation is far too slow a process to explain the behavior she had observed, she told me. “How can they be adapted to something they have never experienced in their real world?” She noted that some of her plants learned faster than others, evidence that “this is not an innate or programmed response.” Many of the scientists in her audience were just getting used to the ideas of plant “behavior” and “memory” (terms that even Fred Sack said he was willing to accept); using words like “learning” and “intelligence” in plants struck them, in Sack’s words, as “inappropriate” and “just weird.” When I described the experiment to Lincoln Taiz, he suggested the words “habituation” or “desensitization” would be more appropriate than “learning.” Gagliano said that her mimosa paper had been rejected by ten journals: “None of the reviewers had problems with the data.” Instead, they balked at the language she used to describe the data. But she didn’t want to change it. “Unless we use the same language to describe the same behavior”—exhibited by plants and animals—“we can’t compare it,” she said.
Rick Karban consoled Gagliano after her talk. “I went through the same thing, just getting totally hammered,” he told her. “But you’re doing good work. The system is just not ready.” When I asked him what he thought of Gagliano’s paper, he said, “I don’t know if she’s got everything nailed down, but it’s a very cool idea that deserves to get out there and be discussed. I hope she doesn’t get discouraged.”
Scientists are often uncomfortable talking about the role of metaphor and imagination in their work, yet scientific progress often depends on both. “Metaphors help stimulate the investigative imagination of good scientists,” the British plant scientist Anthony Trewavas wrote in a spirited response to the Alpi letter denouncing plant neurobiology. “Plant neurobiology” is obviously a metaphor—plants don’t possess the type of excitable, communicative cells we call neurons. Yet the introduction of the term has raised a series of questions and inspired a set of experiments that promise to deepen our understanding not only of plants but potentially also of brains. If there are other ways of processing information, other kinds of cells and cell networks that can somehow give rise to intelligent behavior, then we may be more inclined to ask, with Mancuso, “What’s so special about neurons?”
Mancuso is the poet-philosopher of the movement, determined to win for plants the recognition they deserve and, perhaps, bring humans down a peg in the process. His somewhat grandly named International Laboratory of Plant Neurobiology, a few miles outside Florence, occupies a modest suite of labs and offices in a low-slung modern building. Here a handful of collaborators and graduate students work on the experiments Mancuso devises to test the intelligence of plants. Giving a tour of the labs, he showed me maize plants, grown under lights, that were being taught to ignore shadows; a poplar sapling hooked up to a galvanometer to measure its response to air pollution; and a chamber in which a PTR-TOF machine—an advanced kind of mass spectrometer—continuously read all the volatiles emitted by a succession of plants, from poplars and tobacco plants to peppers and olive trees. “We are making a dictionary of each species’ entire chemical vocabulary,” he explained. He estimates that a plant has three thousand chemicals in its vocabulary, while, he said with a smile, “the average student has only seven hundred words.”
Mancuso is fiercely devoted to plants—a scientist needs to “love” his subject in order to do it justice, he says. He is also gentle and unassuming, even when what he is saying is outrageous. In the corner of his office sits a forlorn Ficus benjamina, or weeping fig, and on the walls are photographs of Mancuso in an astronaut’s jumpsuit floating in the cabin of a zero-gravity aircraft; he has collaborated with the European Space Agency, which has supported his research on plant behavior in micro- and hyper-gravity. (One of his experiments was carried on board the last flight of the space shuttle Endeavor, in May of 2011.) A decade ago, Mancuso persuaded a Florentine bank foundation to underwrite much of his research and help launch the Society for Plant Neurobiology; his lab also receives grants from the European Union.
Early in our conversation, I asked Mancuso for his definition of “intelligence.” Spending so much time with the plant neurobiologists, I could feel my grasp on the word getting less sure. It turns out that I am not alone: philosophers and psychologists have been arguing over the definition of intelligence for at least a century, and whatever consensus there may once have been has been rapidly slipping away. Most definitions of intelligence fall into one of two categories. The first is worded so that intelligence requires a brain; the definition refers to intrinsic mental qualities such as reason, judgment, and abstract thought. The second category, less brain-bound and metaphysical, stresses behavior, defining intelligence as the ability to respond in optimal ways to the challenges presented by one’s environment and circumstances. Not surprisingly, the plant neurobiologists jump into this second camp.
“I define it very simply,” Mancuso said. “Intelligence is the ability to solve problems.” In place of a brain, “what I am looking for is a distributed sort of intelligence, as we see in the swarming of birds.” In a flock, each bird has only to follow a few simple rules, such as maintaining a prescribed distance from its neighbor, yet the collective effect of a great many birds executing a simple algorithm is a complex and supremely well-coördinated behavior. Mancuso’s hypothesis is that something similar is at work in plants, with their thousands of root tips playing the role of the individual birds—gathering and assessing data from the environment and responding in local but coördinated ways that benefit the entire organism.
“Neurons perhaps are overrated,” Mancuso said. “They’re really just excitable cells.” Plants have their own excitable cells, many of them in a region just behind the root tip. Here Mancuso and his frequent collaborator, František Baluška, have detected unusually high levels of electrical activity and oxygen consumption. They’ve hypothesized in a series of papers that this so-called “transition zone” may be the locus of the “root brain” first proposed by Darwin. The idea remains unproved and controversial. “What’s going on there is not well understood,” Lincoln Taiz told me, “but there is no evidence it is a command center.”
How plants do what they do without a brain—what Anthony Trewavas has called their “mindless mastery”—raises questions about how our brains do what they do. When I asked Mancuso about the function and location of memory in plants, he speculated about the possible role of calcium channels and other mechanisms, but then he reminded me that mystery still surrounds where and how our memories are stored: “It could be the same kind of machinery, and figuring it out in plants may help us figure it out in humans.”
The hypothesis that intelligent behavior in plants may be an emergent property of cells exchanging signals in a network might sound far-fetched, yet the way that intelligence emerges from a network of neurons may not be very different. Most neuroscientists would agree that, while brains considered as a whole function as centralized command centers for most animals, within the brain there doesn’t appear to be any command post; rather, one finds a leaderless network. That sense we get when we think about what might govern a plant—that there is no there there, no wizard behind the curtain pulling the levers—may apply equally well to our brains.
In Martin Amis’s 1995 novel, “The Information,” we meet a character who aspires to write “The History of Increasing Humiliation,” a treatise chronicling the gradual dethronement of humankind from its position at the center of the universe, beginning with Copernicus. “Every century we get smaller,” Amis writes. Next came Darwin, who brought the humbling news that we are the product of the same natural laws that created animals. In the last century, the formerly sharp lines separating humans from animals—our monopolies on language, reason, toolmaking, culture, even self-consciousness—have been blurred, one after another, as science has granted these capabilities to other animals.
Mancuso and his colleagues are writing the next chapter in “The History of Increasing Humiliation.” Their project entails breaking down the walls between the kingdoms of plants and animals, and it is proceeding not only experiment by experiment but also word by word. Start with that slippery word “intelligence.” Particularly when there is no dominant definition (and when measurements of intelligence, such as I.Q., have been shown to be culturally biased), it is possible to define intelligence in a way that either reinforces the boundary between animals and plants (say, one that entails abstract thought) or undermines it. Plant neurobiologists have chosen to define intelligence democratically, as an ability to solve problems or, more precisely, to respond adaptively to circumstances, including ones unforeseen in the genome.
“I agree that humans are special,” Mancuso says. “We are the first species able to argue about what intelligence is. But it’s the quantity, not the quality” of intelligence that sets us apart. We exist on a continuum with the acacia, the radish, and the bacterium. “Intelligence is a property of life,” he says. I asked him why he thinks people have an easier time granting intelligence to computers than to plants. (Fred Sack told me that he can abide the term “artificial intelligence,” because the intelligence in this case is modified by the word “artificial,” but not “plant intelligence.” He offered no argument, except to say, “I’m in the majority in saying it’s a little weird.”) Mancuso thinks we’re willing to accept artificial intelligence because computers are our creations, and so reflect our own intelligence back at us. They are also our dependents, unlike plants: “If we were to vanish tomorrow, the plants would be fine, but if the plants vanished . . .” Our dependence on plants breeds a contempt for them, Mancuso believes. In his somewhat topsy-turvy view, plants “remind us of our weakness.”
“Memory” may be an even thornier word to apply across kingdoms, perhaps because we know so little about how it works. We tend to think of memories as immaterial, but in animal brains some forms of memory involve the laying down of new connections in a network of neurons. Yet there are ways to store information biologically that don’t require neurons. Immune cells “remember” their experience of pathogens, and call on that memory in subsequent encounters. In plants, it has long been known that experiences such as stress can alter the molecular wrapping around the chromosomes; this, in turn, determines which genes will be silenced and which expressed. This so-called “epigenetic” effect can persist and sometimes be passed down to offspring. More recently, scientists have found that life events such as trauma or starvation produce epigenetic changes in animal brains (coding for high levels of cortisol, for example) that are long-lasting and can also be passed down to offspring, a form of memory much like that observed in plants.
While talking with Mancuso, I kept thinking about words like “will,” “choice,” and “intention,” which he seemed to attribute to plants rather casually, almost as if they were acting consciously. At one point, he told me about the dodder vine, Cuscuta europaea, a parasitic white vine that winds itself around the stalk of another plant and sucks nourishment from it. A dodder vine will “choose” among several potential hosts, assessing, by scent, which offers the best potential nourishment. Having selected a target, the vine then performs a kind of cost-benefit calculation before deciding exactly how many coils it should invest—the more nutrients in the victim, the more coils it deploys. I asked Mancuso whether he was being literal or metaphorical in attributing intention to plants.
“Here, I’ll show you something,” he said. “Then you tell me if plants have intention.” He swivelled his computer monitor around and clicked open a video.
Time-lapse photography is perhaps the best tool we have to bridge the chasm between the time scale at which plants live and our own. This example was of a young bean plant, shot in the lab over two days, one frame every ten minutes. A metal pole on a dolly stands a couple of feet away. The bean plant is “looking” for something to climb. Each spring, I witness the same process in my garden, in real time. I always assumed that the bean plants simply grow this way or that, until they eventually bump into something suitable to climb. But Mancuso’s video seems to show that this bean plant “knows” exactly where the metal pole is long before it makes contact with it. Mancuso speculates that the plant could be employing a form of echolocation. There is some evidence that plants make low clicking sounds as their cells elongate; it’s possible that they can sense the reflection of those sound waves bouncing off the metal pole.
The bean plant wastes no time or energy “looking”—that is, growing—anywhere but in the direction of the pole. And it is striving (there is no other word for it) to get there: reaching, stretching, throwing itself over and over like a fly rod, extending itself a few more inches with every cast, as it attempts to wrap its curling tip around the pole. As soon as contact is made, the plant appears to relax; its clenched leaves begin to flutter mildly. All this may be nothing more than an illusion of time-lapse photography. Yet to watch the video is to feel, momentarily, like one of the aliens in Mancuso’s formative science-fiction story, shown a window onto a dimension of time in which these formerly inert beings come astonishingly to life, seemingly conscious individuals with intentions.
In October, I loaded the bean video onto my laptop and drove down to Santa Cruz to play it for Lincoln Taiz. He began by questioning its value as scientific data: “Maybe he has ten other videos where the bean didn’t do that. You can’t take one interesting variation and generalize from it.” The bean’s behavior was, in other words, an anecdote, not a phenomenon. Taiz also pointed out that the bean in the video was leaning toward the pole in the first frame. Mancuso then sent me another video with two perfectly upright bean plants that exhibited very similar behavior. Taiz was now intrigued. “If he sees that effect consistently, it would be exciting,” he said—but it would not necessarily be evidence of plant intention. “If the phenomenon is real, it would be classified as a tropism,” such as the mechanism that causes plants to bend toward light. In this case, the stimulus remains unknown, but tropisms “do not require one to postulate either intentionality or ‘brainlike’ conceptualization,” Taiz said. “The burden of proof for the latter interpretation would clearly be on Stefano.”
Perhaps the most troublesome and troubling word of all in thinking about plants is “consciousness.” If consciousness is defined as inward awareness of oneself experiencing reality—“the feeling of what happens,” in the words of the neuroscientist Antonio Damasio—then we can (probably) safely conclude that plants don’t possess it. But if we define the term simply as the state of being awake and aware of one’s environment—“online,” as the neuroscientists say—then plants may qualify as conscious beings, at least according to Mancuso and Baluška. “The bean knows exactly what is in the environment around it,” Mancuso said. “We don’t know how. But this is one of the features of consciousness: You know your position in the world. A stone does not.”
In support of their contention that plants are conscious of their environment, Mancuso and Baluška point out that plants can be rendered unconscious by the same anesthetics that put animals out: drugs can induce in plants an unresponsive state resembling sleep. (A snoozing Venus flytrap won’t notice an insect crossing its threshold.) What’s more, when plants are injured or stressed, they produce a chemical—ethylene—that works as an anesthetic on animals. When I learned this startling fact from Baluška in Vancouver, I asked him, gingerly, if he meant to suggest that plants could feel pain. Baluška, who has a gruff mien and a large bullet-shaped head, raised one eyebrow and shot me a look that I took to mean he deemed my question impertinent or absurd. But apparently not.
“If plants are conscious, then, yes, they should feel pain,” he said. “If you don’t feel pain, you ignore danger and you don’t survive. Pain is adaptive.” I must have shown some alarm. “That’s a scary idea,” he acknowledged with a shrug. “We live in a world where we must eat other organisms.”
Unprepared to consider the ethical implications of plant intelligence, I could feel my resistance to the whole idea stiffen. Descartes, who believed that only humans possessed self-consciousness, was unable to credit the idea that other animals could suffer from pain. So he dismissed their screams and howls as mere reflexes, as meaningless physiological noise. Could it be remotely possible that we are now making the same mistake with plants? That the perfume of jasmine or basil, or the scent of freshly mowed grass, so sweet to us, is (as the ecologist Jack Schultz likes to say) the chemical equivalent of a scream? Or have we, merely by posing such a question, fallen back into the muddied waters of “The Secret Life of Plants”?
Lincoln Taiz has little patience for the notion of plant pain, questioning what, in the absence of a brain, would be doing the feeling. He puts it succinctly: “No brain, no pain.” Mancuso is more circumspect. We can never determine with certainty whether plants feel pain or whether their perception of injury is sufficiently like that of animals to be called by the same word. (He and Baluška are careful to write of “plant-specific pain perception.”) “We just don’t know, so we must be silent.”
Mancuso believes that, because plants are sensitive and intelligent beings, we are obliged to treat them with some degree of respect. That means protecting their habitats from destruction and avoiding practices such as genetic manipulation, growing plants in monocultures, and training them in bonsai. But it does not prevent us from eating them. “Plants evolved to be eaten—it is part of their evolutionary strategy,” he said. He cited their modular structure and lack of irreplaceable organs in support of this view.
The central issue dividing the plant neurobiologists from their critics would appear to be this: Do capabilities such as intelligence, pain perception, learning, and memory require the existence of a brain, as the critics contend, or can they be detached from their neurobiological moorings? The question is as much philosophical as it is scientific, since the answer depends on how these terms get defined. The proponents of plant intelligence argue that the traditional definitions of these terms are anthropocentric—a clever reply to the charges of anthropomorphism frequently thrown at them. Their attempt to broaden these definitions is made easier by the fact that the meanings of so many of these terms are up for grabs. At the same time, since these words were originally created to describe animal attributes, we shouldn’t be surprised at the awkward fit with plants. It seems likely that, if the plant neurobiologists were willing to add the prefix “plant-specific” to intelligence and learning and memory and consciousness (as Mancuso and Baluška are prepared to do in the case of pain), then at least some of this “scientific controversy” might evaporate.
Indeed, I found more consensus on the underlying science than I expected. Even Clifford Slayman, the Yale biologist who signed the 2007 letter dismissing plant neurobiology, is willing to acknowledge that, although he doesn’t think plants possess intelligence, he does believe they are capable of “intelligent behavior,” in the same way that bees and ants are. In an e-mail exchange, Slayman made a point of underlining this distinction: “We do not know what constitutes intelligence, only what we can observe and judge as intelligent behavior.” He defined “intelligent behavior” as “the ability to adapt to changing circumstances” and noted that it “must always be measured relative to a particular environment.” Humans may or may not be intrinsically more intelligent than cats, he wrote, but when a cat is confronted with a mouse its behavior is likely to be demonstrably more intelligent.
Slayman went on to acknowledge that “intelligent behavior could perfectly well develop without such a nerve center or headquarters or director or brain—whatever you want to call it. Instead of ‘brain,’ think ‘network.’ It seems to be that many higher organisms are internally networked in such a way that local changes,” such as the way that roots respond to a water gradient, “cause very local responses which benefit the entire organism.” Seen that way, he added, the outlook of Mancuso and Trewavas is “pretty much in line with my understanding of biochemical/biological networks.” He pointed out that while it is an understandable human prejudice to favor the “nerve center” model, we also have a second, autonomic nervous system governing our digestive processes, which “operates most of the time without instructions from higher up.” Brains are just one of nature’s ways of getting complex jobs done, for dealing intelligently with the challenges presented by the environment. But they are not the only way: “Yes, I would argue that intelligent behavior is a property of life.”
To define certain words in such a way as to bring plants and animals beneath the same semantic umbrella—whether of intelligence or intention or learning—is a philosophical choice with important consequences for how we see ourselves in nature. Since “The Origin of Species,” we have understood, at least intellectually, the continuities among life’s kingdoms—that we are all cut from the same fabric of nature. Yet our big brains, and perhaps our experience of inwardness, allow us to feel that we must be fundamentally different—suspended above nature and other species as if by some metaphysical “skyhook,” to borrow a phrase from the philosopher Daniel Dennett. Plant neurobiologists are intent on taking away our skyhook, completing the revolution that Darwin started but which remains—psychologically, at least—incomplete.
“What we learned from Darwin is that competence precedes comprehension,” Dennett said when I called to talk to him about plant neurobiology. Upon a foundation of the simplest competences—such as the on-off switch in a computer, or the electrical and chemical signalling of a cell—can be built higher and higher competences until you wind up with something that looks very much like intelligence. “The idea that there is a bright line, with real comprehension and real minds on the far side of the chasm, and animals or plants on the other—that’s an archaic myth.” To say that higher competences such as intelligence, learning, and memory “mean nothing in the absence of brains” is, in Dennett’s view, “cerebrocentric.”
All species face the same existential challenges—obtaining food, defending themselves, reproducing—but under wildly varying circumstances, and so they have evolved wildly different tools in order to survive. Brains come in handy for creatures that move around a lot; but they’re a disadvantage for ones that are rooted in place. Impressive as it is to us, self-consciousness is just another tool for living, good for some jobs, unhelpful for others. That humans would rate this particular adaptation so highly is not surprising, since it has been the shining destination of our long evolutionary journey, along with the epiphenomenon of self-consciousness that we call “free will.”
In addition to being a plant physiologist, Lincoln Taiz writes about the history of science. “Starting with Darwin’s grandfather, Erasmus,” he told me, “there has been a strain of teleology in the study of plant biology”—a habit of ascribing purpose or intention to the behavior of plants. I asked Taiz about the question of “choice,” or decision-making, in plants, as when they must decide between two conflicting environmental signals—water and gravity, for example.
“Does the plant decide in the same way that we choose at a deli between a Reuben sandwich or lox and bagel?” Taiz asked. “No, the plant response is based entirely on the net flow of auxin and other chemical signals. The verb ‘decide’ is inappropriate in a plant context. It implies free will. Of course, one could argue that humans lack free will too, but that is a separate issue.”
I asked Mancuso if he thought that a plant decides in the same way we might choose at a deli between a Reuben or lox and bagels.
“Yes, in the same way,” Mancuso wrote back, though he indicated that he had no idea what a Reuben was. “Just put ammonium nitrate in the place of Reuben sandwich (whatever it is) and phosphate instead of salmon, and the roots will make a decision.” But isn’t the root responding simply to the net flow of certain chemicals? “I’m afraid our brain makes decisions in the same exact way.”
“Why would a plant care about Mozart?” the late ethnobotanist Tim Plowman would reply when asked about the wonders catalogued in “The Secret Life of Plants.” “And even if it did, why should that impress us? They can eat light, isn’t that enough?”
One way to exalt plants is by demonstrating their animal-like capabilities. But another way is to focus on all the things plants can do that we cannot. Some scientists working on plant intelligence have questioned whether the “animal-centric” emphasis, along with the obsession with the term “neurobiology,” has been a mistake and possibly an insult to the plants. “I have no interest in making plants into little animals,” one scientist wrote during the dustup over what to call the society. “Plants are unique,” another wrote. “There is no reason to . . . call them demi-animals.”
When I met Mancuso for dinner during the conference in Vancouver, he sounded very much like a plant scientist getting over a case of “brain envy”—what Taiz had suggested was motivating the plant neurologists. If we could begin to understand plants on their own terms, he said, “it would be like being in contact with an alien culture. But we could have all the advantages of that contact without any of the problems—because it doesn’t want to destroy us!” How do plants do all the amazing things they do without brains? Without locomotion? By focussing on the otherness of plants rather than on their likeness, Mancuso suggested, we stand to learn valuable things and develop important new technologies. This was to be the theme of his presentation to the conference, the following morning, on what he called “bioinspiration.” How might the example of plant intelligence help us design better computers, or robots, or networks?
Mancuso was about to begin a collaboration with a prominent computer scientist to design a plant-based computer, modelled on the distributed computing performed by thousands of roots processing a vast number of environmental variables. His collaborator, Andrew Adamatzky, the director of the International Center of Unconventional Computing, at the University of the West of England, has worked extensively with slime molds, harnessing their maze-navigating and computational abilities. (Adamatzky’s slime molds, which are a kind of amoeba, grow in the direction of multiple food sources simultaneously, usually oat flakes, in the process computing and remembering the shortest distance between any two of them; he has used these organisms to model transportation networks.) In an e-mail, Adamatzky said that, as a substrate for biological computing, plants offered both advantages and disadvantages over slime molds. “Plants are more robust,” he wrote, and “can keep their shape for a very long time,” although they are slower-growing and lack the flexibility of slime molds. But because plants are already “analog electrical computers,” trafficking in electrical inputs and outputs, he is hopeful that he and Mancuso will be able to harness them for computational tasks.
Mancuso was also working with Barbara Mazzolai, a biologist-turned-engineer at the Italian Institute of Technology, in Genoa, to design what he called a “plantoid”: a robot designed on plant principles. “If you look at the history of robots, they are always based on animals—they are humanoids or insectoids. If you want something swimming, you look at a fish. But what about imitating plants instead? What would that allow you to do? Explore the soil!” With a grant from the European Union’s Future and Emerging Technologies program, their team is developing a “robotic root” that, using plastics that can elongate and then harden, will be able to slowly penetrate the soil, sense conditions, and alter its trajectory accordingly. “If you want to explore other planets, the best thing is to send plantoids.”
The most bracing part of Mancuso’s talk on bioinspiration came when he discussed underground plant networks. Citing the research of Suzanne Simard, a forest ecologist at the University of British Columbia, and her colleagues, Mancuso showed a slide depicting how trees in a forest organize themselves into far-flung networks, using the underground web of mycorrhizal fungi which connects their roots to exchange information and even goods. This “wood-wide web,” as the title of one paper put it, allows scores of trees in a forest to convey warnings of insect attacks, and also to deliver carbon, nitrogen, and water to trees in need.
When I reached Simard by phone, she described how she and her colleagues track the flow of nutrients and chemical signals through this invisible underground network. They injected fir trees with radioactive carbon isotopes, then followed the spread of the isotopes through the forest community using a variety of sensing methods, including a Geiger counter. Within a few days, stores of radioactive carbon had been routed from tree to tree. Every tree in a plot thirty metres square was connected to the network; the oldest trees functioned as hubs, some with as many as forty-seven connections. The diagram of the forest network resembled an airline route map.
The pattern of nutrient traffic showed how “mother trees” were using the network to nourish shaded seedlings, including their offspring—which the trees can apparently recognize as kin—until they’re tall enough to reach the light. And, in a striking example of interspecies coöperation, Simard found that fir trees were using the fungal web to trade nutrients with paper-bark birch trees over the course of the season. The evergreen species will tide over the deciduous one when it has sugars to spare, and then call in the debt later in the season. For the forest community, the value of this coöperative underground economy appears to be better over-all health, more total photosynthesis, and greater resilience in the face of disturbance.
In his talk, Mancuso juxtaposed a slide of the nodes and links in one of these subterranean forest networks with a diagram of the Internet, and suggested that in some respects the former was superior. “Plants are able to create scalable networks of self-maintaining, self-operating, and self-repairing units,” he said. “Plants.”
As I listened to Mancuso limn the marvels unfolding beneath our feet, it occurred to me that plants do have a secret life, and it is even stranger and more wonderful than the one described by Tompkins and Bird. When most of us think of plants, to the extent that we think about plants at all, we think of them as old—holdovers from a simpler, prehuman evolutionary past. But for Mancuso plants hold the key to a future that will be organized around systems and technologies that are networked, decentralized, modular, reiterated, redundant—and green, able to nourish themselves on light. “Plants are the great symbol of modernity.” Or should be: their brainlessness turns out to be their strength, and perhaps the most valuable inspiration we can take from them.
At dinner in Vancouver, Mancuso said, “Since you visited me in Florence, I came across this sentence of Karl Marx, and I became obsessed with it: ‘Everything that is solid melts into air.’ Whenever we build anything, it is inspired by the architecture of our bodies. So it will have a solid structure and a center, but that is inherently fragile. This is the meaning of that sentence—‘Everything solid melts into air.’ So that’s the question: Can we now imagine something completely different, something inspired instead by plants?” 


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Joaquim Machado

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Dec 23, 2013, 5:06:15 PM12/23/13
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3D Printing Industry
class 3d printing 3D Systems

North Carolina Middle School Kids Get Bitten by the 3D Printing Bug

Scott J Grunewald BY SCOTT J GRUNEWALD ON  · EDUCATION,INDUSTRY NEWS

North Carolinas Socrates Academy students getting their hands on a CubeX Duo perfectly illustrates how access to new and cutting edge technologies is vital to producing the next generation of scientists, engineers and inventors.

“As an educator, nothing that I have done with my scholars sticks out more than something that was hands-on, relevant, current, and engaging,” says George Latzos, Socrates Academy science teacher. “3D printing is one of those things and if we can place just one in every school, I think we can spark a new generation of ingenuity and innovation,” he concluded.

The students’ reactions after the demonstration spoke volumes for the dividends this kind of outreach can produce. As they returned to school the next day, sharing YouTube videos on 3D printing and their smartphones full of 3D design apps, it was clear that the impact made on them was substantial. Schools can teach all the subject’s from a book that they want, but unless the students are engaged they’re most likely not learning much, simply memorizing what they need to know for the test. Demonstrating technology is always the best way to get people to adopt it, that’s why anyone can go into any electronics store and touch all the demo units that they can dream of. This was likely the reason Socrates Academy parent Kris Dell, who demo’s 3D printers for a living with Applied Software, allowed the students to use her 3D printer in the first place.

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“It allowed the scholars to see that creation and invention don’t have to take place in a foreign country in some unknown factory, that the process is not out of reach,” states Latzos.  “Instead, the scholars were able to see that manufacturing is a process that can occur in their own homes and that creativity and invention can be a reality and not an unattainable dream.”

Getting 3D printers into American schools is becoming a higher priority, but as science and math test scores in the United States continue to lag globally, the need for access to new technology is never more evident. As schools focus more and more on job training and test scores, valuable skills essential for any innovator or engineer like critical thinking are beginning to be sidelined. Just presenting kids with the idea that one day we could print human organs is nice, but letting them learn how the technology works by actually letting them use it is how those same kids become the people who invent the technology to do it.

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Scott J Grunewald
ABOUT THE AUTHOR

Scott J Grunewald

Scott J Grunewald often writes about comics, pop culture, technology and social issues and has a keen interest in what happens when the needs of commerce, art and science inevitably intersect. He also likes writing about bacon. This isn't the greatest bio in the world. This is just a tribute.


Joaquim Machado

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Dec 26, 2013, 10:26:24 AM12/26/13
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Joaquim Machado

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BotBQ 3D Printing Beef

BotBQ New Nozzle Testing – 3D Printed Food

3D Printing Industry BY 3D PRINTING INDUSTRY ON  · 3D PRINTING3DP APPLICATIONSFOODVIDEOS

Have you heard of BotBQ? Who knows, maybe this time next year you will be 3D Printing your Xmas meals with this little piece of innovation. That’s right, we’re talking about 3D Printing food with BotBQ extruder, first introduced to the public on September at the #OS3DC in Frankfurt. Check the video below to see how BotBQ’s new nozzle works. The BotBQ Extruder is open-source, so anyone pining for their own 3D Printed Burger get yourself here for some instructions.

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ABOUT THE AUTHOR

3D Printing Industry

The Author under 3D Printing Industry is a member of our editorial team. Our dedicated team of writers all have a background in technology and are keen to provide news, views and insight into the latest trends in 3D printing across the board including the pioneering home users, the maker community and industrialists.

    3D PRINTING JOBS OF THE DAY

Joaquim Machado

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Joaquim Machado

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Joaquim Machado

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Joaquim Machado

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December 31, 2013

Goodbye, Cameras

Posted by Craig Mod

Light.jpeg

This past October, just before the leaves changed, I went on a six-day hike through the mountains of Wakayama, in central Japan, tracing the path of an ancient imperial pilgrimage called the Kumano Kodo. I took along a powerful camera, believing, as I always have, that it would be an indispensable creative tool. But I returned with the unshakeable feeling that I’m done with cameras, and that most of us are, if we weren’t already.

My passion for cameras began when I was a teen-ager, but I took to them in earnest in 2000, when I arrived in Tokyo as a college student. Back then, the city was rife with used-camera shops overflowing with rows of dusty, greasy, and dented bodies and lenses. I spent several lazy weekday afternoons wandering through the stores, precociously bugging the grouchy owners about the benefits of one camera over another. Deep down, I wanted a classic Leica M3, which cost fifteen hundred dollars at the time, though a choice lens could easily double the price. Constrained by a student’s budget, I chose a used Nikon 8008 body, which the Times had named “the camera of the future” in 1988. I paired it with a cheap 50-mm. lens, then set off for a month hitchhiking the entire breadth of Japan, from Tokyo to Fukuoka, filling my backpack with delicately exposed rolls of film.

I shot exclusively with Fuji Velvia film, partly because of its famous lollipop-like color saturation and partly for the challenge of using I.S.O.-50 slide film. The lower the I.S.O. of a film, the less sensitive it is to light. This makes it more difficult to shoot with, but the images have a smooth, polished quality to them; while high-I.S.O. film needs only a trickle of light to produce a usable picture, the images look rough and grainy, like sandpaper. The experience of waiting for the slides to return from the developer was both petrifying and magical: Had any of the images that appeared in the camera’s viewfinder made it back intact? I was rewarded with hundreds of gorgeous, otherworldly images, and I pored over those slides for weeks.

Two years later, I used eBay to piece together a Hasselblad 500C, the classic medium-format camera. (It also has an impressive geek pedigree: Walter Schirra took one into space on the Mercury rocket, in 1962, igniting NASA’s long-standing love affair with the company, which is based in Sweden.) Depending on the type of medium-format film, the images can be anywhere from two to six times as large as standard 35-mm. photos. While the cameras are larger and less portable, they capture an incredible amount of detail: if you were to take a picture of a man holding a penny from a few feet away with an iPhone, a 35-mm. Nikon, and a medium-format Hasselblad—with equivalent lenses—you would notice the penny in the iPhone shot, you’d clearly see it in the Nikon shot, and you could read the date in the Hasselblad shot.

Holding the 500C, I could hardly believe that I had spent so much money on a box. That’s all a camera is, really: a box with a hole. Film rests at the back of the box and the lens is at the front. The shutter sits between them, and by opening for longer or shorter durations it exposes the film to certain amounts of light. Most cameras have some kind of automation, elevating them beyond a dumb box. The Hasselblad doesn’t: it has no electric parts, no automatic focus, no light meter; it doesn’t even have an automatic film-winding mechanism. It holds only twelve photos per (expensive) roll of film. But it is beautifully machined, with solid, precisely interlocking pieces.

Because of its simplicity, shooting with a 500C is deliberate in ways that few other cameras can match: you line up your shot, take a deep breath, and then, when everything comes together—light, shadow, and subject—squeeze the release and mumble a short prayer as the cloth shutter opens and closes with a thick, satisfying thunk. It almost feels like the camera is munching on the photons of light passing through it. I loved looking at the world through its precisely ground glass, though now it sits idly on my desk, its obstinate, mechanical simplicity a lifeless monument to the designer Sixten Sason’s hard-edged minimalism.

In late 2004, after graduating college, I scrounged together enough cash to buy my first real digital camera: the Nikon D70, which was almost identical to the 8008 except that, when the shutter opened, light hit an array of sensors rather than film. Even though that difference seemed small, the purchase made me nervous. I had developed hundreds, if not thousands, of rolls of black-and-white film in my badly ventilated, chemical-filled university apartment. Would I miss watching ghostly images appear from the silver halide salts, the sting of acetic acid on my hands and in my nostrils?

I stopped using film almost immediately. The benefits were too undeniable: results were immediately visible on the camera’s rear screen, and I could snap thousands of photos on a trip without worrying about fragile rolls of film, which were always an X-ray machine away from erasure. But the D70 was unromantic. It didn’t have the strangely alluring mechanical rawness of the 500C, while the shift to digital imaging disrupted the compartmentalized, meditative processes that had punctuated photography for the previous hundred and fifty years: shooting, developing, and printing. As anyone working in a creative field knows, the perspective gained by spending time away from work is invaluable. Before digital (and outside of Polaroids), photography was filled with such forced perspective. No matter how quickly you worked, it was common for hours—if not days, weeks, or longer—to pass between seeing the image through the viewfinder and reviewing it in the darkroom. Digital technology scrunches these slow, drawn-out processes together.

By late 2009, the five-year-old D70 felt about as fresh as the twenty-year-old 8008. It captured only 6.1 megapixels, less than a current smartphone, and the rear display was laughably small, the size of a postage stamp. On a whim, I picked up a brand-new Panasonic GF1, a so-called micro-four-thirds camera.

The GF1 and its oddly named technology heralded a subtly new type of device. Most professional 35-mm. cameras and their digital equivalents were single-lens reflex cameras. When you look into a typical S.L.R. viewfinder, you see a doubly reversed image, reflected once from a mirror in front of the film (or sensor) and twice more inside the viewfinder’s pentaprism. When you squeeze the button to take a picture, the mirror slaps upward—the loud clack that often echoes from professional-looking cameras—allowing the light to hit the film or sensor, capturing the image. The GF1 dispensed with both the mirror and the viewfinder, making it significantly smaller and lighter. When I went to Annapurna Base Camp, in central Nepal, the GF1 was so slight that I could keep it strung around my neck the entire trip, and the results were extraordinary. Not peering through the viewfinder to shoot provided a unique benefit: it altered the camera’s role in portrait photography. In an extensive field test from the trip, I wrote, “For better or worse, a camera without a viewfinder is less intimidating. You are no longer half-human half-camera … which is wonderful if you want candid, real photographs. Subjects focus on being human rather than being a subject.”

hat-580.jpg

After two and a half years, the GF1 was replaced by the slightly improved Panasonic GX1, which I brought on the six-day Kumano Kodo hike in October. During the trip, I alternated between shooting with it and an iPhone 5. After importing the results into Lightroom, Adobe’s photo-development software, it was difficult to distinguish the GX1’s photos from the iPhone 5’s. (That’s not even the latest iPhone; Austin Mann’s superlative results make it clear that the iPhone 5S operates on an even higher level.) Of course, zooming in and poking around the photos revealed differences: the iPhone 5 doesn’t capture as much highlight detail as the GX1, or handle low light as well, or withstand intense editing, such as drastic changes in exposure. But it seems clear that in a couple of years, with an iPhone 6S in our pockets, it will be nearly impossible to justify taking a dedicated camera on trips like the Kumano Kodo pilgrimage.

One of the great joys of that walk was the ability to immediately share with family and friends the images as they were captured in the mountains: the golden, early-morning light as it filtered through the cedar forest; a sudden valley vista after a long, upward climb. Each time, I pulled out my iPhone, not the GX1, then shot, edited, and broadcasted the photo within minutes. As I’ve become a more network-focussed photographer, I’ve come to love using the smartphone as an editing surface; touch is perfect for photo manipulation. There’s a tactility that is lost when you edit with a mouse on a desktop computer. Perhaps touch feels natural because it’s a return to the chemical-filled days of manually poking and massaging liquid and paper to form an image I had seen in my head. Yet if the advent of digital photography compressed the core processes of the medium, smartphones further squish the full spectrum of photographic storytelling: capture, edit, collate, share, and respond. I saw more and shot more, and returned from the forest with a record of both the small details—light and texture and snippets of life—and the conversations that floated around them on my social networks.

In the same way that the transition from film to digital is now taken for granted, the shift from cameras to networked devices with lenses should be obvious. While we’ve long obsessed over the size of the film and image sensors, today we mainly view photos on networked screens—often tiny ones, regardless of how the image was captured—and networked photography provides access to forms of data that go beyond pixels. This information, like location, weather, or even radiation levels, can transform an otherwise innocuous photo of an empty field near Fukushima into an entirely different object. If you begin considering emerging self-metrics that measure, for example, your routes through cities, fitness level, social status, and state of mind (think Foursquare, Nike+, Facebook, and Twitter), you realize that there is a compelling universe of information waiting to be pinned to the back of each image. Once you start thinking of a photograph in those holistic terms, the data quality of stand-alone cameras, no matter how vast their bounty of pixels, seems strangely impoverished. They no longer capture the whole picture.

It’s clear now that the Nikon D70 and its ilk were a stopgap between that old Leica M3 that I coveted over a decade ago and the smartphones we photograph with today. Tracing the evolution from the Nikon 8008 to the Nikon D70 to the GX1, we see cameras transitioning into what they were bound to become: networked lenses. Susan Sontag once said, “While there appears to be nothing that photography can’t devour, whatever can’t be photographed becomes less important.” Today, it turns out, it’s whatever can’t be networked that becomes less important.

Craig Mod is an independent writer and designer who divides his time between Tokyo and New York. He is the co-author of “Art Space Tokyo” and author of the forthcoming novel, “Stosh.”

Photographs by Craig Mod



Read more: http://www.newyorker.com/online/blogs/elements/2013/12/goodbye-cameras.html?printable=true&currentPage=all#ixzz2pH54VELD

Joaquim Machado

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Jan 2, 2014, 3:29:21 PM1/2/14
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Monday, December 30, 2013

Why processes fail us, and what to do about it



Organizations go through different levels of maturity as they grow. Some will say that they "learn to perform", others will say that they "become ossified and slow", yet others would say that they "mature". In my view neither of these classifications is accurate, they all touch on possible outcomes of a process of "aging". Organizations grow older, but what dynamics do we see in these organizations?

Organizations grow older, they age just like us!

A recurring pattern in organizations is that they create, develop and install processes. Processes are, for practical purposes, sets of rules that define how work should happen in those organizations. They are the rules we follow daily when we work.

These rules are necessary for a common understanding of expectations and roles for each of us. We need those rules or processes so that we know what to expect, and what is expected of us. Or do we?


What is the role for rules in an organization?

In the study of Chaos and Complex systems scientists have found that Complex or Chaotic systems exhibit infinitely complex behavior starting from very simple - perhaps even simplistic - rules. The most common example of these simple rules in documentaries about Chaos and Complexity is the way ants find their way to a new food source. The rules they follow are simple:

  • Walk around randomly and lay a pheromone path
  • When you find food, turn around and follow your pheromone path to the colony
  • While you walk around, if you find (bump into) an existing pheromone path, follow it

PS: you can find a much more detailed explanation here.

Following these simple rules Ants can not only find food, but feed an entire colony. In fact, when observed from an external view point we see complex System behavior even if one Ant alone follows a very simple set of rules.

The complex behavior we witness is Complex, and Adaptive. Hence the term Complex Adaptive System (or CAS).


What does this have to do with us - humans - and companies?

In investigating CAS we have found that the more complex the rules that we define, the less likely that the system (or company/organization) will be Adaptive. In fact, the opposite is true. Companies often put rules in place to "clarify, and specify" the expected behavior, thereby making it simple - or even simplistic. One glaring example of this phenomena is the way companies develop highly sophisticated goal-setting processes that eventually end up setting goals that distort the behavior of the organization in a way that makes it lose sight of what matters: their adapation to the environment they exist in (customers, suppliers, society, etc.).

The more complex the process and rules, the less Adaptable the organization will be!

But there are more examples of this phenomena whereby defining complex rule systems leads, invariably, to simple - even simplistic - behavior.

What's the role for rules?

What is now clear from research, is that simple rules can lead to Complex and Adaptive behavior in the "system" or organization. For us managers, this means that we must avoid the temptation to develop complex set of rules and must be on the lookout for rules that add burden to the organization and possibly constraining behavior to the point that the organization is unable to adapt to the changes it faces in the market.

The recipe to foster adaptability in the organization is simple: when possible remove rules, when in doubt remove rules. Add rules only when the cost of not doing so is prohibitive (legal boundaries for example) or when you've learned something about your environment that should be codified for everybody to follow (you found out that a certain technology is too expensive or unstable).

But here is the most important rule for you: All rules should be created as a result of a root-cause analysis, never as a result of a knee-jerk reaction to some unplanned or unpredictable outcome.

The most important rule: No rules should be established without a thorough Root-cause analysis!

The quote "Keep it Simple" really means: use less rules and more feedback! Like Agile...

Image Credit: John Hammik, follow him on twitter

Joaquim Machado

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Jan 3, 2014, 8:02:13 AM1/3/14
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Caterpillars use 'defensive halitosis' as anti-spider mechanism

SCIENCE

03 JANUARY 14  by OLIVIA SOLON 
Graphical representation of the interaction between the tobacco hornworm Manduca sexta and of the predatory wolf spider Camptocosa parallela: The exhaled via the tracheal toxic nicotine deters the spider
Photo: Danny Kessler; graphics: Pavan Kumar and Sagar Pandit, MPI chem Ecol.

Ecologists have discovered that a caterpillar feeding on tobacco leaves exhales a small fraction of the ingested nicotine to protect itself from being eaten by spiders.

The tobacco hornworm lava's previously unknown defence mechanism was identified by ecologists from the Max Planck Institute for Chemical Ecology.

Wolf spiders would usually reject the nicotine-fed larvae before biting into them and injecting a mixture of digestive enzymes and poisons.

To make sure that the spiders weren't put off because there was nicotine on the larvae's skin, the researchers washed the larvae. The spiders still weren't interested in eating the larvae.

The team put this defence mechanism to the test by manipulating the genes of the tobacco plant and of the hornworm larvae.

Wolf spider attacks a Camptocosa parallela tobacco hornworm in the laboratory
Photo: Pavan Kumar, MPI chem. Ecol.

On one hand, the team planted tobacco plants that were deficient in nicotine to see what effect that would have on caterpillar populations. They also took some hornworm larvae and silenced an enzyme (cytochrome P450 enzyme) that they use to catalyse the nicotine when they eat tobacco leaves. The team then observed what happened to those caterpillars feeding on nicotine deficient plants and compared the results to the caterpillars that lacked the active catalyser for the toxin.

The team found caterpillars that ate the nicotine-deficient plants were much more likely to be eaten by the nocturnal predator -- the wolf spider Camptocosa parallela, which normally avoids eating the larvae. Spiders tend to assess their prey by tapping it with chemosensory endowed legs and palps.

The spiders also preyed on those larvae deficient in theP450 cytochrome. This suggested that the enzyme plays an important role in the defence mechanism.

Further analysis showed that the enzyme is involved in transporting the ingested nicotine into the caterpillar's bloodstream (haemolymph), which lets the nicotine be exhaled from its spiracles (holes in their exoskeleton through which the creature breathes). Caterpillars exhale nicotine and this works as an anti-spider mechanism, although the "defensive halitosis" doesn't protect the caterpillar from other predators.

The paper is published in PNAS.

Joaquim Machado

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Spider webs reach out to entangle airborne prey thanks to electrostatic glue

SCIENCE

08 DECEMBER 13  by OLIVIA SOLON 
Fritz Vollrath

Spider webs reach out and grab airborne prey and particles thanks to an electrostatic glue that coats their surface, zoologists at Oxford University have discovered.

Typically, spider webs consist of sticky silk threads forming a spiral around a wheel of silk "spokes" radiating form a central hub where the spider lurks. Some spiders (cribellate spiders) have threads made out of a dry gossamer, formed of fine fibres with a wool-like consistency. These hold prey using electrostatic charges. Other types of spiders (ecribellate), like the garden cross spider studied, spin a capture spiral coated in wet silk droplets swollen with water and loaded with compounds that give the web a sticky, glue-like surface.

Spider webs
Spider web reaches out towards a charged sphere

This sticky surface attracts water droplets. These droplets carry the glue that traps prey but also build up electrostatic charges. This means that any charged particle that approaches the web will be attracted to the droplets. This results in the sticky, stretch threads of the web literally springing towards an approaching insect -- the web is so fine, light and stretchy that an extremely small electrostatic force is enough to have a dramatic effect.

In order to measure the conductivity of individual spiral threads, Fritz Vollrath, a professor at Oxford University's Department of Zoology, and colleagues built a small Faraday 'cage' to fit under a microscope and hold a one-centimetre long section of thread suspended between two metal holders. The metal holders were attached to an ohm-meter which could measure electrical resistance. The team experimented by taking a small charged metal sphere towards the web to see how it distorted. It found that whether the metal sphere was charged positively or negatively, the web would still be attracted to the sphere. This is because of ion mobility within water droplets. This applies not only to the individual web threads, but to the web spiral as a whole.

"Thus, in a very real sense, the capture spiral becomes active rather than remains passive and extends to entangle charged prey," explain the authors in the paper, published in Naturwissenschaften.

The researchers found that the spider webs are not only actively helping the spiders to catch prey, but are also very efficient and catching particles and pollen. "As a result, harvesting webs for chemical analysis may prove useful in assessing the extent of 'pollution' by airborne particulates," explain the authors.

The droplet-bearing webs can be useful for indicating the presence of heavy metals or pesticides, for example. Because many spiders recycle their webs by eating them, the spiders themselves will also accumulate the pollutants. It may even be possible to detect certain airborne chemicals simply by looking at the shape of the webs.

"Many spiders recycle their webs by eating them, and would include any particles and chemicals that are electrically drawn to the web," explains Vollrath in a press release. "We already know that spiders spin different webs when on different drugs, for example creating beautiful webs on LSD and terrible webs on caffeine. As a result, the web shapes alone can tell us if any airborne chemicals affect the animal's behaviour. Some studies have already shown that certain pesticides have an impact on web building behaviour.

The researchers also found that the webs distort the Earth's electrostatic field on a very local level. They hypothesise that this might mean that insect prey can actually detect the webs -- their antennae act as 'e-sensors' that will move a small amount when they approach a charged object -- but that further research is needed to demonstrate this.

Vollrath says: "Bees already use e-sensors to sense flowers and other bees, so it now remains to be seen whether they might also use them to avoid webs and thus becoming dinner."

Because the electrical disturbances caused by spider webs are so short-ranged, by the time an insect detects the threat, it might be too late.

Vollrath told Wired.co.uk that he was most surprised by the "elegance of the spider's web".  "These glue droplets and their action on the capture threads are not only self-assembling but the way they are able to collect even the smallest airborne objects (like pollen) as well as actively ensnare insects is truly inspirational (I think).  Nature at her best."

Joaquim Machado

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In 1964 Isaac Asimov accurately predicted how technology would look in 2014

CULTURE

03 JANUARY 14  by KATIE COLLINS 

Writing in the New York Times in 1964, science fiction author and biochemistry professor Isaac Asimov predicted what the world would look like 50 years on in 2014. His reflections were inspired by the lack of visions of the future at the New York World Fair. As Open Culture has pointed out, his descriptions of life at this moment in time are uncannily recognisable now that 2014 has finally arrived. Here, Wired.co.uk takes a look at the ways in which Asimov's predictions about how technology would evolve are reflected in the world around us today.

ENVIRONMENT AND LIGHTING

"Men will continue to withdraw from nature in order to create an environment that will suit them better. By 2014, electroluminescent panels will be in common use. Ceilings and walls will glow softly, and in a variety of colours that will change at the touch of a push button," wrote Asimov.

Philips/Desso

This sounds almost like a premonition of the Philips Hue lighting range and its LED carpet development. But while Asimov was right about the developments in lighting technology, our relationship with nature continues to be a complex one and humans have been more reluctant to accept simulations of the natural world than Asimov predicted. While it is true that we can now use lighting technology to simulate sunrises, to treat seasonal affective disorder and to nurture newly born animals, we have not, as Asimov speculated, retreated to living underground in a world where windows to the outside world are "no more than an archaic touch". In fact, bountiful natural light is seen as more desirable than ever in the worlds of architecture and real estate.

ROBOTS

Big Dog - Boston DynamicsBrooks Hargreaves

"Robots will neither be common nor very good in 2014, but they will be in existence. The IBM exhibit at the present fair has no robots but it is dedicated to computers, which are shown in all their amazing complexity, notably in the task of translating Russian into English. If machines are that smart today, what may not be in the works 50 years hence? It will be such computers, much miniaturised, that will serve as the 'brains' of robots."

Kirobo
kibo-robo/YouTube

No doubt Google's Translate tool would have blown Asimov's mind. But while he might be right about the prevalence of robots in our lives outside of industry, he surely would have been impressed by the quality of developments in robotics. From the terrifying robots built by Boston Dynamics, to adorable astronaut pal Kirobo, to Roomba the vacuum cleaner, 'droids have come a long way since the Sixties. Despite this, the role of robots in our world is as up for debate as it ever was, and the technology is constantly evolving still.

FOOD

Wilson Hennessy

"Gadgetry will continue to relieve mankind of tedious jobs. Kitchen units will be devised that will prepare 'automeals', heating water and converting it to coffee; toasting bread; frying, poaching or scrambling eggs, grilling bacon, and so on. Breakfasts will be 'ordered' the night before to be ready by a specified hour the next morning. Complete lunches and dinners, with the food semiprepared, will be stored in the freezer until ready for processing."

Asimov is mostly on the money here with his predictions ofcoffee machines, freezers and countertop microwave ovens, but his vision falls a little flat in its overestimation of the evolution in technology and underestimation of the changes in food culture, including the increased popularity of takeaway and processed convenience foods.

He does, however, spot one very unusual development in food culture, which seems absurd in the minds of many even today.

"The 2014 fair will feature an Algae Bar at which 'mock-turkey' and 'pseudosteak' will be served. It won't be bad at all (if you can dig up those premium prices), but there will be considerable psychological resistance to such an innovation."

Ogilvy

This sounds like a premonition of in-vitro meat creation, which became a reality only recently. In 2013, the world's first test-tube burger was cooked and eaten in London in front of an audience. Just as Asimov predicted, the idea turned the stomachs of many and the vast quantities of cash poured into the development and creation of the burger meant that there was only one of them to go around. Those who did in fact try it also pronounced that it was, to paraphrase, not bad at all.

THE COLONISATION OF SPACE

NASA/JPL-Caltech/Malin Space Science Systems

Asimov makes mention of Moon colonies, which he seems to presume would have been in existence by now. Obviously that's the not the case, but his predictions relating to human exploration of Mars are very close to the mark.

"By 2014, only unmanned ships will have landed on Mars, though a manned expedition will be in the works and in the 2014 Futurama will show a model of an elaborate Martian colony," he writes.

We have indeed sent unmanned spacecraft to the Red Planet, but manned missions and colonisation efforts are still, as yet, much talked-about but unrealised.

CONSUMER TECHNOLOGY AND COMMUNICATION

Apple

"The appliances of 2014 will have no electric cords, of course, for they will be powered by long-lived batteries," Asimov mused.

We don't yet live in a completely wireless world, but we do live in a mobile one, free of many of the cords that once bound appliance use solely to power points. Asimov also provides a startlingly accurate prediction of the mobile phone and tablet trend.

"Communications will become sight-sound and you will see as well as hear the person you telephone. The screen can be used not only to see the people you call but also for studying documents and photographs and reading passages from books. Synchronous satellites hovering in space will make it possible for you to direct-dial any spot on Earth, including the weather stations in Antarctica (shown in chill splendour as part of the '64 General Motors exhibit)."

"As for television," he continues, "wall screens will have replaced the ordinary set; but transparent cubes will be making their appearance in which three-dimensional viewing will be possible."

This is almost bang on. He foresaw flatscreen TVs and even 3D TVs, even if he didn't quite grasp how exactly they would work.

MACHINES REPLACING HUMAN WORKERS

Amazon Prime Airamazon

"The world of AD 2014 will have few routine jobs that cannot be done better by some machine than by any human being. Mankind will therefore have become largely a race of machine tenders," Asimov wrote.

The idea of machines replacing human manual workers has been around since the dawn of the industrial revolution. Everything we now achieve by machine, we once had to do by hand, and Asimov recognised that this was only set to continue with the development of increasingly sophisticated and capable technology. While he doesn't make specific mention of Amazon delivery drones, he takes a fine stab at visualising how robotic vehicles might affect logistics and hints at the driverless car.

"Much effort will be put into the designing of vehicles with 'Robot-brains', vehicles that can be set for particular destinations and that will then proceed there without interference by the slow reflexes of a human driver."

A SUITABLE EDUCATION

Asimov goes on to say: "Schools will have to be oriented in this direction. Part of the General Electric exhibit today consists of a school of the future in which such present realities as closed-circuit TV and programmed tapes aid the teaching process [...] All the high-school students will be taught the fundamentals of computer technology, will become proficient in binary arithmetic and will be trained to perfection in the use of the computer languages that will have developed out of those like the contemporary 'Fortran' (from 'formula translation')."

It is painfully ironic that the importance of teaching coding in schools was recognised all the way back in 1964 and yet has only just started to be taken seriously by those responsible for drawing up education policy. Asimov saw that with the increasing use of technology and machines replacing humans in various workplaces, we would need a suitably adjusted academic curriculum that reflected skillsets demanded by industry. What he failed to predict was our failure to take this seriously until this frankly inexcusably late stage.

ECONOMIC EQUALITY

"Although technology will still keep up with population through 2014, it will be only through a supreme effort and with but partial success. Not all the world's population will enjoy the gadgetry world of the future to the full. A larger portion than today will be deprived and although they may be better off, materially, than today, they will be further behind when compared with the advanced portions of the world. They will have moved backward, relatively."

It is true that price and availability of internet access is still preventing much of the developing world from enjoying "the world of the future" to the full, but Asimov had no way of knowing about the ultra-budget phone and tablet trend and did not perhaps give credit to technology for its transformative power. Technology has not closed the gap between the developing and developed worlds, but it has not set the former back, even relatively.

SCIENCE FICTION VS REALITY

Many of Asimov's predictions for 2014 have become a reality -- some only in the nick of time. Others he got only partially right, and some not at all.

While he foresaw that advances in medicine would increase average life expectancy, causing population sizes to swell, he also imagined a dramatic propaganda campaign relating to birth control that would have taken its grip on society.

Downtown urban areas he thought would be decked out with "moving sidewalks (with benches on either side, standing room in the centre)". He also thought that: "compressed air tubes will carry goods and materials over local stretches, and the switching devices that will place specific shipments in specific destinations will be one of the city's marvels."

At the time Asimov mulled these ideas, there was the possibility that thermonuclear war would make them all irrelevant. As it happens, the war did not take place and what has come to pass is almost, if not quite, the future that Asimov imagined "with buoyant hope" would become a reality.

Joaquim Machado

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January 9, 2014

Writers and Rum

Posted by Adam Gopnik

2669933-580.jpg

“Writers in this office used to drink,” a grizzled veteran of these corridors once said sternly to a couple of pup reporters, whom he had discovered taking turns trying on a good-looking cashmere jacket in another cubicle. The moral, abashing if not shaming, was that in the halls where once real men had roamed, or drank in peaceable closets, now mere jacket-fanciers wandered. Certainly, it’s impossible to turn the past pages of this magazine, or the pages of American literary history, for that matter, without being reminded of how inextricable the drinking life and the writing life—or, to put it more bluntly, alcoholism and art—once were. From St. Clair McKelway to Dorothy Parker and James Thurber, and from Ernest Hemingway to F. Scott Fitzgerald to Sinclair Lewis and beyond, it was not long ago that if you wrote you drank, and if you weren’t drinking it was because you were drying out.

The critic Olivia Laing has just published a good, sad book on this subject called “The Trip To Echo Spring: On Writers And Drinking,” which tells at length the mostly familiar but still melancholy stories of the drinking lives of Fitzgerald and Hemingway and Tennessee Williams and John Berryman and John Cheever and Raymond Carver, complete, it sometimes feels, with tipped-in napkin stains from each of their favorite bars. Oddly fixated, for a Brit, who surely has plenty of scribbling drinkers in her own country, on this one—a reviewer in the Times claims that she “romanticizes the vast American landscape as a place made for rumination,” though rum-ination seems more like it—she entangles the story of these gifted men with tales of her own alcoholic family. We attend an A.A. meeting in her presence, and then are off to Key West, where Hemingway downed many and Tennessee Williams even more. Tender and sympathetic though she is to her subjects’ compulsions, and difficult though it is to be completely immune to the appeal of dissolute lives in our timid time, it mostly makes for depressing reading, which was, perhaps, her point.

I’m just old enough to be able to have seen the tail end of that literary culture of really big drinkers—and a real culture it was, as Laing understands. It may be hard to believe that it was so, when nowadays we mostly ingest our drugs from prescription bottles, early in the morning or late at night—but it existed, and was as alluring as it was utterly toxic.

As I wrote in my book about eating and drinking, “The Table Comes First,” one of my early editorial occupations was taking two remarkable writers, Mordecai Richler and Wilfrid Sheed, once a month out to a largely liquid lunch. Both died before their day. Sheed, at least, did what a writer should, and got a very fine book, “In Love with Daylight”, out of it later on—all about drying out, with pills and cancer thrown into the Job-like bundle—marred only by the rummy’s blind certainty that what he suffered from was merely social drinking, plus a little more. (They can be pulling the tiny bottles out of your hand in the hotel room after the third blackout, and you can still stubbornly believe that it’s just social drinking, maybe a little more.) “I took more from alcohol than alcohol has taken from me,” Sheed liked to quote Churchill as saying—and what that old drinking culture took from alcohol was sociability, of a rather Londonish kind, where the bumps and bruises of literary conflict seemed at least to heal a little sooner and the literary types mingled more freely. (Sheed, for one, was equally at home with the National Review crowd and the New York Review of Books crowd and the New York Daily News crowd, and he wasn’t unique.)

At the other, soberer end, John Updike once said to an admirer that the reason for the astonishing longevity he shared with Philip Roth—not just achieving the second acts that Fitzgerald said were impossible in American lives but third acts and fourth acts and then both men appearing, so to speak, out in the lobby to shake hands and do card tricks after the show—was, simply, that neither drank. He brought it up because he knew it was unusual. Growing up, he had absorbed the notion that a good writer wasn’t just possibly a drunk; a good writer had to be a drunk to be any good at all. (Jazz musicians, I think, believed something similar about the harder stuff, though the price they paid was more obvious in jail time and the advantages they took more obvious, I’m told, in blissed out periods. Bill Evans’s piano playing circa 1961 makes a strong case for heroin.)

Of course, ballplayers and ballerinas and aluminum-siding salesmen, for that matter, all drink, too, or used to. But most aluminum-siding salesmen or ballerinas presumably saw drinking too much as a problem, whereas writers, for a surprisingly long time, as Laing reminds us, saw drinking as an essential feature of the act, a complement to the act of authorship. When Norton and Kramden overindulge at the Raccoon Lodge, they say, “Oh, what a head!” Only writers say, “Oh, what a chapter!”


* * * 

If a theory is called for—and when is it not, in these woods?—to explain this phenomenon, it is that writing is work in which the balance necessary to a sane life of physical and symbolic work has been wrested right out of plumb, or proportion, and alcohol is (wrongly) believed to rebalance it. Anyone not a writer is probably sick of hearing how hard writing is, and obviously writing is not nearly as soul-destroying as coal mining or burger flipping or whatever you like. But writing is, if not uniquely hard work, then uniquely draining work. Some basic human need for a balance between thinking and acting is still kept intact even by the most tedious of other tasks. All rewarding effort involves a balance between wit and work—between the bits you do alone in your head and the bits you do in company with your hands (or voice or body or whatever). Laboring in your head, exclusively, does feels unnatural; whatever else we might have been doing, back out there on the primeval savannah, we weren’t sitting and moving the ends of our fingers minutely on a stone surface for six hours at a stretch.

The dramatic and plastic arts have elements of both wit and work intertwined—actors move around and shout, a director moves them (and shouts at them); painters have the sheer physicality of paint, and the givens of the canvas offer you four lines and a white surface to start with. A writer, on the other hand, stares out mournfully over the abyss of language—there are, truly, an infinite number of ways of forming the sentence you are about to attempt, all save one of them ugly and inadequate. And there’s nowhere to look for help but your own fingers.

The only cure, or hope, is to make the act of writing physical—to move it from your head to your gut—and, in doing so, to make it automatic, aerobic. That’s hard, and can be done in only two ways, both calling for outside assistance. One is to take the drug, or drink, and hope that it helps to ‘physicalize’ the work, move the pedals, and start the breathing—the theory used by those writers, like the elder Hemingway, who do the drinking and the writing simultaneously. Or else, to make the transition from mind to hand sober, knowing that the exhaustion it engenders will call for an antidote. Drained, one wants to replenish, and the whiskey or wine bottle is at hand. This is false reasoning of course, but it is the speciousness of writers.

Or was. No generalization about literature ever survives contact with the enemy, reality—doubtless there’s a young novelist in New York now writing her twelve-hundred-page opus on love and Brooklyn with a bottle of Jack Daniels in hand, and certainly Gary Shteyngart is doing his bit for the virtues of vodka. Still, there’s a general sense that the drugs of choice for writers now are more often little blue pills than big brown bottles. The onset of feminism, which compelled male writers at last to take some responsibility for their kids (one of the things that Laing’s writers certainly were not were present-tense dads), the diffusion of literary life from narrow bands of energy in London and New York and Paris into the academic monasteries of creative-writing programs—all of this has made the evening’s common cocktail a lost communion cup. (You can take the pill, and then send the kids to school.) Writers cope with the drain of writing now with yoga and meditation and marital discord (and, of course, with weed and Oregon Pinot, too) but the heyday of the writer with the whiskey bottle always on his desk seems past.

The price we pay for the end of the drinking life for writers is, perhaps, not so much isolation, though that is so: people can’t believe how few writers actually know other writers; the bars solved that for the old guys, at least. We also pay it, perhaps, in undue cheerfulness and extended youthfulness. The single most astonishing thing about the old-time writers Laing studies is how old they were when still young. Alcohol ages. Fitzgerald died just past forty, but everyone was already treating him like Rip Van Winkle. This was partly because he had out-lived his time but mostly because youth died then with the young. Now hair dye and twenty-four-hour gyms and wild salmon and celery juice or whatever have extended youth or the illusion of youth right to the edge of extreme old age. The unduly extended boyishness of this generation’s fully mature writers is still much spoken of, with annoyance, often by critics of what must seem to the boyish writers unduly extended girlishness. (The boyishness takes the form of being too arch for too long, the girlishness of being too catty too often.) But life is always worth extending on any terms available. “American writers are so strange,” an aging (and alcoholic) British wit once said. “ They’re such … chirpy chappies.” The price of a lot less drink may be far fewer barroom sing-alongs among the bards, but also far fewer early deaths, if ever more chirpy chaps. It seems a decent trade.

Photograph: Evening Standard/Getty.



Read more: http://www.newyorker.com/online/blogs/books/2014/01/writers-and-rum.html?printable=true&currentPage=all#ixzz2q0YpfgrI


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A edicao de jan/fev esta excelente !

Joaquim Machado
mindwings&leblon
Envoyé de mon iPhone

Joaquim Machado

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LIFE SCIENCE TECHNOLOGIES
Brave New RNA World

picture

The discovery of RNAi revealed an entire layer of previously unknown gene regulation; new tools are helping more scientists analyze and manipulate this system to probe the secret lives of cells.

By Alan Dove

Inclusion of companies in this article does not indicate endorsement by either AAAS or Science, nor is it meant to imply that their products or services are superior to those of other companies.

In the beginning there was RNA, at least according to some theorists. While life may have originated with self-replicating RNA molecules, molecular biologists have long focused on DNA. There were good reasons for that bias though. Besides being widely perceived as carrying the definitive copy of life's instructions, DNA was also much easier to work with in the laboratory.

Now, though, both of those rationalizations are crumbling. The discovery of an entire layer of gene regulation based on non-protein–coding pieces of RNA, and the simultaneous development of new tools and techniques for working with those molecules, have spurred intense interest in understanding and exploiting the RNA world. In the past few years, the field's innovations have ranged from solving simple problems, such as preserving RNA preparations for future analysis, to opening entirely new frontiers with methods to sequence all of the RNA transcripts in a single cell. The latter method has become so straightforward that some researchers are even using it to replace transcript-profiling chips. Meanwhile, established techniques such as silencing genes with short interfering RNA (siRNA) have been overhauled for improved reliability.

Decoded Messages

A fundamental advance in studying RNA came in 2008, when researchers described a technique for sequencing all of the transcripts in a population of cells. The method, RNA-Seq, entails reverse-transcribing purified messenger RNA, then using next generation sequencing tools to sequence all of the resulting cDNA. The result is a complete sequence of the cells' transcriptomes.

Sequencing entire transcriptomes is powerful, but the original versions of RNA-Seq had some limitations. "In 2009, our first RNA-Seq kit required at least a microgram of RNA, and it was preferably very high quality [RNA], otherwise you wouldn't get good results," says Gary Schroth, distinguished scientist at Illumina in San Diego, California.

Illumina has since refined the procedure, and now offers kits for performing RNA-Seq on as little as 100 ng of RNA, allowing researchers to sequence transcriptomes of small tissue samples. The company also offers reagents for removing ribosomal RNA, one of the major contaminants that complicated first-generation RNA-Seq.

In an evolution of the technique called Smart-Seq, researchers have even managed to sequence the transcriptomes of individual cells. "The notion of being able to do single-cell [RNA sequencing] is something that a few years ago I would've said 'no way,' but it turns out that it's actually not that difficult to go down to those levels ... when you have an isolated, free-floating cell," says Schroth. Smart-Seq doesn't work on crude tissue preparations, though, so RNA-Seq remains the preferred method for studying those samples.

As transcriptome sequencing continues developing and sequencing costs continue falling, many biologists are now using RNA-Seq for routine transcriptome profiling, a job previously reserved for RNA profiling chips. The chips work by hybridizing RNA to an array of short oligonucleotides to determine which transcripts are present. While that approach has been a workhorse of transcriptome analysis for years, it can only identify the RNA sequences the chipmaker predicted a cell would produce. Because RNA-Seq is unbiased, it often reveals alternatively spliced RNA forms and novel transcripts that don't show up on chips, and allows investigators to dig more deeply into the data. Schroth, whose company makes equipment for both types of analysis, argues that the chips may still have an advantage for some researchers processing large numbers of samples.

Regardless of the transcript profiling strategies they use, biologists are now keenly aware that transcription does not guarantee that a gene product is expressed. In particular, the RNA interference (RNAi) system produces numerous short RNA pieces that bind expressed transcripts and target them for destruction. Researchers initially sought to study this system by sequencing the cell's population of short RNAs and quantifying the relative abundance of different sequences. That proved to be tricky.

"What we found doing some in vitro experiments is that some cell populations of small RNAs just aren't represented as well in sequencing libraries as others," says Brett Robb, senior scientist at New England Biolabs (NEB) in Ipswich, Massachusetts. In particular, many animal and plant cells modify the 3' ends of their small RNAs, and standard sequencing methods underrepresent these modified molecules. To solve that, Robb and his colleagues optimized a ligation-based technique that sticks a specially modified DNA adapter onto the small RNAs before sequencing.

As scientists continue looking more deeply at posttranscriptional gene regulation, they're discovering additional species of RNA. "A lot of the things we've learned as we've been studying small RNAs will be pretty useful for some of the newer things like these long noncoding RNAs (lncRNAs) that have been pretty hot recently," says Robb.

The lncRNAs are pieces of RNA over 200 nucleotides long that don't encode proteins but instead appear to regulate transcription and translation in multiple ways. In large-scale sequencing projects, scientists have estimated that the human genome encodes at least tens of thousands of lncRNAs, suggesting that these molecules represent another major layer of gene regulation.

The lncRNAs are double stranded and can be encoded by either strand of the genomic DNA. That posed a major problem for early lncRNA researchers, who often had difficulty figuring out which DNA strand a particular lncRNA came from. In response, NEB has now developed a kit called NEBNext Ultra to produce strand-specific sequencing libraries.

A Moment of Silence

In addition to sequencing and studying noncoding RNAs, researchers have also been using them as tools to probe gene functions. Knocking down a target protein's expression transiently with synthetic siRNA oligonucleotides has become a standard laboratory technique, and drug developers continue to explore ways to use the RNAi machinery to treat diseases.

Indeed, RNAi-based therapies have followed the same cycle as many other technologies adopted by the biopharmaceutical industry. "When RNAi was discovered of course there was a lot of excitement, and then it's [been] the rise and the fall and then the rise of RNAi," says Nitin Puri, senior product manager for RNAi technologies at Life Technologies in Carlsbad, California.

The initial promise of being able to transiently shut down expression of any gene soon gave way to reality, as researchers discovered that their synthetic siRNAs often targeted multiple transcripts, and often lacked the potency of more traditional drugs. Since that initial letdown, the field has gradually recovered and investigators have begun to address some of those problems. "We see a lot more interest [in siRNA] now with researchers in the last two to three years, because there's this realization of how this technology is helping researchers really understand and get more insights into their high throughput screening," says Puri.

Using improved oligonucleotide design algorithms and chemical modifications, for example, Life Technologies can now synthesize potent and specific siRNAs against individual or multiple genes. By performing high throughput screens with these new siRNAs, scientists can quickly narrow the list of gene products that might be responsible for a particular phenotype.

Even a good high throughput screen still generates a lot of artifacts, though, often highlighting numerous genes that aren't directly related to the phenotype the investigator wants to study. New strategies for searching through the data may help. "We are working with researchers who are developing new approaches, especially bioinformatic approaches, to weed out some of the nonessential genes," says Puri.

Researchers have also learned to keep their expectations for siRNA realistic. "Those who've been in the field for awhile and using RNAi, they've come to understand and be much more accepting of its natural limitations," says Louise Baskin, senior product manager at Thermo Fisher in Waltham, Massachusetts, adding that "it's a promiscuous mechanism by nature—we do what we can to make it very specific, but there's always a chance that something's happening that's unanticipated."

Even highly specific siRNAs against important gene products can fail to produce a phenotype, for reasons biologists know all too well. "One of the frustrations with doing gene-by-gene knockdown is that our cells are very smart, they have secondary pathways and redundant mechanisms to save themselves," says Baskin. To maximize a siRNA screen's chances of success, she suggests using panels of siRNAs against multiple gene targets in a pathway instead of just one. Thermo Fisher supports that strategy with premade libraries of siRNAs to target any known gene in humans, rats, or mice, and the company recently added libraries of siRNAs against long noncoding RNAs as well.

For researchers who want to work with primary cells or intact tissues, just getting siRNAs to their targets can also be a problem, as these cells often resist conventional transformation techniques. To address that, Thermo Fisher has developed a line of self-delivering siRNAs, which carry a chemical modification that allows them to enter cells directly.

A Quick Knockout

While synthetic siRNAs provide a convenient way to knock down gene expression transiently, researchers looking for a more lasting effect usually turn to DNA vectors encoding short hairpin RNAs (shRNA). Cells transformed or transfected with one of these vectors transcribe the shRNA in the nucleus, where it is processed through the natural RNAi machinery to form siRNA against a specific transcript. The vector persists in the cell, permanently silencing the target gene product.

By pooling a set of shRNA vectors targeting different transcripts, investigators can produce a population of cells in which each cell has a different gene silenced. Isolating the cells that display a desired phenotype, then sequencing the vectors they're carrying, provides a quick map of the genes that are likely involved in that phenotype. This pooled approach has drastically reduced the cost and complexity of high throughput shRNA screening. "Instead of taking one shRNA into one well of cells and looking at the results, you put many shRNAs, even thousands, into one plate of cells at a time, and if you plan and carry out your experiment carefully ... you can rapidly screen lots of genes at a much lower cost and much faster," says Shawn Shafer, functional genomics market segment manager at Sigma Life Sciences in St. Louis, Missouri.

To aid those analyses, scientists in the Broad Institute's RNAi Consortium have produced libraries of shRNAs targeting 15,000 human and 15,000 mouse genes. The shRNAs are packaged in lentiviral vectors that can transfect a wide range of cells. Both Sigma and Thermo Fisher now offer these libraries to researchers. The consortium is now trying to create at least two highly potent, validated RNAi-based inhibitors for each human and mouse gene, as well as inhibitors for long noncoding RNAs. Those reagents should make high throughput genetic screens even easier.

As the tools improve, researchers are uncovering new complications. Recent data on the mechanism of RNAi suggest that a small "seed sequence" of only seven nucleotides may determine the specificity of small RNAs. That could help explain the promiscuous effects of many siRNA and shRNA inhibitors; a seven-base sequence can potentially bind many more transcripts than a 22-base sequence. "What they're doing now with pooled screens is requiring two or three shRNAs against the same transcript to pop up as hits, to sort of serve as revalidation of that initial hit," says Shafer.

Sigma also offers kits to apply the same approach to siRNA experiments. In the company's EasyRNA protocol, an experimenter can amplify a segment of a transcript and turn it into a pool of siRNAs covering the entire segment. Targeting the transcript with multiple, custom-made siRNAs may help maximize silencing while minimizing off-target effects.

Designing highly potent shRNAs for long-term gene silencing has been a tougher problem. Originally, biologists simply borrowed the algorithms they'd used to design synthetic siRNAs and applied them to shRNA vectors. That didn't work very well. "If you take a [siRNA] sequence and you put it in and try to express it in a vector, you get a lot of variability in function," says Andy Crouse, senior product manager at TransOMIC in Huntsville, Alabama.

The difference in performance between a siRNA and a shRNA with the same sequence probably stems from their very different pathways through the cell. Crouse explains that while shRNAs are transcribed and processed by the same cellular machinery that runs the natural RNAi system, synthetic siRNAs bypass much of that process and bind directly to their target transcripts.

For awhile, scientists worked around the problem by simply using multiple shRNA vectors against each transcript they wanted to silence, in the hope that one or a combination of them would work well enough. The ability to do pooled shRNA screens eventually allowed researchers to isolate the most effective shRNAs from a large set. Analyzing the pool of successful shRNAs led to a new algorithm that can accurately predict the best shRNA sequence for silencing a given target. TransOMIC now uses that algorithm to design custom sets of shRNAs, and also prebuilt shRNA libraries that target particular families of genes.

As the technologies for studying noncoding RNA continue to develop, experts in the field see a promising future for the RNA world. "Human complexity cannot be accounted for by our proportionally small number of protein-coding genes ... the complexity that we have is in the percentage of our genome that is transcribed into RNA but never actually makes a protein," says Thermo's Baskin. She adds that "it's really infinite possibilities in terms of how to study and what those might really mean to our understanding of biological systems."


Joaquim Machado

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Midwings & Leblon


Prezados Senhores e Senhoras

Em nome do Instituto de Energia e Ambiente da Universidade de São Paulo temos o prazer de convidar para a posse do Prof. Dr. Jose Goldemberg 
na Academia Paulista de Letras que ocorrerá no dia 13 de fevereiro de 2014, às 19h00, no Teatro da Academia Paulista de Letras, Largo do Arouche, 312, São Paulo, SP.

Por favor confirme presença no email ines...@usp.br para que eu possa encaminhar essa informação para a APL.

Atenciosamente,

Ines Iwashita
ST Relações Institucionais e Comunicação
Instituto de Energia e Ambiente da USP
fones 11 3091-2507 e 97205-1827 e 99603-4819
 

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É instrutivo ler a notícia abaixo sobre o Nexo AgroTrader, à luz daquilo publicado também pelo Jornal Valor ontem, sobre o perfil de despesas e de desinvestimentos (em  Inovação, Sanidade, Sustentabilidade ) do Ministério da Agricultura do Brasil. 

A associação de de dificuldades inatas com Planejamento Estratégico - similar ao da Arena de Curitiba & outras - com o movimento estratégico global das Traders & AgroFood Supply Chain, traça um cenário muito interessante.


13/01/2014 às 15h47



Chinesa Cofco negocia participação na holandesa Nidera

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HONG KONG  -  A trading estatal chinesa Cofco fez uma oferta para adquirir participação minoritária na trading holandesa de grãos Nidera, no mais recente movimento do país mais populoso do mundo para adquirir ativos no exterior e garantir acesso a insumos.


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Joaquim Machado

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Jan 22, 2014, 11:03:48 AM1/22/14
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Nosso colega Andres Ochoa, da SYNTECHBIO,  nos envia esta interessante informação:



In Brazil, São Paulo, at São Paulo University

Our first supported project of 2014 is rolling!!

Open call for participation

http://www2.eca.usp.br/hibrida/



Edgar Andrés Ochoa C.
PhD in Biotechnology
Synthetic Biotechnology Research

Research Associate
GaTE - Genomics and Transposable Elements Group
Departamento de Botânica-IB-USP
Rua do Matão, 277
05508-090; São Paulo, SP, BRASIL




Joaquim Machado

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Jan 22, 2014, 11:54:19 AM1/22/14
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JANUARY 21, 2014

SNOWDEN CALLS RUSSIAN-SPY STORY “ABSURD” IN EXCLUSIVE INTERVIEW

POSTED BY JANE MAYER

459251247-290.jpg

Edward J. Snowden, the former National Security Agency contractor turned whistle-blower, strongly denies allegations made by members of Congress that he was acting as a spy, perhaps for a foreign power, when he took hundreds of thousands of classified U.S. government documents. Speaking from Moscow, where he is a fugitive from American justice, Snowden told The New Yorker, “This ‘Russian spy’ push is absurd.”

On NBC’s “Meet The Press,” Mike Rogers, a Republican congressman from Michigan who is the chairman of the House Intelligence Committee, described Snowden as a “thief, who we believe had some help.” The show’s host, David Gregory, interjected, “You think the Russians helped Ed Snowden?” Rogers replied that he believed it was neither “coincidence” nor “a gee-whiz luck event that he ended up in Moscow under the handling of the F.S.B.”


Snowden, in a rare interview that he conducted by encrypted means from Moscow, denied the allegations outright, stressing that he “clearly and unambiguously acted alone, with no assistance from anyone, much less a government.” He added, “It won’t stick…. Because it’s clearly false, and the American people are smarter than politicians think they are.”

If he was a Russian spy, Snowden asked, “Why Hong Kong?” And why, then, was he “stuck in the airport forever” when he reached Moscow? (He spent forty days in the transit zone of Sheremetyevo International Airport.) “Spies get treated better than that.”

In the nine months since Snowden first surfaced, there has been intense speculation about his motives and methods. But “a senior F.B.I. official said on Sunday that it was still the bureau’s conclusion that Mr. Snowden acted alone,” the New York Times reported this weekend, adding that the agency has not publicly revealed any evidence that he was working in conjunction with any foreign intelligence agency or government. The issue is key to shaping the public’s perceptions of Snowden. Congressman Rogers, on “Meet the Press,” went on to allege that “some of the things he did were beyond his technical capabilities. Raises more questions. How he arranged travel before he left. How he was ready to go—he had a go bag, if you will.” Gregory then asked Senator Dianne Feinstein, a Democrat from California who chairs the Senate Intelligence Committee, and who was also a guest on the show, whether she agreed that Snowden may have had help from the Russians. She did not dismiss the notion. “He may well have,” she said. “We don’t know at this stage.” On CBS’s “Face the Nation,” Rogers made similar allegations, saying, “This wasn’t a random smash and grab, run down the road, end up in China, the bastion of Internet freedom, and then Russia, of course, the bastion of Internet freedom.”

Asked today to elaborate on his reasons for alleging that Snowden “had help,” Congressman Rogers, through a press aide, declined to comment.

An aide to Senator Feinstein, meanwhile, stressed that she did no more than ask questions. “Senator Feinstein said, ‘We don’t know at this stage.’ In light of the comments from Chairman Rogers, it is reasonable for Senator Feinstein to say that we should find out.”

Some observers, looking at the possibility that Snowden was in league with the Russian government before taking asylum there, have pointed to a report in a Russian newspaper,Kommersant, that before leaving Hong Kong last June Snowden stayed at the Russian consulate. Snowden’s legal adviser, Ben Wizner, a lawyer with the American Civil Liberties Union, denied that report, however, saying, “Every news organization in the world has been trying to confirm that story. They haven’t been able to, because it’s false.”

Snowden told me that having a “go bag” packed—something that Rogers described as highly suspicious—reflected his work deployed overseas for the C.I.A. He’d had a “go bag packed since 2007. It’s not an exotic practice for people who have lived undercover on government orders,” Snowden said.

“It’s not the smears that mystify me,” Snowden told me. “It’s that outlets report statements that the speakers themselves admit are sheer speculation.” Snowden went on to poke fun at the range of allegations that have been made against him in the media without intelligence officials providing some kind of factual basis: “ ‘We don’t know if he had help from aliens.’ ‘You know, I have serious questions about whether he really exists.’ ”

Snowden went on, “It’s just amazing that these massive media institutions don’t have any sort of editorial position on this. I mean these are pretty serious allegations, you know?” He continued, “The media has a major role to play in American society, and they’re really abdicating their responsibility to hold power to account.”

Asked about this, George Stephanopoulos, the host of ABC’s “This Week,” defended the coverage. Stephanopoulos pointed out that when the congressman Michael McCaul, a Texas Republican and the chairman of the House Homeland Security Committee, alleged that Snowden was “cultivated by a foreign power” and “helped by others,” Stephanopoulos pressed him for details, twice. “I did two follow-ups,” Stephanopoulos said, “and got as much as the congressman was going to give up.”

From Moscow, Snowden explained that “Russia was never intended” to be his place of asylum, but he “was stopped en route.” He said, “I was only transiting through Russia. I was ticketed for onward travel via Havana—a planeload of reporters documented the seat I was supposed to be in—but the State Department decided they wanted me in Moscow, and cancelled my passport.”

As for why he remains there, he said, “When we were talking about possibilities for asylum in Latin America, the United States forced down the Bolivian President’s plane.” If he could travel without U.S. interference, “I would of course do so.”

Snowden was adamant that he wants to help, not hurt, the United States. “Due to extraordinary planning involved, in nine months, no one has credibly shown any harm to national security” from the revelations, he said, “nor any ill intent.” Moreover, he pointed out that “the President himself admitted both that changes are necessary and that he is certain the debate my actions started will make us stronger.”

“If any individual who objects to government policy can take it into their own hands to publicly disclose classified information, then we will not be able to keep our people safe, or conduct foreign policy,” Obama said on Friday. “Moreover, the sensational way in which these disclosures have come out has often shed more heat than light, while revealing methods to our adversaries that could impact our operations in ways that we may not fully understand for years to come.” And Obama told David Remnick, in an interview for The New Yorker, that the leaks “put people at risk” and that, in his view, the benefit of the debate Snowden generated “was not worth the damage done, because there was another way of doing it.”

In the end, Snowden said that he “knew what he was getting into” when he became a whistle-blower. “At least the American public has a seat at the table now,” he said. “It may sound trite,” but if “I end up disgraced in a ditch somewhere, but it helps the country, it will still be worth it.”

Photograph by Barton Gellman/Getty.


Joaquim Machado

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Joaquim Machado

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nog94-cons-washn.pdf

Joaquim Machado

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Joaquim Machado

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Jan 23, 2014, 9:50:32 AM1/23/14
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Microbiol. Mol. Biol. Rev.-2008-Nevoigt-379-412.pdf

Joaquim Machado

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IN PURSUIT OF THE TRAVELING SALESMAN: Mathematics at the Limits of Computation
William J. Cook
Princeton University Press, 2012

Joaquim Machado

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Em tempos de "falta de probidade popperiana", observada na experimentação que busca confirmar o que interessa,  e não exatamente construir hipóteses  e testá-las, deveria ser prática corrente a (re) leitura contínua  e o lecionamento em primeiro semestre, do excelente compêndio universitário:

ENSAIOS ANALÍTICOS
Mário Henrique Simonsen
Editora da Fundação Getúlio Vargas
1994

Joaquim Machado

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Joaquim Machado

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cid:image001.jpg@01CF185D.DF36A800
Invitation

 The São Paulo Research Foundation, FAPESP, within the scope of the Biota-FAPESP Program,
and the National Science Foundation (NSF), invite you to the 

Workshop Dimensions US-BIOTA São Paulo:
A multidisciplinary framework for biodiversity prediction in
the Brazilian Atlantic forest hotspot
 

February 10th - 2014
Venue: FAPESP – Rua Pio XI, 1500 – Alto da Lapa – São Paulo – SP

The workshop will gather renowned scientists in the fields of biogeography, climatology, geology,
ecology and evolution to describe how recent advances in these disciplines improve the documentation
of diversity patterns in the Atlantic forest and enhance our understanding of their underlying processes.

Participants will discuss novel ways to integrate data and identify trans-disciplinary studies that can further help biodiversity prediction and protection in the region.

Registration and updated information
http://www.fapesp.br/eventos/usbiota

This event will be held in English with simultaneous translation to Portuguese

Program
8:30 am
Welcome coffee and registration
9:00 am
Opening remarks
9:10 am
The BIOTA/FAPESP Program: 12 years of a successful experience in combining biodiversity research, capacity building, bioprospection and public-policy impact, in São Paulo, Brazil
Carlos A. Joly – University of Campinas and BIOTA-FAPESP
9:40 am
Dimensions US-BIOTA-São Paulo: A multidisciplinary framework for biodiversity
prediction in the Brazilian Atlantic forest hotspot

Ana C. Carnaval and Cristina Y. Miyaki – The City University of New York and
University of São Paulo
10:10 am
Geomorphology and paleoclimates of the Atlantic Forest, and their potential
evolutionary implications

Francisco W. Cruz, Carlos Grohmann, Silvio Hiruma – University of São Paulo and Geological Institute
10:40 am
Coffee break and poster presentation
11:10 am
Raising the ghosts of communities past (with DNA)
Mike Hickerson – The City University of New York
11:40 am
Temporal scales of climatic changes and paleodiversity patterns in the Atlantic Rainforest 
Marie-Pierre Ledru – Institut de Recherche pour le Développement, Montpellier
12:10 am
Historical biogeography and climatic niche evolution in Leandra s. str. (Melastomataceae)
Marcelo Reginato and Fabian A. Michelangeli – The New York Botanical Garden and The City University of New York
12:40 am
Lunch break (restaurants around FAPESP)
2:30 pm
Atlantic Forest and landscape ecology - a multi-scale perspective
Milton C. Ribeiro – São Paulo State University – Rio Claro
3:00 pm
Climate modeling, INPE´s projections for the 21st century, and the distribution of Brazilian biomes 
Gilvan Sampaio – National Institute for Space Research
3:30 pm
Vulnerability of Atlantic Forest protected areas to climate change
Rafael D. Loyola – Federal University of Goiás
4:00 pm
Coffee break and poster presentation
4:30 pm
The Global Biodiversity Observation Network (GEO BON): some phylogenetic challenges
Dan P. Faith – Australian Museum
5:00 pm
Round table and discussion
5:30 pm
Closing remarks
Cristina Y. Miyaki - The University of São Paulo

cid:image002.jpg@01CF185D.DF36A800

 
 

Joaquim Machado

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Jan 27, 2014, 4:11:38 PM1/27/14
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Joaquim Machado

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Jan 27, 2014, 9:18:43 PM1/27/14
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Scientific American

Creating Tastier and Healthier Fruits and Veggies with a Modern Alternative to GMOs

By combining traditional plant breeding with ever-faster genetic sequencing tools, researchers are making fruits and vegetables more flavorful, colorful, shapely and nutritious
 
Jan 23, 2014 |By Ferris Jabr 
| 
 

Credit: Wikimedia Commons/Peggy Greb, U.S. Department of Agriculture
 
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Armed with toothpicks and sour cream, Michael Mazourek and three friends marched into the field of 600 chili pepper plants. One by one, they pierced the habaneros and brought the juices to their tongues, cooling and cleansing their palates with cream now and then. Habaneros are typically some of the hottest chilies around, ranking as high as 350,000 on the Scoville scale of pepper pungency—40 times hotter than the jalapeno. The habaneros Mazourek and his team had grown in this experimental field at Cornell University were in no way typical, however. The four graduate students knew that, due to an unidentified genetic mutation, a portion of the peppers would not be very spicy. Exactly what they would taste like was a mystery.

If a particular habanero's juices indicated that it was relatively mild, they bit into it like an apple. Some of the peppers were smoky; others astringent. Some tasted faintly of sausage; others had the foul funk of gym socks. But the most interesting peppers by far possessed all the complex aroma and flavor of a habanero, yet none of its heat.

A few months earlier Mazourek had received a shipment of seeds from researchers at New Mexico State University. These seeds, they said, grew into habanero plants whose red peppers did not even register on the Scoville scale. Knowing that Mazourek was a plant breeder interested in pepper pungency, the New Mexico scientists thought he might like to study the tame habaneros himself.

Mazourek raised the seeds he got in the mail into adult plants and mated them with ordinary habaneros. Inside greenhouses he carefully transferred pollen between flowers on the two kinds of plants with tweezers, ensuring that the resulting offspring and, eventually, the 600 grandchildren would have a mix of their parents’ DNA. After growing that third generation in a quarter-acre field, he recruited some fellow scholars for the intrepid taste test.

As the friends ate the unusual peppers, they snipped off leaves from each plant, which they later crushed and liquefied to examine the DNA within. By syncing the results of the DNA analysis with what their palates had told them, the team managed to identify a specific genetic mutation that explained why some of the peppers lacked heat. Chili peppers get their fire from an oily molecule called capsaicin, which is produced by glands within the fruit—those leathery, seed-covered white or yellow bits that people usually cut out of a pepper. As it turns out, the same bucket brigade of chemical reactions responsible for making capsaicin is also essential for concocting a bouquet of associated compounds that give a pepper its scent. The heatless habaneros had inherited a mutation that nearly—but not completely—shut down their capsaicin factories, leaving the glands just functional enough to eke out a drop of capsaicin and fragrant molecules here and there.

Seeing a unique opportunity, Mazourek and his colleagues spent the next several years making crosses between various plants in an attempt to create a single variety that reliably produced habaneros with plenty of zest but no heat. Having illuminated pungency genetics, they no longer had to wait for plants to grow up and work their taste buds overtime simply to find out if the peppers were spicy or not. Instead, they could take a leaf from a young plant, analyze its DNA and determine whether it would produce blazing or bland peppers before deciding whether to raise it to maturity—a trick that made the whole breeding process more efficient. Today, their prized pepper is persimmon orange, a bit longer than a typical habanero and wonderfully piquant. They call it a habanada, as in no burning heat—nada, zip. Cornell hopes to license the habanada to a major seed company soon for wider distribution.

Mazourek belongs to a new generation of plant breeders who combine traditional farming with rapid genetic analysis to create more flavorful, colorful, shapely and nutritious fruits and vegetables. These modern plant breeders are not genetic engineers; in most cases they do not directly manipulate plant DNA in the lab. Rather, they sequence the genomes of many different kinds of plants to build databases that link various versions of genes—known as alleles—to distinct traits. Then, they peek inside juvenile plants to examine the alleles that are already there before choosing which ones to grow in the field and how best to mate one plant with another. In some cases breeders can even analyze the genetic profiles of individual seeds and subsequently select which to sow and which to disregard, saving them a great deal of time and labor.

Plant breeders have, of course, always used the best tools available to them. But in the last 10 years or so they have been able to approach their work in completely new ways in part because genetic sequencing technology is becoming so fast and cheap. “There’s been a radical change in the tools we use,” says Jim Myers of Oregon State University, who has been a plant breeder for more than 20 years and recently created an eggplant-purple tomato. “What is most exciting to me, and what I never thought I would be doing, is going in and looking at candidate genes for traits. As the price of sequencing continues to drop, it will become more and more routine to do sequences for every individual population of plants you’re working with.”

In particular, these tools are helping breeders pivot their attention toward qualities of food that are important to consumers, instead of fixating solely on the needs of growers. Aided by genomics and related molecular tests, breeders have managed to create a cornucopia of new foods that are already available at some grocery stores and farmer’s markets, including cantaloupe that’s firm and ripe in the winter, snack-size bell peppers, broccoli that brims with even more nutrients than usual, onions that do not offend the eye and tomatoes that do not disappoint the tongue.

Sowing change
People have been changing plants to suit their purposes for at least 9,000 years. Just about every fruit and vegetable we eat is a domesticated species that we have transformed through generations of artificial selection and breeding: saving seeds only from plants with the most desirable characteristics and deliberately mating one plant with another to create new combinations of traits. In this way our ancestors turned a scrawny grass named teosinte into tall plump-eared corn and molded a single species of wild cabbage into broccoli, cauliflower, Brussels sprouts and kale.

Until the early 20th century, most crops were open-pollinated, meaning that farmers allowed wind and insects to transport pollen between plants. Over time, however, farmers and scientists alike had noticed that allowing closely related individuals to exchange pollen sometimes resulted in small, sickly plants. Conversely, when plants with very different traits mated they often produced hybrid offspring that were healthier than either parent—plants that grew taller and larger and yielded more fruit, for example. In 1908 George Harrison Shull of Cold Spring Harbor Laboratory in Long Island, N.Y., published a paper demonstrating that a controlled cross between two highly inbred lines of corn created hybrid plants that were incredibly healthy and uniform in their traits—a very desirable outcome for farmers. Although the precise reasons for this "hybrid vigor" remain unclear, many major crops grown today are hybrids created in this fashion.

Instead of working solely with whatever variation was present in a given crop, researchers in the 1920s began exposing plants to radiation and mutagenic chemicals to deliberately induce new genetic mutations, some of which serendipitously proved advantageous. Deep red Rio Star grapefruit, dwarf Calrose 76 rice that does not fall over as easily as taller varieties, fungus-resistant Gold Nijisseiki pears and hundreds of other kinds of vegetables, fruits and grains we eat today are the result of such “mutation breeding,” which has become less popular over time.

By the 1980s, scientists had devised a much more precise way of changing a plant's DNA: genetic engineering, which is usually defined as adding, removing or otherwise directly altering genes in a plant using laboratory tools. Foods engineered in this way, commonly known as genetically modified organisms (GMOs), first appeared on the market in the U.S. in the 1990s. Although more than 70 percent of processed foods in the U.S. contain ingredients made from GMO corn, soybeans and canola, very few of the fresh vegetables and fruits sold in supermarkets have been genetically engineered. Exceptions include virus-resistant papaya, plum and squash, as well as pest-resistant sweet corn.

One reason that so few fresh fruits and veggies are GMOs is that, on the whole, they are far less profitable and less widely grown than the country’s biggest crops: corn, soybeans, hay, wheat, cotton and rice. When it comes to fruits, veggies and other so-called specialty crops, seed companies are not as motivated to deal with the burdensome and costly safety tests and federal regulatory procedures required to approve a GMO for sale.

The other big hurdle to GMO fruit and vegetables is public opposition. Genetic engineering is a technology—a specific way of modifying the plants we eat—and, like all technologies, it has both advantages and risks. Banishing all GMOs in one fell swoop solely because of the way they are made would be equivalent to, say, forbidding any object made by metalwork because some metal objects are dangerous. Instead, GMOs should be evaluated on a case-by-case basis. When not used responsibly, some GMO crops encourage overuse of certain weed-killers and insecticides, which can foster weeds and bugs that are very hard to kill. Yet researchers have alsodocumented cases in which crops genetically engineered to battle pests have significantly decreased the use of toxic insecticides, benefitting both farmers and the overall ecosystem. GMO rice could save millions from the debilitating consequences of vitamin A deficiency and genetic engineering is likely the most effective way to rescue disease-ravaged orange trees in part because it is so much faster than traditional breeding. As for health concerns, the American Association for the Advancement of Science, the World Health Organization and the European Union agree that GMOs are just as safe as foods created via conventional breeding. Despite all this, seed companies know that introducing new GMOs to the produce aisle today could ignite a furor among a large segment of the U.S. population. Most shoppers remain oblivious to the genetically engineered fruits and veggies already in stores because they are usually not labeled as such.

In part to circumvent the controversy surrounding GMOs, fruit and vegetable breeders at both universities and private companies have been turning to an alternative way of modifying the food we eat: a sophisticated approach known as marker-assisted breeding that marries traditional plant breeding with rapidly improving tools for isolating and examining alleles and other sequences of DNA that serve as “markers” for specific traits. Although these tools are not brand-new, they are becoming faster, cheaper and more useful all the time. “The impact of genomics on plant breeding is almost beyond my comprehension,” says Shelley Jansky, a potato breeder who works for both the U.S. Department of Agriculture (USDA) and the University of Wisconsin–Madison. “To give an example: I had a grad student here five years ago who spent three years trying to identify DNA sequences associated with disease resistance. After hundreds of hours in the lab he ended up with 18 genetic markers. Now I have grad students who can get 8,000 markers for each of 200 individual plants within a matter of weeks. Progress has been exponential in last five years.”

Marker-assisted breeding is one of the engines pushing breeders to completely rethink their craft. Whereas the major GMOs and most conventionally created crops on the market were designed primarily to benefit farmers, many breeders are now shifting their attention to the consumer. “Asking what the consumer wants sounds really obvious, but it’s not,” says Harry Klee, a tomato breeder at the University of Florida. “Almost always you see the opposite: people breeding for what the grower wants and pretty much ignoring what the consumer wants. There has been a disconnect between commercial growers and consumers that has in my personal opinion led to the deterioration of flavor and other qualities of our food.”

The palate paradox
Over and over again plant breeders have run into the same dilemma: tailoring plants to the needs of growers and grocers—guaranteeing high yield and the ability to survive days or weeks of shipping and storage in dark, cool conditions—often means sacrificing flavor and texture. Perhaps no food better exemplifies this predicament than the classic supermarket tomato.

For decades, experts have regarded the balance of acids and sugars in a tomato as the primary factor that determines whether people enjoy its taste. In general, people like tomatoes on the sweet side (although focus groups almost always have a few people who want a tomato with a kick). But most breeders have not been primarily concerned with flavor. With large-scale commercial growers in mind, breeders have instead favored tomato plants producing lots and lots of smooth, hardy fruit that remained plump on the sometimes long journey to the supermarket. The more tomatoes a plant makes, however, the fewer sugars it can give to each one. Typical supermarket tomatoes may look pretty, but they simply do not have enough sugar to satisfy our taste buds.

Klee is determined to rescue the industrial tomato from its current gustatory doldrums. At this point, he has screened nearly 200 varieties of heirloom tomatoes in taste tests—older cultivars preserved by small groups of farmers and gardeners and sold at some grocers and farmers' markets. Heirloom tomatoes are known for their vibrant colors and fantastic flavor, but their skin easily cracks and scars, they often go soft quickly and the plants they come from do not make enough fruit to meet the demands of large commercial farmers.

What Klee has learned from his research, however, is that many heirlooms are tastier than standard supermarket tomatoes not because they have more sugar, but rather because they are chock full of a much more elusive component of tomato flavor. In a 2012 study, for example, Klee and his colleagues discovered that people actually enjoy a tomato with moderate levels of sugar if it contains enough of a pungent compound called geranial. Klee suspects that geranial and other volatile compounds—molecules that waft off plants and into our nostrils (think: freshly cut grass or pine trees)—not only give a tomato its scent, but also magnify the fruit’s innate sweetness. In follow-up studies he created tomatoes that lacked geranial and other fragrant molecules. People did not like them. If a tomato had average to high sugar levels but no volatiles, volunteers did not perceive it as sweet.

Lately, Klee has been trying to make hybrid plants that give growers and consumers the best of both tomato worlds, old and new. In past three years he and his colleagues have mated the most delicious heirlooms they could find with modern conventional tomatoes to create crossbreeds that yield well, are firm and smooth-skinned and taste great. Klee routinely stocks up on cheap electric toothbrushes, which he and his team use to gently but thoroughly rattle tomato flowers, gathering the pollen that falls off in test tubes so they can play matchmaker. All the while the breeders have been using hole punches to collect bits of leaves and analyze the plants' DNA, looking for genetic patterns that correspond to high levels of volatiles, for instance, or flawless skin. “Genetic analysis has definitely informed crossing decisions,” Klee says. “Our work has really accelerated in last couple of years with the emergence of the tomato genome sequence.”

The University of Florida has just released two of these hybrids—Garden Gem and Garden Treasure—that they would like to license to a seed company for mass distribution. Although the hybrids do not yield quite as much as commercial tomatoes, they produce more than three times the number of fruit as their heirloom parents, their flavor is tremendous and they can survive a good deal of shipping.

In some ways the cantaloupe is the tomato of the melon world. Many Americans—especially on the east coast—remain sadly unaware of the cantaloupe’s true epicurean delights because they have never eaten the melon within a few days of picking. The vast majority of cantaloupes harvested in the U.S. are grown in California and Arizona and distributed elsewhere from there. When winter arrives, everyone in the nation is out of luck. Cantaloupes are rarely harvested in the continental U.S. from December to April or so—it is simply not warm enough for a melon whose ancestors evolved in the Middle East. Instead, the U.S. imports all the cantaloupes it consumes during the colder months from Honduras, Guatemala and other much more tropical countries.

To make such international exchange possible, breeders had to create unique types of melons. On the vine cantaloupes ripen and soften rather quickly following a burst of a plant hormone known as ethylene. If you pick a melon at its peak ripeness and eat it right away, it’s firm and flavorful. This speedy ripening is problematic when transporting the fruits long distances, however. Even on ice, the melons become mushy by the voyage’s end. Just as tomato breeders have favored hardy tomatoes that could survive shipping, melon breeders were partial to cantaloupes that did not produce as much ethylene as usual, so that they stayed firm on the trip from field to produce aisle. But the chemical reactions responsible for all the volatile compounds that create the characteristic melon aroma and taste do not happen without that spurt of ethylene. The end result: during the winter, U.S. supermarkets sell exceptionally insipid cantaloupes.

Several years ago, a plant breeder named Dominique Chambeyron working for Monsanto in France created a new kind of small, sweet cantaloupe that—amazingly—retained its firmness for weeks after it was harvested. Some grocers in the U.S., such as Sam's Club and Hy-Vee already sell this "Melorange" cantaloupe. Now, Monsanto's Jeff Mills and his colleagues are mating Melorange with conventional long-distance shipping cantaloupes in an attempt to greatly improve the flavor of the latter. Although Mills cannot divulge proprietary details, he confirms that he and his colleagues have identified melon genes underlying several traits, such as resistance to common melon diseases and the overall quality of the fruit.

Mills can look for these markers in cantaloupe seeds before deciding which ones to plant thanks to a group of cooperative and largely autonomous robots, some of which are housed in Monsanto’s molecular breeding lab at its vegetable research and development headquarters in Woodland, Calif. First, a machine known as a seed chipper shaves off a small piece of a seed for DNA analysis, leaving the rest of the kernel unharmed and suitable for sowing in a greenhouse or field. Another robot extracts the DNA from that tiny bit of seed and adds the necessary molecules and enzymes to chemically glue fluorescent tags to the relevant genetic sequences, if they are there. Yet another machine amplifies the number of these glowing tags in order to measure the light they emit and determine whether a gene is present. Monsanto’s seed chippers can run 24 hours a day and the whole system can deliver results to breeders within two weeks.

Like cantaloupe, U.S.-grown sweet onions are not available to most Americans between late fall and spring. Different types of onions require different lengths of daylight to begin forming bulbs underground and, consequently, are harvested at different times of the year. Pungent “long-day” onions need at least 14 hours of sunlight and are harvested in the late summer and fall, whereas sweet “short-day” onions need only 10 to 13 hours and are harvested in spring and early summer. By the time September arrives, however, the U.S. turns south to Peru, Chile, Mexico and other countries for its sweet onions, importing them until homegrown crops are ready for harvest the following spring.

More than a decade ago, Scott Hendricks and his colleagues at Seminis Vegetable Seeds began a project to make U.S.-grown sweet onions available to consumers in the fall. They started by growing fields of pungent long-day yellow onions and saving seed only from those that were sweetest. Instead of tasting onion after onion—an impractical strategy for obvious reasons—Seminis, which was acquired by Monsanto, developed a laboratory test for pungency. Their assay detects a byproduct of the chemical reactions that make onion lachrymatory factor—the volatile gas responsible for tear-soaked chopping boards. When a wedge of onion is liquefied and mixed with certain molecules, that once transparent byproduct turns a shade of amber, explains Monsanto's John Uhlig. He and his colleagues have similar chemical and mechanical tests for just about every vegetable they work with: probes that squish and prick melons and tomatoes to assess their firmness; a series of ice pick-like prongs that measure the crispness of lettuce; machines that distill scents and judge the intensity of pigments.

The final product of the breeding program initiated by Hendricks is known as the EverMild—a yellow long-day onion grown in the Pacific Northwest. Unlike many of its long-day white and yellow cousins, it contains low enough levels of onion lachrymatory factor to qualify as a sweet onion. Now, Jason Cavatorta, another Seminis onion breeder, is working on a mid-day variety of the EverMild to fill the current availability gap right smack in the middle of summer, which is a little too early for the EverMild and too late for typical sweet onion harvest. If he succeeds, the new onions will join two other foods that Monsanto recently created for the produce aisle: snack-size BellaFina bell peppers, which are one third as large as their more familiar cousins and are sold in plastic bags like baby carrots in WalMart and Safeway; and Frescada lettuce, a sweet crispy cross between iceberg and romaine available at Sam's Club.

Seeding innovation
Along with tomatoes, onions and melons, another notable vegetative victim of distribution difficulties is broccoli. About 75 percent of broccoli harvested in the U.S. is grown in California. Broccoli adores cool weather and flourishes in the Salinas Valley’s occasional fog blankets. When forced to endure hot sticky summers in the Northeast, the vegetable produces gnarly heads with buds of mismatched sizes. Each of the small buds that, together, make up broccoli's treetop dome is a flower that has not yet blossomed. Thomas Bjorkmanof Cornell and his colleagues recently discovered that, during a critical period of its development, broccoli counts how many hours of cool temperatures it enjoys and produces a uniform flowering head only if the tally is high enough. That's why broccoli grown on the east coast might end up with an unattractive mix of nice, plump flower buds and dinky, almost imperceptible ones.

Three and a half years ago, Bjorkman, Mark Farnham of the USDA and their many collaborators decided to breed a new kind of broccoli that would thrive in the eastern part of the country. In their lab's growth chamber Bjorkman and his team have been subjecting broccoli to east coast levels of heat and humidity, keeping seeds only from the plants that grow the most attractive flowering heads under these conditions. Although they have a lot of work ahead of them, they have already bred broccoli that can deal with a few more weeks of summer heat than the cultivars currently grown in the east. Meanwhile, the researchers are searching the genomes of the various plants they grow, looking for genes that explain why some broccoli fares better than others. Finding them could shave years off the journey toward their ideal plant.

Creating broccoli that stays beautiful in the heat is not just an exercise in aesthetics—it's also about getting tastier and more nutritious broccoli to farmer's markets and grocers. Fresh broccoli consumed the same day it was harvested is completely different from typical supermarket fare, Bjorkman says—it’s tender, with a mellow vegetative flavor, a hint of honeysuckle and no sharp aftertaste. Trucking broccoli from California to other parts of the country requires storing the vegetable on ice in the dark for days. With no light, photosynthesis halts, which means that cells stop making sugars. Rapidly dropping temperatures rupture cell walls, irrevocably weakening the plant’s structure and diminishing its firmness. When the broccoli is thawed, various enzymes and molecules that escaped their cells bump into one another and trigger a sequence of chemical reactions, some of which degrade both nutritional and flavorful compounds. Giving farmers in the east broccoli they can grow and sell locally solves all these problems. In a separate effort to boost the nutritional value of broccoli, Monsanto released Beneforte broccoli, which has been bred to contain extra high levels of glucoraphanin, a compound that some evidence indicates may fight bacteria and cancer. You can find the florets at some Whole Foods and States Bros.

In order to get the initial grant that kicked off the Eastern Broccoli Project, Bjorkman and Farnham had to assure the USDA that seed companies were genuinely interested in this potential new regional market for broccoli by securing funding from the private sector. Although they are technically competitors, Monsanto, Syngenta and Bejo Seeds are all contributing. In theory, both seed companies and university researchers can benefit from such collaborations. During the research and development phase, they all share information and even exchange seeds. Eventually, however, it is time for negotiations. As is the case for Mazourek and his habanada, as well as Klee and his tasty tomatoes, Bjorkman hopes that once he and his colleagues get closer to their beauteous broccoli, a private company will license those seeds and produce them on a massive scale for commercial growers. Bjorkman and his team simply do not have the capital to do so themselves. Sequencing the genomes of individual plants may be getting cheaper all the time, but generating enormous quantities of seed and marketing it to farmers is still a very costly endeavor.

Some plant breeders worry that because giant seed companies have far more financial and technological resources than do smaller firms and universities, true innovation will wither. “There’s been a rather large decline in public sector breeding programs as the technology has transferred into the private sector,” says Irwin Goldman of the U.W.–Madison, who recently debuted flame orange table beets with concentric gold stripes. “Some people argue that this transfer is a success for this country, but public breeding will do things that private sector won’t do—things that take too long or are too high risk.”

Jack Juvik, who is director of the plant breeding center at the University of Illinois at Urbana–Champaign and first got into breeding in the 1970s, remembers when big companies were not nearly as dominant as they are today. “When I first started, there were a lot of smaller companies selling a lot of seeds, but they have all been basically bought out or driven out of the market by the mega-companies. That has changed the whole texture of the industry,” he says. “Instead of having people at public institutions developing finished varieties, most of us design germplasm [seeds and cultivars] for big companies to work with. These large companies have the resources to do some good testing and make some really good varieties, but they end up controlling most of the germplasm and technology used to make it.”

Goldman and his University of Wisconsin-Madison colleague Jack Kloppenburg belong to a group of 20 breeders and farmers from around the country who are interested in creating the equivalent of open-source software for seeds—nonpatentable varieties that anyone can use. There's really no strong precedent for how to go about this in the 21st-century commercial seedscape, though. One potentially expensive option is for plant breeders to hire lawyers and obtain standard patents or copyright on their seeds with the intent of letting just about anyone use them (excluding mammoth private companies, of course). Alternatively, they could try to create a kind of open source license that allows people to use seeds only if they, too, agree to freely share them and anything they make with them. Goldman has also proposed a compromise in which breeders license some seeds to the private sector to make a profit, but give others away.

Klee also wonders whether a certain degree of conciliation is the best way forward. "The reality is we in academia cannot compete with the Monsantos or other big seed companies," he says. "Breeders at universities are pushed out of big crops and into niche crops. In my department we have a peach breeder, a blueberry breeder and a strawberry breeder. I know a lot of people at Monsanto who have dropped these kinds of crops that are marginal for them." Such dichotomy, he hopes, can be complementary, with the public and private sector relying on one another for distinct specialties.

Ultimately, what Klee cares about more than anything is the same prospect tantalizing more and more modern plant breeders: bridging the gulf between what growers need to make a living and what consumers want on their plates. "Marker-assisted breeding makes it possible to go back and fix things like flavor and texture,” Klee says. “In the end, it's really very simple: Let's give people stuff they like."

lllustration Credit: Marissa Fessenden
 













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ENGLISH VERSION BELOW
header
Directeur de publication
Laurence Tubiana
Rédaction
Pierre Barthélemy
 
JANVIER 2014 N° 47
L’agenda post-2015 : une opportunité pour l’agriculture et la sécurité alimentaire ?
Malgré la persistance de profondes différences régionales, d’importants progrès ont été accomplis en matière de lutte contre l’insécurité alimentaire depuis que la communauté internationale s’est accordée pour porter une attention spécifique à la réduction de la faim dans le cadre des Objectifs du Millénaire pour le développement. D’après les estimations les plus récentes, 842 millions d’individus sont encore en situation de sous-alimentation (FAO, 2013). L’immense majorité d’entre eux, soit 827 millions de personnes, se trouve dans les pays en développement. Au prix d’efforts supplémentaires, l’objectif de réduction de moitié de la proportion de personnes sous-alimentées à l’horizon 2015 pourrait être atteint. Cependant, l’effet combiné du réchauffement climatique, de la dégradation des ressources naturelles, d’une forte croissance démographique et de la volatilité des prix hypothèque le futur d’un monde sans insécurité alimentaire, tandis qu’un déplacement géographique de la sous-alimentation à l’échelle mondiale semble émerger.
C’est dans ce contexte qu’experts, gouvernements et société civile débattent pour concevoir l’agenda de développement post-2015. En matière de sécurité alimentaire, l’heure est au bilan et à la conception d’objectifs qui permettront de faire le lien entre durabilité environnementale, production agricole et sécurité alimentaire. Au-delà de la nécessaire définition d’objectifs de développement durable (ODD) ambitieux, la communauté d’experts se mobilise pour concevoir les moyens de les mettre en œuvre. L’Iddri participe à cette réflexion en organisant le 29 janvier avec la Fondation pour les études et recherches sur le développement international (Ferdi) et le ministère des Affaires étrangères un atelier pour faciliter le dialogue entre les différentes communautés qui pensent l’agriculture et la sécurité alimentaire dans l’agenda post-2015.
En effet, la question de la faim doit être connectée aux enjeux du système agricole et alimentaire. Ce dernier reste en grande partie dépendant d’intrants non renouvelables, affecte négativement les écosystèmes et la santé publique, tout en accélérant le changement climatique. Une transformation dans les politiques publiques et les pratiques est donc nécessaire pour accompagner la transition vers un modèle agricole axé sur l’intensification écologique, qui prenne en compte la multifonctionnalité de l’agriculture (production, mais également fonctions sociale et environnementale), préserve les ressources naturelles et soit générateur de prospérité. Au-delà des controverses entre modèles et pour parvenir à cette transition, il est capital de penser la transformation de l’agriculture, au Nord comme au Sud, par des études prospectives et la conception de scénarios de transition. L’Iddri prend part aux initiatives qui entendent clarifier la compréhension de ces transformations sectorielles, au niveau européen mais aussi dans les pays en développement. Parce que l’aide publique au développement est un élément clé au service de la transition, l’Iddri s’intéresse aussi à la place de l’agriculture dans les agendas des bailleurs, notamment au cours d’un atelier organisé le 10 février avec la fondation Gates et dans le cadre d’un travail de terrain en Éthiopie.
Pour suivre la mise en œuvre et l’atteinte des ODD, les mécanismes de gouvernance mondiale pourraient être sollicités. Le Comité de la sécurité alimentaire mondiale (CSA) pourrait être le lieu de coordination et de revue des politiques publiques. Comme le soulignent les publications récentes de l'Iddri, depuis sa réforme en 2009, il permet la participation de la société civile et de la science aux côtés des États membres. Cependant, le CSA n’est pas la seule enceinte où se discutent les questions relatives à l’alimentation et à l’agriculture. En effet, l’Organisation mondiale du commerce, qui semble sortie de sa paralysie après la conférence de Bali, et la Nouvelle alliance pour la sécurité alimentaire, née au sommet du G8 de 2012, complexifient le paysage de la gouvernance, malgré les espoirs d’une coordination plus efficace nés de la crise alimentaire de 2008.

PUBLICATIONS

Fin de la faim : comment assurer la transition agricole et alimentaire ?
M.-L. Apostolescu et al. Working paper.

Résoudre le problème de la faim dans le monde ne peut se limiter à une simple augmentation de la production agricole. Lutter contre l’insécurité alimentaire passe au contraire par une transition vers un paradigme cohérent et durable qui implique d’agir dans tous les secteurs directement ou indirectement liés aux problématiques alimentaires et nutritionnelles.
 
The Committee on World Food Security reform: impacts on global governance of food security 
K. Eklin et al. Working Paper.

Un article consacré à la réforme du Comité de la sécurité alimentaire mondiale (CSA). Parmi les principaux résultats de cette réforme figurent une participation inédite de la société civile et la création d'une interface science-politique, deux processus permettant une meilleure définition et structuration des débats menés par le CSA sur les questions de sécurité alimentaire.
 
The Committee on World Food Security: moving the reform forward
M. Brun, S. Treyer. Policy Brief.

Un article consacré à la réforme du Comité de la sécurité alimentaire mondiale (CSA). Si le processus de réforme est toujours en cours, il a néanmoins déjà généré une diversité de résultats – inédite en termes de gouvernance – contribuant à une meilleure compréhension des questions de sécurité alimentaire.
 
Une société post-croissance pour le xxie siècle
D. Demailly, L. Chancel, H. Waisman. Policy Brief.

Ce Policy Brief restitue les principaux enseignements de l’étude « Une société post-croissance pour le xxie siècle », publiée en novembre 2013 par l’Iddri. Face à la possibilité d’un ralentissement durable des gains de productivité, une réflexion collective sur les arbitrages à effectuer dans un contexte de croissance structurellement faible est nécessaire, notamment en matière de protection sociale, de redistribution ou de politiques de l’emploi.
 
Les politiques de l’emploi face à la croissance faible
L. Chancel, D. Demailly. Working Paper.

Un article consacré aux liens entre croissance et emploi, synthèse des travaux de recherche et des échanges qui ont eu lieu lors de la 3e séance du séminaire « Croissance et Prospérité » du 16 octobre 2013.
 
Projets citoyens pour la production d’énergie renouvelable : une comparaison France-Allemagne
N. Poize, A. Rüdinger. Working Paper.

Un article consacré aux projets citoyens de production d’énergie ; largement répandus en Allemagne, ils émergent en France. Partant d’une perspective comparative, cet article vise à identifier les principaux obstacles au déploiement plus large de ces initiatives dans le contexte français, et les ajustements possibles pour favoriser cette dynamique.
 
The State of Environmental Migration 2013 - A review of 2012
F. Gemenne, P. Brücker, D. Ionesco. Study.

The State of Environmental Migration 2013 - A review of 2012 est le troisième volume d’une série annuelle, qui entend fournir une information régulièrement mise à jour sur la nature et les dynamiques des migrations environnementales à travers le monde. Écrits par des étudiants de l’École des affaires internationales de Sciences Po Paris (PSIA), les cas d'étude de ce volume décrivent les flux migratoires induits par quelques-unes des perturbations les plus significatives de l’environnement (catastrophes naturelles soudaines ou changements environnementaux à impact plus lents) en 2012.
>> PUBLICATIONS À PARAÎTRE
Parallèlement aux négociations sur le paquet énergie-climat à la Commission européenne, l’Iddri publie dans la semaine du 27 janvier 2014 trois Policy Briefssoulignant la nécessité pour l’UE de développer des solutions communes dans un contexte énergétique notamment marqué par le poids grandissant des importations. Ces publications insistent sur le rôle majeur que doivent jouer dans ce paquet le prix du carbone dans le cadre du Système communautaire d'échange de quotas d'émission, la compétitivité industrielle et les énergies renouvelables.
The 2030 EU Climate and Energy Package: why and how?
T. Spencer, M. Colombier, T. Ribera. Policy Brief.
Addressing industrial competitiveness concerns in the 2030 EU Climate and Energy Package
O. Sartor, M. Colombier, T. Spencer. Policy Brief.
The 2030 EU Climate and Energy Package: why and how?
T. Spencer, M. Colombier, T. Ribera. Policy Brief.
 

VIDÉOTHÈQUE

Mardi 10 décembre - Fiscalité carbone et progrès social, une session du séminaire développement durable et économie de l'environnement (SDDEE), animée par Emmanuel Combet (Cired).

En comparant les performances de plusieurs dispositifs de réforme des prélèvements obligatoires, Emmanuel Combet a mis en lumière l’intérêt d’une réflexion d’ensemble, tenant compte de l’interdépendance des dossiers retraites, climat et finances publiques.
Mardi 19 novembre The power of the single number. A political history of gross domestic product, une session du séminaire développement durable et économie de l'environnement (SDDEE), animée par Philipp Lepenies (IASS).

Lors de cette session, Philipp Lepenies s’est intéressé aux questions soulevées par les critiques sur la croissance économique et son indicateur, le produit intérieur brut (PIB). Les sociétés, en particulier les plus industrialisées, doivent-elles aller « au-delà du PIB » ? Peuvent-elles se passer de cet indicateur et du phénomène de croissance qu’il représente ? Comment passer d’une « culture de l’économie » à une « culture de la soutenabilité ».

ÉVÉNEMENTS À VENIR

Mercredi 29 janvier, Paris - La sécurité alimentaire dans l’agenda post-2015 : quels objectifs pour quels effets ?, un atelier international organisé par la Ferdi et l’Iddri, réunis au sein de l’IDGM, en partenariat avec le ministère des Affaires étrangères.
>> Événément sur invitation uniquement

Cette journée vise à rassembler des acteurs et experts de différents horizons et points de vue pour comprendre comment peuvent être conçus de la manière la plus pertinente des objectifs de développement durable, sur l’exemple de la sécurité alimentaire.
Lundi 10 février, Paris - Les réformes de l’APD française et les enjeux de l’agenda post-2015 : les enjeux d’une aide au secteur agricole, un atelier coordonné par l’Iddri, en partenariat avec le Cirad et la Ferdi, dans le cadre du projet « L’Aide publique au développement française dans l’agenda post-2015 ».
>> Événément sur invitation uniquement

Cet atelier portera sur la question de la nécessaire transformation des agricultures du monde et notamment africaines, suivant une approche prospective ancrée dans l’agenda post-2015, et cherchant à répondre à la fois aux enjeux économiques, environnementaux et sociaux.
Mardi 11 février, Paris - La précarité dans la mobilité quotidienne, une conférence organisée par la Chaire Développement durable de Sciences Po.

Participation de Laurence Tubiana et de Mathieu Saujot (Iddri), aux côtés de Nicolas Hulot et Denis Voisin, à cette conférence organisée par la Chaire Développement durable de Sciences Po, dans le cadre de son partenariat avec la SNCF.
Mercredi 12 février, Paris - Expert workshop on nuclear safety, un atelier conjointement organisé par l'Iddri et l'université Waseda (Japon).

Dans une perspective d'analyse comparative des mécanismes de réglementation de l'énergie nucléaire, cet atelier d'experts a notamment pour objectif de créer un environnement de discussion favorable entre régulateurs européens et chercheurs japonais.
>> Événément sur invitation uniquement
INTERVENTIONS PASSÉES
* L’Iddri (Claudio Chiarolla et Lucien Chabason) a particpé à la 2e session plénière de la Plateforme intergouvernementale scientifique et politique sur la biodiversité et les services écosystémiques (IPBES) qui s’est tenue à Antalya (Turquie) du 9 au 14 décembre 2013. Cette session avait notamment pour objectifs d’adopter un programme de travail pour la période 2014-2018 et de définir la stratégie en matière de participation des acteurs. La valeur ajoutée du programme de travail de l’IPBES prendra la forme d’évaluations régionales et sous-régionales de la biodiversité et des écosystèmes (dimensions peu traitées jusque-là), tandis que la participation des acteurs est conçue pour être la plus large possible. Sur ces deux points cependant, au terme des négociations, une stratégie définitive reste à construire, tant sur la compatibilité temporelle entre agendas de recherche et communication des résultats que sur le volume (quantitatif et qualitatif) de la participation des acteurs.
* L’iddri a co-organisé avec le CERI-Sciences Po les 4-7 décembre 2013 à Malte un séminaire de recherche « Libre circulation et frontières ouvertes : quel(s) impact(s) sur les flux migratoires ? »dans le cadre du projet MobGlob (Gouvernance globale de la mobilité) financé par l’Agence nationale pour la recherche. Les travaux de ce séminaire ont consisté en l’élaboration de scénarios narratifs prospectifs, dans une perspective régionale puis globale, de l’évolution du nombre de migrants. Parmi les impacts possibles de tels scénarios, de nouvelles formes de gouvernance globale émergeraient nécessairement ; tandis que dans une perspective de levée totale des obstacles à la migration, la circularité des flux, et non leur volume, augmenterait de façon significative.

LA VIE DE L'DDRI

  • L'Iddri a le plaisir d'accueillir :

    Henri Waisman, qui rejoint le programme climat en tant que coordinateur projet "Deep Decarbonization pathways", mené conjointement par l’Iddri et le SDSN sur les trajectoires décarbonées des principaux pays émetteurs de gaz à effet de serre.

    Aleksandar Rankovic, chargé d’assurer pour l'Iddri et Sciences Po le secrétariat scientifique du projet « Politiques de la Terre à l'épreuve de l’Anthropocène » pour l’IDEX Sorbonne Paris Cité.

    Marie-Ange Saintagne, qui rejoint l’Iddri pour un mois pour travailler à la préparation d’un l’atelier sur la sûreté nucléaire avec l’université de Waseda (Japon).

    Teng Fei, professeur à l’Institute of Energy, Environment and Economy de l’université de Tsinghua (Pékin, Chine) et membre de la délégation chinoise en charge de la négociation climatique, pour un mois dans le cadre du programme CAI Yuanpei du MAE et du gouvernement chinois, pour travailler avec l’équipe climat sur les marchés carbone.

    Michel Morisset, professeur à la Faculté des sciences de l'agriculture et de l'alimentation de l’université de Laval (Québec, Canada), en tant que chercheur invité au sein du programme Agriculture et Alimentation sur les transformations des structures agricoles et l’influence de ces évolutions sur la formation des politiques publiques sectorielles.

  • Raphaël Billé quitte l’Iddri, qu’il avait rejoint en 2006, pour intégrer le Secrétariat de la Communauté du Pacifique à Nouméa afin d'y coordonner un projet régional AFD/FFEM de gestion des zones côtières sur la Nouvelle Calédonie, la Polynésie française, Fidji et Vanuatu.
     
  • Pauline Brücker quitte l'Iddri, qu'elle avait rejoint en 2011 en tant que chercheure Migrations. Pauline est doctorante au CERI-Sciences Po, associée au CEDEJ (Le Caire/Khartoum) et au Centre d'étude des migrations et des réfugiés, à l'université Américaine du Caire (AUC/CMRS).
     
  • Agathe Clerc, qui travaillait sur le projet relatif aux questions de sûreté nucléaire mené avec l’université de Waseda (Japon), quitte l’Iddri pour développer un projet sur le développement durable au Costa Rica. 
Conformément à la loi « informatique et libertés » N° 78-17 du 6 janvier 1978, tout utilisateur ayant déposé sur le site de l'Iddri des informations nominatives le concernant, dispose d'un droit d'accès, de modification, de rectification et de suppression sur ces mêmes informations. L'Iddri s'engage à ne pas communiquer ces informations à d'autres partenaires extérieurs.
 
header
Director of publications
Laurence Tubiana
Editor
Pierre Barthélemy
Translation
Anna Kiff
JANVIER 2014 N° 47
The post-2015 agenda: an opportunity for agriculture and food security?
Despite the persistence of profound regional differences, considerable progress has been made in combating food insecurity since the international community agreed to give special attention to reducing hunger within the framework of the Millennium Development Goals. According to the latest estimates, 842 million people still do not have enough to eat (FAO, 2013). The vast majority of these, some 827 million people, live in developing countries. If further efforts are made, the goal of halving the proportion of hungry people by 2015 is within reach. However, the combined effect of climate warming, the degradation of natural resources, high population growth and price volatility is mortgaging the future of a world without food insecurity, while a geographical shift in hunger at the global level seems to be emerging.
Against this backdrop, experts, governments and civil society are debating the definition of a post-2015 development agenda. In terms of food security, it is now time to take stock and to set objectives that will build bridges between environmental sustainability, agricultural production and food security. Going beyond the crucial definition of ambitious sustainable development goals (SDGs), the expert community is mobilising to develop the means to implement these goals. IDDRI is taking part in this process, and is organising a workshop on 29 January with FERDI (Fondation pour les études et recherches sur le développement international) and the French Ministry of Foreign Affairs to facilitate dialogue between the different communities concerned by agriculture and food security in the post-2015 agenda.
Indeed, the issue of hunger must be connected to the challenges of the agricultural and food system. This system remains largely dependent on non-renewable inputs, and adversely affects ecosystems and public health while accelerating climate change. A transformation of public policies and practices is therefore necessary to accompany the transition towards an agricultural model based on ecological intensification, which takes into account the multifunctionality of agriculture (production, but also social and environmental functions), preserves natural resources and creates prosperity. Beyond the controversies between models, to achieve this transition it is essential to plan the transformation of agriculture, in both the North and the South, based on forward-looking studies and the development of transition scenarios. IDDRI is participating in initiatives aimed at clarifying the understanding of these sectoral transformations, at the European level but also in developing countries. Because official development assistance is a key element in this transition, IDDRI will also be discussing the role of agriculture in donor agendas, especially during a workshop to be held on 10 February with the Gates Foundation, and as part of a fieldwork study in Ethiopia.
To monitor the implementation and achievement of the SDGs, global governance mechanisms may be called upon. The Committee on World Food Security (CFS) could be the focal point for coordinating and reviewing public policies. As highlighted in recent IDDRI's publications, since its reform in 2009, it has enabled the participation of civil society and science alongside the Member States. However, it is not the only body in which questions relating to food and agriculture are discussed. Indeed, the World Trade Organization, which appears to have overcome its paralysis following the Bali conference, and the New Alliance for Food Security and Nutrition, established at the G8 summit in 2012, are making the governance landscape more complex, despite the hopes of more effective coordination raised during the 2008 food crisis.

PUBLICATIONS

Fin de la faim : comment assurer la transition agricole et alimentaire ?
M.-L. Apostolescu et al. Working paper.

Solving the problem of hunger in the world cannot be limited to simply increasing agricultural production. On the contrary, reducing food insecurity requires a transition towards a coherent, sustainable paradigm, which implies acting in all sectors directly or indirectly linked to food and nutritional issues.
 
The Committee on World Food Security reform: impacts on global governance of food security 
K. Eklin et al. Working Paper.

An article on the main outcomes of the Committee on World Food Security reform—involvement of both civil society and a science-policy interface (High Level Panel of Experts on Food Security and Nutrition, HLPE)—and lessons learned for global governance.
 
The Committee on World Food Security: moving the reform forward
M. Brun, S. Treyer. Policy Brief.

Drawing attention on to the critical issues to ensure the full development of the World Food Security reform appears necessary while "the Committee is ready for the next step".
 
Une société post-croissance pour le xxie siècle
D. Demailly, L. Chancel, H. Waisman. Policy Brief.

This Policy Brief summaries the main findings of the study “Une société post-croissance pour le xxie siècle”, published in November 2013 by IDDRI. Faced with the possibility of a long-term slowdown of productivity gains, collective talks on the choices to be made in a context of structurally low growth are needed, especially regarding social protection, redistribution or employment policies.
 
Les politiques de l’emploi face à la croissance faible
L. Chancel, D. Demailly. Working Paper.

An article focusing on the linkages between growth and employment, summarising the discussions, supplemented by research, that took place during the third session of the “Growth and Prosperity” seminar held on 16 October 2013.
 
Projets citoyens pour la production d’énergie renouvelable : une comparaison France-Allemagne
N. Poize, A. Rüdinger. Working Paper.

An article on citizen energy production projects, which are widespread in Germany, but just emerging in France. Based on a comparative perspective, the aim of this article is to identify the main obstacles to the broader deployment of these initiatives in the French context, and the adjustments that could be made to foster this trend.
 
The State of Environmental Migration 2013 - A review of 2012
F. Gemenne, P. Brücker, D. Ionesco. Study.

This volume is the third of an annual series, which aims to provide the reader with regularly -updated assessments on the changing nature and dynamics of environmental migration throughout the world..
 
>> FORTHCOMING PUBLICATIONS
Alongside negotiations on the Climate and Energy Package at the European Commission, IDDRI is about to publish three Policy Briefs highlighting the need for the EU to develop common solutions in an energy context marked particularly by the growing weight of imports. These publications insist on the key role that must be played in this package by the carbon price in the European Union Emissions Trading Scheme, industrial competitiveness and renewable energy.
The 2030 EU Climate and Energy Package: why and how?
T. Spencer, M. Colombier, T. Ribera. Policy Brief.
Addressing industrial competitiveness concerns in the 2030 EU Climate and Energy Package
O. Sartor, M. Colombier, T. Spencer. Policy Brief.
The 2030 EU Climate and Energy Package: why and how?
T. Spencer, M. Colombier, T. Ribera. Policy Brief.
 

VIDEOS

Tuesday 10 December - Carbon taxation and social progress, a session of the Sustainable Development and Environmental Economics Seminar, led byEmmanuel Combet (Cired).

By comparing the performances of several tax reform mechanisms, Emmanuel Combet highlighted the value of comprehensive discussions, taking into account the interdependence between pensions, climate and public finance issues.
Tuesday 19 November - The power of the single number. A political history of gross domestic product, a session of the Sustainable Development and Environmental Economics Seminar, led by Philipp Lepenies (IASS).

During this session, Philipp Lepenies addressed the questions raised by the criticism economic growth and its statistical indicator, gross domestic product (GDP), are currently facing. Should societies, most notably industrialised societies, start a move beyond GDP? Can they get rid of this indicator and the growth phenomenon it represents? How could an “economy culture” be transformed into a “sustainability culture”?

FORTHCOMING EVENTS

Wednesday 29 January, Paris - Food security in the post-2015 agenda: what objectives for what outcomes?, an international workshop organised by FERDI and IDDRI, meeting within the IDGM, in partnership with the French Ministry of Foreign Affairs.
>> Workshop on invitation only

This event is aimed at bringing together actors and experts from different backgrounds, with different viewpoints, to understand how sustainable development goals can be set in the most relevant manner possible, taking the example of food security.
Monday 10 February, Paris - The reforms of French official development assistance and the challenges of the post-2015 agenda: the case of the assistance to agriculture, a workshop coordinated by IDDRI, in partnership with CIRAD and FERDI, within the framework of the project "Can we improve the performance of development aid?".
>> Workshop on invitation only

This workshop will address the issue of the necessary transformation of world agricultural systems, more specifically in Africa. This transformation will be analysed within the framework of the definition of the post-2015 developmetn agenda seeking to address both environmental, economic and social challenges.
Tuesday 11 February, Paris -Insecurity in daily mobility, a conference organised by the Sciences Po Sustainable Development Centre.

Laurence Tubiana and Mathieu Saujot will take part in this conference, alongside Nicolas Hulot and Denis Voisin. This event is organised by the Sciences Po Sustainable Development Centre within the framework of its partnership with SNCF.
Wednesday 12 February, Paris -Expert workshop on nuclear safety, a workshop organised by IDDRI and Waseda University.

Within the framework of a comparative analysis of European regulatory regimes, this expert workshop will present these different regulatory mechanisms and provide an enabling environment for discussion between European regulators and Japanese researchers.
>> Workshop on invitation only
PAST EVENTS
* IDDRI (Claudio Chiarolla and Lucien Chabason) took part in the second plenary session of the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services (IPBES), which was held in Antalya (Turkey) from 9-14 December 2013. The goals of this session included adopting a work programme for the 2014-2018 period, and drafting the stakeholder engagement strategy. The added value of the IPBES work programme will take the form of regional and sub-regional assessments of biodiversity and ecosystems (dimensions that have received little attention so far), while stakeholder engagement is intended to be as broad as possible. On these two points, however, at the end of the negotiation process, a definitive strategy remains to be defined, in terms of both the temporal compatibility between research agendas and the communication of results, and the volume (quantitative and qualitative) of stakeholder participation.
* From 4-7 December 2013 in Malta, IDDRI co-organised with CERI-Sciences Po a research seminar entitled"Free movement and open borders: what impact(s) on migration flows?" as part of the MobGlob project (on the global governance of mobility) financed by the French National Research Agency. The work of this seminar consisted in developing forward-looking narrative scenarios, from a regional then global perspective, of changes in the number of migrants. Among the possible impacts of such scenarios, new forms of global governance would inevitably emerge, while from the perspective of a total removal of all barriers to migration, circular migration would increase significantly, rather than the volume of migration flows.

LIFE AT IDDRI

  • - IDDRI is pleased to welcome:

    Henri Waisman, who is joining the Climate programme as coordinator of the "Deep decarbonisation pathways” project" launched by IDDRI and The Sustainable Devlopment Solutions Network (SDSN) on low-carbon pathways of 12 countries covering more than 70% of global C02 emissions.

    Aleksandar Rankovic, responsible for IDDRI and Sciences Po of the scientific secretariat of the "Earth policies in the Anthropocene" project for IDEX Sorbonne Paris Cité.

    Marie-Ange Saintagne, who is joining IDDRI to work on the preparation of the international workshop (organised with Waseda University, Japan) on nuclear safety.

    Teng Fei, a lecturer at the Institute of Energy, Environment and Economy at Tsinghua University (Beijing, China), and member of the Chinese delegation to the climate talks, as a visiting scholar in the framework of preparations for COP 21 to be held in Paris in 2015, with the Climate team.

    Michel Morisset, a lecturer at the Faculty of Agriculture and Food Sciences at Université Laval (Quebec, Canada), as a visiting scholar within the Agriculture and Food programme on the transformation of agricultural structures and the influence of these changes on sectoral public policy making.

  • Raphaël Billé is leaving IDDRI, which he joined in 2008, to work for the Secretariat of the Pacific Community in Noumea to coordinate a regional AFD/FFEM project on coastal zone management in New Caledonia, French Polynesia, Fiji and Vanuatu.
     
  • Pauline Brücker is leaving IDDRI, which she joined in 2011 as a research fellow on migrations. Pauline is a PhD student at CERI-Sciences Po, associate to CEDEJ (Cairo/Khartoum) and to The Center for Migration and Refugee Studies at The American University (AUC/CMRS) in Cairo (Egypt).
     
  • Agathe Clerc is leaving IDDRI. She worked on the nuclear safety project launched by IDDRI and Waseda University (Japan). Agathe will develop a sustainable development project in Costa Rica. 
In accordance with the French Data Protection Act (Loi Informatique et Libertés, N° 78-17) of 6 January 1978, any user leaving personal data on IDDRI’s web site has the right to access, modify, rectify and remove this data. IDDRI undertakes not to disclose this information to other external partners.
 

Joaquim Machado

unread,
Jan 28, 2014, 7:08:17 AM1/28/14
to Joaquim Machado, acgs...@usp.br, lmlcos...@gmail.com, davi.bonavides@itamaraty.gov.br bonavides, Maria Cecilia Vieira, Maximiliano da Cunha Henriques Arienzo, claudia Borges Tavares, adrit...@yahoo.com.br, Marisa d´Arce, Ione Egler, ruy caldas, Paulo Brandao, Braulio Dias, Lidio Coradin, Eliana Maria Gouveia Fontes, MARIA JOSE AMSTALDEN M SAMPAIO, victor, Decio Zylbersztajn, Sergio Salles Filho, Maria Beatriz Bonacelli, beatriz bulhoes, Marcio de M. Santos, btc5734_2012@googlegroups.com 2012, btc...@googlegroups.com, SILVIA KANADANI CAMPOS, btc5734_2011-1@googlegroups.com 2011-1, economia_biotec@googlegroups.com biotec, BTC5700 2012, Monica Adriana Salles, Flávia de Lacerda Parames, noos...@terra.com.br, Ivone Alves de Oliveira Lopes, Tejon Megido_fw, Coriolano, Victor Megido, guedes Antonio Carlos, Helio Hara, Andrea Rocha, Luzinete Faria, Palazzo Jr., Beatriz Florence, Paulo Manoel L.C. Protasio, José Hartur Setubal Lima, Simone Ferreira

Joaquim Machado

unread,
Jan 28, 2014, 2:25:47 PM1/28/14
to Joaquim Machado, acgs...@usp.br, lmlcos...@gmail.com, davi.bonavides@itamaraty.gov.br bonavides, Maria Cecilia Vieira, Maximiliano da Cunha Henriques Arienzo, claudia Borges Tavares, adrit...@yahoo.com.br, Marisa d´Arce, Ione Egler, ruy caldas, Paulo Brandao, Braulio Dias, Lidio Coradin, Eliana Maria Gouveia Fontes, MARIA JOSE AMSTALDEN M SAMPAIO, victor, Decio Zylbersztajn, Sergio Salles Filho, Maria Beatriz Bonacelli, beatriz bulhoes, Marcio de M. Santos, Patricia Lopes Olivera, btc5734_2012@googlegroups.com 2012, btc...@googlegroups.com, SILVIA KANADANI CAMPOS, btc5734_2011-1@googlegroups.com 2011-1, economia_biotec@googlegroups.com biotec, BTC5700 2012, Monica Adriana Salles, Flávia de Lacerda Parames, noos...@terra.com.br, Ivone Alves de Oliveira Lopes, Tejon Megido_fw, Coriolano, Victor Megido, guedes Antonio Carlos, Helio Hara, Andrea Rocha, Luzinete Faria, Palazzo Jr., Beatriz Florence, Paulo Manoel L.C. Protasio, José Hartur Setubal Lima, Simone Ferreira

Menciono novamente o livro:

THE SECOND MACHINE AGE: Work, Progress, and Prosperity in a time of brilliant technologies
E. Brynjolfsson & A. McAfee
Norton & Company, 2014

para comentar que os autores utilizam o conto sobre o sábio que pediu ao rei sua recompensa em grãos de arroz segundo uma progressão baseada nas casas do tabuleiro de xadrez,  para sugerir que em termos de big data estamos "na segunda metade do tabuleiro". 

Lendo o livro, é impactante perceber os efeitos dessa progressão sobre a Logística como um todo.

Joaquim Machado

unread,
Jan 28, 2014, 2:31:53 PM1/28/14
to Joaquim Machado, lmlcos...@gmail.com, davi.bonavides@itamaraty.gov.br bonavides, Maria Cecilia Vieira, Maximiliano da Cunha Henriques Arienzo, claudia Borges Tavares, adrit...@yahoo.com.br, Marisa d´Arce, Ione Egler, ruy caldas, Paulo Brandao, Braulio Dias, Lidio Coradin, Eliana Maria Gouveia Fontes, MARIA JOSE AMSTALDEN M SAMPAIO, victor, Decio Zylbersztajn, Sergio Salles Filho, Maria Beatriz Bonacelli, beatriz bulhoes, Marcio de M. Santos, Patricia Lopes Olivera, btc5734_2012@googlegroups.com 2012, btc...@googlegroups.com, SILVIA KANADANI CAMPOS, btc5734_2011-1@googlegroups.com 2011-1, economia_biotec@googlegroups.com biotec, BTC5700 2012, Monica Adriana Salles, Flávia de Lacerda Parames, noos...@terra.com.br, Ivone Alves de Oliveira Lopes, Tejon Megido_fw, Coriolano, Victor Megido, guedes Antonio Carlos, Helio Hara, Andrea Rocha, Luzinete Faria, Palazzo Jr., Beatriz Florence, Paulo Manoel L.C. Protasio, José Hartur Setubal Lima, Simone Ferreira
Anexo envio uma atualização da ementa da Disciplina BTC 5734, edição 2014, ministrada no Interunidades de Biotecnologia (I. Butantan, ICB e IPT ) da Universidade de São Paulo.


BTC5734-2014.pdf

Joaquim Machado

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Jan 28, 2014, 4:26:47 PM1/28/14
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See and Manage Your Organization's Culture

January 27, 2014 
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Organizational culture is the heart and soul of a company. Yet leaders often perceive culture as a nebulous collection of intangible concepts, seemingly impossible to measure and quantify and therefore relegated to the “soft skills” category. Culture belongs in the realm of fine arts and museums, right? It’s the job of diplomats and activists, right? Wrong. Every time a group of people interact, culture develops. From corporate organizations to chess clubs to families, patterns of culture inevitably emerge.

Here’s the thing many people don’t realize: culture can either be designed, or it happens by default. Great leaders understand the value of culture, but the path to designing it is often extremely difficult to see, much less manage.

I’m thrilled to announce that Science House is now the exclusive US partner on the implementation of Culture Map, a tool created by Dr. Simon Sagmeister that allows us to work with clients to make the culture of their organizations visible, tangible and measurable.

What is Culture?

Some employees use the word “politics” to describe what happens when an organization’s culture forces people to navigate in the absence of clear, collective values. Others are far more candid in describing the often ugly reality of what happens when culture is treated like an invisible ghost that sometimes scares people by rattling its chains.

In the seven years since creating the Imagination Age framework for collaboration, I’ve worked with many organizations around the world to transform organizational culture. I created the Imagination Age because the industrial era is fading but not yet gone, and the intelligence era is coming but not yet here. In between, individuals and organizations are getting crushed by the need to constantly change. This problem intrigues me, particularly as we are now increasingly collaborating with software and algorithms to take our own intelligence to a new level and design new systems. I thought it would be helpful to think of this period in between as an era of its own so we could work together to create the mindset necessary to shape strategies for the future instead of just trying to cope with the need for constant change.

The Great Challenge of the Imagination Age

At the beginning of the Imagination Age, I spent four years traveling around the world to understand how different cultures interact within and between themselves during times of crisis and transformation. I worked amid natural disasters, human conflicts and crises during this time, with large multinational corporations, think-tanks, governments, universities, not-for-profits, school districts, startups and organizations of all kinds, even families, to understand the ways in which different types of organizations are structured.

Three years ago, I started collaborating with inventor, investor and entrepreneur James Jorasch to take the Imagination Age to the next level at Science House. We work at the intersection of humanity and technology, specializing in collaboration strategies between the two as companies expand their collaborative networks to include vendors, clients and customers. The most critical business skills in the Imagination Age are the ability to solve problems and spot business opportunities. In order to do either of these things well, collaborative groups need to have the kind of culture that fosters forward motion and deep understanding.

Culture is a very tough issue. As the dust settles on yet another reorganization, the hard reality of transformation begins to creep in. Is it working? Was this massive effort was worth the time and effort? I knew I needed a way to make the story of culture visible, and I’ve been looking for one for years. I’ve met with lots of people who have come up with measurement systems, but the problem is that no matter how clever or effective, these systems are still generally just a bunch of words and numbers on a page.

That all changed when Dr. Simon Sagmeister showed up at Science House with his Culture Map. As soon as he spread out the visual components of his system on the gray chesterfield sofa in the Celestial Salon, I texted James, who was upstairs in his office: Please come down immediately.

Within minutes we were in the Imagination Room at Science House and Simon was sharing details of his system.

Culture Map

Remember what it was like to drive before GPS? Holding a paper map on the steering wheel, cursing under your breath as you missed a turn, knowing that you were going to be late or maybe even hit a deer or an ice patch on an unfamiliar country road? Imagine what it must have been like for captains and sailors on ships during a storm before latitude and longitude could be determined and matched with a location on a map. When I saw the Culture Map™, I felt like I did the first time my GPS warned me that a turn was coming up.

Culture Map is that simple, effective and powerful.

For a bit of background, Simon is the nephew of my friend Stefan Sagmeister, a renowned designer who has a great habit of takingcreative sabbaticals. This habit inspired the next generation of his family, and it was during such a creative period that Simon took his Culture Map tool, initially conceived during his PhD dissertation process, to the next level.

The first image Simon showed us was an iceberg, with the visible tip representing all the tangible aspects of organizational culture (like the dress code, org charts and office layout), and the part underneath hiding all the intangible things (like morale, how people interact and feel). The Culture Map is a color-coded system situated below the surface to make those previously invisible components tangible and measurable. All organizations have seven components, to various degrees, and sometimes there’s a requirement for a heavy concentration in one area or another. In other cases, however, an organization can make a conscious decision to grow or shrink one of the areas through specific actions.

The Colors of Culture

Simon began to explain the meanings behind the colors:

Purple organizations are like sports teams, with a strong leader who lays down the law and everybody else listens and takes action. Such groups have strong rituals and mascots. Red organizations aren’t afraid of conflict. They move quickly and aggressively without stopping to overthink the consequences. Blue represents order, regulation and rules. Orange represents an entrepreneurial group, focused on finding new opportunities and beating the competition. Green means harmony, the human skills and empathy. Yellow symbolizes analytics, reason, knowledge and logic. Aqua is the realm of systems thinking.

Academic organizations tend to be yellow and aqua, but what if they don’t have enough blue to organize or red to push new ideas through? Investment banks tend to be very orange and red, focused on wins and opportunity, but the wake of regulatory compliance is requiring them to be more blue and even more aqua as they try to understand how to balance their focus on profit with the greater good.

Nothing Soft about People Skills

Another huge benefit of this system is that it applies to individuals as well as groups, enabling us to collaborate on the development of communication strategies. For example, a yellow colleague might not mind reading a 250 page manual and responding with a 1,500 word email, while a red colleague might just want the bullet points. The yellow colleague might think the red colleague is lazy, and the red colleague might think the yellow one is wasting precious time. How can you bridge the gap between them, enabling them both to contribute without feeling so frustrated?

People and teams should be rewarded for their contributions in different ways. A green team values group harmony, so singling someone out for recognition, a better parking spot, for example, might disrupt team harmony. Sending a green team out for a fun bonding lunch is a better solution. A purple team goes wild when the leader publicly praises their efforts. Every person has a different color profile, and a different way of perceiving and celebrating success. We work with leadership teams to tailor performance and behavior rewards that are meaningful to recipients.

Moving Toward the Future Now

Once a current snapshot of your group’s culture is established, we work with you to create a future map that reflects the needs of the group and goals of the organization. Maybe your organization is too blue, riddled with legacy systems and bureaucracy, and you want to see the organization become more orange, more entrepreneurial, competitive and looking for opportunities. The next step is to brainstorm the action items that will be taken to move from the current map to the future one. This is where you can start measuring results immediately, with your entire team and organization understanding what the orange (or purple, or red, etc) goals and behaviors are that will get you there and how to motivate people along the way.

While the Culture Map system aligns with the way we already conduct our work, it also brings a level of simplicity, clarity and visual impact that will usher in a new, smarter era of the Imagination Age. Culture Map even has a color for that. Welcome to the future!

Image copyright Dr. Simon Sagmeister 2014.

Top graphic: Victoria Kalinina / shutterstock


Joaquim Machado

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Jan 30, 2014, 9:12:55 AM1/30/14
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Joaquim Machado

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Joaquim Machado

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Monsanto Is Going Organic in a Quest for the Perfect Veggie

  • BY BEN PAYNTER
  • 01.21.14
  • 7:00 AM
Monsanto’s new veggies are sweeter, crunchier, and more nutritious—with none of the “Frankenfoods” ick factor.   Nicholas Cope

In a windowless basement room decorated with photographs of farmers clutching freshly harvested vegetables, three polo-shirt-and-slacks-clad Monsanto execu­tives, all men, wait for a special lunch. A server arrives and sets in front of each a caprese-like salad—tomatoes, mozzarella, basil, lettuce—and one of the execs, David Stark, rolls his desk chair forward, raises a fork dramatically, and skewers a leaf. He takes a big, showy bite. The other two men, Robb Fraley and Kenny Avery, also tuck in. The room fills with loud, intent, wet chewing sounds.

Eventually, Stark looks up. “Nice crisp texture, which people like, and a pretty good taste,” he says.

“It’s probably better than what I get out of Schnucks,” Fraley responds. He’s talking about a grocery chain local to St. Louis, where Monsanto is headquartered. Avery seems happy; he just keeps eating.

The men poke, prod, and chew the next course with even more vigor: salmon with a relish of red, yellow, and orange bell pepper and a side of broccoli. “The lettuce is my favorite,” Stark says afterward. Fraley concludes that the pepper “changes the game if you think about fresh produce.”

Changing the agricultural game is what Monsanto does. The company whose name is synonymous with Big Ag has revolutionized the way we grow food—for better or worse. Activists revile it for such mustache-twirling practices as suing farmers who regrow licensed seeds or filling the world with Roundup-resistant super­weeds. Then there’s Monsanto’s reputation—scorned by some, celebrated by others—as the foremost purveyor of genetically modified commodity crops like corn and soybeans with DNA edited in from elsewhere, designed to have qualities nature didn’t quite think of.

So it’s not particularly surprising that the company is introducing novel strains of familiar food crops, invented at Monsanto and endowed by their creators with powers and abilities far beyond what you usually see in the produce section. The lettuce is sweeter and crunchier than romaine and has the stay-fresh quality of iceberg. The peppers come in miniature, single-serving sizes to reduce leftovers. The broccoli has three times the usual amount of glucoraphanin, a compound that helps boost antioxidant levels. Stark’s department, the global trade division, came up with all of them.

“Grocery stores are looking in the produce aisle for something that pops, that feels different,” Avery says. “And consumers are looking for the same thing.” If the team is right, they’ll know soon enough. Frescada lettuce, BellaFina peppers, and Bene­forté broccoli—cheery brand names trademarked to an all-but-anonymous Mon­santo subsidiary called Seminis—are rolling out at supermarkets across the US.

But here’s the twist: The lettuce, peppers, and broccoli—plus a melon and an onion, with a watermelon soon to follow—aren’t genetically modified at all. Monsanto created all these veggies using good old-fashioned crossbreeding, the same tech­nology that farmers have been using to optimize crops for millennia. That doesn’t mean they are low tech, exactly. Stark’s division is drawing on Monsanto’s accumulated scientific know-how to create vegetables that have all the advantages of genetically modified organisms without any of the Frankenfoods ick factor.

And that’s a serious business advantage. Despite a gaping lack of evidence that genetically modified food crops harm human health, consumers have shown a marked resistance to purchasing GM produce (even as they happily consume pro­ducts derived from genetically modified commodity crops). Stores like Whole Foods are planning to add GMO disclosures to their labels in a few years. State laws may mandate it even sooner.

 Nicholas Cope

Beneforté 
(broccoli)
Launched
Fall 2010
Availability
Year-round
Trait
Compared with standard broccoli, contains up to three times the amount of glucora­phanin, a compound that increases antioxidant levels
Method
Crossbreeding commercial broccoli with a strain growing wild in southern Italy
Region Grown
Arizona, California, Mexico
Price 
$2.50 per pound

But those requirements won’t apply to Monsanto’s new superveggies. They may be born in a lab, but technically they’re every bit as natural as what you’d get at a farmers’ market. Keep them away from pesticides and transport them less than 100 miles and you could call them organic and locavore too.

John Francis Queeny formed Monsanto Chemical Works in 1901, primarily to produce the artificial sweetener saccharin. Monsanto was the family name of Queeny’s wife, Olga. It was a good time for chemical companies. By the 1920s, Monsanto had expanded into sulfuric acid and polychlorinated biphenyl, or PCB, a coolant used in early transformers and electric motors, now more famous as a pernicious environmental contaminant. The company moved on to plastics and synthetic fabrics, and by the 1960s it had sprouted a division to create herbicides, including the Vietnam-era defoliant Agent Orange. A decade later, Monsanto invented Roundup, a glyphosate-based weed killer that farmers could apply to reduce overgrowth between crops, increasing productivity. In the early 1990s, the company turned its scientific expertise to agriculture, working on novel crop strains that would resist the effects of its signature herbicide.

Now, breeding new strains of plants is nothing new. Quite the opposite, in fact—optimizing plants for yield, flavor, and other qualities defined the earliest human civilizations. But for all the millennia since some proto-farmer first tried it, successfully altering plants has been a game of population roulette. Basically, farmers breed a plant that has a trait they like with other plants they also like. Then they plant seeds from that union and hope the traits keep showing up in subsequent generations.

They’re working with qualities that a biologist would call, in aggregate, phenotype. But phenotype is the manifestation of genotype, the genes for those traits. The roulettelike complications arise because some genes are dominant and some are recessive. Taking a tree with sweet fruit and crossing it with one that has big fruit won’t necessarily get you a tree with sweeter, bigger fruit. You might get the opposite—or a tree more vulnerable to disease, or one that needs too much water, and on and on. It’s a trial-and-error guessing game that takes lots of time, land, and patience.

The idea behind genetic modification is to speed all that up—analyze a species’ genes, its germplasm, and manipulate it to your liking. It’s what the past three decades of plant biology have achieved and continue to refine. Monsanto became a pioneer in the field when it set out to create Roundup-resistant crops. Stark joined that effort in 1989, when he was a molecular biology postdoc. He was experiment­ing with the then-new science of transgenics.

Monsanto was focusing on GM commodity crops, but the more exciting work was in creating brand-new vegetables for consumers. For example, Calgene, a little biotech outfit in Davis, California, was building a tomato it called the Flavr Savr. Conventional tomatoes were harvested while green, when they’re tough enough to withstand shipping, and then gassed with ethylene at their destination to jump-start ripening. But the Flavr Savr was engineered to release less of an enzyme called polygalacturonase so that the pectin in its cell walls didn’t break down so soon after picking. The result was a tomato that farmers could pick and ship ripe.

In the mid-1990s, Monsanto bought Calgene and reassigned Stark, moving him from Roundup research to head a project that almost accidentally figured out how to engineer flavor into produce. He began tinkering with genes that affect the production of ADP-glucose pyrophosphorylase, an enzyme that correlates to higher levels of glycogen and starch in tomatoes and potatoes. Translation: more viscous ketchup and a French fry that would shed less water when cooked, maintaining mass without absorbing grease. And he succeeded. “The texture was good,” Stark says. “They were more crisp and tasted more like a potato.”

 Nicholas Cope

BellaFina
(bell pepper)
Launched
Fall 2011
Availability
Year-round
Trait
A third the size of regular bell peppers when ripe, mini-
mizing waste and allowing for flexibility while cooking

Method
Selectively breeding plants with smaller and smaller peppers
Region grown
California, Florida, North Carolina
Price
$1.50 per three-pepper bag

They never made it to market. Aside from consumer backlash, the EPA deemed StarLink corn, a new biotech strain from another company, unfit for human consumption because of its potential to cause allergic reactions. Another geneti­cally modded corn variety seemed to kill monarch butterflies. Big food conglom­erates including Heinz and McDonald’s—which you might recognize from their famous tomato and potato products—abandoned GM ingredients; some European countries have since refused to grow or import them. Toss in the fact that production costs on the Flavr Savr turned out to be too high and it’s easy to see why Monsanto shut down Stark’s division in 2001. Large-scale farms growing soy or cotton, or corn destined for cattle feed—or corn syrup—were happy to plant GM grain that could resist big doses of herbicide. But the rest of the produce aisle was a no-go.

Furthermore, genetically modifying consumer crops proved to be inefficient and expensive. Stark estimates that adding a new gene takes roughly 10 years and $100 million to go from a product concept to regulatory approval. And inserting genes one at a time doesn’t necessarily produce the kinds of traits that rely on the inter­actions of several genes. Well before their veggie business went kaput, Monsanto knew it couldn’t just genetically modify its way to better produce; it had to breed great vegetables to begin with. As Stark phrases a company mantra: “The best gene in the world doesn’t fix dogshit germplasm.”

What does? Crossbreeding. Stark had an advantage here: In the process of learning how to engineer chemical and pest resistance into corn, researchers at Monsanto had learned to read and understand plant genomes—to tell the difference between the dogshit germplasm and the gold. And they had some nifty technology that allowed them to predict whether a given cross would yield the traits they wanted.

The key was a technique called genetic marking. It maps the parts of a genome that might be associated with a given trait, even if that trait arises from multiple genes working in concert. Researchers identify and cross plants with traits they like and then run millions of samples from the hybrid—just bits of leaf, really—through a machine that can read more than 200,000 samples per week and map all the genes in a particular region of the plant’s chromosomes.

 Nicholas Cope

Melorange
(melon)
Launched
Winter 2011
Availability
December through April
Trait
Tastes up to 30 percent sweeter 
than cantaloupe 
grown in winter

Method
Crossbreeding cantaloupe and European heritage melons with a gene for a fruity and floral aroma
Region Grown
Arizona, Central America
Price
$3 per melon

They had more toys too. In 2006, Monsanto developed a machine called a seed chipper that quickly sorts and shaves off widely varying samples of soybean germplasm from seeds. The seed chipper lets researchers scan tiny genetic variations, just a single nucleotide, to figure out if they’ll result in plants with the traits they want—without having to take the time to let a seed grow into a plant. Monsanto computer models can actually predict inheritance patterns, meaning they can tell which desired traits will successfully be passed on. It’s breeding without breeding, plant sex in silico. In the real world, the odds of stacking 20 different characteristics into a single plant are one in 2 trillion. In nature, it can take a millennium. Monsanto can do it in just a few years.

And this all happens without any genetic engineering. Nobody inserts a single gene into a single genome. (They could, and in fact sometimes do, look at their crosses by engineering a plant as a kind of beta test. But those aren’t intended to leave the lab.) Stark and his colleagues realized that they could use these technologies to identify a cross that would have highly desirable traits and grow the way they wanted. And they could actually charge more for it—all the benefits of a GMO with none of the stigma. “We didn’t have those tools the first time around in vegetables,” Stark says.

Also in 2005, Monsanto bought the world’s largest vegetable seed company, Seminis. Think of it as a wholesale supplier of germplasm. It turned out Seminis came with another benefit: something in the pipeline that Stark could turn into his division’s first test product. A decade prior, swashbuckling plant scientists had discovered on the limestone cliffs of western Sicily a strain of Brassica villosa, ancestor of modern broccoli. Thanks to a gene called MYB28, this weedy atavist produced elevated levels of glucoraphanin. Stark’s team bred further enhance­ments to that antioxidant-increasing compound into a more familiar-looking plant—good old broccoli.

In 2010 Monsanto started test-marketing the new crop, calling it Beneforté. The strategy was coming together: enhanced premium veggies for an elite buyer. Beneforté broccoli came in a bag of ready-to-cook florets—so convenient!—labeled with a bar graph telegraphing how its antioxidant levels stacked up against regular broccoli and cauliflower. It sold, but Monsanto researchers knew that future veggies would need a more compelling hook. Everybody already knows that they’re supposed to eat their broccoli.

 Nicholas Cope

EverMild
(onion)
Launched
Fall 2010
Availability
September through March
Trait
Mild and sweet, less tear-inducing
Method
Selecting for individual plants that have lower levels of pyruvate, which affects pungency, and lachrymatory factor
Region grown
Pacific Northwest
Price
$0.70 to $2 per pound

Stark’s group had one last angle: flavor. In produce, flavor comes from a combina­tion of color, texture, taste (which is to say, generally, sweetness or lack of bitterness), and aroma. But the traits that create those variables are complicated and sometimes nonobvious.

For example, Monsanto created an onion—the EverMild—with reduced levels of a chemical called lachrymatory factor, the stuff that makes you cry. That wasn’t too hard. But making a sweet winter version of a cantaloupe took more effort. Stark’s team first found genes that helped a French melon keep from spoiling after harvest. Through crossbreeding, they learned to keep those genes turned on. Now farmers could harvest the melon ripe, and it stayed ripe longer with full aroma. But the researchers didn’t stop there—they also made sure the fruit had the gene for citron, a molecule associated with fruity and floral aromas. They called the final product the Melorange.

Figuring out these relationships takes place at a sophisticated sensory and genetics lab perched amid hundreds of acres of experimental farmland in the rural, sun-scorched outskirts of Woodland, a farming town in California’s ag belt. White-coated scientists hover amid tubs full of fruits and vegetables in a lab, probing them with the intensity of forensic investigators. Penetrometers measure squishiness. Instruments called Brix meters track sugar content. Gas spectro­graphs, liquid chromatographs, and magnetic resonance imagers isolate specific aromatic molecules and their concentrations.

Eventually volunteers eat the experimental foods and give feedback. In one tasting session, sensory scientist Chow-Ming Lee passes out five plastic cups filled with bite-size squares of cantaloupe, harvested from outside and brought in from a store, to a dozen melon growers and distributors. Each cup is labeled with a three-digit code. Score sheets have two columns: “Sweet/Flavorful” and “Juicy.”

 Nicholas Cope

Frescada
(lettuce)
Launched
Spring 2012
Availability
Year-round
Trait
Crisp leaves with a longer shelf life, plus 146 percent more folate and 74 percent more vitamin C than ordinary iceberg lettuce
Method
Crossing iceberg lettuce with romaine lettuce
Region grown
Arizona, California
Price
$2.25 to $2.50 per pound

After sampling each batch and writing down their assessments, the participants punch their scores into devices that connect to Lee’s laptop, which plots the room’s general sentiment on a screen along a four-quadrant grid ranging from low to high flavor on one axis and low to high juiciness on the other. None of the melons man­age to crack the upper corner of the far right quadrant, the slot Monsanto hopes to fill: a sweet, juicy, crowd-pleasing melon.

In the adjoining fields a few hours later, Monsanto breeders Jeff Mills and Greg Tolla conduct a different kind of taste test. There they slice open a classic cantaloupe and their own Melorange for comparison. Tolla’s assessment of the conventional variety is scathing. “It’s tastes more like a carrot,” he says. Mills agrees: “It’s firm. It’s sweet, but that’s about it. It’s flat.” I take bites of both too. Compared with the standard cantaloupe, the Melorange tastes supercharged; it’s vibrant, fruity, and ultrasweet. I want seconds. “That’s the shtick,” Mills says.

Of course, sweeter fruit isn’t necessarily better fruit, and it’s perhaps no surprise that critics of Monsanto are unconvinced that this push toward non-GM products represents good corporate citizenship. They question whether these new fruits and vegetables will actually be as healthy as their untweaked counterparts. In 2013, for example, consumer-traits researchers prototyped their Summer Slice watermelon, designed with a more applelike texture (to cut down on the dreaded watermelon-juice-dripping-down-your-chin phenomenon that has scarred so many childhoods). But the denser texture made it taste less sweet. So Stark’s team is breeding in a higher sugar content.

Is that unhealthy? No one really knows, but it’s certainly true that the law doesn’t require Monsanto to account for potential long-term effects. (The FDA considers all additive-free, conventionally bred produce to be safe.) Nobody has ever tinkered with sugar levels the way Monsanto is attempting; it’s essentially an experiment, says Robert Lustig, a pediatric endocrinologist and president of the Institute for Responsible Nutrition. “The only result they care about is profit.”

Monsanto, of course, denies that charge. Make fruit taste better and people will eat more of it. “That’s good for society and, let’s face it, good for business,” Stark says.

Monsanto is still Monsanto. The company enforces stringent contracts for farmers who buy its produce seeds. Just as with Roundup Ready soybeans, Monsanto prohibits regrowing seeds from the new crops. The company maintains exclusion clauses with growers if harvests don’t meet the standards of firmness, sweetness, or scent—pending strict quality-assurance checks. “The goal is to get the products recognized by the consumer, trusted, and purchased,” Stark says. “That’s what I really want. I want to grow sales.”

But he gets coy about the company’s longer-term agenda. “I’m not sure we ever really projected what kind of market share we’ll have,” he says. The vegetable division cleared $821 million in revenue in 2013, a significant potential growth area for a $14 billion-a-year company that leans heavily on revenue from biotech corn and soy. More telling is the company’s steady stream of acquisitions, which sug­gests a continuing commitment to the produce aisle. It owns a greenhouse in the Guatemalan mountains, where the dry, warm air allows three or four growth cycles a year—great for research. In 2008 Monsanto bought De Ruiter, one of the world’s biggest greenhouse seed companies, and in 2013 it picked up Climate Cor­poration, a big-data weather company that can provide intel on what field traits might be needed to survive global warming in a given region. Mark Gulley, an analyst at BGC Financial, says the company is following the “virtuous cycle” approach; it spends heavily on marketing and pours much of the proceeds back into R&D.

The new crops keep coming. In 2012 Monsanto debuted Performance Series Broccoli, a conventionally bred line that stands taller, enabling cheaper, faster mechanical harvesting as opposed to handpicking. Breeders are also growing watermelons with the green-and-white-striped rind patterns familiar to US consumers but also the tiger-striped variety favored in Spain and the oval jade version loved by Australians. “It’s supposed to remind you of where you grew up,” says Mills, the Monsanto melon breeder. That suggests the division plans to be a player in the trillion-dollar global produce market.

For his part, Stark hopes that when Monsanto’s affiliation with some of its best sellers becomes more widely known, the company might win back some trust. “There isn’t a reputation silver bullet, but it helps,” he says. In that basement dining room at Monsanto headquarters, he waxes rhapsodic about the lettuce long after he has cleaned his plate. During a recent trip to Holland, where Frescada is gaining popularity, Stark saw folks peeling leaves straight off the heads and munching them without dressing, like extra-large potato chips. “People just ate it like a snack, which was not the intent, but …” Stark trails off and looks around the room. His napkin is still on his lap. He’s savoring the potential.

I CAN’T BELIEVE IT’S NOT GMO

Agriculture giant Monsanto may be best known for genetic modification—like creating corn that resists the effects of Monsanto’s weed killer Roundup. But when it comes to fruits and vegetables you buy in the store, genetic modification is off the menu. Monsanto thinks no one will buy Frankenfoods, so the company is tweaking its efforts—continuing to map the genetic basis of a plant’s desirable traits but using that data to breed new custom-designed strains the way agronomists have for millennia. Here’s how it works—and how the results differ from GMO crops. Thanks to this cross between high and low tech, a new era of super-produce may be upon us. —Victoria Tang
The Old Way
 Identify plants with recognizable, desirable traits.
 Crossbreed those plants together.
 Grow the offspring.
 Wait to see if the traits show up. Repeat as necessary.
The Genetic Modification Way
 Identify plants or other organisms with recognizable, desirable traits.
 Isolate the genes that manifest those traits.
 Use enzymes to clip out those genes and paste them into the genomes of other plants, or inject them using a “gene gun” (for real) or by piggybacking them on a bacteria or virus.
 Grow the plant with the inserted gene. If the gene has successfully incorporated into the plant, you’ll have a novel phenotype.
The New Monsanto Way
 Identify plants with recognizable, desirable traits.
 Crossbreed the plants.
 Sift through the offspring genome for known markers for desirable traits.
 Grow only the plants with those markers.

Joaquim Machado

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THE IDEA FACTORY: learning to think at MIT
Pepper White
The MIT Press, 2001


THE IDEA FACTORY: Bell Labs and the Great Age of American Innovation
Jon Gertner
The Penguin Press,  2012

Joaquim Machado

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Marrying tissue engineering with systems biology

Linda Griffith combines in vitro models with deep molecular analysis to accelerate drug discovery.
Eric Bender
MIT Industrial Liaison Program

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“Together, we’re building interactive organs,” says Linda Griffith, professor of biological and mechanical engineering. That’s the goal of the Defense Advanced Research Projects Agency (DARPA) research program known formally as the Microphysiological Systems program and informally as the “body on a chip” program.

“DARPA had a vision to replicate all 10 human physiological systems on a single research platform to allow the researcher to look at crosstalk between the systems, such as the liver with the gut or with reproductive systems,” Griffith says. She directs the Barrier-Immune-Organ: MIcrophysiology, Microenvironment Engineered TIssue Construct Systems (BIO-MIMETICS) program, one effort under the DARPA program. BIO-MIMETICS has numerous collaborators at MIT as well as the Charles Stark Draper Laboratory, the University of Pittsburgh, Northeastern University, and Zyoxel of Oxford, United Kingdom.

Griffith’s work builds on her lab’s earlier development of a three-dimensional “bioreactor” model of the human liver, now being commercialized by Zyoxel for use in drug discovery.

Additionally, her latest research draws heavily on systems biology, which investigates how cells integrate information across multiple scales, including genes, RNA, proteins, protein activity states, and metabolites. “Now we can make high-information-content measurements on all of these scales of information flow in a cell,” Griffith says. The research, which includes several MIT biological engineering faculty members, focuses particularly on protein activity states and the effects of those states — for example, how a cell responds to a molecular growth factor — using mathematics to model cell behavior.

“We view the merging of tissue engineering and systems biology as an incredibly powerful marriage for the future of the whole drug development process, everywhere along the pipeline up to clinical trials,” Griffith says. “This will let us relate the kinds of measurements we can make in a patient to the kinds of measurements we can make in our in vitro model. It’s about more than if the cells metabolize the drug; it’s about actually understanding how the drug works.”

Modeling liver inflammation and metastatic cancer

One “body on a chip” program that Griffith leads examines interactions between models of the gut and the liver. “We’re building a very detailed model of the gut/liver interaction that lets us actually start to put real patient gut bacteria in a model of the human intestine and have it interact with the liver,” she says.

“All the blood in your intestine immediately goes to the liver, which regulates your metabolism, but your gut’s also filled with microbes, and little pieces of microbes leak across the gut wall all the time and interact with the immune system in the liver,” she explains. “If you get a gastrointestinal disease or take a drug that changes the gut permeability, now all of a sudden the liver can see a lot more bacterial products than it’s used to, and it can get inflamed. That may be okay, but if you’re taking a drug or you have some kind of stress, you may harm your liver.”

In another closely related project, funded by the National Institutes of Health, Griffith collaborates with colleagues at MIT and the University of Pittsburgh to investigate metastatic triple-negative breast cancer tumors placed in a 3-D liver bioreactor.

“I myself had triple-negative breast cancer, and I came to appreciate how hard it is to develop new cancer drugs to treat patients,” Griffith says. “We don’t know why chemotherapies fail in a very significant percentage of patients with triple-negative breast cancer.”

Those patients typically die of metastasized tumors that have spread to the liver and other organs. Tiny metastatic tumors in these organs may lie dormant for years, and the combination of tissue engineering with systems biology provides new opportunities to study what triggers the tumors’ activation. 

“You can put cancer cells in our liver bioreactors and get them to quiet down, just as one of these silent micrometastases might do in a patient,” Griffith says. “Now we have a human model that lets us study what stimulates those cancer cells to die or proliferate.” 

These highly aggressive cancer cells typically keep growing when placed in normal cell cultures, but Griffith and her research partners have created what they think is the first evidence that cells can be kept inactive in vitro. “That’s a huge advance, because now we can start to bring them in and out of that quiescent state in tissue, and really have a model for them,” she says.

Advances in endometriosis

Griffith and her colleagues also take a systems-biology approach in an investigation of endometriosis, a painful and sometimes debilitating condition in which pieces of the uterine lining migrate out of the uterus and grow in the abdominal cavity. The disease afflicts up to 10 percent of women, often takes years to diagnose, and is typically treated only with surgery.

Griffith has collaborated with MIT professor Douglas Lauffenburger (a leader in systems biology research) and surgeon Keith Isaacson of Newton-Wellesley Hospital on a clinical study of inflammation mechanisms in endometriosis. 

Analyzing patient samples for levels of 50 cytokines involved in immune cell signaling, the researchers found that in one group of patients the levels of 13 cytokines were elevated together, suggesting that the cytokines were part of a common molecular network. Further study revealed details of how the inflammation process is driven by macrophage immune cells. Moreover, the findings pointed to a molecular pathway that hadn’t previously been implicated in endometriosis and that can be inhibited in cell culture by existing small-molecule agents.

While this research is still in its early stages, its promise of drug treatment for endometriosis has provoked excitement among gynecologists. “We’ve galvanized a whole international community to think about the disease in a new way,” Griffith says.

More broadly, “there are tremendous opportunities for this systems-biology approach in women’s reproductive health,” Griffith says. She is also bringing her tissue-engineering expertise to the field; the “body on a chip” program that she directs will incorporate tissue models addressing aspects of women’s reproductive health.

Griffith directs the MIT Center for Gynepathology Research, established in 2009 to help meet what she calls “a huge unmet need in women’s reproductive health” — finding better treatments for conditions such as endometriosis, fibroids, and adenomyosis that have seen relatively little federal research funding and few advances in recent years. 

The Center brings together a broad group of MIT researchers with gynecological surgeons and industry partners. “We’re working very closely with wonderful advisors in industry who are cheering us on, because until they have models of efficacy and can unravel a new research direction it’s very hard for companies to make a commitment to these diseases,” Griffith says.

Partnering with pharmaceuticals

The Center is just one framework in which Griffith works with numerous pharmaceutical partners. 

“Drug companies have a pipeline, and we’re adding to the tools in their pipeline,” she says. “What we’re building is not replacing regular cell culture or animals, it’s adding the ability to bring part of a clinical trial further up in the lab. So before you go into people, you’re actually trying to bring the people to the lab, in a miniature form, and test things on them.”

“There really is a huge interest in how do we bridge the in vitro-in vivo correlations for drug efficacy and toxicity,” she says. “And we now appreciate that it’s very complicated by individual patient situations, such as taking another drug or having an underlying stressor such as obesity.”

“There are many different facets of patient states that we need to capture, and we need to do it in an efficient way,” Griffith adds. “We communicate very frequently with our industry advisors about this topic, and it’s a very interesting two-way flow of information. We send people to their labs so we can see how Amgen, Novartis, Pfizer, or Sanofi would actually use a model. We don’t want to make it too complicated for them to use in a meaningful way.”

Joaquim Machado

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Joaquim Machado

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SUMMER COURSE – CREATIVE BY NATURE: BIONICS AND BIOMIMETICS

Dates: February 3 to 7, 2014
Language: English
Time Schedule: 15H, Monday to Friday (7:30pm – 10:30pm)
Location: IED RIO (Urca’s Old Cassino) Avenida João Luis Alves, 13 – Urca Rio De Janeiro – Rj

OBJECTIVE

This course explores some natural associations between natural structures and their specific functions, with a focus on Brazilian ecosystems. It addresses key strategies for creating and processing used by nature in the development of structures, systems, materials and solutions, drawing parallels with human projective methods.

– Stimulate the development of fundamental skills for creative practice with inspiration in nature
- Deepen the power of observation and curiosity, seeking other interpretations of nature’s “design principles”
- Practice interdisciplinary thinking, making connections between different areas of knowledge as Biology, Physics, Mathematics and Design
- Identify opportunities observing nature as a source of inspiration for creative projects
- Exercise the capacity to think unconventionally, making links between nature and artificial technologies
- Understand the mechanisms of nature as a strategic tool

TARGET

Students and creative professionals, such as artists, designers, architects, engineers, advertisers and others.

FACULTY

Daniel MalagutiDaniel Pan
Currently professor of design and researcher at the Laboratory for Research in Free Design ( LILD ) at PUC -Rio. Develops design projects and consultancy focused on sustainability and lightweight structures and teaches free courses on Permaculture and Bioconstruction.

- DSc in Design – PUC -Rio
- Master of Design – PUC -Rio
- Education Specialist – PUC-Rio/Hebrew University of Jerusalem
- BFA in Industrial Design (product design) – EBA / UFRJ
- Permacultor and instructor of PDC ( Permaculture Design Course ) certified permaculture Infuse Network

Tiago de PaulaTiago de Paula
Permacultor founder of AS – Atelier Sustentável. Develops projects and research focused on ecodesign, resource productivity and energy efficiency. Teaches free courses and workshops in educational institutions and support organizations for young people.

- Master in Design – PUC -Rio
- BFA in Industrial Design (product design) – EBA / UFRJ
- Permacultor Certified Network Pervade of permaculture
- Building Technician – CEFET / RJ

ÁREAS DE ESTUDO

Concepts: means and methods of nature. From units to systems. Differences and similarities of both natural and artificial means of creation and replication.

Research: Practical exploration and personal research on problematic situations suggested by the teachers.

Construction and cooperation: materialization of ideas in simplified models using affordable materials. Presentation and critique among students and teachers. Lectures and hands-on classes.

Class 1. Lecture
- Overview of the course
- Application of bionics in the development of creative projects
- Organizing principles of living elements
- Permaculture and design - imitating nature with ethical principles
- Patterns, fractals and spirals

Class 2. Lecture and practice
- Bionics in determining the form: the golden ratio and the Fibonacci sequence
- Analysis of formal solutions inspired in nature
- Exercises generation and modeling shapes

Class 3. Lecture and practice
- Bionics in Structures: optimizing the use of materials
- Analysis of structural solutions inspired by nature
- Exercises generation and modeling of structures

Class 4. Lecture and practice
- Bionics in planning functions: Natural Strategies
- Translating concepts of biology
- Analysis of functional solutions inspired by nature
- Exercise to generate functional solutions inspired by nature

Class 5. Practice
- Practical application of concepts given by drafting a blueprint
- Making a physical model of project presentation
- Presentation and defense of the idea



Joaquim Machado

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Joaquim Machado

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white house 3d printing 250 x 250

Coming Soon: the White House Maker Faire

Michael Molitch-Hou BY MICHAEL MOLITCH-HOU ON  · NORTH AMERICA 1 COMMENT

We recently covered the story of Joey Hudy, a young Afiniac who had made an impression at the White House Science Fair in 2012 with his marshmallow cannon.  Inspired by Joey’s tenacity and the growing Maker movement, the White House has announced that it will be hosting its first ever Maker Faire.  Details about the event are still vague, but Makers across the country are encouraged to e-mail ma...@ostp.gov or tweet with the hashtag #IMadeThis to make the White House aware of your own projects.

As the White House blog points out, the US government has already encouraged the Maker attitude in its citizens with a number of projects.  The US Army has crowd-sourced solutions for military problems with ArmyCoCreate and a military hack-a-thon.  DARPA worked with the Veteran’s Administration to create a TechShop in Pittsburgh, which started an apprenticeship program through Carnegie Mellon, the AFL-CIO, and the Department of Labor.  The Americorps’ Maker Education Initiative is hoping to give young people the skills needed to take on their own DIY projects.  The White House even gave a member of the Maker Movement, Dale Dougherty, the honorary status ofChampion of Change.  And we can’t forget that last year saw the launch of America Makes, the country’s own 3D printing institute.

Until the White House releases further details about their “all-hands-on-deck effort to provide even more students and entrepreneurs access to the tools, spaces, and mentors needed to Make” to be launched later this year, their blog suggests a few ways for US society at large to support the Maker movement.  They suggest that “companies could support Maker-spaces in schools and after-school programs” and give their employees time off to mentor in such programs, that universities launch their own Makerspaces, that “mayors and communities could pursue initiatives likedesign/production districts“, and that non-profits give “matching grants to communities that are interested in embracing Making“, especially ones that encourage the representation of women and minorities in STEM programs.

We’ll definitely keep you updated with details about the event because where there’s Making, there’s 3D printing. If it’s anything like Joey’s visit to the White House, it’s sure to be fun.  Check out Joey’s visit below:

Source: The White House



Joaquim Machado

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ANNALS OF SCIENCE

A VALUABLE REPUTATION

After Tyrone Hayes said that a chemical was harmful, its maker pursued him.

by Rachel AvivFEBRUARY 10, 2014

Hayes has devoted the past fifteen years to studying atrazine, a widely used herbicide made by Syngenta. The company’s notes reveal that it struggled to make sense of him, and plotted ways to discredit him.

Hayes has devoted the past fifteen years to studying atrazine, a widely used herbicide made by Syngenta. The company’s notes reveal that it struggled to make sense of him, and plotted ways to discredit him. Photograph by Dan Winters.

In 2001, seven years after joining the biology faculty of the University of California, Berkeley, Tyrone Hayes stopped talking about his research with people he didn’t trust. He instructed the students in his lab, where he was raising three thousand frogs, to hang up the phone if they heard a click, a signal that a third party might be on the line. Other scientists seemed to remember events differently, he noticed, so he started carrying an audio recorder to meetings. “The secret to a happy, successful life of paranoia,” he liked to say, “is to keep careful track of your persecutors.”

Three years earlier, Syngenta, one of the largest agribusinesses in the world, had asked Hayes to conduct experiments on the herbicide atrazine, which is applied to more than half the corn in the United States. Hayes was thirty-one, and he had already published twenty papers on the endocrinology of amphibians. David Wake, a professor in Hayes’s department, said that Hayes “may have had the greatest potential of anyone in the field.” But, when Hayes discovered that atrazine might impede the sexual development of frogs, his dealings with Syngenta became strained, and, in November, 2000, he ended his relationship with the company.

Hayes continued studying atrazine on his own, and soon he became convinced that Syngenta representatives were following him to conferences around the world. He worried that the company was orchestrating a campaign to destroy his reputation. He complained that whenever he gave public talks there was a stranger in the back of the room, taking notes. On a trip to Washington, D.C., in 2003, he stayed at a different hotel each night. He was still in touch with a few Syngenta scientists and, after noticing that they knew many details about his work and his schedule, he suspected that they were reading his e-mails. To confuse them, he asked a student to write misleading e-mails from his office computer while he was travelling. He sent backup copies of his data and notes to his parents in sealed boxes. In an e-mail to one Syngenta scientist, he wrote that he had “risked my reputation, my name . . . some say even my life, for what I thought (and now know) is right.” A few scientists had previously done experiments that anticipated Hayes’s work, but no one had observed such extreme effects. In another e-mail to Syngenta, he acknowledged that it might appear that he was suffering from a “Napoleon complex” or “delusions of grandeur.”

For years, despite his achievements, Hayes had felt like an interloper. In academic settings, it seemed to him that his colleagues were operating according to a frivolous code of manners: they spoke so formally, fashioning themselves as detached authorities, and rarely admitted what they didn’t know. He had grown up in Columbia, South Carolina, in a neighborhood where fewer than forty per cent of residents finish high school. Until sixth grade, when he was accepted into a program for the gifted, in a different neighborhood, he had never had a conversation with a white person his age. He and his friends used to tell one another how “white people do this, and white people do that,” pretending that they knew. After he switched schools and took advanced courses, the black kids made fun of him, saying, “Oh, he thinks he’s white.”

He was fascinated by the idea of metamorphosis, and spent much of his adolescence collecting tadpoles and frogs and crossbreeding different species of grasshoppers. He raised frog larvae on his parents’ front porch, and examined how lizards respond to changes in temperature (by using a blow-dryer) and light (by placing them in a doghouse). His father, a carpet layer, used to look at his experiments, shake his head, and say, “There’s a fine line between a genius and a fool.”

Hayes received a scholarship to Harvard, and, in 1985, began what he calls the worst four years of his life. Many of the other black students had gone to private schools and came from affluent families. He felt disconnected and ill-equipped—he was placed on academic probation—until he became close to a biology professor, who encouraged him to work in his lab. Five feet three and thin, Hayes distinguished himself by dressing flamboyantly, like Prince. The Harvard Crimson, in an article about a campus party, wrote that he looked as if he belonged in the “rock-’n’-ready atmosphere of New York’s Danceteria.” He thought about dropping out, but then he started dating a classmate, Katherine Kim, a Korean-American biology major from Kansas. He married her two days after he graduated.

They moved to Berkeley, where Hayes enrolled in the university’s program in integrative biology. He completed his Ph.D. in three and a half years, and was immediately hired by his department. “He was a force of nature—incredibly gifted and hardworking,” Paul Barber, a colleague who is now a professor at U.C.L.A., says. Hayes became one of only a few black tenured biology professors in the country. He won Berkeley’s highest award for teaching, and ran the most racially diverse lab in his department, attracting students who were the first in their families to go to college. Nigel Noriega, a former graduate student, said that the lab was a “comfort zone” for students who were “just suffocating at Berkeley,” because they felt alienated from academic culture.

Hayes had become accustomed to steady praise from his colleagues, but, when Syngenta cast doubt on his work, he became preoccupied by old anxieties. He believed that the company was trying to isolate him from other scientists and “play on my insecurities—the fear that I’m not good enough, that everyone thinks I’m a fraud,” he said. He told colleagues that he suspected that Syngenta held “focus groups” on how to mine his vulnerabilities. Roger Liu, who worked in Hayes’s lab for a decade, both as an undergraduate and as a graduate student, said, “In the beginning, I was really worried for his safety. But then I couldn’t tell where the reality ended and the exaggeration crept in.”

Liu and several other former students said that they had remained skeptical of Hayes’s accusations until last summer, when an article appeared in Environmental Health News that drew on Syngenta’s internal records. Hundreds of Syngenta’s memos, notes, and e-mails have been unsealed following the settlement, in 2012, of two class-action suits brought by twenty-three Midwestern cities and towns that accused Syngenta of “concealing atrazine’s true dangerous nature” and contaminating their drinking water. Stephen Tillery, the lawyer who argued the cases, said, “Tyrone’s work gave us the scientific basis for the lawsuit.”

Hayes has devoted the past fifteen years to studying atrazine, and during that time scientists around the world have expanded on his findings, suggesting that the herbicide is associated with birth defects in humans as well as in animals. The company documents show that, while Hayes was studying atrazine, Syngenta was studying him, as he had long suspected. Syngenta’s public-relations team had drafted a list of four goals. The first was “discredit Hayes.” In a spiral-bound notebook, Syngenta’s communications manager, Sherry Ford, who referred to Hayes by his initials, wrote that the company could “prevent citing of TH data by revealing him as noncredible.” He was a frequent topic of conversation at company meetings. Syngenta looked for ways to “exploit Hayes’ faults/problems.” “If TH involved in scandal, enviros will drop him,” Ford wrote. She observed that Hayes “grew up in world (S.C.) that wouldn’t accept him,” “needs adulation,” “doesn’t sleep,” was “scarred for life.” She wrote, “What’s motivating Hayes?—basic question.”

Syngenta, which is based in Basel, sells more than fourteen billion dollars’ worth of seeds and pesticides a year and funds research at some four hundred academic institutions around the world. When Hayes agreed to do experiments for the company (which at that time was part of a larger corporation, Novartis), the students in his lab expressed concern that biotech companies were “buying up universities” and that industry funding would compromise the objectivity of their research. Hayes assured them that his fee, a hundred and twenty-five thousand dollars, would make their lab more rigorous. He could employ more students, buy new equipment, and raise more frogs. Though his lab was well funded, federal support for research was growing increasingly unstable, and, like many academics and administrators, he felt that he should find new sources of revenue. “I went into it as if I were a painter, performing a service,” Hayes told me. “You commissioned it, and I come up with the results, and you do what you want with them. It’s your responsibility, not mine.”

Atrazine is the second most widely used herbicide in the U.S., where sales are estimated at about three hundred million dollars a year. Introduced in 1958, it is cheap to produce and controls a broad range of weeds. (Glyphosate, which is produced by Monsanto, is the most popular herbicide.) A study by the Environmental Protection Agency found that without atrazine the national corn yield would fall by six per cent, creating an annual loss of nearly two billion dollars. But the herbicide degrades slowly in soil and often washes into streams and lakes, where it doesn’t readily dissolve. Atrazine is one of the most common contaminants of drinking water; an estimated thirty million Americans are exposed to trace amounts of the chemical.

In 1994, the E.P.A., expressing concerns about atrazine’s health effects, announced that it would start a scientific review. Syngenta assembled a panel of scientists and professors, through a consulting firm called EcoRisk, to study the herbicide. Hayes eventually joined the group. His first experiment showed that male tadpoles exposed to atrazine developed less muscle surrounding their vocal cords, and he hypothesized that the chemical had the potential to reduce testosterone levels. “I have been losing lots of sleep over this,” he wrote one EcoRisk panel member, in the summer of 2000. “I realize the implications and of course want to make sure that everything possible has been done and controlled for.” After a conference call, he was surprised by the way the company kept critiquing what seemed to be trivial aspects of the work. Hayes wanted to repeat and validate his experiments, and complained that the company was slowing him down and that independent scientists would publish similar results before he could. He decided to resign from the panel, writing in a letter that he didn’t want to be “scooped.” “I fear that my reputation will be damaged if I continue my relationship and associated low productivity with Novartis,” he wrote. “It will appear to my colleagues that I have been part of a plan to bury important data.”

Hayes repeated the experiments using funds from Berkeley and the National Science Foundation. Afterward, he wrote to the panel, “Although I do not want to make a big deal out of it until I have all of the data analyzed and decoded—I feel I should warn you that I think something very strange is coming up in these animals.” After dissecting the frogs, he noticed that some could not be clearly identified as male or female: they had both testes and ovaries. Others had multiple testes that were deformed.

In January, 2001, Syngenta employees and members of the EcoRisk panel travelled to Berkeley to discuss Hayes’s new findings. Syngenta asked to meet with him privately, but Hayes insisted on the presence of his students, a few colleagues, and his wife. He had previously had an amiable relationship with the panel—he had enjoyed taking long runs with the scientist who supervised it—and he began the meeting, in a large room at Berkeley’s Museum of Vertebrate Zoology, as if he were hosting an academic conference. He wore a new suit and brought in catered meals.

After lunch, Syngenta introduced a guest speaker, a statistical consultant, who listed numerous errors in Hayes’s report and concluded that the results were not statistically significant. Hayes’s wife, Katherine Kim, said that the consultant seemed to be trying to “make Tyrone look as foolish as possible.” Wake, the biology professor, said that the men on the EcoRisk panel looked increasingly uncomfortable. “They were experienced enough to know that the issues the statistical consultant was raising were routine and ridiculous,” he said. “A couple of glitches were presented as if they were the end of the world. I’ve been a scientist in academic settings for forty years, and I’ve never experienced anything like that. They were after Tyrone.”

Hayes later e-mailed three of the scientists, telling them, “I was insulted, felt railroaded and, in fact, felt that some dishonest and unethical activity was going on.” When he explained what had happened to Theo Colborn, the scientist who had popularized the theory that industrial chemicals could alter hormones, she advised him, “Don’t go home the same way twice.” Colborn was convinced that her office had been bugged, and that industry representatives followed her. She told Hayes to “keep looking over your shoulder” and to be careful whom he let in his lab. She warned him, “You have got to protect yourself.”

Hayes published his atrazine work in the Proceedings of the National Academy of Sciences a year and a half after quitting the panel. He wrote that what he called “hermaphroditism” was induced in frogs by exposure to atrazine at levels thirty times below what the E.P.A. permits in water. He hypothesized that the chemical could be a factor in the decline in amphibian populations, a phenomenon observed all over the world. In an e-mail sent the day before the publication, he congratulated the students in his lab for taking the “ethical stance” by continuing the work on their own. “We (and our principles) have been tested, and I believe we have not only passed but exceeded expectations,” he wrote. “Science is a principle and a process of seeking truth. Truth cannot be purchased and, thus, truth cannot be altered by money. Professorship is not a career, but rather a life’s pursuit. The people with whom I work daily exemplify and remind me of this promise.”

He and his students continued the work, travelling to farming regions throughout the Midwest, collecting frogs in ponds and lakes, and sending three hundred pails of frozen water back to Berkeley. In papers in Nature and in Environmental Health Perspectives, Hayes reported that he had found frogs with sexual abnormalities in atrazine-contaminated sites in Illinois, Iowa, Nebraska, and Wyoming. “Now that I have realized what we are into, I cannot stop it,” he wrote to a colleague. “It is an entity of its own.” Hayes began arriving at his lab at 3:30 A.M. and staying fourteen hours. He had two young children, who sometimes assisted by color-coding containers.

According to company e-mails, Syngenta was distressed by Hayes’s work. Its public-relations team compiled a database of more than a hundred “supportive third party stakeholders,” including twenty-five professors, who could defend atrazine or act as “spokespeople on Hayes.” The P.R. team suggested that the company “purchase ‘Tyrone Hayes’ as a search word on the internet, so that any time someone searches for Tyrone’s material, the first thing they see is our material.” The proposal was later expanded to include the phrases “amphibian hayes,” “atrazine frogs,” and “frog feminization.” (Searching online for “Tyrone Hayes” now brings up an advertisement that says, “Tyrone Hayes Not Credible.”)

In June, 2002, two months after Hayes’s first atrazine publication, Syngenta announced in a press release that three studies had failed to replicate Hayes’s work. In a letter to the editor of the Proceedings of the National Academy of Sciences, eight scientists on the EcoRisk panel wrote that Hayes’s study had “little regard for assessment of causality,” lacked statistical details, misused the term “dose,” made vague and naïve references, and misspelled a word. They said that Hayes’s claim that his paper had “significant implications for environmental and public health” had not been “scientifically demonstrated.” Steven Milloy, a freelance science columnist who runs a nonprofit organization to which Syngenta has given tens of thousands of dollars, wrote an article for Fox News titled “Freaky-Frog Fraud,” which picked apart Hayes’s paper in Nature, saying that there wasn’t a clear relationship between the concentration of atrazine and the effect on the frog. Milloy characterized Hayes as a “junk scientist” and dismissed his “lame” conclusions as “just another of Hayes’ tricks.”

Fussy critiques of scientific experiments have become integral to what is known as the “sound science” campaign, an effort by interest groups and industries to slow the pace of regulation. David Michaels, the Assistant Secretary of Labor for Occupational Safety and Health, wrote, in his book “Doubt Is Their Product” (2008), that corporations have developed sophisticated strategies for “manufacturing and magnifying uncertainty.” In the eighties and nineties, the tobacco industry fended off regulations by drawing attention to questions about the science of secondhand smoke. Many companies have adopted this tactic. “Industry has learned that debating the science is much easier and more effective than debating the policy,” Michaels wrote. “In field after field, year after year, conclusions that might support regulation are always disputed. Animal data are deemed not relevant, human data not representative, and exposure data not reliable.”

In the summer of 2002, two scientists from the E.P.A. visited Hayes’s lab and reviewed his atrazine data. Thomas Steeger, one of the scientists, told Hayes, “Your research can potentially affect the balance of risk versus benefit for one of the most controversial pesticides in the U.S.” But an organization called the Center for Regulatory Effectiveness petitioned the E.P.A. to ignore Hayes’s findings. “Hayes has killed and continues to kill thousands of frogs in unvalidated tests that have no proven value,” the petition said. The center argued that Hayes’s studies violated the Data Quality Act, passed in 2000, which requires that regulatory decisions rely on studies that meet high standards for “quality, objectivity, utility, and integrity.” The center is run by an industry lobbyist and consultant for Syngenta, Jim Tozzi, who proposed the language of the Data Quality Act to the congresswoman who sponsored it.

The E.P.A. complied with the Data Quality Act and revised its Environmental Risk Assessment, making it clear that hormone disruption wouldn’t be a legitimate reason for restricting use of the chemical until “appropriate testing protocols have been established.” Steeger told Hayes that he was troubled by the circularity of the center’s critique. In an e-mail, he wrote, “Their position reminds me of the argument put forward by the philosopher Berkeley, who argued against empiricism by noting that reliance on scientific observation is flawed since the link between observations and conclusions is intangible and is thus immeasurable.”

Nonetheless, Steeger seemed resigned to the frustrations of regulatory science and gently punctured Hayes’s idealism. When Hayes complained that Syngenta had not reported his findings on frog hermaphroditism quickly enough, he responded that it was “unfortunate but not uncommon for registrants to ‘sit’ on data that may be considered adverse to the public’s perception of their products.” He wrote that “science can be manipulated to serve certain agendas. All you can do is practice ‘suspended disbelief.’ ” (The E.P.A. says that there is “no indication that information was improperly withheld in this case.”)

After consulting with colleagues at Berkeley, Hayes decided that, rather than watch Syngenta discredit his work, he would make a “preëmptive move.” He appeared in features in Discover and the San Francisco Chronicle, suggesting that Syngenta’s science was not objective. Both articles focussed on his personal biography, leading with his skin color, and moving on to his hair style: at the time, he wore his hair in braids. Hayes made little attempt to appear disinterested. Scientific objectivity requires what the philosopher Thomas Nagel has called a “view from nowhere,” but Hayes kept drawing attention to himself, making blustery comments like “Tyrone can only be Tyrone.” He presented Syngenta as a villain, but he didn’t quite fulfill the role of the hero. He was hyper and a little frantic—he always seemed to be in a rush or on the verge of forgetting to do something—and he approached the idea of taking down the big guys with a kind of juvenile zeal.

Environmental activists praised Hayes’s work and helped him get media attention. But they were concerned by the bluntness of his approach. A co-founder of the Environmental Working Group, a nonprofit research organization, told Hayes to “stop what you are doing and take time to actually construct a plan” or “you will get your ass handed to you on a platter.” Steeger warned him that vigilantism would distract him from his research. “Can you afford the time and money to fight battles where you are clearly outnumbered and, to be candid, outclassed?” he asked. “Most people would prefer to limit their time in purgatory; I don’t know anyone who knowingly enters hell.”

Hayes had worked all his life to build his scientific reputation, and now it seemed on the verge of collapse. “I cannot in reasonable terms explain to you what this means to me,” he told Steeger. He took pains to prove that Syngenta’s experiments had not replicated his studies: they used a different population of animals, which were raised in different types of tanks, in closer quarters, at cooler temperatures, and with a different feeding schedule. On at least three occasions, he proposed to the Syngenta scientists that they trade data. “If we really want to test repeatability, let’s share animals and solutions,” he wrote.

In early 2003, Hayes was considered for a job at the Nicholas School of the Environment, at Duke. He visited the campus three times, and the university arranged for a real-estate agent to show him and his wife potential homes. When Syngenta learned that Hayes might be moving to North Carolina, where its crop-protection headquarters are situated, Gary Dickson—the company’s vice-president of global risk assessment, who a year earlier had established a fifty-thousand-dollar endowment, funded by Syngenta, at the Nicholas School—contacted a dean at Duke. According to documents unsealed in the class-action lawsuits, Dickson informed the dean of the “state of the relationship between Dr. Hayes and Syngenta.” The company “wanted to protect our reputation in our community and among our employees.”

There were several candidates for the job at Duke, and, when Hayes did not get it, he concluded that it was due to Syngenta’s influence. Richard Di Giulio, a Duke professor who had hosted Hayes’s first visit, said that he was irritated by Hayes’s suggestion: “A little gift of fifty thousand dollars would not influence a tenure hire. That’s not going to happen.” He added, “I’m not surprised that Syngenta would not have liked Hayes to be at Duke, since we’re an hour down the road from them.” He said that Hayes’s conflict with Syngenta was an extreme example of the kind of dispute that is not uncommon in environmental science. The difference, he said, was that the “scientific debate spilled into Hayes’s emotional life.”

In June, 2003, Hayes paid his own way to Washington so that he could present his work at an E.P.A. hearing on atrazine. The agency had evaluated seventeen studies. Twelve experiments had been funded by Syngenta, and all but two showed that atrazine had no effect on the sexual development of frogs. The rest of the experiments, by Hayes and researchers at two other universities, indicated the opposite. In a PowerPoint presentation at the hearing, Hayes disclosed a private e-mail sent to him by one of the scientists on the EcoRisk panel, a professor at Texas Tech, who wrote, “I agree with you that the important issue is for everyone involved to come to grips with (and stop minimizing) the fact that independent laboratories have demonstrated an effect of atrazine on gonadal differentiation in frogs. There is no denying this.”

The E.P.A. found that all seventeen atrazine studies, including Hayes’s, suffered from methodological flaws—contamination of controls, variability in measurement end points, poor animal husbandry—and asked Syngenta to fund a comprehensive experiment that would produce more definitive results. Darcy Kelley, a member of the E.P.A.’s scientific advisory panel and a biology professor at Columbia, said that, at the time, “I did not think the E.P.A. made the right decision.” The studies by Syngenta scientists had flaws that “really cast into doubt their ability to carry out their experiments. They couldn’t replicate effects that are as easy as falling off a log.” She thought that Hayes’s experiments were more respectable, but she wasn’t persuaded by Hayes’s explanation of the biological mechanism causing the deformities.

The E.P.A. approved the continued use of atrazine in October, the same month that the European Commission chose to remove it from the market. The European Union generally takes a precautionary approach to environmental risks, choosing restraint in the face of uncertainty. In the U.S., lingering scientific questions justify delays in regulatory decisions. Since the mid-seventies, the E.P.A. has issued regulations restricting the use of only five industrial chemicals out of more than eighty thousand in the environment. Industries have a greater role in the American regulatory process—they may sue regulators if there are errors in the scientific record—and cost-benefit analyses are integral to decisions: a monetary value is assigned to disease, impairments, and shortened lives and weighed against the benefits of keeping a chemical in use. Lisa Heinzerling, the senior climate-policy counsel at the E.P.A. in 2009 and the associate administrator of the office of policy in 2009 and 2010, said that cost-benefit models appear “objective and neutral, a way to free ourselves from the chaos of politics.” But the complex algorithms “quietly condone a tremendous amount of risk.” She added that the influence of the Office of Management and Budget, which oversees major regulatory decisions, has deepened in recent years. “A rule will go through years of scientific reviews and cost-benefit analyses, and then at the final stage it doesn’t pass,” she said. “It has a terrible, demoralizing effect on the culture at the E.P.A.”

In 2003, a Syngenta development committee in Basel approved a strategy to keep atrazine on the market “until at least 2010.” A PowerPoint presentation assembled by Syngenta’s global product manager explained that “we need atrazine to secure our position in the corn marketplace. Without atrazine we cannot defend and grow our business in the USA.” Sherry Ford, the communications manager, wrote in her notebook that the company “should not phase out atz until we know about” the Syngenta herbicide paraquat, which has also been controversial, because of studies showing that it might be associated with Parkinson’s disease. She noted that atrazine “focuses attention away from other products.”

Syngenta began holding weekly “atrazine meetings” after the first class-action suit was filed, in 2004. The meetings were attended by toxicologists, the company’s counsel, communications staff, and the head of regulatory affairs. To dampen negative publicity from the lawsuit, the group discussed how it could invalidate Hayes’s research. Ford documented peculiar things he had done (“kept coat on”) or phrases he had used (“Is this line clean?”). “If TH wanted to win the day, and he had the goods,” she wrote, “he would have produced them when asked.” She noted that Hayes was “getting in too deep w/ enviros,” and searched for ways to get him to “show his true colors.”

In 2005, Ford made a long list of methods for discrediting him: “have his work audited by 3rd party,” “ask journals to retract,” “set trap to entice him to sue,” “investigate funding,” “investigate wife.” The initials of different employees were written in the margins beside entries, presumably because they had been assigned to look into the task. Another set of ideas, discussed at several meetings, was to conduct “systematic rebuttals of all TH appearances.” One of the company’s communications consultants said in an e-mail that she wanted to obtain Hayes’s calendar of speaking engagements, so that Syngenta could “start reaching out to the potential audiences with the Error vs. Truth Sheet,” which would provide “irrefutable evidence of his polluted messages.” (Syngenta says that many of the documents unsealed in the lawsuits refer to ideas that were never implemented.)

To redirect attention to the financial benefits of atrazine, the company paid Don Coursey, a tenured economist at the Harris School of Public Policy, at the University of Chicago, five hundred dollars an hour to study how a ban on the herbicide would affect the economy. In 2006, Syngenta supplied Coursey with data and a “bundle of studies,” and edited his paper, which was labelled as a Harris School Working Paper. (He disclosed that Syngenta had funded it.) After submitting a draft, Coursey had been warned in an e-mail that he needed to work harder to articulate a “clear statement of your conclusions flowing from this analysis.” Coursey later announced his findings at a National Press Club event in Washington and told the audience that there was one “basic takeaway point: a ban on atrazine at the national level will have a devastating, devastating effect upon the U.S. corn economy.”

Hayes had been promoted from associate to full professor in 2003, an achievement that had sent him into a mild depression. He had spent the previous decade understanding his self-worth in reference to a series of academic milestones, and he had reached each one. Now he felt aimless. His wife said she could have seen him settling into the life of a “normal, run-of-the-mill, successful scientist.” But he wasn’t motivated by the idea of “writing papers and books that we all just trade with each other.”

He began giving more than fifty lectures a year, not just to scientific audiences but to policy institutes, history departments, women’s health clinics, food preparers, farmers, and high schools. He almost never declined an invitation, despite the distance. He told his audiences that he was defying the instructions of his Ph.D. adviser, who had told him, “Let the science speak for itself.” He had a flair for sensational stories—he chose phrases like “crime scene” and “chemically castrated”—and he seemed to revel in details about Syngenta’s conflicts of interest, presenting theories as if he were relating gossip to friends. (Syngenta wrote a letter to Hayes and his dean, pointing out inaccuracies: “As we discover additional errors in your presentations, you can expect us to be in touch with you again.”)

At his talks, Hayes noticed that one or two men in the audience were dressed more sharply than the other scientists. They asked questions that seemed to have been designed to embarrass him: Why can’t anyone replicate your research? Why won’t you share your data? One former student, Ali Stuart, said that “everywhere Tyrone went there was this guy asking questions that made a mockery of him. We called him the Axe Man.” 

Hayes had once considered a few of the scientists working with Syngenta friends, and he approached them in a nerdy style of defiance. He wrote them mass e-mails, informing them of presentations he was giving and offering tips on how to discredit him. “You can’t approach your prey thinking like a predator,” he wrote. “You have to become your quarry.” He described a recent trip to South Carolina and his sense of displacement when “my old childhood friend came by to update me on who got killed, who’s on crack, who went to jail.” He wrote, “I have learned to talk like you (better than you . . . by your own admission), write like you (again better) . . . you however don’t know anyone like me . . . you have yet to spend a day in my world.” After seeing an e-mail in which a lobbyist characterized him as “black and quite articulate,” he began signing his e-mails, “Tyrone B. Hayes, Ph.D., A.B.M.,” for “articulate black man.”

Syngenta was concerned by Hayes’s e-mails and commissioned an outside contractor to do a “psychological profile” of Hayes. In her notes, Sherry Ford described him as “bipolar/manic-depressive” and “paranoid schizo & narcissistic.” Roger Liu, Hayes’s student, said that he thought Hayes wrote the e-mails to relieve his anxiety. Hayes often showed the e-mails to his students, who appreciated his rebellious sense of humor. Liu said, “Tyrone had all these groupies in the lab cheering him on. I was the one in the background saying, you know, ‘Man, don’t egg them on. Don’t poke that beast.’ ”

Syngenta intensified its public-relations campaign in 2009, as it became concerned that activists, touting “new science,” had developed a “new line of attack.” That year, a paper in Acta Paediatrica, reviewing national records for thirty million births, found that children conceived between April and July, when the concentration of atrazine (mixed with other pesticides) in water is highest, were more likely to have genital birth defects. The author of the paper, Paul Winchester, a professor of pediatrics at the Indiana University School of Medicine, received a subpoena from Syngenta, which requested that he turn over every e-mail he had written about atrazine in the past decade. The company’s media talking points described his study as “so-called science” that didn’t meet the “guffaw test.” Winchester said, “We don’t have to argue that I haven’t proved the point. Of course I haven’t proved the point! Epidemiologists don’t try to prove points—they look for problems.”

A few months after Winchester’s paper appeared, the Times published an investigation suggesting that atrazine levels frequently surpass the maximum threshold allowed in drinking water. The article referred to recent studies in Environmental Health Perspectives and the Journal of Pediatric Surgery that found that mothers living close to water sources containing atrazine were more likely to have babies who were underweight or had a defect in which the intestines and other organs protrude from the body.

The day the article appeared, Syngenta planned to “go through the article line by line and find all 1) inaccuracies and 2) misrepresentations. Turn that into a simple chart.” The company would have “a credible third party do the same.” Elizabeth Whelan, the president of the American Council on Science and Health, which asked Syngenta for a hundred thousand dollars that year, appeared on MSNBC and declared that the Times article was not based on science. “I’m a public-health professional,” she said. “It really bothers me very much to see the New York Times front-page Sunday edition featuring an article about a bogus risk.”

Syngenta’s public-relations team wrote editorials about the benefits of atrazine and about the flimsy science of its critics, and then sent them to “third-party allies,” who agreed to “byline” the articles, which appeared in the Washington Times, the Rochester Post-Bulletin, the Des Moines Register, and the St. CloudTimes. When a few articles in the “op-ed pipeline” sounded too aggressive, a Syngenta consultant warned that “some of the language of these pieces is suggestive of their source, which suggestion should be avoided at all costs.”

After the Times article, Syngenta hired a communications consultancy, the White House Writers Group, which has represented more than sixty Fortune 500 companies. In an e-mail to Syngenta, Josh Gilder, a director of the firm and a former speechwriter for Ronald Reagan, wrote, “We need to start fighting our own war.” By warning that a ban on atrazine would “devastate the economies” of rural regions, the firm tried to create a “state of affairs in which the new political leadership at E.P.A. finds itself increasingly isolated.” The firm held “elite dinners with Washington influentials” and tried to “prompt members of Congress” to challenge the scientific rationale for an upcoming E.P.A. review of atrazine. In a memo describing its strategy, the White House Writers Group wrote that, “regarding science, it is important to keep in mind that the major players in Washington do not understand science.”

In 2010, Hayes told the EcoRisk panel in an e-mail, “I have just initiated what will be the most extraordinary academic event in this battle!” He had another paper coming out in the Proceedings of the National Academy of Sciences, which described how male tadpoles exposed to atrazine grew up to be functional females with impaired fertility. He advised the company that it would want to get its P.R. campaign up to speed. “It’s nice to know that in this economy I can keep so many people employed,” he wrote. He quoted both Tupac Shakur and the South African king Shaka Zulu: “Never leave an enemy behind or it will rise again to fly at your throat.”

Syngenta’s head of global product safety wrote a letter to the editor of the Proceedings of the National Academy of Sciences and to the president of the National Academy of Sciences, expressing concern that a “publication with so many obvious weaknesses could achieve publication in such a reputable scientific journal.” A month later, Syngenta filed an ethics complaint with the chancellor of Berkeley, claiming that Hayes’s e-mails violated the university’s Standards of Ethical Conduct, particularly Respect for Others. Syngenta posted more than eighty of Hayes’s e-mails on its Web site and enclosed a few in its letter to the chancellor. In one, with the subject line “Are y’all ready for it,” Hayes wrote, “Ya fulla my j*z right now!” In another, he told the Syngenta scientists that he’d had a drink after a conference with their “republican buddies,” who wanted to know about a figure he had used in his paper. “As long as you followin me around, I know I’m da sh*t,” he wrote. “By the way, yo boy left his pre-written questions at the table!”

Berkeley declined to take disciplinary action against Hayes. The university’s lawyer reminded Syngenta in a letter that “all parties have an equal responsibility to act professionally.” David Wake said that he read many of the e-mails and found them “quite hilarious.” “He’s treating them like street punks, and they view themselves as captains of industry,” he said. “When he gets tapped, he goes right back at them.”

Michelle Boone, a professor of aquatic ecology at Miami University, who served on the E.P.A.’s scientific advisory panel, said, “We all follow the Tyrone Hayes drama, and some people will say, ‘He should just do the science.’ But the science doesn’t speak for itself. Industry has unlimited resources and bully power. Tyrone is the only one calling them out on what they’re doing.” However, she added, “I do think some people feel he has lost his objectivity.”

Keith Solomon, a professor emeritus at the University of Guelph, Ontario, who has received funding from Syngenta and served on the EcoRisk panel, noted that academics who refuse industry money are not immune from biases; they’re under pressure to produce papers, in order to get tenure and promotions. “If I do an experiment, look at the data every which way, and find nothing, it will not be easy to publish,” he said. “Journals want excitement. They want bad things to happen.”

Hayes, who had gained more than fifty pounds since becoming tenured, wore bright scarves draped over his suit and silver earrings from Tibet. At the end of his lectures, he broke into rhyme: “I see a ruse / intentionally constructed to confuse the news / well, I’ve taken it upon myself to defuse the clues / so that you can choose / and to demonstrate the objectivity of the methods I use.” At some of his lectures, Hayes warned that the consequences of atrazine use were disproportionately felt by people of color. “If you’re black or Hispanic, you’re more likely to live or work in areas where you’re exposed to crap,” he said. He explained that “on the one side I’m trying to play by the ivory-tower rules, and on the other side people are playing by a different set of rules.” Syngenta was speaking directly to the public, whereas scientists were publishing their research in “magazines that you can’t buy in Barnes and Noble.”

Hayes was confident that at the next E.P.A. hearing there would be enough evidence to ban atrazine, but in 2010 the agency found that the studies indicating risk to humans were too limited. Two years later, during another review, the E.P.A. determined that atrazine does not affect the sexual development of frogs. By that point, there were seventy-five published studies on the subject, but the E.P.A. excluded the majority of them from consideration, because they did not meet the requirements for quality that the agency had set in 2003. The conclusion was based largely on a set of studies funded by Syngenta and led by Werner Kloas, a professor of endocrinology at Humboldt University, in Berlin. One of the co-authors was Alan Hosmer, a Syngenta scientist whose job, according to a 2004 performance evaluation, included “atrazine defence” and “influencing EPA.”

After the hearing, two of the independent experts who had served on the E.P.A.’s scientific advisory panel, along with fifteen other scientists, wrote a paper (not yet published) complaining that the agency had repeatedly ignored the panel’s recommendations and that it placed “human health and the environment at the mercy of industry.” “The EPA works with industry to set up the methodology for such studies with the outcome often that industry is the only institution that can afford to conduct the research,” they wrote. The Kloas study was the most comprehensive of its kind: its researchers had been scrutinized by an outside auditor, and their raw data turned over to the E.P.A. But the scientists wrote that one set of studies on a single species was “not a sufficient edifice on which to build a regulary assessment.” Citing a paper by Hayes, who had done an analysis of sixteen atrazine studies, they wrote that “the single best predictor of whether or not the herbicide atrazine had a significant effect in a study was the funding source.”

In another paper, in Policy Perspective, Jason Rohr, an ecologist at the University of South Florida, who served on an E.P.A. panel, criticized the “lucrative ‘science for hire’ industry, where scientists are employed to dispute data.” He wrote that a Syngenta-funded review of the atrazine literature had arguably misrepresented more than fifty studies and made a hundred and forty-four inaccurate or misleading statements, of which “96.5% appeared to be beneficial for Syngenta.” Rohr, who has conducted several experiments involving atrazine, said that, at conferences, “I regularly get peppered with questions from Syngenta cronies trying to discount my research. They try to poke holes in the research rather than appreciate the adverse effects of the chemicals.” He said, “I have colleagues whom I’ve tried to recruit, and they’ve told me that they’re not willing to delve into this sort of research, because they don’t want the headache of having to defend their credibility.”

Deborah Cory-Slechta, a former member of the E.P.A.’s science advisory board, said that she, too, felt that Syngenta was trying to undermine her work. A professor at the University of Rochester Medical Center, Cory-Slechta studies how the herbicide paraquat may contribute to diseases of the nervous system. “The folks from Syngenta used to follow me to my talks and tell me I wasn’t using ‘human-relevant doses,’ ” she said. “They would go up to my students and try to intimidate them. There was this sustained campaign to make it look like my science wasn’t legitimate.”

Syngenta denied repeated requests for interviews, but Ann Bryan, its senior manager for external communications, told me in an e-mail that some of the studies I was citing were unreliable or unsound. When I mentioned a recent paper in the American Journal of Medical Genetics, which showed associations between a mother’s exposure to atrazine and the likelihood that her son will have an abnormally small penis, undescended testes, or a deformity of the urethra—defects that have increased in the past several decades—she said that the study had been “reviewed by independent scientists, who found numerous flaws.” She recommended that I speak with the author of the review, David Schwartz, a neuroscientist, who works for Innovative Science Solutions, a consulting firm that specializes in “product defense” and strategies that “give you the power to put your best data forward.” Schwartz told me that epidemiological studies can’t eliminate confounding variables or make claims about causation. “We’ve been incredibly misled by this type of study,” he said.

In 2012, in its settlement of the class-action suits, Syngenta agreed to pay a hundred and five million dollars to reimburse more than a thousand water systems for the cost of filtering atrazine from drinking water, but the company denies all wrongdoing. Bryan told me that “atrazine does not and, in fact, cannot cause adverse health effects at any level that people would ever be exposed to in the real-world environment.” She wrote that she was “troubled by a suggestion that we have ever tried to discredit anyone. Our focus has always been on communicating the science and setting the record straight.” She noted that “virtually every well-known brand, or even well-known issue, has a communications program behind it. Atrazine’s no different.”

Last August, Hayes put his experiments on hold. He said that his fees for animal care had risen eightfold in a decade, and that he couldn’t afford to maintain his research program. He accused the university of charging him more than other researchers in his department; in response, the director of the office of laboratory-animal care sent detailed charts illustrating that he is charged according to standard campus-wide rates, which have increased for most researchers in recent years. In an online Forbes op-ed, Jon Entine, a journalist who is listed in Syngenta’s records as a supportive “third party,” accused Hayes of being attached to conspiracy theories, and of leading the “international regulatory community on a wild goose chase,” which “borders on criminal.”

By late November, Hayes’s lab had resumed work. He was using private grants to support his students rather than to pay outstanding fees, and the lab was accumulating debt. Two days before Thanksgiving, Hayes and his students discussed their holiday plans. He was wearing an oversized orange sweatshirt, gym shorts, and running shoes, and a former student, Diana Salazar Guerrero, was eating fries that another student had left on the table. Hayes encouraged her to come to his Thanksgiving dinner and to move into the bedroom of his son, who is now a student at Oberlin. Guerrero had just put down half the deposit on a new apartment, but Hayes was disturbed by her description of her new roommate. “Are you sure you can trust him?” he asked.

Hayes had just returned from Mar del Plata, Argentina. He had flown fifteen hours and driven two hundred and fifty miles to give a thirty-minute lecture on atrazine. Guerrero said, “Sometimes I’m just, like, ‘Why don’t you let it go, Tyrone? It’s been fifteen years! How do you have the energy for this?’ ” With more scientists documenting the risks of atrazine, she assumed he’d be inclined to move on. “Originally, it was just this crazy guy at Berkeley, and you can throw the Berserkley thing at anyone,” she said. “But now the tide is turning.”

In a recent paper in the Journal of Steroid Biochemistry and Molecular Biology, Hayes and twenty-one other scientists applied the criteria of Sir Austin Bradford Hill, who, in 1965, outlined the conditions necessary for a causal relationship, to atrazine studies across different vertebrate classes. They argued that independent lines of evidence consistently showed that atrazine disrupts male reproductive development. Hayes’s lab was working on two more studies that explore how atrazine affects the sexual behavior of frogs. When I asked him what he would do if the E.P.A., which is conducting another review of the safety of atrazine this year, were to ban the herbicide, he joked, “I’d probably get depressed again.”

Not long ago, Hayes saw a description of himself on Wikipedia that he found disrespectful, and he wasn’t sure whether it was an attack by Syngenta or whether there were simply members of the public who thought poorly of him. He felt deflated when he remembered the arguments he’d had with Syngenta-funded pundits. “It’s one thing if you go after me because you have a philosophical disagreement with my science or if you think I’m raising alarm where there shouldn’t be any,” he said. “But they didn’t even have their own opinions. Someone was paying them to take a position.” He wondered if there was something inherently insane about the act of whistle-blowing; maybe only crazy people persisted. He was ready for a fight, but he seemed to be searching for his opponent.

One of his first graduate students, Nigel Noriega, who runs an organization devoted to conserving tropical forests, told me that he was still recovering from the experience of his atrazine research, a decade before. He had come to see science as a rigid culture, “its own club, an élite society,” Noriega said. “And Tyrone didn’t conform to the social aspects of being a scientist.” Noriega worried that the public had little understanding of the context that gives rise to scientific findings. “It is not helpful to anyone to assume that scientists are authoritative,” he said. “A good scientist spends his whole career questioning his own facts. One of the most dangerous things you can do is believe.” 


Read more: http://www.newyorker.com/reporting/2014/02/10/140210fa_fact_aviv?printable=true&currentPage=all#ixzz2sShOfWEo

Joaquim Machado

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Vertical farming explained: how cities could be food producers of the future

Growing food in population centres would increase yields, cut transport costs and overcome limited land area
vertical farming
Vertical farming overcomes a limited land area. Photograph: Observer

Populations are growing and cities are booming – but could we soon see skyscrapers turned into centres for crop production? From Chicago warehouses to the south pole growth chamber in Antarctica, the concept of growing food indoors is catching on. Plant scientist Dr Erik Murchie, from the University of Nottingham, reveals how agriculture could be turned on its head.

What is vertical farming?

It's vertical because you are trying to grow more crops on a smaller land area and this usually means going upwards into buildings. It normally means that, instead of having a single layer of crops over a large land area, you have stacks of crops going upwards. It's also associated with city farming and urban farming.

Why do we need it?

It is the need to increase crop yield without increasing the land area for crops. If we can move some of that away from the countryside into the city, and get some of that food production close to the high concentrations of population, then we can make a real impact. People want to do it as well – it puts the food supply in the control of people living in the cities.

How high are we talking – skyscrapers?

The beauty of vertical farming is that you can go as high as you want – if you have a system that works efficiently. The only risk with that is getting things that plants need like water and nutrients up there. And you need a way of getting your product out efficiently.

Can we grow all crops like this?

Wheat, maize and rice – these things that provide the bulk of our calories- will be very difficult to grow on a vertical farm because you need to accumulate a massive biomass for those crops - you might expect typically anything between 5 and 12 tonnes per hectare of grain from something like wheat, but to do that you have to accumulate upwards of 20 tonnes per hectare of dry weight of plant. So it's the weight of the plant. The crops that are likely to be grown are high-value nutritious crops – like tomatoes, lettuces, green crops.

What's holding us back?

Energy will be the great limiting factor for this. Plants need a lot of light for photosynthesis. There's a couple of examples in the US of warehouses being converted into stacks of plants. They use LED lights which are cool, efficient lights you can put close to the plants. They are very efficient at making plants grow and you can control plant growth very well, but again you need energy to do that.

How do you see this developing?

What will drive it is technology – the technology to have new buildings, or convert old buildings, where you can have high concentrations of plants; where you can get enough light in there for the plants to grow, and have the recycling of water and nutrients.

You don't need soil for this, you can do it hydroponically. It's good to keep soil out of it, then you can keep it clean and control the nutrient cycling and water cycling very efficiently. There is plenty of opportunity for biological control of pests and diseases.

Joaquim Machado

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3D Bioprinting Netherlands

3D Bioprinting Inching Closer to Reality in New Utrecht Biofabrication Facility

Davide Sher BY DAVIDE SHER ON  · BIOPRINTING,EUROPEINDUSTRY NEWSRESEARCH

It all starts with (or continues through) education. We just reported that in the US, Makerbot is investing in creating MakerBot Innovation Centers for college students to learn about new advanced manufacturing processes. Now in Holland, a country that (along with the enthusiasm for consumer 3D printing) has already been investing heavily in biocompatible 3D printed products for the Health sector, the University of Utrecht (UMC) has announced an extremely ambitious program related to organ and living tissue bioprinting (which seems to be a hot subject these days).

bioprinting utrechtThrough a 775,000 euro investment, scientists at the Utrecht Science Park will soon be able to fabricate living tissue using special 3D bioprinters at a new Utrecht Biofabrication Facility. Tha facility will be equipped both with an actual BioScaffolder and regular FDM/Stereolithography 3D printers, used to study possible adaptations as bioprinters or for printing with biocompatible materials.

Before we tell you all about how the structure will work (which is quite incredible in and of itself), you should probably watch the video below in which Dr. Wouter Dhert, one of the two faculty representatives for this project (together with Dr. Jos Malda) illustrates in incredibly clear terms how the process of bioprinting bones and cartilages will work.

Another aspect that is particularly important in relation to this project is – as we mentioned earlier – its educational implications: Utrecht University, along with Universität Würzburg (Germany), Queensland University of Technology and the University of Wollongong (both in Australia), have announced a new specific study program, the first of its kind, named BIOFAB (Biofabrication Training for Future Manufacturing), which will start in 2014 and combine with the current Master’s program in Regenerative Medicine & Technology.

Micro Array Holstege 3D Bioprinting Netherlands

Students will be able to access the new experimental facility, the only one in the world at a public level, and focus on topics such as orthopaedic applications and healing of cartilage and bones (does anyone think there will be a demand for that? Nah, I don’t know anyone who suffers from back or knee pain… Actually I suffer from both). “Instead of waiting until a joint is almost completely worn out,” said Dr. Malda, “we can study how to simulate or stimulate the body’s natural healing process with a piece of bone or cartilage that has been produced layer by layer by a bioprinter.”

The main issue is that of thermoforming. Plastics can be heated and melted, metals can be made into powder and sintered: organic tissues cannot. “By adjusting the printing temperature and the use of a special ‘bioink’ developed in Utrecht,” Dr. Malda continued, “it is possible to print 3D structures using living cells. The fact that tissue structures must not only be three dimensional, but also perform a function, makes it more complex.”

bioscaffolder 3D BioprintingThe Utrecht tissue factory will consist of two clean rooms where bioprinters and cell culture facilities will be installed. As a leading European knowledge centre for biofabrication it will offer a wide range of opportunities to researches including prototyping (CAD and MRI/CT-based anatomical models), scaffold fabrication (these are the biocompatible structures to grow cell cultures on), cell Printing (the actual bioplotting with live cell material), biomaterial (cell array preparation & robotic dispensing), development of new bioinks and 3D tissue construct.

The facility will be equipped with a SysEng Bioscaffolder bioprinter (with printheads for both low temperature gels and high temperature thermoplastics), a few Dutch-made Ultimaker standard FDM 3D Printers, an integrated bioprinter setup (with multiple printheads) and a high resolutions stereolithography apparatus. Can anyone imagine a better place to work, learn, discover and create …. not to mention, potentially heal?


Joaquim Machado

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Joaquim Machado

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Feb 11, 2014, 9:45:06 AM2/11/14
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"Change is the new constant" is a saying you hear a lot at technology conferences. "But change is not constant," said inventor and futurologist Ray Kurzweil at a conference I attended last week. The world is changing more and more rapidly, fueled by information technology. Unlike some of us given to mouthing such statements, the recipient of the National Medal of Technology had his argument teed up.

Linda Tucci Linda Tucci

Consider our first information technology, he said -- spoken language. A byproduct of our large brains, human language took hundreds of thousands of years to evolve. Written language, the next big advance in information technology, took tens of thousands of years to develop. The printing press took 400 years to become commonplace. The telephone, 50 years. The mass uptake of the cell phone by Western populations took seven years, according to his calculations, social networks even less time.

Three-dimensional printing, not yet ready for prime time, will revolutionize the manufacturing industry. A state-of-the-art 3-D printer priced at $10,000 today can print out 70% of the parts one needs to print out another 3-D printer. In five years, that will be 100% of the parts. Artificial intelligence, fallen from grace after the 1950s, is back on track.

The big change to come? Look within.

Our neocortex -- the convoluted rind of the brain responsible for this sustained technology evolution -- has already been extended by our computer-enabled access to information. In the next few decades, said Kurzweil, author of How to Create a Mindour brains will essentially grow by harnessing the power of information technology. Why, if we can hang on long enough, information technology will extend not only our brains but our lives, perhaps forever.

IT can conquer death? Tell that to a CIO, is my reaction.

Exponential, not linear change

Kurzweil has been in the technology limelight since his teens, when he already was writing software programs and winning national science competitions. His theory of how the brain is organized dates back to a paper he wrote at 14. He is the inventor of the first charge-coupled device, or CCD, flatbed scanner; the first omni-font character recognition technology; the first print-speech reading machine for the blind; the first text-to-speech synthesizer; and the first music synthesizer capable of recreating the sounds of orchestral instruments. Recently he was named director of engineering at Google, where he is working on understanding natural language.

It is the application of linear logic to how technology will change that gets us into trouble.

"Imagine asking prehuman humanoids, 'What's it going to be like when you invent language, art and science?'" he said. "Today, we can understand the question and take a guess."

Or some can. The fundamental mistake people make about IT -- CIOs, CEOs, journalists, Kurzweil's critics -- is thinking linearly. "It is the application of linear logic to how technology will change that gets us into trouble," he argued. The technology that makes an impact improves exponentially on three axes: price, performance and size, and he could point to one of his own inventions to demonstrate that. The first Kurzweil Reading Machine cost $50,000 and was the size of a washing machine. A few years ago he debuted a reading machine that cost a few hundred dollars and could fit into your pocket. Now the technology is built seamlessly into the software, has essentially no physical size and can read any book.

"The world changes rapidly, and in fact, it changes more and more rapidly, fueled by the exponential growth of our information technology," Kurzweil said to the audience of information management professionals, many of them from Kodak Alaris, the conference sponsor. "It is the application of linear logic to how technology will change that gets us into trouble."

The linear grasp of the future doesn't look so different from exponential growth in the early stages: "1, 2, 3, 4" is not so far apart from "2, 4, 8, 16," but wait until you get out to 2 to the 30th power, and you're at over 1 billion. That's the kind of gap that can get us in trouble, Kurzweil said.

How true, many in the audience must have been thinking. Kodak Alaris is a new entity spun off from Kodak when it emerged from bankruptcy in September, and is its current best hope for keeping the legacy of the legendary brand alive.

Ptolemy was right

Kurzweil put up graphs depicting the consistent, exponential growth of IT in recent times, through thick and thin, with no dips, not during World War I or the Great Depression, World War II, the Cold War, or our recession. The progression is fueled by human passion and curiosity, by people who have the right idea at the time in the right place; so the exponential growth of IT may be inexorable, but it is not on automatic pilot, he said. Just as inventors must anticipate what the world will be like when their invention is finished, IT and business leaders must think in the same way. "You have to understand the present in the context of the changes going on," he said in answer to a question about balancing the needs of the present with what's coming.

MORE CIO MATTERS COLUMNS

The CEO mind-set: Go growth or go home

IT leaders tout the power of the collective IQ

When machines call the shots

At some point the talk on stage turned to big data (the theme of the conference) and search. The moderator raised an interesting problem. If much of the world's information is still not digitized, how do we know that the big data we're capturing and mining is the right information? Why, if Google existed at the time of Ptolemy, people would think the sun revolved around the earth, based on the documents.

"There was a way Ptolemy was right," was Kurzweil's quick response. "He had a human-centric view of the earth -- humanity and humans were central to the universe, so he expressed that in terms of this astronomical view that everything circulated around the earth." As far as we know, we are the only intelligent species -- at least in our region of the universe -- to this day, he said.

"So, all of these other planets and stars may not actually revolve around the earth, but this humble planet … does have the unique phenomenon of being the first to create an intelligence that is expanding rapidly."

Let us know what you think about the story; email Linda Tucci, Executive Editor.

Joaquim Machado

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February 11, 2014

Oh, Spicy Day!

When I reached Ed Currie this morning, he was elbow-deep in a bucket of chili peppers, getting started on a new batch of hot sauce. I had last spoken to Currie—Smokin’ Ed, as he likes to be called—in November, when I reported on the race to breed the world’s hottest chili pepper. The competition, as I wrote, was both antic and cutthroat—a Will Ferrell movie in the pepper patch. The Australian grower Alex de Wit, who held the Guinness World Record at the time, might have been the Ferrell character, brash and self-assured. (“I really do not have the time or energy for dicks [excusez le mot],” he wrote to me, closing his e-mail, “I wish you a spicy day.”) Currie, of Fort Mill, South Carolina’s Puckerbutt Pepper Company, was Ben Stiller, the lovably needy also-ran. Currie had been trying for more than two years to get his prize specimen, the Carolina Reaper, recognized by Guinness, to no avail. On November 14th, he checked his e-mail. “I had a message from Guinness, and I thought, O.K., what the hell have I done wrong now?” Currie recalled. Guinness had written to announce that it was going to recognize the Carolina Reaper, ringing in at 1,569,300 Scoville heat units, as the hottest chili. “I literally dropped to my knees and started crying,” Currie said. “Your patience has finally been rewarded, Ed!” a supporter wrote on the Guinness Web site. “Your heart is bigger than this pepper is hot and I am glad that the critics have finally been silenced.”

Perhaps not silenced, but muted: the chili world—the only setting in which I have ever heard one man call another a “palooka” aloud—seems to have entered a period of détente. Jim Duffy, Currie’s chief frenemy, wrote, in an e-mail, that he was happy for his competitor. “Ed spent a lot of money to get public and media attention and gathering of data to get Guinness to give him this record and put him and his company Puckerbutt on the map,” he wrote. (Still, he couldn’t resist a more explicit dig: “Media has seen about five pepper records in three years so it’s not really big news.”)

Currie is making the rounds on TV—here he is on “CBS This Morning” (where the anchor curiously pronounced his name “Ed Curie,” as though he had discovered radioactivity). He says that appearances on “The View” and “Letterman” are in the works. According to Currie, there are more record-breaking chilis where the Carolina Reaper came from. “The next one is going to be the HP-28, yet to be named,” he said. “That one’s coming in at over two million Scovilles, on average.” Meanwhile, he said, in a chilihead’s riff on Casey Kasem, “My hands are in the dirt.”

Photograph of Ed Currie by Melissa Cherry/The Herald/AP.



Read more: http://www.newyorker.com/online/blogs/culture/2014/02/new-hottest-chili-pepper-record-set.html?printable=true&currentPage=all#ixzz2t7qQlzCv
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