Post-doctoral Fellows

[Adam]

POSTDOCTORAL POSITIONS

Two postdoctoral positions are available in the Department of
Biochemistry and Molecular Biology, in the laboratory of Carolyn K.
Suzuki, Ph.D. Associate Professor at the University of Medicine and
Dentistry of New Jersey (UMDNJ). See detailed contact information
below.

My lab focuses on the role of mitochondrial ATP-dependent proteases
and chaperones in protein quality control, mitochondrial DNA
stability, apoptosis and cancer.

Qualifications: Candidate must possess a Doctoral level degree in
biochemistry, cell biology or a relevant scientific discipline.
Experience in some or all of the following areas is required:
mammalian cell culture, RNA interference, microscopy, protein
purification, enzyme kinetics, DNA:protein interaction analysis,
molecular biology.
There are 3 broad project areas currently being explored:
(1) Analysis of human mitochondrial Tid1- a potential tumor suppressor
and homolog of the bacterial molecular chaperone DnaJ. Tid1 is
important as a chaperone in the folding and degradation of proteins
within mitochondria, as well as in the cytosol. Tid1 modulates
intracellular signaling pathways associated with the innate immune
response and apoptosis. Experiments will be conducted using cultured
mammalian cells, yeast Saccharomyces cerevisae and/or purified
proteins.

(2) Understanding the role of the mitochondrial ATP-dependent
proteases Lon and ClpXP in the quality control of mitochondrial
proteins and mitochondrial DNA. Experiments will address the role of
Lon and ClpXP in response to cellular stresses such as hypoxia,
oxidative stress, cardiac ischemia and hypertrophy. Experiments will
be conducted using cultured mammalian cells, yeast Saccharomyces
cerevisae and/or purified proteins.

(3) Development of high throughput screening assays for identifying
small molecule inhibitors and activators of Lon and/or ClpXP.
Biochemical as well as cell culture assays are being developed.

Under the supervision of the mentor, the post-doctoral fellow will be
expected to design, conduct and optimize experiments, and to interpret
data. Detailed records of experimental procedures and data analysis
must clearly and accurately recorded in laboratory notebooks. The
fellow is expected to present original data at laboratory and
departmental meetings, as well as at national or international
conferences. With the supervision of the mentor, the fellow is
expected to contribute substantially to the writing and preparation of
manuscripts and grant proposals. The fellow will also participate in
the orientation and training of students and other more junior post-
doctoral fellows in the lab.

Please send curriculum vitae (CV) and a personal statement of
interests and goals to:
Carolyn K. Suzuki, Ph.D.
UMDNJ- New Jersey Medical School
Department of Biochemistry and Molecular Biology
185 South Orange Avenue MSB E-633
Newark, New Jersey 07103
Email: suzu...@umdnj.edu

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Carolyn K. Suzuki, Ph.D.
New Jersey Medical School
University of Medicine and Dentistry of New Jersey
Department of Biochemistry and Molecular Biology
MSB E-633
185 South Orange Avenue
Newark, New Jersey 07103
USA

Tel:
++ (973) 972-1555 office
++ (973) 972-1556 lab

Fax:
++ (973) 972-5594

Email:
suzu...@umdnj.edu