[Toxicology] Depiction of the antioxidant enzyme defense system

[ian.jager]

Please forgive, but I lifted this abbreviated antioxidant enzyme
defense system (in ASCII form) scheme from Dr. Mark Kukucka's PhD
dissertation because I couldn't find anything else like it online!

Mechanisms by which hypoxia augments Leydig cell viability and
differentiated cell function in vitro

by Mark A. Kukucka, MS, DVM, PhD

Department of Biomedical Sciences
Virginia-Maryland Regional College of Veterinary Medicine
Virginia Polytechnic Institute & State University
Blacksburg, Virginia 24061-0442

found at:
http://scholar.lib.vt.edu/theses/available/etd-06062008-170416/

H2O
/\
|
| Catalase
|
oxidases SOD | Fe+2
O2 --------> O2*- --------> H2O2 ----\----> OH* --------> H2O
| Fe+3
|
| 2GSH
| / /\
| Glutathione Glutathione
| peroxidase reductase
| \/ /
| GSSG
\/
H2O

Figure 1. The Antioxidant Enzyme Defense System Scheme

Other publications by Dr. Mark A. Kukucka
http://www.nextbio.com/b/literature/literature.nb?author=MA+Kukucka

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