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Apiradee Onsri

Apr 20, 1999, 3:00:00 AM4/20/99

>>Dear ISMB Participant:
>>We would like to call your attention to the following
>>Protein Structure Prediction in Biology and Medicine
>>Paper Submissions Due: July 13, 1999.
>>This session will be part of the Pacific Symposium on Biocomputing 2000
>>which will be held January 5-9, 2000, in Honolulu, Hawaii
>>If you **might** submit a paper, please send an immediate statement of
>>interest to:
>>Adam Godzik <>
>>Protein structure prediction is one of the most active fields in
>>computational biology. The interest in structure prediction is fueled by
>>the extraordinary pace of discovery of new protein sequences in genome
>>sequencing experiments. A third or more of all protein sequences can be
>>assigned folds with existing remote homology detection and fold
>>recognition methods.
>>The next challenge is to demonstrate that protein fold and structure
>>prediction can indeed contribute to understanding of important biological
>>problems. To do that, we need to develop and demonstrate methods, not
>>only for structure prediction, but also for analyzing our predicted
>>structures in terms of biological function. These two elements must come
>>together, if computational biology is to play a significant role in the
>>genomic revolution.
>>Having this in mind, we hereby invite contributions focusing on various
>>aspects of protein structure prediction and its application to
>>understanding protein function in the context of important biological
>>We especially invite contributions addressing the following points:
>>* Successful applications of protein structure prediction in cases of
>> general interest for biology and medicine, with specific emphasis on
>> cases where successful structure prediction provided unique insights and
>> guidance for experiment.
>>* Critical evaluation and comparison of specific assumptions and
>> methodologies used for protein structure prediction, as well as novel
>> methodological developments.
>>* Analysis of sequence-structure-function relationships in proteins,
>> including features, other than structure itself, that may be important
>> for function. For instance not just structure per se, but flexibility
>> and disorder are often hypothesized as having special importance for
>> protein function.
>>* Analysis of thermodynamic and kinetic features of proteins that may have
>> an influence on protein function. For example, protein flexibility,
>> disorder, and disorder-to-order transitions are often hypothesized as
>> having special importance for protein function.
>>Papers will be evaluated and selected for oral presentation and
>>publication in the conference proceedings on the basis of their scientific
>>quality as measured by careful peer review. Papers should follow PSB
>>guidelines (available at ) and
>>can be submitted in electronic format to with the
>>designation for "Protein Structure and Function" session by July 13. The
>>Pacific Symposium on Biocomputing is indexed by Medline and is available
>>electronically, so work published herein receives attention and is readily
>>The Pacific Symposium on Biocomputing (PSB)
>>PSB has been held in Hawaii each January since 1993 as part of a computer
>>science meeting and since 1996 as a stand alone symposium, making it one
>>of the longest running meetings in this domain. PSB brings together
>>computational biologists from the U.S. and Europe, but with an especially
>>large Pacific Rim participation. The data-rich areas of molecular biology
>>are emphasized. Typically, more than 200 scientists attend PSB
>>Besides our session on Protein Structure Prediction in Biology and
>>Medicine, there will be seven additional sessions covering other important
>>areas of research in computational biology, from data mining and knowledge
>>discovery to applications of natural language processing. The keynote
>>speaker for PSB 2000 will be Nobel Laureate Robert Huber who will provide
>>an experimentalist's perspective on our computational activities.
>>Sessions at PSB include not only the oral presentations resulting
>>from the accepted papers, but in addition the sessions typically have
>>associated tutorials and workshops as well. And of course there is
>>opportunity for informal discussion throughout the meeting. Many previous
>>participants have remarked that the PSB venue seems to stimulate
>>productive discussions.
>>In addition to the session-specific activities, there are general poster
>>sessions and live software demonstrations. Those who are interested in
>>PSB but who don't want to submit full papers are encouraged to submit
>>abstracts and present posters or demonstrations at the meeting.
>>We would like to encourage the participants of our session to mount
>>posters and to hold software demonstrations if appropriate. These
>>activities greatly increase the opportunities for interacting with fellow
>>conference participants and usually lead to enhanced discussion of the
>>participant's oral presentation.
>>A limited number of travel awards will be available to meeting
>>participants. Students, postdoctoral fellows and presenters of accepted
>>papers receive priority in the award decisions. However, it should be
>>kept in mind that these awards typically do not cover the full costs of
>>attending the meeting.
>>For more information about PSB 2000 and past PSB meetings, please visit
>>the following URL:
>>Important Dates:
>>Manuscript Submissions Due: July 13, 1999
>>Notification of Paper Acceptance: August 22, 1999
>>Final Paper Deadline: September 22, 1999
>>Abstract Deadline: October 1, 1999
>>Conference: January 5-9, 2000
>>We hope to see you in Hawaii!
>>Roland Dunbrack Keith Dunker Adam Godzik

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