Inhibitors of Protein kinases
Miss M.S. Teng
I'm working on a poster on inhibitors of protein kinases and its
therapeutic applications. Can someone point out to me useful sources in
the internet as well as good review articles on this topic?
Many thanks
Michelle
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Department of Biochemistry
Imperial College of Science, London
South Kensington
SW7 2AZ
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DR JULIA GEE
Dear ALL! I would also be very keen to know about sites/reviews
regarding available protein kinase inhibitors. We are just getting
into the field and are at a loss where to start!
Julia
Tenovus Cancer Research Centre, UWCM, Cardiff CF4 4XX, UK
Jeff
A recent review was published in the journal of Pharmacological
Therapeutics (Pharmacol. Ther. Vol. 77, No. 2, pp81-114, 1988) by David S.
Lawrence and Jinkui Niu. Although it only covers the tyrosine kinase world
of inhibitors, it is a terrific source of current information and
summarizes just about every relevant compound out there. A very thorough
review. There was also a review article published in Science a few years
ago - I'll see if I can dig up that reference though I think that was also
aimed specifically at tyrosine kinases.
Cheers,
Jeff Till
Dept. Physiology and Biophysics
SUNY @ Stony Brook
Pierre Hubert
Michelle, Julia and Thomas wrote :
>I'm working on a poster on inhibitors of protein kinases and its
>therapeutic applications. Can someone point out to me useful sources in
>the internet as well as good review articles on this topic?
>
>Dear ALL! I would also be very keen to know about sites/reviews
>regarding available protein kinase inhibitors. We are just getting
>into the field and are at a loss where to start!
>
>Please send the information to the list too. I too have started with the
>kinase work, in fact casein kinases. Thank you.
I don't know of any Web site devoted to kinases and phosphatases
inhibitors. However, one useful source of information is the
Calbiochem-Novabiochem company. They claim to have the most comprehensive
selection of kinase-related products, and they do have some useful
information in their catalogs and documentations. Their web site is :
http://www.calbiochem.com/
On the old-fashioned library side, you can try :
Kamb, A. (1998). "Cyclin-dependent kinase inhibitors and human cancer."
Curr Top Microbiol Immunol 227: 139-48.
Klohs, W. D., D. W. Fry, et al. (1997). "Inhibitors of tyrosine kinase."
Curr Opin Oncol 9(6): 562-8.
Groundwater, P. W., K. R. Solomons, et al. (1996). "Protein tyrosine kinase
inhibitors." Prog Med Chem 33: 233-329.
Lee, J. C. and J. L. Adams (1995). "Inhibitors of serine/threonine
kinases." Curr Opin Biotechnol 6(6): 657-61.
Meijer, L. (1995). "Chemical inhibitors of cyclin-dependent kinases." Prog
Cell Cycle Res 1: 351-63.
MacKintosh, C. and R. W. MacKintosh (1994). "Inhibitors of protein kinases
and phosphatases." Trends Biochem Sci 19(11): 444-8.
Hope this helps.
Pierre
(Of course I'm not affiliated with Calbiochem)
===================================================
Pierre Hubert
INSERM U. 338 - 5 rue Blaise Pascal
67084 Strasbourg Cedex - France
tel (33) 03 88 45 67 20 / fax (33) 03 88 60 08 06
hub...@neurochem.u-strasbg.fr
===================================================
thomas.yong
Hi Fellow Researchers,
Please send the information to the list too. I too have started with the
kinase work, in fact casein kinases. Thank you.
Cheers,
Thomas
>Dear ALL! I would also be very keen to know about sites/reviews
>regarding available protein kinase inhibitors. We are just getting
>into the field and are at a loss where to start!
>
>Julia
>
>Tenovus Cancer Research Centre, UWCM, Cardiff CF4 4XX, UK
>
>> I'm working on a poster on inhibitors of protein kinases and its
>> therapeutic applications. Can someone point out to me useful sources in
>> the internet as well as good review articles on this topic?
>>
>> Many thanks
>> Michelle
>
>