Symposia and Workshops Schedule
Dianne McGavin
Symposia and Workshops Schedule
The following Symposia and Workshops are scheduled as follows. Updated information will appear in the Abstract Issue and Annual Meeting Program.
Sunday, February 13
8:30 am: Symposium 1
Muscle Crossbridges: Stepping
into the Millennium
Hugh Huxley, Chair
What X-Rays have Shown Us:
Then and Now
Hugh Huxley, Brandeis University
The Millennium Bug and
its Crossbridges
Michael Reedy, Duke University
The Motions of Myosin Heads
that Drive Muscle Contraction:
Structure-Function Studies on
Isolated Fibers
Malcolm Irving
King*s College, London
Conventional and Unconventional
Myosins: Variations on a Theme
Kathy Trybus, University of Vermont
11:00 am: Symposium 2
Membrane Transport Proteins:
Schlepping through the Bilayer
H. Ronald Kaback, Organizer
Structure of the Fo Sector of the H-
Transporting Rotary/ATP Synthase
Robert Fillingame
University of Wisconsin
What to Do While Awaiting Crystals of a Membrane Transport
Protein and Thereafter
H. Ronald Kaback
University of California, Los Angeles
Symport by Conformational Change
Ernest Wright
University of California, Los Angeles
3:45 pm: Symposium 3
Structural Biology in Genomic Analysis
Gaetano T. Montelione, Organizer
Predicting Targets for
Structural Genomics
Peer Bork
European Molecular Biology Laboratory, Heidelberg
X-ray Crystallography and
Structural Genomics
Stephen Burley
The Rockefeller University
Protein NMR and
Structural Genomics
Geatano T. Montelione
Rutgers University
Structure-based Analysis of
Sequence and Function
Barry Honig, Columbia University
3:45 pm: Symposium 4
G Protein Signaling: From Receptor
to Effector (Sponsored by the CPOW)
Heidi E. Hamm, Organizer
Structural Origin of
Rhodopsin Activation
Wayne Hubbell
University of California, Los Angeles
Insight into G Protein
Function and Regulation from
Structural Studies
Heidi E. Hamm
Northwestern University
Conformational Control of
GTP Hydrolysis by G Proteins
Steve Sprang
Howard Hughes Medical Institute
University of California,
San Francisco
5:00 pm: Workshop I
Single Molecule Experiments: Revealing the Role of Protein Fluctuations
Shimon Weiss, Organizer
Single-Molecule Enzymology
Sunney Xie, Harvard University
Steps, Arrests, and Pauses
to Elongation
Carlos Bustamante
University of California, Berkeley
Studying the Action of Single
David Bensimon
Ecole Normale Superieure
Stepping Rotation in a
Protein Machine Revealed by
Single Molecule Imaging
Kazuhiko Kinosita, Keio University
The Voltage-sensing Machinery
of Potassium Channels
Fred Sigworth, Yale University
5:00 pm: Workshop II
New Approaches to Measuring and Manipulating Intracellular Messengers
Richard H. Kramer, Organizer
Local Signaling by IP3 and Ca2+ in
Dendrites of Purkinje Neurons
Elizabeth A. Finch, Duke University
Real-Time Patch-Cram Detection
of Cyclic GMP in Intact Cells
Richard H. Kramer
University of Miami
New Molecules for Peeking at or
Poking Intracellular Messengers
Roger Y. Tsien
University of California, San Diego
Engineered Channels and Enzymes
for Monitoring and Controlling
Cell Signaling
Hagan Bayley
Texas A & M Health Science Center
5:00 pm: Workshop III
Closing the Reductionist Loop: Going from Biophysics to Network Dynamics
Eve Marder, Organizer
Going from the Biophysics of
Currents to the Dynamics of
Rhythmic Circuits
Eve Marder, Brandeis University
Modeling Signaling Pathways
Ravi Iyengar, Mt. Sinai Medical School
Integrative Models of
Cardiac Excitation and Arrhythmias
Yoram Rudy
Case Western Reserve University
Dynamics and Neural Codes
Gilles Laurent
California Institute of Technology
Monday, February 14
8:30 am: Symposium 5
Protein Folding: An Urgent Problem in the Postgenomic Era
Lila Gierasch, Organizer
The Roles of Local Sequence and
Global Interactions in the
Folding of Predominantly
b-sheet Protein
Lila Gierasch
University of Massachusetts
Listening to the Music of Evolution:
Folding Theme with
Functional Variations
Eugene Shakhnovich
Harvard University
Global and Local Cooperativity in
Protein Folding and Function
Ernesto Freire
The Johns Hopkins University
Folding of the Collagen
Triple Helix and Misfolding
in Disease
Jean Baum, Rutgers University
11:00 am: Symposium 6
Membrane Trafficking and
Vesicle Fusion
Wolfhard Almers, Organizer
Kinetic Analysis of Secretory
Protein Traffic
Jennifer Lippincott-Schwartz
National Institutes of Health
Insights from Studying Single
Exo- and Endocytic Events
Wolfhard Almers, Vollum Institute
Mechanism of SNARE Proteins in
Membrane Fusion
Reinhard Jahn
Max Planck Institute for
Biophysical Chemistry
Structural and Functional Insights
in the Mechanism of
Synaptic Exocytosis
Axel Brunger, Yale University
11:00 am: Symposium 7
Folding, Form and Function of RNA and DNA Molecules
Anna Marie Pyle, Organizer
Active-Site Structure and Catalytic
Mechanism of a Large Ribozyme:
The Group II Intron
Anna Marie Pyle, Columbia University
Thermodynamics and the Fast,
Error-free Folding of a
Large Ribozyme
Tobin Sosnick, University of Chicago
Structures and Assembly of O. nova
Telomeric Protein-ss
DNA Complexes
Steve Schultz, University of Colorado
Structure and Electron Transfer in
Synthetic DNA Hairpins
Fred Lewis, Northwestern University
3:45 pm: Symposium 8
Public Policy Forum: Science for All Americans in the New Millennium
Jonathan King, Organizer
Patricia Dehmer, Department of Energy
(Other speakers to be announced)
Tuesday, February 15
8:30 am: Symposium 9 Phosphatidylinositides in Cell Signaling
Donald Hilgemann, Organizer
Regulation of Ion Transporters and Channels by
Phosphatidylinositides
Donald Hilgemann
University of Texas,
Southwestern Medical Center
Visualizing Signaling in the
Phosphatidylinositol Pathway
Tobias Meyer, Duke University
Of FYVEs, Flounders, and Flattened
Folds: Structural Biology of
Phosphoinositide Signaling
James H. Hurley
National Institutes of Health
Phosphatidylinositol Phosphate
Kinases Regulate
PtdInsP2-dependent Signaling
Christopher L. Carpenter
Harvard University
8:30 am: Symposium 10
Molecular Motors: Design and Performance
David M. Warshaw, Organizer
Myosin Molecular Motors:
Design and Performance
David M. Warshaw
University of Washington
The ATP Hydrolysis Cycle
of Kinesin and its Coupling
to Molecular Force
Jonathon Howard
University of Washington
Structural Mechanisms of Kinesins
Robert Fletterick
University of California,
San Francisco
Unconventional Myosins:
Structural and Functional Diversity
Mark Mooseker, Yale University
11:00 am: Symposium 11
Awards Symposium
Distinguished Service Award
Helen Berman, Rutgers University
Elisabeth Roberts Cole Award
Carolyn Cohen, Brandeis University
Michael and Kate Bárány Award for
Young Investigators
Elizabeth Komives
University of California, San Diego
3:45 pm: Symposium 12
Transmitter-gated Channel Structure and Function
Mark Mayer, Organizer
Allosteric Modulation and
Pore Block in Ionotropic
Glutamate Receptors
Mark Mayer
National Institutes of Health
Biochemical and Crystallograhic
Studies of Ionotropic
Glutamate Receptors
Eric Gouaux, Columbia University
Acetylcholine Receptor at 4.6 Ĺ
Resolution
Nigel Unwin
MRC Laboratory of
Molecular Biology, Cambridge
Gating and Electrostatics in
the Acetylcholine Receptor Channel
Arthur Karlin, Columbia UniversityWednesday, February 16
8:30 am: Symposium 13
Hybrid Crystallography and Electron Cryomicroscopy: Elucidating Macromolecular Complexes
Wah Chiu, Organizer
Introduction
Wah Chiu
Baylor College of Medicine
Synergy of X-ray Crystallography
and Electron Microscopy for the
Structural Biology of
Macromolecular Assemblies
Stephen Harrison, Harvard University
New Twists in Actin Structure and
Regulation Revealed by Electron
Cryomicroscopy and X-ray
Crystallography
Amy McGough
Baylor College of Medicine
High Reslution Model of the
Microtubule by Electron
Crystallography
Eva Nogales
University of California, Berkeley
The Chemical Basis of Virus
Polymorphism Determined by X-ray
Crystallography and Electron
Cryomicroscopy
Jack Johnson
The Scripps Research Institute
8:00 am: Symposium 14
Sensational Molecules: Mechanisms of Sensory Transduction
Anita L. Zimmerman, Organizer
Deactivation Mechanisms of
Retinal Rods
Marie Burns, Stanford University
Transduction and Adaptation
in Olfactory Sensory Neurons
Anna Menini
Istituto di Cibernetica e Biofisica,
CNR, Genova
Activation of Light Sensitive
Channels, TRP and TRPL,
in Drosophila
Padinjat Raghu
Cambridge University
Dancing on the Head of a Pin:
Motor Proteins in Hair-Cell
Adaptation
David Corey, Harvard University