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Nature Conference on Inflammation and Cancer
This meeting will bring together a diverse group of researchers from the many interconnected areas of immunology and cancer to discuss how inflammation affects tumour development and metastasis. Presentations will focus on the most recent findings on the tumour-promoting and -suppressing effects of inflammation, the immune tumour environment, and therapeutic approaches.
October 23-25, 2018 | Beijing, China
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TABLE OF CONTENTS
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September 2018 Volume 18, Issue 9 |
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Research Highlights
Reviews
Perspectives
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Now accepting applications! Lung Cancer Innovation QuickFire Challenge
Up to $750,000 in total grants will be awarded to up to three innovators with the best ideas, technologies, or solutions that address the complete spectrum of lung health - related to preventing, intercepting or curing lung cancer.
Learn more about this challenge and apply here by September 14, 2018. |
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Register for the latest nature.com webcast
Tissue-based profiling for confident decisions in immuno-oncology
Learn how standardizing tissue profiling in drug development and trial designs in immuno-oncology will improve decision making.
Thursday 12th September 2018
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| Communications Biology: Open for Submissions Communications Biology is a new open access journal that publishes high-quality primary research articles, reviews and commentary representing significant advances and new insights to the field of biology. The journal is now open for submissions. Find out more >> |  |
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COMMENT | |
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Clinical tumour sequencing for precision oncology: time for a universal strategy
Michael L. Cheng, Michael F. Berger, David M. Hyman & David B. Solit
pp527 - 528 | doi:10.1038/s41568-018-0043-2
Comprehensive genomic characterization of patient tumours has the potential to advance therapies and inform basic cancer research. In this Comment, David B. Solit and colleagues provide their personal perspective on the implementation of an enterprise-wide, prospective clinical sequencing strategy and make a call for a universal approach to next-generation sequencing-based tumour profiling.
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RESEARCH HIGHLIGHTS | |
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How to predict the future
Anna Dart
p529 | doi:10.1038/s41568-018-0046-z
Two groups have used targeted sequencing to identify features of clonal haematopoiesis in healthy individuals including the number of somatic mutations, the presence of specific mutations and clonal size, which predict risk of developing acute myeloid leukaemia years before diagnosis.
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| The sugar loop
Ulrike Harjes
pp530 - 531 | doi:10.1038/s41568-018-0049-9
PI3K inhibition in solid cancers driven by PI3K catalytic subunit-α has shown limited clinical benefit. This might be due to activation of a glucose–insulin feedback loop, which can be interrupted by dietary or pharmaceutical approaches, thereby improving therapy outcome.
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| Subclones work together
Sarah Seton-Rogers
pp530 - 531 | doi:10.1038/s41568-018-0047-y
Vinci et al. provide evidence for subclonal cooperation driving the maintenance of tumour heterogeneity in paediatric high-grade gliomas.
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| Second chances
Anna Dart
p531 | doi:10.1038/s41568-018-0044-1
Mutant KRAS has so far proven to be an undruggable target for lung adenocarcinoma and a widely held assumption is that KRAS mutations confer independence from upstream signalling. Two groups have now independently shown this might not be the case and suggest pan-ERBB inhibitors could be used to treat patients with KRAS-driven lung cancer
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REVIEWS | |
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Every step of the way: integrins in cancer progression and metastasis
Hellyeh Hamidi & Johanna Ivaska
pp533 - 548 | doi:10.1038/s41568-018-0038-z
In this Review, Hamidi and Ivaska discuss the contribution of integrins to the different steps of cancer progression, highlighting some of the recently identified unconventional roles of integrins and novel opportunities to target integrin signalling.
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Collection: Cancer at Nature Research
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Deciphering the cells of origin of squamous cell carcinomas
Adriana Sánchez-Danés & Cédric Blanpain
pp549 - 561 | doi:10.1038/s41568-018-0024-5
This Review discusses the origins of squamous cell carcinoma (SCC), with a focus on skin, lung, oesophageal and head and neck cancer, and describes how oncogenic mutations and the cell of origin cooperate in determining the rise of SCC.
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Collection: Cancer origins
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PERSPECTIVES | |
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Adapting to stress — chaperome networks in cancer
Suhasini Joshi, Tai Wang, Thaís L. S. Araujo, Sahil Sharma, Jeffrey L. Brodsky et al.
pp562 - 575 | doi:10.1038/s41568-018-0020-9
In this Opinion, Joshi et al. argue that in cancer cells, a state of chaperome hyperconnectivity is obtained by increasing the interaction strength among chaperome machinery members. These chaperome scaffolding platforms act to increase the functional diversity of oncogenic processes and have implications for the development of chaperome inhibitors.
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Eco-evolutionary causes and consequences of temporal changes in intratumoural blood flow
Robert J. Gillies, Joel S. Brown, Alexander R. A. Anderson & Robert A. Gatenby
pp576 - 585 | doi:10.1038/s41568-018-0030-7
This Opinion proposes that temporal variations in intratumoural blood flow are the result of eco-evolutionary dynamics. It describes adaptive strategies to stochastically varying environments that may strongly affect observed cancer phenotypes and clinical outcomes including formation of metastases and response to treatment.
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Collection: Cancer at Nature Research
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Targeting ATR in cancer
Emilio Lecona & Oscar Fernandez-Capetillo
pp586 - 595 | doi:10.1038/s41568-018-0034-3
This Opinion provides insight into the potential of targeting the replication stress response in cancer and discusses the strategy of inhibiting ataxia telangiectasia and Rad3-related protein (ATR) and the need for reliable biomarkers to enable patient stratification.
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Collection: Cancer at Nature Research
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