iScience: June 2026 (Volume 29, Issue 6)

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Issue cover
Jun 19, 2026
Vol. 29, Iss. 6
Open Access

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Highlights

Announcements

Cell Symposia is now Cell Press Symposia

Explore the story behind the change.

Cell Press in the news

Research from across our journals was covered in top newspapers, magazines, broadcasts, and more in 2025.

Liquid metals for the booming of space exploration

Read this new perspective from Liu and colleagues published in Cell Press Blue.

Cell Press webinar: Marine microbiology in a changing climate

June 23, 2026, 10:00 a.m. ET | available live & on demand

Table of Contents

Reviews

Microbial processes in geological carbon sequestration: Mechanisms, methods, and engineering implications
Liangchao Huang, Zhengmeng Hou, Jianhua Liu, Tianle Shi, Qichen Wang, Yilin Guo, Lin Wu

Earth sciences; Biogeochemistry; Biogeoscience; Global carbon cycle; Microbiology; Applied microbiology

Active surveillance for low-risk papillary thyroid carcinoma: Integrating guidelines, emerging evidence, and directions
Zijing Wu, Kaiang Zhang, Huixian Zhou, Leyi Wan, Jingyuan Zhong, Chunhua Li, Lianggeng Gong, Yun Peng

Oncology; diagnostics

Oncolytic myxoma virus and engineering strategies for advanced cancer immunotherapy
A.D. Trujillo Yeriomenko, A.S. Isaeva, E.E. Idota, S.P. Zhivoderov, S.G. Yurkov, A.S. Malogolovkin

Immunology; Therapeutics; Cancer

MicroRNAs as master regulators of macrophage function in atherosclerosis: From polarization to therapeutic potential
Yuji Zhan, Xinxing Song, Yan Fang, Xiaojing Wan, Zeyu Gao, Dong Fu, Liqiu Yan, Yabin Wang

Therapeutics; Disease; Molecular interaction

Lactylation modification in extracellular vesicles: A key regulator of cellular communication
Yangyu Ning, Zijun Qu, Zehang Xie, Shujun Wan, Weiya Pei, Kun Lv

Cell biology; Epigenetics; Molecular biology

Emerging role of SIRT1 in asthma and COPD from molecular mechanisms to translational therapy
Muhammad Wasim, Rabia Parveen, Riling Chen, Yajun Wang, Guoda Ma

Immune system; Molecular interaction; Non-infectious disease

A comparative study of five telerehabilitation therapies for improving core symptoms in stroke patients: A network meta-analysis (2,833 patients)
Yi Xia, Sihan Jin, Weijie Zhou, Rui Huang, Shangjun Huang

Health sciences

Mechanistic actions of eldecalcitol and alfacalcidol across the muscle-metabolic axis: A selectivity perspective in sarcopenia and type 2 diabetes
Maria Teresa Cambria, Mariachiara Campanella, Cristina Russo, Aleksandra Agafonova, Sofia Surdo, Maria Stella Valle, Lucia Malaguarnera

Health sciences

Harnessing artificial intelligence for pediatric health: Current trends and future opportunities
Jialin Wu, Bonan Chen, Kate Ching-Ching Chan, Mingyu Liang, Yang Lyu, Peiyao Yu, Tiejun Feng, Fuda Xie, Sifan Yu, Fengbin Zhang, Terry Cheuk-Fung Yip, Wei Kang

Applied sciences; Artificial intelligence; Artificial intelligence applications; Computer science; Computing methodology; Health sciences; Medical specialty; Medicine; Pediatrics

Inorganic thermoelectric thin films: From synthesis to application
Teng Wang, Fan Sun, Jae Sung Son

Chemistry; Physics; Materials science

Mechanistic insights into subclinical Plasmodium infections: Unveiling the silent drivers of malaria transmission
Ritesh Ranjha, Aditi Gupta, Kuldeep Singh, Ruhi Sikka, Anup R. Anvikar, Himanshu Gupta, Praveen K. Bharti

Health sciences; Clinical finding; Disease

Research progress on precision targeted therapy strategies for breast cancer based on tumor microenvironment
Yunbo Luo, Panlin Xie, Shaokang Yang, Peng Qu, Lingmi Hou, Qun Yi

Cancer; microenvironment; therapeutics

Applications of human-machine collaborative decision-making: A review of research with recent developments
Yun Luo, Yanpuze Hao, Haochen Gong, Bo Li

Applied sciences; Computer science; Computing methodology; Artificial intelligence; Social sciences; Decision science; Linguistics

Radiotherapy, EMP and dormancy in TME: An integrated perspective on tumor microenvironments and long-term relapse
Yebin Lee, Byeongseok Jang, Hae-Yun Jung

Radiation biology; molecular biology; cancer systems biology

A VOC-centric web of biological interaction on corpse: Consideration for forensic PMI estimation
Han Han, Yali Guo, Mandie Liu, Yifei Luo, Binta J.J. Jallow, Afito Luciano, Jifeng Cai, Jingjing Huang, Fanming Meng

Pathology; Medical event; Death; Forensic toxicology

Deciphering the neurotoxic effects of emerging pollutants: Bisphenols and phthalates as disruptors of brain function and mental health
Claudia Angélica Garay-Canales, Yair Rodríguez-Santiago, Diana Lizeth Ruiz-Antonio, Karen E. Nava-Castro, María del Sol Ríos-Avila, César Antonio Zavala-López, Yareni Danae Chavez-Ramos, Laura Sánchez-García, Luis Enrique Jiménez-Hernández, Lenin Pavón, Jorge Morales-Montor

Environmental science; Environmental health; Neuroscience; Developmental biology

Recent advancements of wastewater treatment by photocatalysis: A comprehensive review
K. Rajanikara Swamy, G. Shyamala, Thirumala Rao Gurugubelli, Gobinath Ravindran, Babu Bathula

Applied sciences; Engineering; Water resources engineering

Aging transforms marine microplastics into reactive interfaces with environmental consequences
Chaoran Li, Lingchen Zhang, Junheng Li, Zhonglai Zhou, Zhihang Chen, Dayong Zhao, Fei He, Min Xu

Pollution, Environmental toxicology, Microbiofilms

Optical mapping: pioneering the frontier of preclinical antiarrhythmic drug evaluation
Yangpeng Li, Yuqing Zheng, Ruirui Dong, Miao Lin, Tangting Chen, Jianhong Li, Rui Zhang, Ting Liu, Xiaoqiu Tan, Guoliang Hao, Xianhong Ou

medicine; optical imaging; biophysics

Recent advancement in prediction of thermoelectric performance in two-dimensional telluride monolayers
Appu Kumar Singh, Sumit Kumar, Douglas S. Galvão, Tarun Kumar Kundu, Chandra Sekhar Tiwary

Applied sciences; Materials science; Nanomaterials.

Vitamin D as a cellular endocrine system: Tissue-specific microcircuits, immune reprogramming, and metabolic resistance
Jialiang Feng, Jun Xiao, Zhiyuan Gao, Hui Zhou, Xilian Li, Yini Tian, Biao Gao

Biological sciences

Current trends in electrospun nanofibers combined with mesenchymal stem cells for diabetic foot ulcer repair and regenerative therapy
Hai Du, Xiaofan Yang, Zhenbing Chen

Bioengineering; Biomaterials; Nanomaterials; Tissue engineering

Tumor infiltrating B cells and tertiary lymphoid structures in pancreatic cancer prognosis and therapy
Zichen Pan, Fusheng Zhang, Cuixia Zhang, Xingyue Li, Yongsu Ma, Yinmo Yang, Xiaodong Tian

Public health; Medical surveillance; Environmental health; Molecular biology; Microbiology; Animal health management

Aberrant mitochondria in endometriosis: From pathogenic mechanisms to therapeutic opportunities
Yishen S. Rong, Jue Zhu, Chi Chiu Wang, Jing Zhang, Yichen C. Chen

Health sciences; Medicine; Reproductive medicine

The osteoporotic niche as a metabolic sanctuary for breast cancer dormancy and reactivation: A mechanistic perspective
Haojun Duan, Junpeng Qi, Xianwen Hu

Health sciences; Medicine; Medical specialty; Internal medicine; Oncology; Natural sciences; Biological sciences; Systems biology; Cancer systems biology; Cancer

The hazards of metal exposure mediated by crops to human health from perspective of environmental health and control strategies
Huanhuan Yang, Fulan Zhang, Jiacun Zhou, Jiyao Zhu, Dayong Cui, Xu Zhang, Zhibin Zhang

health technology; hazard identification; applied sciences

Overcoming high-temperature performance limitations: Multidimensional design and innovation of thin-film thermocouples
Zhongkai Zhang, Tianci Zhang, Zhaojun Liu, Meng Wang, Guoliang Zhou, Xiang Liu, Chen Wu, Xudong Fang, Duanzhi Duan, Bian Tian

Classification Description: Thermodynamics; Applied sciences; Mechanical engineering

Unraveling the gut microbiota-brain axis: Mechanisms, pathophysiology, and therapeutic opportunities
Changsheng Jiang, Wedad M. Nageeb, Shumaila Batool, Amro Hashish, Sabah M. Alkhawagah, Hoda Atef Abdelsattar Ibrahim, Wenlong Zhu, Chuanyan Che, Xiaojin Li, Mengmeng Jin, Xiaoqian Zhang, Ahmed H. Ghonaim, Man Ren, Shenghe Li

Psychiatry; Precision medicine; Neuroscience; Immunology; Microbiology; Systems biology

Review on thread profile modification methods for the planetary roller screw mechanism
Yanqiang Sun, Kun Zhang, Zhaoyao Shi, Guiping Xie, Xinyu Lv, Huiming Cheng, Zhengyi Tang

Applied sciences; Engineering

Biological Determinants and non-pharmacological management of orthodontic pain
Yifan Wang, Shaoling Yu, Yubing Zhang, Xinlong Yang, Ting OuYang, Gaiping Shi, Lili Chen

Medical science; Dentistry; Pain management in health technology

Frailty syndrome in older adults: Research advances and management strategies
Yu Guo, Yuxin Hu, Ruoyu Chen, Yiwen Yang, Chunhong Hu, Hui Yao, Yunyan Su

Health sciences; Medicine; Medical specialty; Gerontology

Social science for climate-resilient grasslands: Strategies to support individual and systemic adaptation
Sarah Gonzalez-Coffin, Christine D. Miller Hesed, Heather M. Yocum, Ryan Roberts

Health sciences; Environmental science; Social sciences

The competition of amino acid among tumors, tumor-associated macrophages and T cells based on metabolic reprogramming
Chenyang Xianyu, Yuxiao Song, Ci Zhao, Qian Min, Zhixu Wang, Mingbo Zhang, Bicheng Zhang

Human metabolism; Immune response; Cancer systems biology; Cancer

Modulation of satellite cell function to alleviate age-related sarcopenia: Electrical stimulation & Ca²⁺ signaling combined approach
Canyu Chen, Yersen Mulat, Dongsheng Jiang, Haodong Lin

Geriatrics; stem cells research; biomedical engineering

Use of hollow fiber systems to model treatment of infections: A practical guide
Jelmer Raaijmakers, Fernando Sanz-García, Zahra Sadouki, Diana A. Aguilar-Ayala, Andrew Mead, John B. Readman, Timothy D. McHugh, L. Pelligand, Joseph F. Standing, Santiago Ramón-García, Jakko van Ingen, Frank Kloprogge, Ainhoa Lucía

Natural sciences; Biological sciences; Microbiology; Medical microbiology

TRP channels as critical pathways in temperature-induced asthma
Shihan Deng, Xinnan Zhou, Zhihao Wang, Jian He, Qinghua Gao, Lina Wang

disease; molecular biology

Perspectives

Biomass carbon removal can help sustainable aviation fuels achieve on-time arrival
Matthew Langholtz, Charlotte Levy, John Field, Daniel L. Sanchez, Pete Christensen, Lawrence Murdoch, Daniel de la Torre Ugarte, Oluwafemi Oyedeji, Ryan Jacobson, Ning Zeng, Emily A. Heaton, Charles Forsberg, William Joe Sagues

Environmental science; biomass; bioresources; bioenvironmental engineering

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