Cell: February 2, 2023 (Volume 186, Issue 3)

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Feb 02, 2023 Vol. 186, Iss. 3 Website Table of Contents Online Now Archive

Highlights Announcements Cell Press Community Review: A new approach to peer review and publication Learn how you can find the right home for your paper. Cell Symposia: Infection biology in the age of the microbiome June 7—9, 2023 | Paris, France. Cell Symposia: Viruses in health and disease March 19—21, 2023 | Sitges, Spain. Webinar: Spatial transcriptomics and epigenetics in neuroscience February 1, 2023, 12:00pm ET | available live & on demand. Featured article Touch neurons underlying dopaminergic pleasurable touch and sexual receptivity Abdus-Saboor and colleagues Featured Leading Edge article Microbial foods for improving human and planetary health Sommer and colleagues

Table of Contents Leading edge Previews Spin glasses, error correcting codes, and synchronization of human stem cell organoids Matt Thomson Magnetic spins, pendulum clocks, and fireflies all self-organize into coherent collectives when arranged into groups of spatially coupled and interacting individuals. Ramanathan and colleagues demonstrate that spatial coupling of human stem cell organoids induces coherent progression through developmental transitions, allowing the dissection of molecular circuits underlying human development. Picking a (neuroimmune) fight against fragile regulation of addiction Min Woo Kim, Jonathan Kipnis T cells and their derived cytokines have been shown to modulate brain function. In this issue of Cell, Zhu, Yan, and colleagues demonstrate that opioid use impacts the crosstalk between the CNS and the peripheral immune system. Regulatory T cell (Treg)-derived IFN-γ signaling translates into synaptic weakening in the nucleus accumbens (NAc) to impart withdrawal-induced behavioral dysfunction. When IL-17 gets on your nerves Iliyan D. Iliev, Woan-Yu Lin, Sarah L. Gaffen Microbiota-induced IL-17 production mediates CNS processes and animal behavior. However, its role on the peripheral nervous system (PNS) remains largely unknown. Enamorado et al. demonstrate that commensal-specific Th17 cells are recalled following tissue injury to support local nerve regeneration, a process orchestrated by IL-17 signaling on peripheral neurons. Perspective Microbial foods for improving human and planetary health Leonie J. Jahn, Vayu M. Rekdal, Morten O.A. Sommer Microorganisms are potential enablers of a more sustainable and healthy food system. This perspective reviews current approaches and discusses future advances in science-driven fermentation, synthetic biology, and sustainable feedstocks that will set up the next generation of microbial foods. Articles Graded mesoderm assembly governs cell fate and morphogenesis of the early mammalian heart Martin H. Dominguez, Alexis Leigh Krup, Jonathon M. Muncie, Benoit G. Bruneau Cardiac development is reconstructed at single-cell resolution in live mouse embryos using light sheet imaging and improved computational tools. Controlling organoid symmetry breaking uncovers an excitable system underlying human axial elongation Giridhar M. Anand, Heitor C. Megale, Sean H. Murphy, Theresa Weis, Zuwan Lin, Yichun He, Xiao Wang, Jia Liu, Sharad Ramanathan A machine learning-driven bioengineering approach generates a robust stem cell model of human axial elongation that uncovers molecular mechanisms underlying self-sustained and stable elongation. Controlling human organoid symmetry breaking reveals signaling gradients drive segmentation clock waves Yusuf Ilker Yaman, Sharad Ramanathan A robust human stem cell model of axial morphogenesis shows that FGF signaling governs both the dynamics of segmentation clock waves and the somite determination front. Cyclin E-induced replicative stress drives p53-dependent whole-genome duplication Jingkun Zeng, Stephanie A. Hills, Eiko Ozono, John F.X. Diffley Open Access DNA replication stress-induced whole-genome duplication (WGD) requires p53 function, in contrast to WGD induced by DNA damage; these findings provide mechanistic insight into cancer genome evolution in p53+/+ tumors. All-optical physiology resolves a synaptic basis for behavioral timescale plasticity Linlin Z. Fan, Doo Kyung Kim, Joshua H. Jennings, He Tian, Peter Y. Wang, Charu Ramakrishnan, Sawyer Randles, Yanjun Sun, Elina Thadhani, Yoon Seok Kim, Sean Quirin, Lisa Giocomo, Adam E. Cohen, Karl Deisseroth Open Access An all-optical physiology approach is developed to study synaptic transmission and plasticity in single identified cells in behaving mammals, which reveals that presynaptic CA2/3 activity is required for CA1 plasticity and place field induction during behavior. Neural mechanism underlying depressive-like state associated with social status loss Zhengxiao Fan, Jiarui Chang, Yilan Liang, Hong Zhu, Chaoyi Zhang, Diyang Zheng, Junying Wang, Ying Xu, Qi-Jing Li, Hailan Hu A psychological and non-violent behavioral paradigm is developed and used to understand the neural mechanisms behind depressive-like behaviors following a decline in social status. Touch neurons underlying dopaminergic pleasurable touch and sexual receptivity Leah J. Elias, Isabella K. Succi, Melanie D. Schaffler, William Foster, Mark A. Gradwell, Manon Bohic, Akira Fushiki, Aman Upadhyay, Lindsay L. Ejoh, Ryan Schwark, Rachel Frazer, Brittany Bistis, Jessica E. Burke, Victoria Saltz, Jared E. Boyce, Anissa Jhumka, Rui M. Costa, Victoria E. Abraira, Ishmail Abdus-Saboor Open Access Mrgprb4-lineage touch neurons in the skin are required for sexual receptivity and dopamine release that makes this type of social touch rewarding. Opioid-induced fragile-like regulatory T cells contribute to withdrawal Yongsheng Zhu, Peng Yan, Rui Wang, Jianghua Lai, Hua Tang, Xu Xiao, Rongshan Yu, Xiaorui Bao, Feng Zhu, Kena Wang, Ye Lu, Jie Dang, Chao Zhu, Rui Zhang, Wei Dang, Bao Zhang, Quanze Fu, Qian Zhang, Chongao Kang, Yujie Chen, Xiaoyu Chen, Qing Liang, Kejia Wang Opioids drive the peripheral expansion of fragile-like regulatory T cells that cross the blood-brain barrier and, through IFN-γ, mediate synaptic instability and subsequent withdrawal symptoms. Immunity to the microbiota promotes sensory neuron regeneration Michel Enamorado, Warakorn Kulalert, Seong-Ji Han, Indira Rao, Jérémie Delaleu, Verena M. Link, Daniel Yong, Margery Smelkinson, Louis Gil, Saeko Nakajima, Jonathan L. Linehan, Nicolas Bouladoux, Josette Wlaschin, Juraj Kabat, Olena Kamenyeva, Liwen Deng, Inta Gribonika, Alexander T. Chesler, Isaac M. Chiu, Claire E. Le Pichon, Yasmine Belkaid Tissue-resident commensal-specific T cells accelerate peripheral sensory neuron regeneration upon injury via IL-17A. Human IRF1 governs macrophagic IFN-γ immunity to mycobacteria Jérémie Rosain, Anna-Lena Neehus, Jérémy Manry, Rui Yang, Jérémie Le Pen, Wassim Daher, Zhiyong Liu, Yi-Hao Chan, Natalia Tahuil, Özden Türel, Mathieu Bourgey, Masato Ogishi, Jean-Marc Doisne, Helena M. Izquierdo, Takayoshi Shirasaki, Tom Le Voyer, Antoine Guérin, Paul Bastard, Marcela Moncada-Vélez, Ji Eun Han, Taushif Khan, Franck Rapaport, Seon-Hui Hong, Andrew Cheung, Kathrin Haake, Barbara C. Mindt, Laura Pérez, Quentin Philippot, Danyel Lee, Peng Zhang, Darawan Rinchai, Fatima Al Ali, Manar Mahmoud Ahmad Ata, Mahbuba Rahman, Jessica N. Peel, Søren Heissel, Henrik Molina, Yasemin Kendir-Demirkol, Rasheed Bailey, Shuxiang Zhao, Jonathan Bohlen, Mathieu Mancini, Yoann Seeleuthner, Marie Roelens, Lazaro Lorenzo, Camille Soudée, María Elvira Josefina Paz, María Laura González, Mohamed Jeljeli, Jean Soulier, Serge Romana, Anne-Sophie L’Honneur, Marie Materna, Rubén Martínez-Barricarte, Mathieu Pochon, Carmen Oleaga-Quintas, Alexandre Michev, Mélanie Migaud, Romain Lévy, Marie-Alexandra Alyanakian, Flore Rozenberg, Carys A. Croft, Guillaume Vogt, Jean-François Emile, Laurent Kremer, Cindy S. Ma, Jörg H. Fritz, Stanley M. Lemon, András N. Spaan, Nicolas Manel, Laurent Abel, Margaret R. MacDonald, Stéphanie Boisson-Dupuis, Nico Marr, Stuart G. Tangye, James P. Di Santo, Qian Zhang, Shen-Ying Zhang, Charles M. Rice, Vivien Béziat, Nico Lachmann, David Langlais, Jean-Laurent Casanova, Philippe Gros, Jacinta Bustamante Open Access Studies in humans with interferon regulatory factor 1 (IRF1) deficiency reveal differences in how type I and type II interferons protect humans against different types of pathogens. Resource Mining metatranscriptomes reveals a vast world of viroid-like circular RNAs Benjamin D. Lee, Uri Neri, Simon Roux, Yuri I. Wolf, Antonio Pedro Camargo, Mart Krupovic, Peter Simmonds, Nikos Kyrpides, Uri Gophna, Valerian V. Dolja, Eugene V. Koonin Open Access A large-scale survey of covalently closed circular RNA across ecosystems reveals that viroids infect a wide range of host species, extending beyond plants, and identifies additional types of ribozyme activity as well as functional features in these molecules. SnapShot SnapShot: Clinical and preclinical utility of click chemistry Sigitas Mikutis, Gonçalo J.L. Bernardes Click reactions in a biological setting serve as a way to join two components—for example, a caged prodrug and a decaging agent or a drug and an antibody. Click chemistry has already made several inroads into the clinic with more therapeutic platforms in the making. To view this SnapShot, open or download the PDF.