96-well parallel peptide synthesis

[Michael A. Gelman]

Hi, all. I'm with an academic group synthesizing unnatural peptides by
standard Fmoc chemistry. We have had the most success with continuous-flow
synthesizers over manual methods. We are now interested in making biased
libraries, making the biasing element on an automated synthesizer and then
combinatorializing at the N-terminus.

I'm interested in hearing whether there are reasonable automation solutions
for small libraries in 96-well plates. Is there continuous-flow technology
adapted for this purpose that could run with a minimum of manual
intervention? Ideally what I'd look for is something like a 96-well
Synergy-type machine, but I'm under the impression that this does not exist
commercially. Also, since we are an academic group, I'd be interested in
knowing what type of price points we are looking at.

Thanks,
-Michael.

Note: please reply to mic...@gelmans.com, not to the list....

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