Cancer Probes - Cerebellum & Aging - Transparent Fish - Whale Dialects

[Breedlove, S]

https://www.wired.com/story/three-people-have-gotten-cancer-detecting-brain-implants/

3 People Have Gotten Cancer-Detecting Implants in Their Brains

A San Francisco startup with ties to Elon Musk’s Neuralink has started testing its brain implant to detect and treat cancer in humans.

Coherence Neuro says it temporarily placed its coin-sized implant in the brains of three people undergoing surgery to have brain tumors removed at the Royal Melbourne Hospital in Australia. The implant was in place for roughly 30 minutes before being removed, providing an important safety check before the device can be implanted long-term in patients with brain cancer.

Known as a brain-computer interface, the Coherence Neuro device is designed to sense the unique electrical signals of tumors and deliver mild electrical stimulation to prevent their growth. In the time the implant was in the patients’ brains, the company was able to see how it performed for a short period. (The patients had consented prior to surgery.)

Matthew MacDougall, Neuralink’s head neurosurgeon, is an adviser and investor in Coherence. Rory Murphy, a neurosurgeon at the Barrow Neurological Institute in Arizona who is an investigator in one of Neuralink’s trials, is also slated to be involved in future trials of the Coherence device.

The idea behind treating brain tumors with electrical stimulation comes from the long-held observation that cancerous tissue has distinctive electrical properties. “These are electrical conditions, just like epilepsy, just like depression. This is a network problem in the brain,” says Ben Woodington, chief executive officer and cofounder of Coherence.

© 2026 Condé Nast. 
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https://www.sciencenews.org/article/cerebellum-brain-aging-boost

The ‘little brain’ may give the aging mind a big boost

By Jackie Rocheleau

The cerebellum, the wizened “little brain” nestled in the base of the skull, may help keep us sharp as we age.

Regions at the back of the cerebellum that resisted shrinkage with age were tied to better mental functioning, or cognition, even in people in the early stages of Alzheimer’s disease, researchers report June 10 in Nature Neuroscience.

Though traditionally thought of as a movement control center, scientists now know the cerebellum is a key player in cognition. Researchers also know that parts of the cerebellum don’t age in unison, but the aging cerebellum is a relatively new area of research.

In the new study, the team first analyzed brain scans and cognitive test scores from more than 700 U.S. adults whose data was collected as part of the Human Connectome Project, a brain mapping initiative. The test measured abilities including short-term memory, attention, language and visualizing 3-D objects.

A clear trend emerged: The cerebellum tended to be smaller with increasing age, but the bigger the cerebellum, particularly in regions in the rear of the little brain, the higher the score on cognitive tests. The trend held even after adjusting for the different levels of education among participants, Princeton University neuroscientist Frederick d’Oleire Uquillas and colleagues report.

The researchers found the same link in more than 35,000 adults in the U.K. Biobank, a biomedical database. The findings point to a larger cerebellum preserving cognition with greater age, says d’Oleire Uquillas. The researchers confirmed that scans of the larger cerebellums showed more brain tissue and connections between nerve cells, a 

© Society for Science & the Public 2000–2026. 
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https://www.science.org/content/article/how-ai-1-billion-and-transparent-fish-could-transform-neuroscience

 How AI, $1 billion, and a transparent fish could transform neuroscience

 Zoe Beketova 

When Adam Douglass began to study the tiny, transparent fish in the Danionella genus about 10 years ago, he had to get his animals from an out-of-state fish shop, where they were sold as an exotic pet breed. “The only information at all about trying to grow them in captivity came from online,” says Douglass, a neurobiologist at the University of Utah. Compared with zebrafish, which by that point had been a model species for biology research for decades, Danionella was little known to scientists.

How things have changed. Last week, the Janelia Research Campus, the in-house research arm of the behemoth Howard Hughes Medical Institute (HHMI), announced a 10-year, roughly $1 billion research effort focused on using Danionella as a model for how brain cells and circuits drive complex behaviors in vertebrates. The effort will also draw on cutting-edge artificial intelligence (AI) tools to make sense of all the new data on the fish.

“I think this is one of the most exciting opportunities that we’ve faced in the entire history of Janelia,” says neuroscientist Nelson Spruston, Janelia’s vice president and executive director. “There are a lot of structures in the brain and the rest of the body of fish that are identifiably similar to those of humans,” he adds, and there’s a long history of simple model organisms “leading to important insights that eventually result in cures and treatments for devastating diseases.”

Danionella’s growing popularity comes from one (literally) clear advantage: Unlike zebrafish, which are transparent only for the first few weeks of their 3- to 4-year lives, Danionella remain so, meaning their brain is still visible—and easier to image—when they reach adulthood and engage in behaviors such as schooling, navigation, and courtship.

The fish, only about the size of a grain of rice, never grow scales, develop pigmentation, or form a complete, bony skull. “All of these features that stand in the way of being able to get photons into and out of your skull [for imaging] are not there,” says Douglass, who has watched Danionella become a focus of dozens of labs worldwide
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https://www.thetransmitter.org/synapses/designer-synapses-edit-brain-circuits-in-living-animals/

 Designer synapses edit brain circuits in living animals

By Simon Makin

A new tool makes it possible to probe brain circuit function without the kind of external stimulation required in optogenetics and chemogenetics.

The method uses engineered electrical synapses to edit brain circuits. These designer synapses function in living mice, altering activity in cells, circuits and networks, with corresponding effects on behavior. 

In contrast to tools that involve external stimulation, the result is autonomous. “Here, all the information is completely natural; it’s only how the brain manipulates this information that’s being altered,” says Ithai Rabinowitch, assistant professor of neurobiology at the Hebrew University of Jerusalem, who was not involved in the work. “This is really important, in my view.”

The technique, called LinCx (long-term integration of circuits using connexins) could be used to investigate relationships between circuit structure and function, as well as the duties of natural electrical synapses. “It’s potentially a useful tool if it’s used intelligently and thoughtfully to ask questions about the role of electrical synapses in brain circuits,” says Eve Marder, professor of biology at Brandeis University, who was not involved in the study.

Electrical synapses consist of gap junctions that, in vertebrates, are composed of connexin proteins, of which there are 21 isoforms in humans. These proteins sit in the membranes of touching cells, docked together to create channels that ions pass through, coupling the cells’ activity. 

Gap junctions in invertebrates are composed of innexins, which don’t interact with connexins, so expressing a mammalian connexin in Caenorhabditis elegans enabled researchers to rewire an olfactory circuit and flip the worms’ behavior from odor attraction to avoidance, according to a 2014 study.
© 2026 Simons Foundation

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https://www.theguardian.com/environment/2026/jun/24/sperm-whale-dialects-detected-mediterranean

Different sperm whale ‘dialects’ detected on separate sides of the Mediterranean

Nicola Davis Science correspondent

From “Howdy” to “G’day”, English – like other languages – is rich in dialects. Now researchers have found sperm whales on different sides of the Mediterranean show similar variations in their vocalisations.

Sperm whales communicate vocally using sequences of short clicks called codas. However, the rhythmic pattern of these clicks, known as the dialect, can differ between different matriarchal groups.

Crucially, one group of sperm whales will only associate with another if they share the same dialect and hence belong to the same “vocal clan”.

“The dialect is used to form social structures, within which these animals will cooperate,” said Dr Luke Rendell, of the University of St Andrews and a co-author of the new study, noting similarities in how humans might be more comfortable striking up a conversation with someone who sounds similar to themselves.
a whale

Now Rendell and colleagues say they have discovered two different dialects among Mediterraean sperm whales – a small, endangered population of a few thousand individuals that are thought to have first entered these waters about 20,000 years ago.

What’s more, they say the finding offers new insights into how sperm whale dialects arise.

Writing in the journal Proceedings of the Royal Society B, the team note genetic studies have previously suggested Mediterranean sperm whales have become isolated from other sperm whales. There are also signs that mating between those in the western and eastern Mediterranean basins is restricted, although individuals have been spotted moving between the two.

© 2026 Guardian News & Media Limited 
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