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For increasing norepinephrine, maybe you mean L-tyrosine, N-acetyl-L-
tyrosine, or L-phenylalanine.
Be careful with nicotine. That stuff is addictive. Effective, yes.
But addictive. While occasional use has been shown to improve
performance, my understanding is that prolonged use eliminates those
benefits and leaves you dependent.
As for dietary antioxidants, I think they don't do anything. I think
the scientific studies on the subject either falsely generalized from
in vitro studies or falsely attributed the benefits of eating fruits
and vegetables to antioxidants.
There's very, very little caffeine and theobromine in cocoa. If you
want caffeine, I suggest taking it in pill form. That way you get
precise dosing, and you don't have to deal with the side-effects
caused by the other ingredients in coffee (e.g. increased stomach
acidity, diarrhea). It's about $4 for 16 x 200mg. As for
theobromine, it's a natural metabolite of caffeine in humans, so you
can just take caffeine and let your body do the rest. I don't know
about the other components of cocoa, though; they may be effective,
or they may just be advertising hype from the chocolate industry, like
with phenylethylamine.
Incidentally, caffeine is vasoconstrictive. But caffeine also boosts
both cognitive and athletic performance. (It improves endurance by
something like 15% during aerobic exercise and also reduces muscle
pain by ~50% during anaerobic exercise.) Under normal situations,
blood flow to the brain is more than sufficient. People think that
increasing blood flow is a good idea because blood flow and neural
activity are correlated; however, caffeine increases neural activity
while decreasing blood flow. (It blocks adenosine receptors in the
brain; adenosine triphosphate [ATP] is released by astrocytes and
stimulates neural activity, but after some time, it gets degraded to
ADP, then AMP, then plain adenosine; the presence of adenosine
inhibits neural activity and stimulates blood flow, sort of as a
signal that this part of the brain is tired and needs rest and
recuperation. It appears that this rest-promoting mechanism is
suboptimally tuned.)
Aerobic exercise is good. Do it. It'll also help with your HDL.
Don't worry too much about your friends who died young; they're just
statistical anomalies. Exercise will make you about 3 IQ points
smarter, happier, and longer-lived. The idea with HIIT is that the
best stimulus for increasing cardiovascular capacity is engaging in an
activity that uses 100% of your available cardiovascular capacity;
endurance aerobic exercise usually only uses about 70% of it.
However, the benefits of endurance exercise on cognition and blood
lipids may or may not result from HIIT, so I suggest doing some
endurance exercise as well as HIIT.
Dual N-back is also good. Do it.
What about creatine? It's ridiculously cheap, it's readily available
(just go to GNC), it's probably very effective, and it's safe. (The
2003 study by Rae et al. found a 1 standard deviation improvement in
working memory and intelligence in their sample, which probably
translates to around 12 IQ points.)
What about modafinil? Yes, it's prescription-only and schedule IV,
but it's definitely effective, and it's pretty safe. Safer than
caffeine.
What about piracetam or aniracetam? They're readily available, cheap
(for piracetam, at least), and safe.
What about other cholinergics, such as choline citrate (or other salts
of choline) and L-huperzine? They're safer than nicotine and readily
available, though I'm not certain they help. (L-huperzine, like
Aricept[TM]/donepezil, is a cholinesterase inhibitor.)
Jonathan
> What about creatine? It's ridiculously cheap, it's readily available (just
> go to GNC), it's probably very effective, and it's safe. (The 2003 study by
> Rae et al. found a 1 standard deviation improvement in working memory and
> intelligence in their sample, which probably translates to around 12 IQ
> points.)
In case we've forgotten already, remember that Rae was only with
vegetarians. (And Rawson didn't find anything.)
--
gwern
I was wrong about the quantity of theobromine in cocoa; turns out it's
around 2% theobromine by weight, and around 0.2% caffeine.
Theobromine is significantly less potent than caffeine, though, so 2g
of theobromine from 100g of cocoa is a moderate dose. Theobromine has
the same mechanism of action as caffeine, but is relatively less
potent in the CNS compared to the periphery, so it would have more
intense side-effects (like heart-rate changes) at the dose required to
produce the same cognitive effects. As for production of theobromine
from caffeine metabolism, only around 10% of caffeine is turned into
theobromine. (80% becomes paraxanthine.)
Caffeine reduces cerebral blood flow (CBF):
http://stroke.ahajournals.org/cgi/content/abstract/16/5/814
Caffeine reduces CBF, and caffeine withdrawal increases CBF above
normal levels:
http://www3.interscience.wiley.com/journal/119506411/abstract
As for theobromine, it doesn't do much for CBF:
http://books.google.com/books?id=1McDQwLB6hMC&lpg=PA95&ots=eXa8SetERj&dq=theobromine%20cerebral%20vasoconstriction%20OR%20vasodilation&lr&pg=PA101#v
=onepage&q=theobromine&f=false
It appears that methylxanthines (e.g. caffeine, theophylline) have
opposite effects on cerebral and peripheral blood flow, where they
decrease CBF and increase blood flow in the periphery. That might be
the root of why you thought theobromine increases CBF.
I don't know enough about non-alkaloid, non-monoamine components of
cocoa to comment intelligently.
Yeah, Provigil/modafinil is a much better idea than Provera. While
modafinil does weakly inhibit the so-called norepinephrine transporter
(which removes from synapses both dopamine in the prefrontal cortex
and norepinephrine everywhere), the primary mechanism of action of
modafinil appears to not be dopaminergic or norepinephrinergic, since
modafinil still has the same effect on mice given adrenergic receptor
and dopamine receptor antagonists. A better guess is that it exerts
its effect on the orexin system, a sort of stay-awake-and-work vs. eat-
and-rest system. But, as far as I know, nobody really knows.
Donepezil's half-life is more like 70 hours, making it more of an all-
week drug than an all-day one. I used to do psychophysics experiments
on people with the stuff. We gave them 2 weeks of washout between the
placebo-or-drug and the drug-or-placebo pills. (Double-blind
crossover design.) In either case, the research on cholinesterase
inhibitors is odd and inconsistent, with some studies reporting
improved performance and other studies reporting reduced performance.
It may be that donepezil (and L-huperzine?) is good for some brain
functions and bad for others, but I haven't been able to figure out
what it's good and bad for yet.
I'm not dissuaded by cocoa, just unconvinced. This may be a result of ignorance.
I was wrong about the quantity of theobromine in cocoa; turns out it's around 2% theobromine by weight, and around 0.2% caffeine. Theobromine is significantly less potent than caffeine, though, so 2g of theobromine from 100g of cocoa is a moderate dose. Theobromine has the same mechanism of action as caffeine, but is relatively less potent in the CNS compared to the periphery, so it would have more intense side-effects (like heart-rate changes) at the dose required to produce the same cognitive effects. As for production of theobromine from caffeine metabolism, only around 10% of caffeine is turned into theobromine. (80% becomes paraxanthine.)
Caffeine reduces cerebral blood flow (CBF):
http://stroke.ahajournals.org/cgi/content/abstract/16/5/814
Caffeine reduces CBF, and caffeine withdrawal increases CBF above normal levels:
http://www3.interscience.wiley.com/journal/119506411/abstract
As for theobromine, it doesn't do much for CBF:
http://books.google.com/books?id=1McDQwLB6hMC&lpg=PA95&ots=eXa8SetERj&dq=theobromine%20cerebral%20vasoconstriction%20OR%20vasodilation&lr&pg=PA101#v=onepage&q=theobromine&f=false
It appears that methylxanthines (e.g. caffeine, theophylline) have opposite effects on cerebral and peripheral blood flow, where they decrease CBF and increase blood flow in the periphery. That might be the root of why you thought theobromine increases CBF.
I don't know enough about non-alkaloid, non-monoamine components of cocoa to comment intelligently.
Yeah, Provigil/modafinil is a much better idea than Provera. While modafinil does weakly inhibit the so-called norepinephrine transporter (which removes from synapses both dopamine in the prefrontal cortex and norepinephrine everywhere), the primary mechanism of action of modafinil appears to not be dopaminergic or norepinephrinergic, since modafinil still has the same effect on mice given adrenergic receptor and dopamine receptor antagonists. A better guess is that it exerts its effect on the orexin system, a sort of stay-awake-and-work vs. eat-and-rest system. But, as far as I know, nobody really knows.
Donepezil's half-life is more like 70 hours, making it more of an all-week drug than an all-day one. I used to do psychophysics experiments on people with the stuff. We gave them 2 weeks of washout between the placebo-or-drug and the drug-or-placebo pills. (Double-blind crossover design.) In either case, the research on cholinesterase inhibitors is odd and inconsistent, with some studies reporting improved performance and other studies reporting reduced performance. It may be that donepezil (and L-huperzine?) is good for some brain functions and bad for others, but I haven't been able to figure out what it's good and bad for yet.
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Here's the research done on spirulina and muscle performance
http://journals.sfu.ca/ijmbs/index.php/ijmbs/article/view/51/146
> system, a sort of stay-awake-and-work vs. eat-and-rest system. But, as far
Just a few days ago I tried i-doser.com they try to simulate different
drugs by using binaural brainwaves, kind of the "dark side" of
binaural beats.
Unexplainable.net has gotten a lot of positive feedback so does brain
evolution system. Having said that, I always seem to return to brain
sync. Kelly Howell has some real good and programs developed over many
years that many people seem to like.
/pontus
> ...
>
> read more »
> ...
>
> read more »
>
> read more »
> ...
>
> read more »
> Rather than worrying about "boosting IQ" I'd suggest working on
> functioning at your highest level of general ability (whatever that
> may be) more often. You seem to know exactly what to do to achieve
> this re n back and nootropics and education. It's not mysterious. What
> is hard is consistency. Gains are made by consistency applied over
> time -- not by shot-in-the-arm magic bullets.
>
> You take two people who start N-backing, both are eager and excited at
> the outset. One gets so excited about n backing he starts n backing 2
> 19 sessions a day, gets to 3 back, and then a month later quits. Six
> months later this person wants to get back at it and does for a month,
> then quits for a few more months until resolve sets in again and he
> starts to hit 4 back, resumes double sessions but can't hit 5. After a
> year, he claims dual n back is bullshit. The other person n backs 3
> times a week for a year, every week without fail, and can't hit 5
> either but sees greater consistency in scores. Who is going to be the
> winner? Law of compound interest says the latter is going to win,
> crush person number 1 over the very long term. If this trend continues
> over the period of a lifetime, person 2 is going to reap max benefits
> of dual n back, whatever those long term benefits are (which remain
> unknown at this point).
A Finn in #wikipedia once told me that in Finnish there is a popular
expression - that the right way to do stuff is to do it with 'a
killing slowness'. His example was the Finnish resistance to Stalin in
the Winter War (during WWII): the Finns slowly wore down the Soviets,
doing so sustainably and never overstretching themselves. Slow and
surely wins the race.
However, just long-term benefits aren't enough. There are opportunity
costs involved, and our lifespans are finite, after all. One can
formalize the benefits of self-improvement and try to calculate how
much is profitable. (One has to guess at a number of parameters like
how exactly valuable n-backing is, but as Babbage said, "Errors using
inadequate data are much less than those using no data at all.")
One interesting formalization is
http://lesswrong.com/lw/28e/when_to_selfimprove/
--
gwern
The alternative to not trusting any models is not loaning at all.
Welcome back to the dark ages. I don't know about you, but I prefer a
modern economy using models that screw up spectacularly occasionally
to a subsistence economy where I am a serf hoping the rain won't come
too late.
--
gwern
gwern
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No professional tests. My WM is probably a strength.
> Have you done any IQ or WM testing?
Curious. If I recall correctly, the Morris water platform task
subjects the rat to the risk of fatal drowning if it can't find the
platform, and certainly it sounded stressful to me. So I suppose the
take-away here is that one shouldn't get too stressed out about one's
performance or lack thereof.
(Mission accomplished! Still at D4B averaging 60%, not stressed out.)
--
gwern
This is an important article to read to aid our understanding of the
consequences involved in types of working memory training. I do not
have access to the full article, does anyone have privileges from
PubMed? The value I have stressed is only comparative to the title of
the journal not it's substance. Hopefully someon
----Working memory training decreases hippocampal neurogenesis----
Abstract
The relationship between adult hippocampal neurogenesis and cognition
appears more complex than suggested by early reports. We aimed to
determine if the duration and task demands of spatial memory training
differentially affect hippocampal neurogenesis. Adult male rats were
trained in the Morris water maze in a reference memory task for 4
days, or alternatively working memory for either 4 or 14 days. Four
days of maze training did not impact neurogenesis regardless of
whether reference or working memory paradigms were used.
Interestingly, 2 weeks of working memory training using a hidden
platform resulted in fewer newborn hippocampal neurons compared with
controls that received either cue training or no maze exposure. Stress
is a well-established negative regulator of hippocampal neurogenesis.
We found that maze training in general, and a working memory task in
particular, increased levels of circulating corticosterone after 4
days of training. Our study indicates that working memory training
over a prolonged period of time reduces neurogenesis, and this
reduction may partially be mediated by increased stress.
http://www.ncbi.nlm.nih.gov/pubmed/16962715
Also, mindfulness meditation; very interesting GoogleTech talk.
Cognitive Neuroscience of Mindfulness Meditation =
http://www.youtube.com/watch?v=sf6Q0G1iHBI
Regards,
likeprestige
On Aug 9, 8:22 pm, Pontus Granström <lepon...@gmail.com> wrote:
> Mindball uses alpha waves to move a ball, it's intended to reinforce our
> ability to generate alpha waves and thereby increase our memory and IQ.http://www.mindball.pl/cz/katalog.htm
>
> On Mon, Aug 9, 2010 at 9:16 AM, cev <ubiquity...@hotmail.co.uk> wrote:
> > No professional tests. My WM is probably a strength.
>
> > > Have you done any IQ or WM testing?
>
> > --
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