Seminar announcement - Special seminar on Aug 23rd 3:30pm
Subramaniam K
Dear all,
There will be a special seminar by a visitor, Dr. Ramkumar Sambasivan, InStem, Bangalore as per the following schedule:
Title: Guiding skeletal muscle differentiation from pluripotent stem cells by recapitulating developmental cues
Time: 3:30pm
Date: August 23rd, 2018
Venue: BT Seminar Hall
Abstract:
Guided pluripotent stem cell differentiation into regenerative cell types or organoids holds the potential to revolutionize disease modeling and medicine. Rational design of guided differentiation methods for specific cell types / organoids are based on the mechanisms driving their embryonic development. This has motivated a resurgence of interest in addressing the developmental program governing the specification of progenitor cell fate. Our interest is to study mechanisms governing the early cell fate commitment during vertebrate development, with a specific focus on mesoderm. Our work has revealed the developmental pathways governing two key stem cell types in vertebrate embryos, 1) cardiopharyngeal mesoderm (CPM), the common progenitor of heart and head skeletal muscles and 2) neuromesoderm axial progenitors (NM), which contributes to spinal cord and musculoskeletal system below neck. We have shown that the inhibitors of Wnt/b-catenin and Nodal (TGFb) pathways secreted from a key signaling center instructs CPM specification. These inhibitors act via a distinct transcription factor network compared to that driving posterior mesoderm subtypes. Leveraging the knowledge of CPM development arising from our work, we have directed the differentiation of pluripotent cells to cardiomyocytes as well as skeletal muscle. The generation of CPM-derived skeletal muscle from pluripotent cells is a significant breakthrough as it creates possibilities to model muscle wasting diseases involving head musculature. On the other hand, our findings on NM progenitors has provided insights into the mechanism governing the exit of these progenitors from stem cell state towards mesoderm fate. Since a major derivative of NM lineage is skeletal muscle, this work will also provide insights into the program driving skeletal muscle differentiation. Our ongoing efforts focus on further elucidation of developmental mechanisms of CPM and NM, which we will exploit to develop a method to efficiently differentiate pluripotent cells into skeletal muscle. A robust directed differentiation method has the potential to impact advances in modeling as well as treating muscle degenerative diseases known as muscular dystrophies. In future, we aim to employ the directed differentiation method to model and treat muscular dystrophies.
About the speaker:
Dr. Ramkumar Sambasivan worked at CCMB for his PhD thesis under the mentorship of Prof. Jyotsna Dhawan, and was a postdoctoral fellow at the Institut Pasteur, Paris during 2004-2011. He is currently a Research Investigator and Ramalingaswami Fellow at the Institute for Stem Cell Biology and Regenerative Medicine, Bangalore since 2012.
All are cordially invited to attend the seminar.
Regards,
Subramaniam
K. Subramaniam
Professor
BT 206, Department of Biotechnology
Bhupat and Jyoti Mehta School of Biosciences
Indian Institute of Technology – Madras
Chennai 600 036
Tel:+91-44-22574119
Mobile:9445436062
Email: su...@iitm.ac.in
Office Biotechnology
Dear all,
This is a gentle reminder for the special seminar scheduled
on 23rd August at 3.30 pm in BT seminar Hall by
Dr Ramkumar.
All are cordially welcome to attend.
BT Office
Department of Biotechnology
Bhupat and Jyoti Mehta School of Biosciences
Sent: Thursday, August 16, 2018 10:08 AM
To: Office Biotechnology; Head Biotechnology; Amal Kanti; Anju Chadha; Athi Narayanan N; Baskar R; Chandraraj K; Gopala Krishna A; Guhan Jayaraman; Hamsa Priya Mohana Sundaram; Himanshu Sinha; Karthik Raman; Karunagaran D; Kesavan V; Madhulika Dixit; Mahalingam S; Manoj N; Michael Gromiha M; Rajamanickam Murugan; Nitish R Mahapatra; Rama Shanker Verma; Sanjib Senapati; Sathyanarayana N Gummadi; Smita Srivastava; Srinivasa Chakravarthy V; Suraishkumar G K; Suresh Kumar Rayala; Vani Janakiraman; Vignesh MuthuVijayan; Doble Mukesh; Chandra T S; Jayakrishnan A
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Subject: Seminar announcement - Special seminar on Aug 23rd 3:30pm
Subramaniam K
Just a gentle reminder.......
Sent: Thursday, August 16, 2018 10:08 AM
Cc: bt0...@googlegroups.com; bt20...@googlegroups.com; bt2014s...@googlegroups.com; bt1...@googlegroups.com; bt20...@googlegroups.com; bt1...@googlegroups.com; bt1...@googlegroups.com; bt1...@googlegroups.com; o201...@googlegroups.com; bt2...@googlegroups.com
Subject: Seminar announcement - Special seminar on Aug 23rd 3:30pm
Dear all,