LATEST RESEARCHGENETICS AND GENOMICS Jie Li, Lei Yue ... Xiuzhu Dong Term-seq, genetic and biochemical experiments reveal that the trans-action factor aCPSF1 and the terminator U-tract cis-element work in a noteworthy two-in-one termination mode in archaea, and may represent an archetypal mode of the eukaryotic RNA polymerase II termination machinery. BIOCHEMISTRY AND CHEMICAL BIOLOGY Bruk Mensa, Nicholas F Polizzi ... William F DeGrado Mutations along the signaling pathway of the E. coli sensor histidine kinase PhoQ alter signal gain and ligand-sensitivity by altering thermodynamic allosteric coupling between domains. GENETICS AND GENOMICS, MICROBIOLOGY AND INFECTIOUS DISEASE Alba Pacheco-Moreno, Francesca L Stefanato ... Andrew W Truman Genomics and genetics were used to identify specialized metabolites employed by Pseudomonas bacteria to suppress the growth of potato pathogens, which revealed a key role for cyclic lipopeptides. MICROBIOLOGY AND INFECTIOUS DISEASE Pedro Escoll, Lucien Platon ... Carmen Buchrieser During infection, L. pneumophila reverses the ATP-synthase activity of the mitochondrial FOF1-ATPase to ATP-hydrolase activity in a type 4 secretion-dependent manner to prevent early cell death, thereby preserving its replication niche. DEVELOPMENTAL BIOLOGY Adel Avetisyan, Yael Glatt ... Adi Salzberg Novel binding sites within a chordotonal-specific enhancer of the delilah gene integrates opposing signals of Prospero and D-Pax2 to control the alternative differentiation programs of cap versus scolopale cells. NEUROSCIENCE Jiedong Zhang, Yong Jiang ... Sheng He Consistent spatial clustering and fine-scale neural tuning to different face parts were found within the face-processing regions, which may be the neural implementation of efficient neural computation for face identification. NEUROSCIENCE Gregg Wildenberg, Anastasia Sorokina ... Bobby Kasthuri 3D serial electron microscopy reveals that individual dopamine axons in the nucleus accumbens contain different varicosity types based on their vesicle contents, rarely make synapses, and undergo major structural plasticity in response to cocaine. NEUROSCIENCE Seksiri Arttamangkul, Emily J Platt ... David Farrens Endogenous µ- and δ-opioid receptors do not form stable heterodimers in cholinergic interneurons. BIOCHEMISTRY AND CHEMICAL BIOLOGY, CELL BIOLOGY Sven Dennerlein, Sabine Poerschke ... Peter Rehling Definition of the mitoribosome interactome revealed inner membrane proteins and elucidated new assembly factors of the cytochrome c reductase and cytochrome c oxidase. IMMUNOLOGY AND INFLAMMATION Katherine A Deets, Randilea Nichols Doyle ... Russell E Vance A mouse model of inducible inflammasome activation in intestinal epithelial cells reveals separate inflammasome-dependent and -independent cross-presentation pathways for epithelial cell-derived antigen. NEUROSCIENCE Xinyi Jenny He, Janki Patel ... Matthew R Banghart Mu and delta opioid receptors signal independently in hippocampal parvalbumin interneurons to regulate somato-dendritic excitability and synaptic transmission, with the delta opioid receptor dominating the response to enkephalin. NEUROSCIENCE Ai Phuong S Tong, Alex P Vaz ... Kareem A Zaghloul A continuum of ripple oscillations in human anterior temporal lobe reflects the dynamic synchrony of populations of neurons during memory retrieval. NEUROSCIENCE Simon Schug, Frederik Benzing, Angelika Steger Presynaptic plasticity in simulated neural networks with a simple biologically plausible learning rule improves metabolic efficiency and lifelong learning capabilities. CELL BIOLOGY Yasuo Yamazaki, Yuka Eura, Koichi Kokame A V-ATPase component and protein kinase D are required for the segregation of Weibel–Palade bodies from the trans-Golgi network. MEDICINE Marcia A Munoz, Emma K Fletcher ... Michael J Rogers As well as preventing bone loss, bisphosphonate drugs may boost early immune responses in the lung by acting directly on alveolar macrophages that form one of the first lines of defence against infection. ECOLOGY, EVOLUTIONARY BIOLOGY Erich R Eberts, Christopher G Guglielmo, Kenneth C Welch Ruby-throated hummingbirds switch from using torpor to survive nighttime energy emergencies in the breeding season to using it to spare fat stores and gain premigratory mass in the late summer. CANCER BIOLOGY, CELL BIOLOGY Xuebin Zhang, Penghu Lian ... Hanzhong Li A novel multi-hormones secreting chromaffin-like cell type was identified using single-cell RNA sequencing, suggesting the molecular mechanism of ectopic ACTH and CRH pheochromocytoma associated with Cushing’s syndrome. | 
