Positions Available

[Eric Carstens]

Openings are currently available in my lab for both graduate students
and a Post Doctoral Fellow. A variety of research projects in molecular
virology related to the mechanisms and regulation of baculovirus DNA
replication are available. For example, we have recently shown that a
baculovirus single stranded DNA binding protein appears to be
responsible for the nuclear localization of another viral protein, P143.
Both of these proteins are essential for viral DNA replication. We would
like to know whether the interaction of LEF3 with P143 is essential for
the function of P143 during DNA replication. Although predicted to carry
helicase activity, to date, no one has successfully demonstrated that
P143 actually can carry out this important function.
P143 has also been implicated in host range determination. Therefore,
we are looking at the species specificity of P143 activity by
characterizing and comparing the biochemical properties of P143 derived
from different baculovirus species. These studies will provide valuable
information not only on the function of P143 but also on our ability to
manipulate viral genes to modify their host range in order to construct
more efficient and specific virus pesticides. In the long run, these
studies will form the foundation of other studies to determine the
suitability and practicality of using baculoviruses as agents for gene
therapy.

To apply, send a copy of your transcript, a statement of interest, a
CV and the names of three referees to:

Dr. Eric B. Carstens
Department of Microbiology and Immunology
Queen's University
Kingston, ONT, K7L 3N6
Canada
FAX: (613) 545-6796
Eamil: cars...@post.queensu.ca