BioNF Summer Seminar August 22nd, 3pm
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Ingo Ebersberger
Aug 10, 2014, 6:03:12 PM8/10/14
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Dear all,
Please find attached the invitation for our BioNF Summer Seminar.
Patrick Tschopp from the Harvard Medical School is visiting Frankfurt and will give a talk about
"The transcriptome as a phenotypic trait - revisiting the evolutionary origin of external genitalia".
Date: August, 22nd
Time: 15:00
Place: Biologicum Seminar room 1 -1.201
I am looking forward to seeing many of you.
All the best,
Ingo
Abstract:
Gene transcription plays an integral part in executing the developmental program encoded in an organism’s genome. Accordingly, gene expression data has been used to infer homology of anatomical structures, based on the premise that gene regulatory networks control their morphological development and thereby reflect historical continuity. Moreover, the transcriptome is a direct manifestation of the genotype and hence can be considered a phenotypic trait by itself. The advent of next-generation sequencing technologies has greatly empowered these approaches, allowing the elucidation of non-model organism transcriptomes at unprecedented depth and detail.
With this in mind, we revisited a long-standing question concerning the adaptation of vertebrates to a terrestrial lifestyle, a process in which both their locomotory apparatus and reproductive organs were prominently changed. Similarities in patterning genes expressed during the development of limbs and external genitalia have been proposed as evidence for a potential evolutionary link between the two structures, yet without providing any underlying developmental mechanism. Here, using cross-species RNA-Seq-based molecular profiling and developmental biology tools, we show that the origin of external genitalia has shifted considerably through evolution. Unlike in mammals, reptile limbs and genitalia share a common primordium, as evidenced by gene-regulatory network similarities and lineage tracing experiments. The recruitment of different cell populations for genital outgrowth follows a repositioning of the cloaca, the genitalia organizing center. Our results support a limb-like developmental origin of external genitalia as the ancestral condition. Furthermore, they suggest that repositioning the cloaca has led to an altered developmental route of external genitalia in mammals, while preserving parts of the ancestral limb transcriptional circuitry due to a common evolutionary origin.
Please find attached the invitation for our BioNF Summer Seminar.
Patrick Tschopp from the Harvard Medical School is visiting Frankfurt and will give a talk about
"The transcriptome as a phenotypic trait - revisiting the evolutionary origin of external genitalia".
Date: August, 22nd
Time: 15:00
Place: Biologicum Seminar room 1 -1.201
I am looking forward to seeing many of you.
All the best,
Ingo
Abstract:
Gene transcription plays an integral part in executing the developmental program encoded in an organism’s genome. Accordingly, gene expression data has been used to infer homology of anatomical structures, based on the premise that gene regulatory networks control their morphological development and thereby reflect historical continuity. Moreover, the transcriptome is a direct manifestation of the genotype and hence can be considered a phenotypic trait by itself. The advent of next-generation sequencing technologies has greatly empowered these approaches, allowing the elucidation of non-model organism transcriptomes at unprecedented depth and detail.
With this in mind, we revisited a long-standing question concerning the adaptation of vertebrates to a terrestrial lifestyle, a process in which both their locomotory apparatus and reproductive organs were prominently changed. Similarities in patterning genes expressed during the development of limbs and external genitalia have been proposed as evidence for a potential evolutionary link between the two structures, yet without providing any underlying developmental mechanism. Here, using cross-species RNA-Seq-based molecular profiling and developmental biology tools, we show that the origin of external genitalia has shifted considerably through evolution. Unlike in mammals, reptile limbs and genitalia share a common primordium, as evidenced by gene-regulatory network similarities and lineage tracing experiments. The recruitment of different cell populations for genital outgrowth follows a repositioning of the cloaca, the genitalia organizing center. Our results support a limb-like developmental origin of external genitalia as the ancestral condition. Furthermore, they suggest that repositioning the cloaca has led to an altered developmental route of external genitalia in mammals, while preserving parts of the ancestral limb transcriptional circuitry due to a common evolutionary origin.
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