gandha prasarini - Paederia foetida

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sheji ramkumar

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May 18, 2010, 7:44:50 AM5/18/10
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sanskrit  - gandha prasarini
Family     - Rubiaceae.
 
[From Dr. S.N.Murthy]
paederia_foetida.gif

tanay bose

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May 18, 2010, 8:59:48 AM5/18/10
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Paederia foetida Linn.

STINKVINE

A climbing, herbaceous. hairy or smooth slender vine. The name derives from the distinct odor of carbon bisulphide when the leaves are crushed. Leaves are ovate to oblong-ovate, 6 to 10 cm long, 3.5 to 5 cm wide, pointed at the tip, rounded or slightly heart-shaped at the base. Flowers are stalkless, in axiallary, lax, peduncled inflorescences. Corolla is about 1 cm long, cylindrical, pale purple to white outside, deep purple and villous inside; limb is spreading with 5 undulate lobes. Fruit is rounded, about 5 mm diameter.

Distribution
In thickets at low and medium altitudes.

Constituents and properties

Upon distillation, a volatile oil is obtained with the offensive odor of the fresh crushed leaves.


Two alkaloids are obtained: a- and b-Paederine.The leaves yield an indole.
Leaves are rich in carotene and vitamin C.Considered anodyne, emollient, carminative, tonic, stomachic, vermifuge.Plant yields friedelan-3-1, beta-sitosterol and epifriedelinol.Leaves yield iridoid glycosides, asperuloside, paederoside and scandoside; sitosterol, stigmasterol, campesterol, ursolic acid, palmitic acide and methyl mercaptan. The methyl mercaptan is responsible for the foetid odor of the plant.

Uses
Folkloric
Used for rheumatism.


The leaves, boiled and mashed, applied to the abdomen for urinary retention.
Decoction of leaves also used for urinary retention and for urinary bladder stones.
Decoction-soaked cloths applied to the forehead for fevers and taken internally at the same time.


Bark decoction used as emetic.Decoction of leaves used for antirheumatic baths.

Pounded leaves applied to the abdomen for flatulence.


Decoction of roots for expelling gas.


Fruit used for toothaches and to blacken the teeth.
Decoction of whole plant used for abdominal pain, abscesses, arthritis.
In many Asia traditional therapies, used for diarrhea and dysentery.


In Bangladesh, used for diarrhea. Poultice of leaves used to relieve distention and flatulence


Roots and bark used as emetic, and in the treatment of piles and liver inflmmation.
Fruit used for toothache.


In India used for rheumatism and stiffness of the joints. Poultice of leaves applied to abdomen to relieve distention and flatulence. Juice of the root is used for piles, liver and spleen ailments.



Studies
• Antidiarrheal:
Antidiarrhoeal activity of the ethanol extract of Paederia foetida Linn. (Rubiaceae): Study showed P. foetida has antidiarrheal activity by inhibiting intestinal motility supporting its use in traditional medicine.
• Antiinflammatory:
Investigation of the anti-inflammatory effects of Paederia foetida: The study sought to find pharmacologic basis for the ethnomedical use of the plant.


• Antispasmodic:
Ethanolic extract exhibited antispasmodic activity on isolated guinea-pig ileum.


• Anthelmintic: Juice of leaves showed potent anthelmintic effect against bovine helminths–Strongyloides spp, Trichostrongylus and Haemonchus spp.


• Antitussive Activity : Study showed the ethanolic extract of P foetida had a cough suppressant effect, with decrease in cough intensity and frequency.

The effect was less than codeine but similar to non-narcotic dropropizine. The effect could be related to its demonstrated antiinflammatory activity.


• Antioxidant Activity : Study showed that P. foetida had high antioxidant activity, with fresh samples having higher phenolic contents and better antioxidant activity than the dried samples. It suggests PF could be a significant source of natural antioxidant compounds.


• Hepatoprotective Activity : Study showed the methanol extract to have moderate hepatoprotective activity.


• Anticancer Activity : Study showed the 50% ethanolic extract to have anticancer activity against human nasopharyngeal epidermoid canrcinoma in tissue culture.


sheji

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May 18, 2010, 9:07:40 AM5/18/10
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thank you Tanay ji

On May 18, 5:59 pm, tanay bose <tanaybos...@gmail.com> wrote:
> *Paederia foetida **Linn.*
> *STINKVINE
>
> *
>
> A climbing, herbaceous. hairy or smooth slender vine. The name derives from
> the distinct odor of carbon bisulphide when the leaves are crushed. Leaves
> are ovate to oblong-ovate, 6 to 10 cm long, 3.5 to 5 cm wide, pointed at the
> tip, rounded or slightly heart-shaped at the base. Flowers are stalkless, in
> axiallary, lax, peduncled inflorescences. Corolla is about 1 cm long,
> cylindrical, pale purple to white outside, deep purple and villous inside;
> limb is spreading with 5 undulate lobes. Fruit is rounded, about 5 mm
> diameter.
>
> *Distribution
> *In thickets at low and medium altitudes.
>
> *Constituents and properties*
>
> Upon distillation, a volatile oil is obtained with the offensive odor of the
> fresh crushed leaves.
>
> Two alkaloids are obtained: a- and b-Paederine.The leaves yield an indole.
> Leaves are rich in carotene and vitamin C.Considered anodyne, emollient,
> carminative, tonic, stomachic, vermifuge.Plant yields friedelan-3-1,
> beta-sitosterol and epifriedelinol.Leaves yield iridoid glycosides,
> asperuloside, paederoside and scandoside; sitosterol, stigmasterol,
> campesterol, ursolic acid, palmitic acide and methyl mercaptan. The methyl
> mercaptan is responsible for the foetid odor of the plant.
>
> *Uses
> **Folkloric **
> *Used for rheumatism.
>
> The leaves, boiled and mashed, applied to the abdomen for urinary retention.
> Decoction of leaves also used for urinary retention and for urinary bladder
> stones.
> Decoction-soaked cloths applied to the forehead for fevers and taken
> internally at the same time.
>
> Bark decoction used as emetic.Decoction of leaves used for antirheumatic
> baths.
>
> Pounded leaves applied to the abdomen for flatulence.
>
> Decoction of roots for expelling gas.
>
> Fruit used for toothaches and to blacken the teeth.
> Decoction of whole plant used for abdominal pain, abscesses, arthritis.
> In many *Asia* traditional therapies, used for diarrhea and dysentery.
>
> In *Bangladesh*, used for diarrhea. Poultice of leaves used to relieve
> distention and flatulence
>
> Roots and bark used as emetic, and in the treatment of piles and liver
> inflmmation.
> Fruit used for toothache.
>
> In *India* used for rheumatism and stiffness of the joints. Poultice of
> leaves applied to abdomen to relieve distention and flatulence. Juice of the
> root is used for piles, liver and spleen ailments.
>
> *
>
> **Studies**
> • Antidiarrheal: *Antidiarrhoeal activity of the ethanol extract of Paederia
> foetida Linn. (Rubiaceae): Study showed P. foetida has antidiarrheal
> activity by inhibiting intestinal motility supporting its use in traditional
> medicine.*
> • Antiinflammatory: *Investigation of the anti-inflammatory effects of
> Paederia foetida: The study sought to find pharmacologic basis for the
> ethnomedical use of the plant.
>
> *
> • Antispasmodic: *Ethanolic extract exhibited antispasmodic activity on
> isolated guinea-pig ileum.
>
> *• Anthelmintic: *Juice of leaves showed potent anthelmintic effect against
> bovine helminths–Strongyloides spp, Trichostrongylus and Haemonchus spp.
>
> *• Antitussive Activity : *Study showed the ethanolic extract of P foetida
> had a cough suppressant effect, with decrease in cough intensity and
> frequency.
>
> The effect was less than codeine but similar to non-narcotic dropropizine.
> The effect could be related to its demonstrated antiinflammatory activity.
>
> *• Antioxidant Activity : *Study showed that P. foetida had high antioxidant
> activity, with fresh samples having higher phenolic contents and better
> antioxidant activity than the dried samples. It suggests PF could be a
> significant source of natural antioxidant compounds.
>
> *• Hepatoprotective Activity : *Study showed the methanol extract to have
> moderate hepatoprotective activity.
>
> *• Anticancer Activity : *Study showed the 50% ethanolic extract to have

tanay bose

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May 18, 2010, 10:26:30 AM5/18/10
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Welcome Sheji ji
Tanay
--
Tanay Bose
+91(033) 25550676 (Resi)
9830439691(Mobile)
9674221362 (Mobile)

Dr. Hari Venkatesh.K.Rajaraman

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May 24, 2010, 2:01:25 PM5/24/10
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Thank you Sheji ji for posting this plant...this is the first time iam seeing the flowers of this plant. . .ALso thanks to Murthy sir for providing the photograph...
this is confused with Prasarani in Ayurveda and is usually taken as Gandha prasarini due to its foetid smell. . .INDOLE is the chemical which is responsible for the foetid odour of this plant...
A PG scholar in koppa Ayurveda college has chosen this plant for his dissertation to prove the aphrodisiac property of this plant...in Albino rats. . .

Dr. Hari Venkatesh.K.Rajaraman

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May 24, 2010, 2:01:48 PM5/24/10
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Thank you Tanay ji for the medicinal information
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