iScience: April 2026 (Volume 29, Issue 4)

[Virtual Post Bioclues]

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Apr 17, 2026 Vol. 29, Iss. 4 Open Access Website Table of Contents Online Now Archive Highlights Announcements Forums on Sustainability: Meeting increasing water demands through circular water management April 21, 2026, 9:30 a.m. ET | available live & on demand Cell Press Webinar: The chemistry driving a new era of separations April 29, 2026, 10:00 a.m. ET | available live & on demand In the news: Horses whinny by producing high-frequency sounds and lower tones at the same time Recent Current Biology research talked about by NPR, the New York Times, Popular Science, and more. Cell Press Multi-Journal Submission Editors' picks collection for 2025. Table of Contents Backstory Workshop report—Vulnerability in multi-hazard risks: Addressing its complexity and dynamics Alexandre Pereira Santos, Silvia De Angeli, Franziska Stefanie Hanf, Charlotta Mirbach, Nicole van Maanen, Vitus Benson, Marleen Carolijn de Ruiter, Alexandre Dunant, Stefano Terzi, Pia-Johanna Schweizer, Taís Maria Nunes Carvalho, Mariana Madruga de Brito, Kelley De Polt, Robert Šakić Trogrlić, Marc van den Homberg Reviews Reinforcement learning for dynamic speed control in connected and autonomous vehicles: A review of applications and challenges Tareq Alhmiedat, Saleh Albelwi, Mohammed Alotaibi, Mohammed Mustafa, Fares Alquier, Munkhajargal Gochoo, Fady Alnajjar Applied sciences; Engineering Unraveling the complexities: A comprehensive review of severe fever with thrombocytopenia syndrome and its associated complications Yumo Zhou, Yanfu Wang, Yixi Wu, Zhuhao Zhang, Yuwen Zhang, Chenghao Chen, Yiqin Chen, Yanjun Zhang, Lei Fang Health sciences Precise perioperative assessment and anesthesia strategy for painless gastrointestinal endoscopy in high-risk cardiovascular disease patients Yanhong Li, Huili Xiao, Hong Zheng, Rurong Wang Health sciences Microwave-induced energy activation: Mechanisms and material advances Chaoyue Han, Fangzhou Wu, Qi Lin, Fengqi Zhao, Siyu Xu Applied sciences; Energy application; Materials science Biomechanical regulation of stem cells: Implications for cell therapeutics Angela Chen, Carly Harris, Erin Yoo, Cheng-Kui Qu Therapeutics; Cell; Biomechanics CAR T-cells in hematologic malignancies: Advances, challenges, and future directions Karol J. Hernández-Idarraga, Andrea J. Arias-Rozo, Martha L. Arango-Rodríguez, Claudia L. Sossa, Silvia M. Becerra-Bayona Oncology; Therapeutics Decoding chemerin proteolytic processing and isoform signaling across disease contexts Jing Wang, Jiangming Deng, Ting Xiao, Wen Meng Health sciences Plant natural products targeting NLRP3 inflammasome in Parkinson's disease: Molecular activation and regulation to therapeutics Hao Lu, Fengyi Zeng, Jiao Sun, Baiyang Li, Zhimei Lei, Chenyu Zeng, Chendan Zhu, Yanmei Sheng, Quekun Peng, Yiran Sun, Shiyan Zhang Health sciences; Medicine; Natural product chemistry; Neurology The interplay of ketones and succinate: Seeking metabolic balance and novel therapeutic strategies in myocardial hypertrophy and heart failure Yaling Li, Sheng quan Liu, Chun Chu, Jun Yang Cardiovascular medicine; Therapeutics; Precision medicine; Human metabolism; Signal modeling; Interdisciplinary application studies Idiopathic pulmonary fibrosis from a multiscale mechanobiology perspective: Mechanisms and future therapeutic prospects Tingting Xia, Xi Wang, Zhao Yang, Runze Zhao Mechanobiology; Disease Progress in siRNA therapy and delivery platforms for osteoarthritis Shitang Song, Wei Liu, Siqi Wang, Ningyi Guo, Mengfan Li, Jing Xie, Xiaobo Luo, Xin Yan, Bingbing Xu, Yan Xu Molecular biology; Medical biotechnology; Biomedical materials Targeting the lethal weakness of SFTSV: Latest advances in antiviral strategies and immune prevention Ruiqi Weng, Hao Wu, Yutong Xu, Zhiyi Wang, Siyi Gu, Keda Chen Health sciences Flexible polymeric materials and wearable biosensors for smart diabetes mellitus diagnostics and monitoring Valentine Saasa, Thandi Gumede, Nkosikhona Theoren Msweli Health sciences; biological sciences; materials science Regulatory networks of iron sulfur cluster biology in cancer mechanisms and therapeutic perspectives Shenshen Yao, Hongbo Guan, Jun Chai, Xiaomei Liu Cancer; Cell biology; Functional aspects of cell biology The core mechanism of hypertension-linked renal fibrosis: “RAAS-ROS-inflammation-fibrosis” axis Ying Wang, Junyu Chen, Wenwen Wang, Xinyu Yi, Siyi Xing, Xianying Lei, Huan Chen, Xiang Xie Cardiovascular medicine; Health sciences; Medicine; Nephrology Single-cell technologies drive mechanistic insights and therapeutic translation in skeletal system research Guoyang Zhang, Weixuan Lin, Linghuan Guo, Ziyun Li, Yu Xiang, Luo Wang, Xiaoyu Yan Musculoskeletal medicine; Bioengineering; Transcriptomics Post-traumatic stress disorder and cardiometabolic dysfunction: Molecular mechanisms and therapeutic targets Juhyun Song Health sciences; Medicine; Psychiatry; Cardiovascular medicine; Endocrinology Bisphenol A and breast cancer: Can mechanistic plausibility be reconciled with epidemiological inconsistency? Ying Liu, Hongliang Cao, Shuaiyang Zhang, Qianhui Li, Xin Wang, Mingyue Ma, Yang Zhou, Bing Han Health sciences; Medicine; Oncology; Public health Liquid-liquid phase separation in cancer therapy resistance Peng Hu, Huaze Ding, Ningning Yue, Jianxin Ye, Shengzhe Ruan, Yike Qian, Changping Wang, Dianwen Song Cancer; Molecular biology; Oncology The rise of chiral carbon nanomaterials: From chirality-governed mechanisms to future environmental applications Yalian Tang, Yuke Zhu, Haoran Liu, Wantong Zhao, Yingjian Zhou, Ye Tang, Da Ouyang, Kun Tian, Xiangyong Zheng, Min Zhao, Ruihuan Chen Materials science; Nanomaterials Modulation of the gut-heart axis by exercise in diabetic cardiomyopathy: Microbial mechanisms and clinical implications Jun Chen, Zhiwei Fan, Yuan Li, Rui Duan, Binghong Gao Health sciences; Medicine; Medical specialty; Internal medicine; Cardiovascular medicine; Endocrinology Pathophysiology and multi-target prevention strategies for cyclophosphamide-induced bladder injury Xuchang Liu, Jinxuan Li, Xujia Zhang, Xiong Yan, Pengyu Yan, Chun Liu Health sciences Perspective Experts and end users discuss best practices and obstacles for deploying PM2.5 sensors in scientific, community, and educational settings Kristen Okorn, Juthi Rani Mitra, Margaret Pippin, Kevin Czajkowski, Frank Marsik, Sara Mierzwiak Analytical chemistry; Sensor; Atmospheric science; Atmospheric observation; Education Accelerating innovation in sustainable development through transdisciplinary impact research Rebekah Brown, Brett Davis, Matthew French, Tony Wong, Diego Ramirez-Lovering, Steven L. Chown, Thomas Clasen, David Johnston, Ansariadi Ansariadi, Amelia Turagabeci, Kerrie Burge, Chris Greening, David McCarthy, Stephen Luby, Karin Leder Global change; Interdisciplinary application studies Articles Platelet DKK1 promotes tolerogenic dendritic cells and non-healing responses in cutaneous leishmaniasis Olivia C. Ihedioha, Anutr Sivakoses, Haley Q. Marcarian, Malini Sajeev, Diane McMahon-Pratt, Alfred L.M. Bothwell Immunology; cell biology Compensatory responses to glaucoma pathology in the dorsolateral geniculate nucleus Shaylah McCool, Arnav Jain, Jennie C. Smith, Victoria Schaal, Gurudutt Pendyala, Sowmya Yelamanchili, Matthew J. Van Hook Pathology; Molecular neuroscience; Sensory neuroscience Synthesis and characterization of γ-acyloxyl-ε-caprolactones Greyson Greischar, Tapiwa Gono Phiri, Ellie Haljun, Jenna Ray, Meheret Ourgessa, Garrett Thesing, Lila Lofving, Aidan Clarkson, Suzanna Bator, Durwynn Jno Baptise, Wyatt Cole, Michael Itschner, Yutan D.Y.L. Getzler Chemistry; Organic chemistry; Organic synthesis; Organic compound Accumulated mtDNA mutations are linked to specific impairments in NADH-linked respiration Edziu Franczak, McLane M. Montgomery, Zoe S. Terwilliger, Raphael T. Aruleba, Polina Krassovskaia, Ilya N. Boykov, James T. Hagen, Emely A. Pacheco, Brett R. Chrest, Tonya N. Zeczycki, Kayla J. Vandiver, P. Darrell Neufer, Joseph M. McClung, Kelsey H. Fisher-Wellman Biochemistry; Genomics; Molecular biology Inferring gene-regulatory networks using epigenomic priors Thomas E. Bartlett, Melodie Li, Chenyu Song, Yuche Gao, Qiulin Huang Gene regulatory networks; Epigenomics; Biostatistics; breast cancer Gamma and beta oscillatory signatures of the human olfactory bulb encode odor valence and sampling Shubin Li, Coralie Mignot, Susanne Weise, Thomas Hummel Neuroscience; sensory neuroscience; cognitive neuroscience Genetic analysis of Mycobacterium abscessus reveals genomic diversity linked to global plasmid distribution Kensuke Ohse, Atsushi Yoshida, Keisuke Kamada, Hironobu Kitazawa, Yusuke Ito, Takayo Shoji, Kenichiro Watanabe, Hiroshi Koganemaru, Ken Kikuchi, Masashi Toyoda Phylogenetics; Microbial genomics; Genomic analysis; Sequence homology Plateau pika control degrades grasslands while grazing exclusion provides no habitat improvement Yue Wang, Ning Chai, Wenjin Li, Wenjuan Zhang, Feng Zhang Environmental science; Environmental management; Agricultural science The potential of Protaetia brevitarsis as a functional food that enhances immune function and gut microbiota in mice Nan Chen, Shuai Zhao, Zhiyong Yin, Samiullah Khan, Jianjun Guo, Min Zhao Immunology; Microbiome; Special foods A machine learning model for predicting adverse prognostic events in patients with neurosyphilis: Results from the DEFEAT-NS study Zhen Lu, Jun Zou, Hanlin Zhang, Meiyin Zou, Yanhua Fu, Renfang Zhang, Haoran Shi, Weibo Wu, Bichen Xue, Ruonan Wang, Xiaoyan Yang, Jing Cai, Lin Gan, Shangbin Liu, Yong Cai, Zhihang Peng, Jun Li, Liuqing Yang, Jun Chen, Huachun Zou Neurology; Artificial intelligence; Preventive medicine Adipose extracellular vesicles carrying miR-210-3p drive macrophage inflammation and nicotine-induced atherosclerosis Yanchao Li, Mengyue Yang, Hongyu Li, Yiyi Lei, Meng Zhang, Ziyu Yang, Xingtao Huang, Yufei Sun, Qi Liu, Xuedong Wang, Jingbo Hou Cardiovascular medicine; molecular medicine; molecular biology experimental approach