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DMG - causing cancer ?

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Robert A Jensen

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Feb 21, 1998, 3:00:00 AM2/21/98
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Raemdonck wrote:
>
> I've heard from a dutch pharmacist that DMG (dimethylglycine) is causing
> cancer ? and therefore FED will forbidden it in USA ???
>
> Is this true ???
>
> please send info to tri...@tornado.be
>
> An
On the contrary, DMG in a number of studies has been shown to be
beneficial in treating cancer.
Regards,
Bob Jensen
---------------------------------------------------------------------
Gann 1984 Mar;75(3):253-259

Host-mediated antitumor effect of DMG, a degraded
D-manno-D-glucan from Microellobosporia grisea culture
fluid.

Nakajima H, Hashimoto S, Nagao S, Kita Y, Khono M, Ogawa H, Abe S,
Mizuno D

DMG, a new polysaccharide with a well-characterized structure, isolated
from the culture filtrate of
an actinomycetes and then degraded by acid treatment, was tested for
antitumor activity on
allogeneic and syngeneic tumors in mice. In the allogeneic Ehrlich solid
tumor system, DMG showed
antitumor activity over a wide dose range, its optimal dose being 10-100
mg/kg. The optimal time of
DMG administration was 1-2 weeks after tumor inoculation, but DMG was
also effective when
given before tumor inoculation. DMG was effective when given ip, sc, it
(intratumorally) or iv. DMG
also had antitumor effects on syngeneic tumors. It rapidly inhibited the
growth of MM46 mammary
carcinoma, MH134 hepatoma, and Meth A fibrosarcoma, and also inhibited
spontaneous
pulmonary metastases of B16-BL6 melanoma. However, it had no direct
cytocidal action on tumor
cells in vitro. Its antitumor activity was much less in athymic nude
mice and in mice
immunosuppressed by whole-body X-irradiation than in normal hosts.Thus,
DMG was shown to
exert antitumor activity via host-mediated mechanisms. Its antitumor
activity is discussed in
comparison with those of other antitumor polysaccharides.

PMID: 6233200, UI: 84209619

Althea Schildroth

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Feb 21, 1998, 3:00:00 AM2/21/98
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I have not heard this, but then who knows...please let me know if you do hear from someone who's heard about this.  My son takes DMG.  Did the pharmacist cite any research studies or give you any more information than that?

As far as I know the FDA has no authority (yet) to restrict DMG since it's considered a food supplement not a drug (here in the USA).

----------
> From: Raemdonck <tri...@TORNADO.BE>
> To: AUT...@MAELSTROM.STJOHNS.EDU
> Subject: DMG   - causing cancer ?
> Date: Saturday, February 21, 1998 6:42 PM

Raemdonck

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Feb 22, 1998, 3:00:00 AM2/22/98
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C.G.Meskers

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Feb 22, 1998, 3:00:00 AM2/22/98
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Raemdonck schreef:

This is what the Dutch pharmacist give to me when i ask him about Vitamine
B15, i made a scan from it.

Drugs Consults: COGNITIVE ENHANCER EFFICACY
VITMIN B15” is not a vitamin, but a mixture of substances isolated from
apricot pits (Herbert 1979), known as PANGAMIC ACID. It was isolated and
advertised by the promoter of laetrile (Pilla, 1979). Studies on pangamic
acid from Russia could never be verified, and no evidence exists for its
role as a cognitive enhancer. This mixiur includes diilsopropylarnine,
dichloroacetate, and dirnethylgicine, which may, induce cyanosis,
mutagenicity, and carcinogenicity (Herbert, 1979). Pangamic acid has been
banned in Canada. Although the FDA has no indication for marketing pangainic
acid as a drug, and no evidence of its safety as a food additive
disaIlowing its sale as dietary supplement, "vitamin B15" is obtainable at
health food stores.

(c)1974-1997 Micromedex Inc. Volume 94 Expiration Date: 31/i2~97


He also give me an aticle in Dutch, it is not possible for me to translate
it into English, but meby somebody els can do this.


Vitamine B15

CHECK, W. A. (1980) Vitamin B 15 - whatever it is, it won't help. J. Am.
Med. Assoc. 243, 2473; CHECK, W. A. (1980) FDA'S hands loosely tied. J. Am.
Med. Assoc. 243, 2480. In de rubriek Medisch nieuws gaat de auteur in op de
situatie rond vitamine B15. Dit 'preparaat', ook bekend als pangamineruur of
calcitimpan-gamaat, wordt in de Verenigde Staten nog steeds veel verkocht,
hetzij als voedingssupplement, hetzij als geneesmiddel ('wondermiddel'). Het
is referent bekend dat het ook in Nederland in de handel is.
In de strijd tegen dit soort middelen is nu bekend geworden dat twee stoffen
die in de meest verkocht vitamine B 15-preparaten voorkomen, te weten
dimethylglycinehydro-chloride en diisopropylaminedichlooracetaat in
aanwezighijd van nitriet onder invloed van omstandigheden die in de maag
heersen, in staat zijn stoffen te vormen die in de Ames-test mutageen zijn,
en dus mogelijk carcinogeen.
De auteur gaat in op de problemen die de FDA ondervindt bij haar processen
tegen de fabrikanten van deze preparaten. Ze wordt met name gehinderd
doordat de naam vitarnine B15, pangaminezuur of calciurnpangamaat niets
zegt over de eigenlijke inhoud. Zoals ook vermeld is in de rubriek Vraag en
Antwoord van de documentatie- en Inforrnatiedienst KNMP [Pharm. Weekblad
(1979) 114, 99-10] zijn verschillende samenstellingen mogelijk en de
fabrikanten kunnen deze van de ene op de andere dag veranderen. Hierdoor
zijn zij soms ongrijpbaar. Incidenteel worden door do FDA successen geboekt,
maar totaal gezien blijft het zeer moeilijk om vitamine B15 uit de handel te
laten nemen.

J. VAN DER GEUGTEN- VAN
ENGELDORP GASTELAARS


Cees Meskers


Jenny and Steve Wendling

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Feb 22, 1998, 3:00:00 AM2/22/98
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In a message dated 98-02-21 18:41:16 EST, you write:

<< I've heard from a dutch pharmacist that DMG (dimethylglycine) is causing
cancer ? and therefore FED will forbidden it in USA ???

Is this true ??? >>

We cannot live without DMG, if you here anything, I'd appreciate it if you
could pass it along.

Thanks.

Jenny
MJ...@aol.com
Mother of Olivia, 4, autism
Homeschooler, NACD, 5 months

"Do what you can and then pray that God will give you the power to do what you
cannot." St. Augustine

jba...@iname.com

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Feb 23, 1998, 3:00:00 AM2/23/98
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In article <34EF6E...@erols.com>,
raje...@erols.com wrote:

>
> Raemdonck wrote:
> >
> > I've heard from a dutch pharmacist that DMG (dimethylglycine) is causing
> > cancer ? and therefore FED will forbidden it in USA ???
> >
> > Is this true ???
> >
> > please send info to tri...@tornado.be
> >
> > An
> On the contrary, DMG in a number of studies has been shown to be
> beneficial in treating cancer.
> Regards,
> Bob Jensen
> ---------------------------------------------------------------------
> Gann 1984 Mar;75(3):253-259
>
> Host-mediated antitumor effect of DMG, a degraded
> D-manno-D-glucan from Microellobosporia grisea culture
> fluid.

The DMG in this article refers to D-manno-D-glucan, not the Dimethylglycine
used in autism.

Judy

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Teri Edgar

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Feb 24, 1998, 3:00:00 AM2/24/98
to

Thanks for clarifying this for us, Judy. I take DMG and I've never seen
anything about it being dangerous. I feel safe with it.

Teri E.

Judy Badner

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Feb 24, 1998, 3:00:00 AM2/24/98
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Teri Edgar wrote:
>
> Thanks for clarifying this for us, Judy. I take DMG and I've never seen
> anything about it being dangerous. I feel safe with it.

I can't say anything about whether DMG (Dimethylglycine) does or
does not cause cancer. My post was just meant to clarify that the
DMG in the article that was cited was not referring to Dimethylglycine.

Judy

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