p38, jnk inhibitors

[Jack Bui]

The classic p38 inhibitor SB202190 can be used at 40-80 uM to inhibit both
p38 and JNK. See Jacinto and Karin, Immunity 1998.

Depending on cell type and stimulus, the MKK family when overexpressed as a
dominant interfering form, can inhibit p38, JNK, or both. There is also
some evidence that the cell cycle inbibitor p21 can block JNK activity.

Does someone know of inhibitors, drugs or overexpression of some
protein thqt could specificaly inhibit p38 or JNK pathways.

Thank you

Silvia Moreno

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Jack Bui Jack Bui
Hedrick Lab Medical Scientist Training
Program
1088 CMM East School of Medicine
Department of Biology University of California,
San Diego
University of California, San Diego 9500 Gilman Drive
9500 Gilman Drive La Jolla, California 92093-0606
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phone: 619-534-6559
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