special seminar
Office Biotechnology
Department of Biotechnology
Bhupat & Jyoti Mehta School of Biosciences Building
IIT Madras, Chennai
Cordially invite you to attend the
Special Seminar
By
Dr. Javed N Agrewala, Professor and Dean Research
Indian Institute of Technology Ropar, Punjab
On
A Transformation of Immunosuppressive Molecule: From Mud to Money
on 17th July 2018 at 11 am at BT Seminar Hall
Abstract:
‘Caerulomycin A’ isolated from Actinomycetes spitiensis shows antifungal and antibiotic properties but its role as an immunosuppressive agent, remains widely unknown. We report for the first time that Caerulomycin A possesses immunosuppressive property by alleviating the arthritis symptoms by generating regulatory T cells (Tregs). It was observed that Caerulomycin A substantially augmented the percentage of Tregs. Further, it suppressed the number of Th1 cells and Th17 cells. Furthermore, we established the mechanism and observed that Caerulomycin A interfered with IFN-γ induced STAT1 signalling by augmenting SOCS1 expression. An increase in the TGF-β mediated Smad3 activity was also noted. Caerulomycin A rescued Tregs from IFN-γ induced inhibition. In essence, our results suggest a novel role of Caerulomycin A in the formation of Tregs. This finding proposes that Caerulomycin A has sufficient potential to be considered as a future drug to treat arthritis.
BT Office
Department of Biotechnology
Bhupat and Jyoti Mehta School of Biosciences
IIT Madras, Pin - 600 036
Phone : 044-2257 4100
Email : btof...@iitm.ac.in
Office Biotechnology
The spl seminar today at 11 am is postponed to 3 pm.
All are welcome.
BT Office
Department of Biotechnology
Bhupat and Jyoti Mehta School of Biosciences
IIT Madras, Pin - 600 036
Phone : 044-2257 4100
Email : btof...@iitm.ac.in
Sent: Monday, July 16, 2018 11:31 AM
To: Office Biotechnology; Head Biotechnology; Amal Kanti; Anju Chadha; Athi Narayanan N; Baskar R; Chandraraj K; Gopala Krishna A; Guhan Jayaraman; Hamsa Priya Mohana Sundaram; Himanshu Sinha; Karthik Raman; Karunagaran D; Kesavan V; Madhulika Dixit; Mahalingam S; Manoj N; Michael Gromiha M; Rajamanickam Murugan; Nitish R Mahapatra; Rama Shanker Verma; Sanjib Senapati; Sathyanarayana N Gummadi; Smita Srivastava; Srinivasa Chakravarthy V; Subramaniam K; Suraishkumar G K; Suresh Kumar Rayala; Vani Janakiraman; Vignesh MuthuVijayan
Cc: bt0...@googlegroups.com; bt20...@googlegroups.com; bt2014s...@googlegroups.com; bt1...@googlegroups.com; bt20...@googlegroups.com; bt1...@googlegroups.com; bt1...@googlegroups.com; bt1...@googlegroups.com; o201...@googlegroups.com; bt2...@googlegroups.com
Subject: special seminar
Office Biotechnology
Please note that the seminar scheduled today at 3 pm is
cancelled due to ill-health of the speaker.
BT Office
Department of Biotechnology
Bhupat and Jyoti Mehta School of Biosciences
IIT Madras, Pin - 600 036
Phone : 044-2257 4100
Email : btof...@iitm.ac.in
Sent: Tuesday, July 17, 2018 10:32 AM
To: Office Biotechnology; Head Biotechnology; Amal Kanti; Anju Chadha; Athi Narayanan N; Baskar R; Chandraraj K; Gopala Krishna A; Guhan Jayaraman; Hamsa Priya Mohana Sundaram; Himanshu Sinha; Karthik Raman; Karunagaran D; Kesavan V; Madhulika Dixit; Mahalingam S; Manoj N; Michael Gromiha M; Rajamanickam Murugan; Nitish R Mahapatra; Rama Shanker Verma; Sanjib Senapati; Sathyanarayana N Gummadi; Smita Srivastava; Srinivasa Chakravarthy V; Subramaniam K; Suraishkumar G K; Suresh Kumar Rayala; Vani Janakiraman; Vignesh MuthuVijayan
Cc: bt0...@googlegroups.com; bt20...@googlegroups.com; bt2014s...@googlegroups.com; bt1...@googlegroups.com; bt20...@googlegroups.com; bt1...@googlegroups.com; bt1...@googlegroups.com; bt1...@googlegroups.com; o201...@googlegroups.com; bt2...@googlegroups.com