Nystatin 10000 Cream
Stephany Tousley
Nystatin is a polyene antimycotic obtained from Streptomyces noursei. It is a yellow to light tan powder with a cereal-like odor, very soluble in water, and slightly to sparingly soluble in alcohol. Structural formula:
Nystatin Cream contains the antifungal antibiotic nystatin at a concentration of 100,000 USP Nystatin Units per gram in an aqueous, perfumed cream base containing purified water, propylene glycol, methylparaben, propylparaben, white petrolatum, glyceryl monostearate, polyethylene glycol 400 monostearate, ceteareth-15, medical antifoam AF emulsion, aluminum hydroxide gel, titanium dioxide, sorbitol solution, and, if necessary, sodium hydroxide for pH adjustment.
Nystatin provides specific therapy for all localized forms of candidiasis. Symptomatic relief is rapid, often occurring within 24 to 72 hours after the initiation of treatment. Cure is effected both clinically and mycologically in most cases of localized candidiasis.
Common side effects of nystatin cream include skin irritation, itching, or redness. Tell your doctor if you have side effects such as severe burning, itching, rash, or pain where nystatin cream is applied.
Nystatin preparations should be applied liberally to affected areas twice a day or as indicated until healing is complete. Nystatin cream is usually preferred to nystatin ointment in candidiasis involving areas of the skin that may come in contact with other areas of the skin; very moist lesions are best treated with Nystatin topical powder.
It is not likely that other drugs you take orally or inject will have an effect on topically applied Nystatin Cream. But many drugs can interact with each other. Tell your doctor all prescription and over-the-counter medications and supplements you use.
Nystatin cream for topical use, contains 100,000 USP nystatin units per gram in a cream base containing aluminum hydroxide gel, ceteareth-15, glyceryl monostearate, polyethylene glycol 400 monostearate, propylene glycol, purified water, simethicone emulsion, sorbitol solution, titanium dioxide, white petrolatum, methylparaben, propylparaben, and sodium hydroxide.
If irritation or sensitization develops, treatment shouldbe discontinued and appropriate measures taken as indicated. It is recommendedthat KOH smears, cultures, or other diagnostic methods be used to confirm thediagnosis of cutaneous or mucocutaneous candidiasis and to rule out infectioncaused by other pathogens.
No long-term animal studies have been performed toevaluate the carcinogenic potential of nystatin. No studies have been performedto determine the mutagenicity of nystatin or the effects on male or female fertility.
Animal reproduction studies have not been conducted withany nystatin cream. It also is not known whether this cream can cause fetalharm when used by a pregnant woman or can affect reproductive capacity.Nystatin cream should be prescribed for a pregnant woman only if the potentialbenefit to the mother outweighs the potential risk to the fetus.
Clinical studies with nystatin cream did not includesufficient numbers of subjects aged 65 years and older to determine whetherthey respond differently than younger subjects. Other reported clinical experiencehas not identified differences in responses between elderly and youngerpatients, but greater sensitivity of some older individuals cannot be ruledout.
Nystatin is an antibiotic which is both fungistatic andfungicidal in vitro against a wide variety of yeasts and yeast-like fungi,including Candida albicans, C. parapsilosis, C. tropicalis, C.guilliermondi, C. pseudotropicalis, C. krusei, Torulopsis glabrata, Tricophytonrubrum, T. mentagrophytes. Nystatin acts by binding to sterols in the cellmembrane of susceptible species resulting in a change in membrane permeabilityand the subsequent leakage of intracellular components. On repeatedsubculturing with increasing levels of nystatin, Candida albicans doesnot develop resistance to nystatin. Generally, resistance to nystatin does notdevelop during therapy. However, other species of Candida (C. tropicalis,C. guilliermondi, C. krusei, and C. stellatoides) become quite resistant ontreatment with nystatin and simultaneously become cross resistant toamphotericin as well. This resistance is lost when the antibiotic is removed.Nystatin exhibits no appreciable activity against bacteria, protozoa, orviruses.
It also comes mixed with steroids, antiseptics or antibacterials as a cream or ointment. Brand names for creams and ointments containing nystatin include Trimovate, Timodine, Nystaform and Nystaform HC.
It usually takes nystatin liquid around a week to treat oral thrush, but you'll need to continue taking it for 2 days after this to make sure all the fungus has been killed. Take it for as long as your doctor advises.
If you're using cream or ointment containing nystatin mixed with other ingredients, you may only need to use it for 7 to 14 days but it will depend on your skin condition. Your doctor will tell you how long to use it for.
If you're using a cream or ointment containing nystatin, take care that your baby does not touch any areas of your body where you've used it. Wash your hands after you've used it and before picking up your baby.
If you're breastfeeding and you have thrush (candida) of the breast, you can use nystatin to treat this, although other treatments are usually more effective. Your baby will also need to be treated at the same time with their own medicine.
When using it on your breasts, wash it off your breasts or nipples, then wash your hands before feeding your baby. It's usually better to use cream rather than ointment when breastfeeding, as it's easier to wash off.
There's not enough information to say that complementary medicines, herbal remedies and supplements are safe to take with nystatin. They're not tested in the same way as pharmacy and prescription medicines. They're generally not tested for the effect they have on other medicines.
This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.
This medication is used to treat vaginal fungal infections, commonly called vaginal yeast infections. It helps to reduce itchiness, redness, and irritating discharge. Nystatin works by stopping the growth of the fungus.
This product is for vaginal use. With clean hands, fill the applicator with this cream to the level indicated. Insert the applicator high into the vagina, then push the plunger to release the medication. Use this medication usually once a day at bedtime, or twice a day in the morning and evening, as directed by your doctor. If the applicator is reusable, follow the product instructions on how to clean it.
To prevent medication from leaking out of the vagina, lie down as soon as possible after use. You may use a sanitary napkin to prevent clothing stains. Do not use tampons while using this medication because they can decrease its effectiveness. In most cases, you should not use medicated douches during nystatin treatment. Ask your doctor or pharmacist if you have any questions.
Continue to use this medication for the full time prescribed, even if symptoms disappear after a few days and even if you get your menstrual period. Stopping the medication too early may allow the fungus to continue to grow, which may result in a relapse of the infection.
Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Before using nystatin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
This medication should be used with caution during pregnancy and only when clearly needed. Check with your doctor before using the applicator if you are or think you may be pregnant. Discuss the risks and benefits with your doctor.
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.
If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 9-1-1. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. This medication may be harmful if swallowed.
Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
Selected from data included with permission and copyright by First DataBank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.
Conditions of Use: The information in this database is intended to supplement, not substitute for the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. The display and use of this drug information is subject to express Terms of Use.
c80f0f1006