Fwd: actinomycetes tournament & open drug discovery (initial group-mail discussion)

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Martin Malthe Borch

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Oct 31, 2013, 7:30:40 AM10/31/13
to bios...@googlegroups.com


---------- Forwarded message ----------
From: kingjacob <king...@gmail.com>
Date: 2013/10/31
Subject: Re: actinomycetes tournament & open drug discovery


Hi all, one of the questions I got here at ICG that I didn't really have an answer to was "When a novel and effective antibiotic is discovered. What are the next steps?" It's a bit of putting the cart before the horse worrying about regulatory hurdles and distribution but probably worth at least starting to think about.


On Thu, Oct 31, 2013 at 6:45 PM, Martin Malthe Borch <mmb...@gmail.com> wrote:

Hi Everybody...

Yes sounds really great with a biostrike googlegroup.

And sorry for not posting anything yesterday, but don't worry besides a little cold we are still alive, feeling well and progressing nicely..

cheers -  Pieter & Malthe




2013/10/31 Yair Reshef <yai...@gmail.com>
added tlv members, again



On Wed, Oct 30, 2013 at 12:02 AM, Martin Malthe Borch <mmb...@gmail.com> wrote:
Added another biologigaragen member 
Søren Borch


2013/10/29 Pieter van Boheemen <pieterva...@gmail.com>
Hi Simon,

Thanks for the great advice. Our eye still needs a bit of training, so perhaps you and others would like to help out:
https://www.flickr.com/photos/pietervanboheemen/tags/plate/
After clicking on a photo you can create rectangles on them by clicking and dragging, for adding notes about specific parts of the picture.
Do you think that there are any Actinomycetes on these plates?

In some of the plates that we created today we added Brentan (miconazolnitrate) as an antifungal agent. So let's see what happens there.

The incubator starts smelling like wet earth, so everything seems promising!



On Tue, Oct 29, 2013 at 9:37 PM, <s.p...@surrey.ac.uk> wrote:
Even as pure cultures, with no competition, Actinomyces are quite slow growing compared to other soil bacteria so it's unilkey any will have grown overnight but you never know!
 
If the medium that you are using is too rich then you might get a lot of mould growth or overgrowth by other soil bacteria that might stop the growth of any actinomyces or cover them.
 
Their colonies are quite distinctive and once you get an eye for them they're very easy to differentiate from other bacteria
 
If mould becomes a problem you could try a specific antifungal. Try an over the counter treatment for Thrush (Canestan)
 
I hope this helps
 
Best wishes
 
Simon
 
From: Pieter van Boheemen [pieterva...@gmail.com]
Sent: 29 October 2013 18:13
To: Marc Dusseiller
Cc: Patrik D'haeseleer; Urs Gaudenz; kate lu; gabriella levine; vivian xu; William Hooi; Thomas Landrain; andreas siagian; Eric Boyd; Rüdiger Trojok; Martin Malthe Borch; Sachiko K; Denisa Kera; Kristijan Tkalec; Park SF Dr (Sch of Biosci & Med); Mojca Zaloznik; Mackenzie Cowell; Stefania Druga; Jacob Shiach; Justin Pahara | Synbiota Inc.; Connor Dickie; Cathal Garvey; Luca Paolo Pescatore; Nur Akbar; Yair Reshef; pan...@synbiota.ca; Benjamin Bacon; David Li; Lucas Evers

Subject: Re: actinomycetes tournament & open drug discovery

Thanks for all the on the fly peer reviews everyone!

Right now Malthe and I are testing even more protocols, did some shopping at the pharmacy and made additional growth mediums. The plates of yesterday are already showing some interesting colonies.

We are switching platforms for documentation all the time too. Synbiota is not so convenient for real time collaboration (sorry Connor), so that's why we use this google drive as a collab hub: https://drive.google.com/folderview?id=0BzADIb9rSQQ3WTI4Z0pWOGl2bzg&usp=sharing
It allows for faster editing, we'll structure everything on the go towards the end of the week, Synbiota has nice features for that.
Anyway, as more people jump in things will converge to a certain platform along the way. You'll see that by the next email we have adopted another platform again. Perhaps this experience is also worth writing about in BioCoder

Next step in the BioStrike project: identifying which ones are actinomyces. We are working on a guide on the go, any help is much appreciated https://docs.google.com/document/d/1hf8miZtC13zMwe9J3R_55-6pSS1xFnbrNp9dp-NoLK4

I also added Lucas Evers (Waag) to this conversation.


On Tue, Oct 29, 2013 at 6:14 PM, Marc Dusseiller <ma...@dusseiller.ch> wrote:

sorry... i was reading the thread backwards.

m
On Oct 29, 2013 5:58 PM, "Patrik D'haeseleer" <pat...@gmail.com> wrote:
On Tue, Oct 29, 2013 at 5:30 AM, Marc Dusseiller <ma...@dusseiller.ch> wrote:
hoied mitenand,

maybe we should summarize the discussion... piratepad? or hackteria wiki?


I thought we were going to use Synbiota?

https://synbiota.com/projects/328/workspace_pages

I'm not wedded to any one platform, but that's where we have most material on this project so far...

Also, any objection to moving the email discussion to a google group or some other place where we can archive the threads?

Patrik





--
Med venlig hilsen,            Martin Malthe Borch

@MMBorch  |  +45 61713656



--
yair99@gmail
050-6301212
tlv, israel



--
Med venlig hilsen,            Martin Malthe Borch

@MMBorch  |  +45 61713656



--



--
Med venlig hilsen,            Martin Malthe Borch

@MMBorch  |  +45 61713656
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