| | Cotranslational assembly of protein complexes in eukaryotes revealed by ribosome profiling
Cotranslational assembly is a prevalent mechanism for the formation of oligomeric complexes in Saccharomyces cerevisiae, with one subunit serving as scaffold for the translation of partner subunits.
Ayala Shiber, Kristina Döring, Ulrike Friedrich et al. | Integrating time from experience in the lateral entorhinal cortex
Temporal information that is useful for episodic memory is encoded across a wide range of timescales in the lateral entorhinal cortex, arising inherently from its representation of ongoing experience.
Albert Tsao, Jørgen Sugar, Li Lu et al. | Jurassic stem-mammal perinates and the origin of mammalian reproduction and growth
A well-preserved clutch of Kayentatherium wellesi perinates sheds light on the timing of the evolution of mammalian traits, including reduced clutch sizes and the allometric lengthening of the face during ontogeny.
Eva A. Hoffman, Timothy B. Rowe | Role of glutamine synthetase in angiogenesis beyond glutamine synthesis
The enzyme glutamine synthetase is active in endothelial cell migration during angiogenesis, through autopalmitoylation and the regulation of RHOJ signalling.
Guy Eelen, Charlotte Dubois, Anna Rita Cantelmo et al. | Acceleration of electrons in the plasma wakefield of a proton bunch
E. Adli, A. Ahuja, O. Apsimon et al. | A Brownian quasi-crystal of pre-assembled colloidal Penrose tiles
A lithographic patterning and release method is used to create a dense, fluctuating, Brownian system of mobile colloidal kite- and dart-shaped Penrose tiles over large areas that retains quasi-crystalline order.
Po-Yuan Wang, Thomas G. Mason | Required growth facilitators propel axon regeneration across complete spinal cord injury
Stimulating the intrinsic growth capacity of neurons and providing growth-supportive substrate and chemoattraction can allow axon regrowth across anatomically complete spinal cord injuries in adult rodents.
Mark A. Anderson, Timothy M. O’Shea, Joshua E. Burda et al. | Structures of filaments from Pick’s disease reveal a novel tau protein fold
The structures of tau filaments from patients with the neurodegenerative disorder Pick’s disease show that the filament fold is different from that of the tau filaments found in Alzheimer’s disease.
Benjamin Falcon, Wenjuan Zhang, Alexey G. Murzin et al. | Protein complexes assemble as they are being made
An investigation finds that most protein complexes in yeast cells assemble before the subunits have fully formed. This mechanism might prevent the formation of toxic protein aggregates.
Christine Mayr | Structural mechanisms of selectivity and gating in anion channelrhodopsins
Crystal structures and molecular simulations of the designed anion-conducting channelrhodopsin iC++ provide molecular insights that enable structure-based design of channelrhodopsins with desirable properties for use as optogenetic tools.
Hideaki E. Kato, Yoon Seok Kim, Joseph M. Paggi et al. | Crystal structure of the natural anion-conducting channelrhodopsinGtACR1
The crystal structure of anion channelrhodopsin-1 (ACR1) from the algae Guillardia theta provides insights into the basis of anion conductance.
Yoon Seok Kim, Hideaki E. Kato, Keitaro Yamashita et al. | Ancient herders enriched and restructured African grasslands
Isotopic and sedimentary analyses of soils at Pastoral Neolithic archaeological sites in Kenya demonstrate the long-term influence of nutrient enrichment on savannah environments that has accompanied pastoralist settlement over the past three millennia.
Fiona Marshall, Rachel E. B. Reid, Steven Goldstein et al. | Spotlight on proteins that aid malaria
The multiprotein complex PTEX enables malaria-causing parasites to survive inside red blood cells. Studies reveal how PTEX assembles, and identify a function for one of the complex’s proteins, EXP2.
Tania F. de Koning-Ward | The NORAD lncRNA assembles a topoisomerase complex critical for genome stability
The long non-coding RNA NORAD interacts with proteins involved in DNA replication and repair, and controls the ability of RBMX to form a ribonucleoprotein complex that helps to maintain genomic stability.
Mathias Munschauer, Celina T. Nguyen, Klara Sirokman et al. | Malaria parasite translocon structure and mechanism of effector export
Cryo-electron microscopy analysis of the purified Plasmodium translocon of exported proteins (PTEX) reveals two distinct resolved states, suggesting a mechanism by which Plasmodium falciparum exports malarial effector proteins into erythrocytes.
Chi-Min Ho, Josh R. Beck, Mason Lai et al. | All-inorganic perovskite nanocrystal scintillators
All-inorganic perovskite nanocrystals containing caesium and lead provide low-cost, flexible and solution-processable scintillators that are highly sensitive to X-ray irradiation and emit radioluminescence that is colour-tunable across the visible spectrum.
Qiushui Chen, Jing Wu, Xiangyu Ou et al. | Past experience shapes sexually dimorphic neuronal wiring through monoaminergic signalling
In Caenorhabditis elegans, starvation early in life suppresses later sex-specific pruning of synapses through lasting changes in monoaminergic signalling.
Emily A. Bayer, Oliver Hobert | Widespread intronic polyadenylation inactivates tumour suppressor genes in leukaemia
The inactivation of tumour suppressor genes at the level of mRNA occurs by the generation of truncated proteins in leukaemia.
Shih-Han Lee, Irtisha Singh, Sarah Tisdale et al. |
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Tissue-based profiling for confident decisions in immuno-oncology
Learn how standardizing tissue profiling in drug development and trial designs in immuno-oncology will improve decision making. Thursday 12th September 2018 Sponsored by Definiens |
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Subwavelength integrated photonics
Subwavelength-grating metamaterial structures, their main operation principles and their implementation in integrated photonic devices are reviewed.
Pavel Cheben, Robert Halir, Jens H. Schmid et al. |
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The emergence of Zika virus and its new clinical syndromes
The rapid development of cell culture and animal models has facilitated a new understanding of ZIKV biology and made it possible to generate multiple ZIKV vaccine candidates, which are advancing through clinical trials.
Theodore C. Pierson, Michael S. Diamond |
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Structure of paused transcription complex Pol II–DSIF–NELF
The cryo-electron microscopy structure of a paused transcription elongation complex of RNA polymerase II bound to DRB sensitivity-inducing factor and negative elongation factor is reported at 3.2 Å resolution.
Seychelle M. Vos, Lucas Farnung, Henning Urlaub et al. |
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Structure of activated transcription complex Pol II–DSIF–PAF–SPT6
The cryo-electron microscopy structure of an activated transcription elongation complex of RNA polymerase II bound to DRB sensitivity-inducing factor and the elongation factors PAF1 complex and SPT6 is reported at 3.1 Å resolution.
Seychelle M. Vos, Lucas Farnung, Marc Boehning et al. |
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