Thank you all.
Major treatises of Ayurveda have not delineated or described Parnayavani. It is a European or Central Asian plant. It is described in the Arabic and Parsi books in India for the first time.
Probably it entered the Indian Materia Medica during 9th Cen.A.D. P.V.Sharmaji reported that "Yavani vishesha" of Dhanvantari nighantu is Parnayavani. However it appears as "Khurasani Ajwain". Vrinda Madhava quoted it as Krimighna(anthelminthic) for the first time.
It is noticed that C.forskohlii is commonly used as Parnayavani.
Therapeutic uses - in Diarrhoeal disorders, liver disorders, urinary problems and in worm infestations.
Research on C.forskohlii :-
* Infusion of forkolin (0.2 micro gm / kg / min) in anaesthetised dog increased renal blood flow(RBF) and glomerular filtration rate(GFR) to same degree. It also increased urine flow and urinary Sodium excretion. Increase in RBF and GFR may be due to preferential action of forskolin in dilating afferent arterioles (Jap. J. Pharmacol. 1991. 55, 161).
* Forskolin showed positive inotropic and chronotropic effects on isolated spontaneously beating guinia pig atrium (C.R.Seances Soc. Biol. Fil. 1085, 179, 777).
* Forskolin induced maximum immuno-stimulant activity at 5mg/kg dose in female mice [Eur. 126, 313(1984) Nov.28]
* Forkolin at 25.78 micro gm increased percentage of motile spermatozoa in bull (Andrologia 1989, 21, 293).
* 1,9 - dideoxy forskolin showed anti inflammatory activity in Carrageenin induced rat paw oedema (ED-50 2.2 mg/kg, i.p.) - (Chem. Abstr. 1989, 110, 147859k).
* Forskolin (0.5 mg) lowered intra ocular pressure in rabbits and suppressed contraction of electrically stimulated CNS, partly by inhibiting sympathetic neuronal function (Curr. Eye. Res. 1985, 4, 87).
* In anaesthetised rabbits, forskolin (10 micro gm / kg / min) increased blood flow in cerebrum and increased flow to myocardium and kidney despite decrease in mean arterial pressure (Stroke 1986, 17, 1299).
Thank you,
Divya Khare.