Blood types: O moms of A kids

[mchooi]

I am getting desperate. Can someone please tell me how to remove my name from
the mailing list. I
have emailed to AUS...@MALESTROM.STJOHNS.EDU seven times!
thanks.

----------
> From: Mark Remlin <m...@DASW.COM>
> To: AUT...@MAELSTROM.STJOHNS.EDU
> Subject: Re: Blood types: O moms of A kids
> Date: Tuesday, August 12, 1997 9:39 PM
>
> I am A+ my wife is O- and our autistic son is A+
>
> Mark

[Mark Remlin]

[[Wendy Nemitz]]

In a message dated 97-08-11 16:25:02 EDT, you write:

<< (1)
Kay LA.
Cellular basis of immune response to antigens of ABO blood-group
system. Capacity to provide help during response to T-cell-dependent
ABO-system antigens is restricted to individuals of blood group O.
Lancet. 2(8416):1369-71, 1984 Dec 15.
It is postulated that the near-identity of the A and B antigens in man
makes it impossible for individuals of groups A, A2, or B to provide
T-cell help during a response to T-dependent non-self antigens by B2
lymphocytes. Thus, people of these groups are unable to produce immune IgG
antibody. The presence of naturally occurring IgM antibody to non-self
antigen from the age of 6 months is due to a separate system of
T-cell-independent B1 cells which have arisen during evolution to protect
the host against polysaccharide-encapsulated bacterial pathogens.
>>
Teresa very interesting information, I am O+, I am going to call my sons
doctor to get his type, this makes me think about the ties between autism and
immune disorders, this would be a very strong case for allergies or
intolerences because of weakened immune response or lack of one, or
heightened immune response , in other words the body is working to keep the
body healthy from serious immune attacks and when attacked by minor intruders
such as allergens or intolerences it is not capable of fighting them because
it's troops are fighting bigger battles (fending off more serious attacks).
Just a theory. If I made sense. Wendy (Dylan's Mom;-)

[Teresa Binstock]

Wendy,

Your impression seems to convey a primary significance of blood-type
and blood-type differences, ie, they are akin to risk-factors and/or to
suboptimality factors, with a very strong immunological aspect, and that
aspect intertwined with a number of physiological factors that we see
from time to time on the autism list -- eg, tendencies towards or away
from certain types of infections, gastrointestinal tract, complement 4b
alleles, etc.

Of course, if the O percentage is 47%, then nearly half the moms ought be
type-O; nonetheless, the literature I've been browsing has many links to
topics on the autism-list and that, along with the immunologicals you
mention, make the topic worth considering, for its ramifications in some
cases (ie, a subgroup) of autism pathogenesis.

Also, if the kind of autoimmune-response Wendy mentions is occurring in a
subgroup, individuals therein could be experiencing hemolytic processes
that would be altering metabolism of iron and its various metabolites,
thereby also modifying bilirubin and albumin, as well as tryptophan-
related enzymes such as tryptophan-pyrrolase, thereby leading to
alterations in serum serotonin...

So, Wendy, in the tradition of autism moms, you looked at an abstract
with a very complex topic and saw therein some of its possible
signficances in autism...

Teresa

On Tue, 12 Aug 1997, [Wendy Nemitz] wrote:
> >>
> ...very interesting information, I am O+, I am going to call my sons

[Jim Arvanete]

Just like to add I'm an O- and it is my #2 child effected..... chord around
the neck , early c-section, as if the lights were on but nobody home at
birth....couldn't nurse at first, but snapped out of it at 3 months....
then started to loose him after a DTP shot .... given my private practice
PA. nanci

----------
From: Diana Gray[SMTP:Dia...@AOL.COM]
Sent: Wednesday, August 13, 1997 8:58 AM

To: AUT...@MAELSTROM.STJOHNS.EDU
Subject: Re: Blood types: O moms of A kids

In a message dated 97-08-11 21:30:37 EDT, Teresa write:

<< n a very technical article is written:

"...almost without exception mothers of infants with ABO haemolytic
disease of the newborn are group O (Am J Ob Gyn 79.567 1960). The
observations that the firstborn is commonly affected..." (1)
[another "risk" factor"? ? ?]
>>

Teresa,

Is ABO haemolytic disease the same thing as ABO incompatibility? I am an
O+
mom, and my son was jaundiced due to the above as a newborn -- a
neonatologist kept a watchful eye on his bilirubin counts, and he received
phototherapy -- no transfusions -- and was released after 5 days. Although
I've asked several times, the pediatrician tells me Joey's blood has never
been typed. I have 4 sibs, and I'm the only one with O+. Also, Joey is my
second child.

Interesting connection!...Diana

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[Diana Gray]

In a message dated 97-08-13 21:46:15 EDT, you write:

<< Although the two concepts are closely related, "ABO haemolytic disease" is
not quite the same as "ABO incompatibility", in the following way, ABO
incompatibility can lead to ABO haemolytic disease of the newborn. >>

Teresa,

Thank you for this post and the subsequent post on ABO haemolytic disease.
I'm still wondering at what point does ABO incompatibility lead to ABO HD?
Also, there is a reference to the newborn not showing this problem at
birth, but later on -- how much later on? My son's ABO incompatibility (and
jaundice) was detected about 24 hours after birth. It's not that it really
matters anymore (he is almost 14 now), unless that could have implications
for his health now, but I've always been curious about that aspect of his
birth. Also, he was face up, rather than face down, and had to be turned
before he was delivered -- that seems to be a fairly common birth factor
according to the many moms I've talked to.

I really appreciate that you have helped me to understand ABO incompatibility
-- we are very fortunate to have you on this list. I, for one, am very
impressed with your desire and ability to help other families with issues
that may or may not be personally relevant to your own life -- that's very
generous of you. Thank you.

Diana