Diagnostics for non-linear mixed-effects (population) models from 'NONMEM' . 'xpose' facilitates data import, creation of numerical run summary and provide 'ggplot2'-based graphics for data exploration and model diagnostics.
Xpose 4 is a collection of functions to be used as a model building aid for nonlinear mixed-effects (population) analysis using NONMEM. It facilitates data set checkout, exploration and visualization, model diagnostics, candidate covariate identification and model comparison.
Xpose 4 is free software: you can redistribute it and/or modify it under the terms of the GNU Lesser General Public License as published by the Free Software Foundation, either version 3 of the License, or (at your option) any later version.
This program is distributed in the hope that it will be useful, but WITHOUT ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the GNU Lesser General Public License for more details
XPose! Secure and XPose! SecurePlus both include the unique Continuous Calibration Technology (CCT). During the exposure, the performance of every laser is monitored and automatically adjusted if necessary. Costly incorrect exposures can be eliminated thereby.
The optional fleXtreme! optic is an in-house development by Lscher and allows the selection of any desired resolution. The changeover is fully automatic and tailored to requirements. This means that every job could be exposed in any resolution.
Any model of the XPose! SecureLine can also be configured as a hybrid system upon special request. XPose! TH, for instance, is the hybrid version to process thermal offset plates, conventional UV plates and letterpress plates as well as rotary screens. And XPose! UV-Flex is the hybrid version to process conventional UV and letterpress plates as well as rotary screens, such as Screeny by Gallus, TecScreen by Kocher + Beck or RotaPlate by spg.
colorChanges the **lines, points and text** color. Should be a vector of 3 values (i.e. DV, IPRED, PRED). This color argument is a special case in xpose as it applies to three different layers (geom_line, geom_point and geom_text). This special case is due to the fact that in ggplot2 it is not possible to have two different color scales for different layers.
Plots can be customized by mapping arguments to specific layers. The naming convention is layer_option where layer is one of the names defined in the list below and option is any option supported by this layer e.g. point_color = 'blue', smooth_method = 'lm', etc.
Xpose 4 is a collection of functions to be used as a model building aidfor nonlinear mixed-effects (population) analysis using NONMEM. Itfacilitates data set checkout, exploration and visualization, modeldiagnostics, candidate covariate identification and model comparison.
Xpose 4 is free software: you can redistribute it and/or modify it underthe terms of the GNU Lesser General Public License as published by theFree Software Foundation, either version 3 of the License, or (at youroption) any later version.
This program is distributed in the hope that it will be useful, butWITHOUT ANY WARRANTY; without even the implied warranty ofMERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the GNU LesserGeneral Public License for more details
manual_importIf NULL (default) the names of the output tablesto import will be obtained from the model file. To manually import files asin previous versions of xpose, the check the functionmanual_nm_import.
check_extLogical, if TRUE will provide an error message if theextension of the NONMEM input file is not one of '.lst', '.out', '.res','.mod' or '.ctl' for NONMEM. If FALSE any file extension can beused.
Dressed in a Tactile Green, Energy Blue and Blue Night color scheme. This Xpose version of the adidas Pure Boost features a mesh upper that wraps around and underneath the midfoot for a supportive fit and maximum ventilation. The energy-returning Boost midsole propels you forward with each step, and the stretchy outsole flexes to adapt to the way your foot strikes the ground.
The vision of nlmixr2 is to develop a R-based open-source nonlinear mixed-effects modeling software package that can compete with commercial pharmacometric tools and is suitable for regulatory submissions.
Once the compilers are setup and a compatible version of symengine is installed, you can install the development version of nlmixr2 and its nlmixr2-family dependencies either by using the r-universe or by installing manually.
If you are using a Ubuntu latest flavor (at the time of this writing jammy) you can also use the binaries (though if you use bspm you should install any dependencies first to reduce your computation time)
If you have difficulties due to errors while compiling models, it may be useful to re-install all of nlmixr2 and its dependencies. For development versions, please use the remotes::install_github() or the install.package() with the r-universe above. For the stable version, please use the following command:
For Pirana 3.0 and previous versions, users can initialize ModelResults directly from RStudio by first creating the xpdbobject from the Pirana model output folder. This xpdbobject can be supplied to the xpdb argument to launch ModelResults (e.g., resultsUI(xpdb = xpdb)).
After executing one or more RsNLME models (.mmdl) from Pirana,identify the Project Folder and ModelNames to be used with Model Results. This information isrequired to create the xpdb objects in R and initializeModel Results.
Since we are using RsNLME with Pirana (.mmdl), we will need to usethe xposeNlme() function from theCertara.Xpose.NLME package to generate ourxpdb object in R. We will supply the name of our model tothe argument modelName and the NLME model output directoryto the dir argument.
After executing one or more NONMEM models in Pirana, identify theProject Folder and Model Names to beused with Model Results. This information is required to create thexpdb objects in R and initialize Model Results.
We will use the runno argument to specify the run numberof one of our model file names identified above. We will use the defaultvalues prefix = "run" and ext = ".lst".Finally, we must supply the path of our Pirana Project Folderto the dir argument below. For further details, see?xpose::xpose_data.
Cost - FREEPirana is a flexible, extendible pharmacometrics workbench that provides modelers with structure, tools, and a graphical user interface to facilitate the iterative processes used to create pharmacometric models and perform simulations. This tutorial will guide you through building models, conducting a covariate search, evaluating covariate models, and reporting results in Pirana.
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VirtualXposed is a modified version of Xposed Framework that allows you to use this system modification even if you don't have root permissions on your Android device. In exchange for not needing to root, its features are more limited than those offered by the full version.
With Xposed, it's possible to modify the appearance and functionality of your Android. Because VirtualXposed doesn't have root permissions, it can't access the system, so it's not possible to make system modifications. Instead, VirtualXposed creates virtual spaces in which it's possible to run APK files as if they were plugins. All running apps are located inside a container. VirtualXposed is in charge of making system calls. Thanks to this, you can run modules and enjoy additional functionalities without having to root the device.
As a result, modules that modify system settings such as GravityBox do not work. However, there are many others that do work, such as XPrivacyLua, XInsta, YouTube Adway, MDWechat, WeXposed, QXposed, and many others.
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