This Week in PNAS
This week's research highlights
News Feature
An in-depth look at trending science issues
Retrospective
Kathryn Anderson, grand dame of developmental biology
Ushma S. Neill and Joan Massagué
Profile
Profile of Michael Manga
Brian Doctrow
The life and work of NAS members
Commentaries
A metagenomics approach to investigate microbiome sociobiology
Sandra B. Andersen and Jonas Schluter
Rapid emergence of virus–host mutualism under stress
Valerian V. Dolja
Perspective
The inflated significance of neutral genetic diversity in conservation genetics
João C. Teixeira and Christian D. Huber
Letters
Infection curves on small-world networks are linear only in the vicinity of the critical point
Łukasz Kuśmierz and Taro Toyoizumi
Reply to Kuśmierz and Toyoizumi: A network-based explanation of why most COVID-19 infection curves are linear
Stefan Thurner, Peter Klimek, and Rudolf Hanel
Richer color vocabulary is correlated with color memory, but its relation to perception is unknown
Shiri Lev-Ari
Reply to Lev-Ari: Operational definition of “color perception”; which task represents the concept better?
Arash Afraz and Maryam Hasantash
Brief Report
Homozygous IL37 mutation associated with infantile inflammatory bowel disease
Zinan Z.
Zhang, Yu Zhang, Tingyan He, Colin L. Sweeney, Safa Baris, Elif
Karakoc-Aydiner, Yikun Yao, Deniz Ertem, Helen F. Matthews, Claudia
Gonzaga-Jauregui, Harry L. Malech, Helen C. Su, Ahmet Ozen, Kenneth G.
C. Smith, and Michael J. Lenardo
Physical Sciences
Applied Physical Sciences
Cell cycle–dependent active stress drives epithelia remodeling
John Devany, Daniel M. Sussman, Takaki Yamamoto, M. Lisa Manning, and Margaret L. Gardel
Chemically controlled pattern formation in self-oscillating elastic shells
Siyu Li, Daniel A. Matoz-Fernandez, Aaveg Aggarwal, and Monica Olvera de la Cruz
Anomalous mechanics of Zn2+-modified fibrin networks
Jing Xia, Li-Heng Cai, Huayin Wu, Frederick C. MacKintosh, and David A. Weitz
Biophysics and Computational Biology
The mechanics and dynamics of cancer cells sensing noisy 3D contact guidance
Jihan Kim, Yuansheng Cao, Christopher Eddy, Youyuan Deng, Herbert Levine, Wouter-Jan Rappel, and Bo Sun
Nonequilibrium dynamics and action at a distance in transcriptionally driven DNA supercoiling
Yair A. G. Fosado, Davide Michieletto, Chris A. Brackley, and Davide Marenduzzo
Chemistry
Boronic acid with high oxidative stability and utility in biological contexts
Brian J. Graham, Ian W. Windsor, Brian Gold, and Ronald T. Raines
Anomalous nanoparticle surface diffusion in LCTEM is revealed by deep learning-assisted analysis
Vida Jamali, Cory Hargus, Assaf Ben-Moshe, Amirali Aghazadeh, Hyun Dong Ha, Kranthi K. Mandadapu, and A. Paul Alivisatos
Mesoscopic protein-rich clusters host the nucleation of mutant p53 amyloid fibrils
David S.
Yang, Arash Saeedi, Aram Davtyan, Mohsen Fathi, Michael B. Sherman,
Mohammad S. Safari, Alena Klindziuk, Michelle C. Barton, Navin
Varadarajan, Anatoly B. Kolomeisky, and Peter G. Vekilov
Three-step nucleation of metal–organic framework nanocrystals
Xiangwen Liu, See Wee Chee, Sanoj Raj, Michal Sawczyk, Petr Král, and Utkur Mirsaidov
Chemical evidence for the persistence of wine production and trade in Early Medieval Islamic Sicily
Léa Drieu,
Paola Orecchioni, Claudio Capelli, Antonino Meo, Jasmine Lundy, Viva
Sacco, Lucia Arcifa, Alessandra Molinari, Martin Carver, and Oliver E.
Craig
Lipid nanoparticle-mediated codelivery of Cas9 mRNA and single-guide RNA achieves liver-specific in vivo genome editing of Angptl3
Min Qiu,
Zachary Glass, Jinjin Chen, Mary Haas, Xin Jin, Xuewei Zhao, Xuehui Rui,
Zhongfeng Ye, Yamin Li, Feng Zhang, and Qiaobing Xu
Bepridil is potent against SARS-CoV-2 in vitro
Erol C.
Vatansever, Kai S. Yang, Aleksandra K. Drelich, Kaci C. Kratch,
Chia-Chuan Cho, Kempaiah Rayavara Kempaiah, Jason C. Hsu, Drake M.
Mellott, Shiqing Xu, Chien-Te K. Tseng, and Wenshe Ray Liu
Shape changes and cooperativity in the folding of the central domain of the 16S ribosomal RNA
Naoto Hori, Natalia A. Denesyuk, and D. Thirumalai
Seipin accumulates and traps diacylglycerols and triglycerides in its ring-like structure
Valeria Zoni, Rasha Khaddaj, Ivan Lukmantara, Wataru Shinoda, Hongyuan Yang, Roger Schneiter, and Stefano Vanni
Earth, Atmospheric, and Planetary Sciences
Ozone pollution in the North China Plain spreading into the late-winter haze season
Ke Li,
Daniel J. Jacob, Hong Liao, Yulu Qiu, Lu Shen, Shixian Zhai, Kelvin H.
Bates, Melissa P. Sulprizio, Shaojie Song, Xiao Lu, Qiang Zhang, Bo
Zheng, Yuli Zhang, Jinqiang Zhang, Hyun Chul Lee, and Su Keun Kuk
Simple stochastic model for geomagnetic excursions and reversals reproduces the temporal asymmetry of the axial dipole moment
Alberto Molina-Cardín, Luis Dinis, and María Luisa Osete
Source apportionment of methane escaping the subsea permafrost system in the outer Eurasian Arctic Shelf
Julia
Steinbach, Henry Holmstrand, Kseniia Shcherbakova, Denis Kosmach, Volker
Brüchert, Natalia Shakhova, Anatoly Salyuk, Célia J. Sapart, Denis
Chernykh, Riko Noormets, Igor Semiletov, and Örjan Gustafsson
Engineering
Elastic amplification of the Rayleigh–Taylor instability in solidifying melts
Etienne Jambon-Puillet, Matthieu Royer Piéchaud, and P.-T. Brun
How the growth of ice depends on the fluid dynamics underneath
Ziqi Wang, Enrico Calzavarini, Chao Sun, and Federico Toschi
Physics
Encoding memory in tube diameter hierarchy of living flow network
Mirna Kramar and Karen Alim
Γ valley transition metal dichalcogenide moiré bands
Mattia Angeli and Allan H. MacDonald
Machine learning active-nematic hydrodynamics
Jonathan
Colen, Ming Han, Rui Zhang, Steven A. Redford, Linnea M. Lemma, Link
Morgan, Paul V. Ruijgrok, Raymond Adkins, Zev Bryant, Zvonimir Dogic,
Margaret L. Gardel, Juan J. de Pablo, and Vincenzo Vitelli
Designing self-assembling kinetics with differentiable statistical physics models
Carl P. Goodrich, Ella M. King, Samuel S. Schoenholz, Ekin D. Cubuk, and Michael P. Brenner
Non–line-of-sight imaging over 1.43 km
Cheng Wu,
Jianjiang Liu, Xin Huang, Zheng-Ping Li, Chao Yu, Jun-Tian Ye, Jun
Zhang, Qiang Zhang, Xiankang Dou, Vivek K. Goyal, Feihu Xu, and Jian-Wei
Pan
High-sensitivity heat-capacity measurements on Sr2RuO4 under uniaxial pressure
You-Sheng
Li, Naoki Kikugawa, Dmitry A. Sokolov, Fabian Jerzembeck, Alexandra S.
Gibbs, Yoshiteru Maeno, Clifford W. Hicks, Jörg Schmalian, Michael
Nicklas, and Andrew P. Mackenzie
Emergence of dynamic vortex glasses in disordered polar active fluids
Amélie Chardac, Suraj Shankar, M. Cristina Marchetti, and Denis Bartolo
Statistics
Integration and transfer learning of single-cell transcriptomes via cFIT
Minshi Peng, Yue Li, Brie Wamsley, Yuting Wei, and Kathryn Roeder
Elevated cerebrospinal fluid cytokine levels in tuberculous meningitis predict survival in response to dexamethasone
Laura J.
Whitworth, Rajan Troll, Antonio J. Pagán, Francisco J. Roca, Paul H.
Edelstein, Mark Troll, David M. Tobin, Nguyen Hoan Phu, Nguyen Duc Bang,
Guy E. Thwaites, Nguyen Thuy Thuong Thuong, Roger F. Sewell, and Lalita
Ramakrishnan
Social Sciences
Anthropology
Chemical evidence for the persistence of wine production and trade in Early Medieval Islamic Sicily
Léa Drieu,
Paola Orecchioni, Claudio Capelli, Antonino Meo, Jasmine Lundy, Viva
Sacco, Lucia Arcifa, Alessandra Molinari, Martin Carver, and Oliver E.
Craig
Environmental Sciences
Human arrival and landscape dynamics in the northern Bahamas
Patricia L. Fall, Peter J. van Hengstum, Lisa Lavold-Foote, Jeffrey P. Donnelly, Nancy A. Albury, and Anne E. Tamalavage
Psychological and Cognitive Sciences
Influence of a COVID-19 vaccine’s effectiveness and safety profile on vaccination acceptance
Robert M. Kaplan and Arnold Milstein
Stunted upward mobility in a learning environment reduces the academic benefits of growth mindsets
Lile Jia, Chun Hui Lim, Ismaharif Ismail, and Yia Chin Tan
Do conversations end when people want them to?
Adam M. Mastroianni, Daniel T. Gilbert, Gus Cooney, and Timothy D. Wilson
Biological Sciences
Agricultural Sciences
Cas9-expressing chickens and pigs as resources for genome editing in livestock
Beate
Rieblinger, Hicham Sid, Denise Duda, Tarik Bozoglu, Romina Klinger,
Antonina Schlickenrieder, Kamila Lengyel, Krzysztof Flisikowski, Tatiana
Flisikowska, Nina Simm, Alessandro Grodziecki, Carolin Perleberg,
Andrea Bähr, Lucie Carrier, Mayuko Kurome, Valeri Zakhartchenko, Barbara
Kessler, Eckhard Wolf, Lutz Kettler, Harald Luksch, Ibrahim T. Hagag,
Daniel Wise, Jim Kaufman, Benedikt B. Kaufer, Christian Kupatt, Angelika
Schnieke, and Benjamin Schusser
A multitaxa assessment of the effectiveness of agri-environmental schemes for biodiversity management
Fabian A.
Boetzl, Jochen Krauss, Jonathan Heinze, Hannes Hoffmann, Jan Juffa,
Sebastian König, Elena Krimmer, Maren Prante, Emily A. Martin, Andrea
Holzschuh, and Ingolf Steffan-Dewenter
Applied Biological Sciences
Lipid nanoparticle-mediated codelivery of Cas9 mRNA and single-guide RNA achieves liver-specific in vivo genome editing of Angptl3
Min Qiu,
Zachary Glass, Jinjin Chen, Mary Haas, Xin Jin, Xuewei Zhao, Xuehui Rui,
Zhongfeng Ye, Yamin Li, Feng Zhang, and Qiaobing Xu
Mutational
fitness landscapes reveal genetic and structural improvement pathways
for a vaccine-elicited HIV-1 broadly neutralizing antibody
Bharat
Madan, Baoshan Zhang, Kai Xu, Cara W. Chao, Sijy O’Dell, Jacy R. Wolfe,
Gwo-Yu Chuang, Ahmed S. Fahad, Hui Geng, Rui Kong, Mark K. Louder, Thuy
Duong Nguyen, Reda Rawi, Arne Schön, Zizhang Sheng, Rajani Nimrania,
Yiran Wang, Tongqing Zhou, Bob C. Lin, Nicole A. Doria-Rose, Lawrence
Shapiro, Peter D. Kwong, and Brandon J. DeKosky
Biochemistry
Boronic acid with high oxidative stability and utility in biological contexts
Brian J. Graham, Ian W. Windsor, Brian Gold, and Ronald T. Raines
Bepridil is potent against SARS-CoV-2 in vitro
Erol C.
Vatansever, Kai S. Yang, Aleksandra K. Drelich, Kaci C. Kratch,
Chia-Chuan Cho, Kempaiah Rayavara Kempaiah, Jason C. Hsu, Drake M.
Mellott, Shiqing Xu, Chien-Te K. Tseng, and Wenshe Ray Liu
Charting the sequence-activity landscape of peptide inhibitors of translation termination
Chetana
Baliga, Tyler J. Brown, Tanja Florin, Sarah Colon, Vallari Shah,
Kornelia J. Skowron, Amira Kefi, Teresa Szal, Dorota Klepacki, Terry W.
Moore, Nora Vázquez-Laslop, and Alexander S. Mankin
Structural basis for recognition of distinct deaminated DNA lesions by endonuclease Q
Ke Shi,
Nicholas H. Moeller, Surajit Banerjee, Jennifer L. McCann, Michael A.
Carpenter, Lulu Yin, Ramkumar Moorthy, Kayo Orellana, Daniel A. Harki,
Reuben S. Harris, and Hideki Aihara
Collagen’s enigmatic, highly conserved N-glycan has an essential proteostatic function
Rasia C. Li, Madeline Y. Wong, Andrew S. DiChiara, Azade S. Hosseini, and Matthew D. Shoulders
Structural insights into α-synuclein monomer–fibril interactions
Pratibha
Kumari, Dhiman Ghosh, Agathe Vanas, Yanick Fleischmann, Thomas Wiegand,
Gunnar Jeschke, Roland Riek, and Cédric Eichmann
Chloride-dependent conformational changes in the GlyT1 glycine transporter
Yuan-Wei Zhang, Stacy Uchendu, Vanessa Leone, Richard T. Bradshaw, Ntumba Sangwa, Lucy R. Forrest, and Gary Rudnick
Architecturally complex O-glycopeptidases are customized for mucin recognition and hydrolysis
Benjamin
Pluvinage, Elizabeth Ficko-Blean, Ilit Noach, Christopher Stuart, Nicole
Thompson, Hayden McClure, Nakita Buenbrazo, Warren Wakarchuk, and
Alisdair B. Boraston
Structural basis for IFN antagonism by human respiratory syncytial virus nonstructural protein 2
Jingjing
Pei, Nicole D. Wagner, Angela J. Zou, Srirupa Chatterjee, Dominika
Borek, Aidan R. Cole, Preston J. Kim, Christopher F. Basler, Zbyszek
Otwinowski, Michael L. Gross, Gaya K. Amarasinghe, and Daisy W. Leung
Biophysics and Computational Biology
Cell cycle–dependent active stress drives epithelia remodeling
John Devany, Daniel M. Sussman, Takaki Yamamoto, M. Lisa Manning, and Margaret L. Gardel
Encoding memory in tube diameter hierarchy of living flow network
Mirna Kramar and Karen Alim
Shape changes and cooperativity in the folding of the central domain of the 16S ribosomal RNA
Naoto Hori, Natalia A. Denesyuk, and D. Thirumalai
Seipin accumulates and traps diacylglycerols and triglycerides in its ring-like structure
Valeria Zoni, Rasha Khaddaj, Ivan Lukmantara, Wataru Shinoda, Hongyuan Yang, Roger Schneiter, and Stefano Vanni
Integration and transfer learning of single-cell transcriptomes via cFIT
Minshi Peng, Yue Li, Brie Wamsley, Yuting Wei, and Kathryn Roeder
Identification of tetracycline combinations as EphB1 tyrosine kinase inhibitors for treatment of neuropathic pain
Mahmoud S.
Ahmed, Ping Wang, Ngoc Uyen Nhi Nguyen, Yuji Nakada, Ivan
Menendez-Montes, Muhammad Ismail, Robert Bachoo, Mark Henkemeyer, Hesham
A. Sadek, and Enas S. Kandil
Computational studies of anaplastic lymphoma kinase mutations reveal common mechanisms of oncogenic activation
Keshav
Patil, Earl Joseph Jordan, Jin H. Park, Krishna Suresh, Courtney M.
Smith, Abigail A. Lemmon, Yaël P. Mossé, Mark A. Lemmon, and Ravi
Radhakrishnan
Structural insights into membrane remodeling by SNX1
Yan Zhang, Xiaoyun Pang, Jian Li, Jiashu Xu, Victor W. Hsu, and Fei Sun
Cadherin cis and trans interactions are mutually cooperative
Connor J. Thompson, Vinh H. Vu, Deborah E. Leckband, and Daniel K. Schwartz
A narrow ear canal reduces sound velocity to create additional acoustic inputs in a microscale insect ear
Daniel
Veitch, Emine Celiker, Sarah Aldridge, Christian Pulver, Carl D.
Soulsbury, Thorin Jonsson, Charlie Woodrow, and Fernando Montealegre-Z
Raf promotes dimerization of the Ras G-domain with increased allosteric connections
Morgan R.
Packer, Jillian A. Parker, Jean K. Chung, Zhenlu Li, Young Kwang Lee,
Trinity Cookis, Hugo Guterres, Steven Alvarez, Md Amin Hossain, Daniel
P. Donnelly, Jeffrey N. Agar, Lee Makowski, Matthias Buck, Jay T.
Groves, and Carla Mattos
Ligand effects on phase separation of multivalent macromolecules
Kiersten M. Ruff, Furqan Dar, and Rohit V. Pappu
Cell Biology
The mechanics and dynamics of cancer cells sensing noisy 3D contact guidance
Jihan Kim, Yuansheng Cao, Christopher Eddy, Youyuan Deng, Herbert Levine, Wouter-Jan Rappel, and Bo Sun
mTORC1-chaperonin CCT signaling regulates m6A RNA methylation to suppress autophagy
Hong-Wen
Tang, Jui-Hsia Weng, Wen Xing Lee, Yanhui Hu, Lei Gu, Sungyun Cho, Gina
Lee, Richard Binari, Cathleen Li, Min En Cheng, Ah-Ram Kim, Jun Xu,
Zhangfei Shen, Chiwei Xu, John M. Asara, John Blenis, and Norbert
Perrimon
Adaptation
of pancreatic cancer cells to nutrient deprivation is reversible and
requires glutamine synthetase stabilization by mTORC1
Pei-Yun
Tsai, Min-Sik Lee, Unmesh Jadhav, Insia Naqvi, Shariq Madha, Ashley
Adler, Meeta Mistry, Sergey Naumenko, Caroline A. Lewis, Daniel S.
Hitchcock, Frederick R. Roberts, Peter DelNero, Thomas Hank, Kim C.
Honselmann, Vicente Morales Oyarvide, Mari Mino-Kenudson, Clary B.
Clish, Ramesh A. Shivdasani, and Nada Y. Kalaany
CENP-A chromatin prevents replication stress at centromeres to avoid structural aneuploidy
Simona
Giunta, Solène Hervé, Ryan R. White, Therese Wilhelm, Marie Dumont,
Andrea Scelfo, Riccardo Gamba, Cheng Kit Wong, Giulia Rancati, Agata
Smogorzewska, Hironori Funabiki, and Daniele Fachinetti
The store-operated Ca2+ entry complex comprises a small cluster of STIM1 associated with one Orai1 channel
Yihan Shen, Nagendra Babu Thillaiappan, and Colin W. Taylor
Metabolic
supervision by PPIP5K, an inositol pyrophosphate kinase/phosphatase,
controls proliferation of the HCT116 tumor cell line
Chunfang Gu, Juan Liu, Xiaojing Liu, Haibo Zhang, Ji Luo, Huanchen Wang, Jason W. Locasale, and Stephen B. Shears
Ki-67 regulates global gene expression and promotes sequential stages of carcinogenesis
Karim
Mrouj, Nuria Andrés-Sánchez, Geronimo Dubra, Priyanka Singh, Michal
Sobecki, Dhanvantri Chahar, Emile Al Ghoul, Ana Bella Aznar, Susana
Prieto, Nelly Pirot, Florence Bernex, Benoit Bordignon, Cedric
Hassen-Khodja, Martin Villalba, Liliana Krasinska, and Daniel Fisher
Developmental Biology
Dynamics of hydraulic and contractile wave-mediated fluid transport during Drosophila oogenesis
Jasmin Imran Alsous, Nicolas Romeo, Jonathan A. Jackson, Frank M. Mason, Jörn Dunkel, and Adam C. Martin
ASCL2 reciprocally controls key trophoblast lineage decisions during hemochorial placenta development
Kaela M.
Varberg, Khursheed Iqbal, Masanaga Muto, Mikaela E. Simon, Regan L.
Scott, Keisuke Kozai, Ruhul H. Choudhury, John D. Aplin, Rebecca
Biswell, Margaret Gibson, Hiroaki Okae, Takahiro Arima, Jay L. Vivian,
Elin Grundberg, and Michael J. Soares
Progenitor cell diversity in the developing mouse neocortex
Xiangbin Ruan, Bowei Kang, Cai Qi, Wenhe Lin, Jingshu Wang, and Xiaochang Zhang
Primary
sex determination in birds depends on DMRT1 dosage, but gonadal sex
does not determine adult secondary sex characteristics
Jason
Ioannidis, Gunes Taylor, Debiao Zhao, Long Liu, Alewo Idoko-Akoh,
Daoqing Gong, Robin Lovell-Badge, Silvana Guioli, Mike J. McGrew, and
Michael Clinton
Lipid droplets in mammalian eggs are utilized during embryonic diapause
Roberta
Arena, Simona Bisogno, Łukasz Gąsior, Joanna Rudnicka, Laura Bernhardt,
Thomas Haaf, Federica Zacchini, Michał Bochenek, Kinga Fic, Ewelina Bik,
Małgorzata Barańska, Anna Bodzoń-Kułakowska, Piotr Suder, Joanna
Depciuch, Artur Gurgul, Zbigniew Polański, and Grażyna E. Ptak
Ecology
Evolutionary
relationships between drought-related traits and climate shape large
hydraulic safety margins in western North American oaks
Robert P.
Skelton, Leander D. L. Anderegg, Jessica Diaz, Matthew M. Kling, Prahlad
Papper, Laurent J. Lamarque, Sylvain Delzon, Todd E. Dawson, and David
D. Ackerly
Selective constraints on global plankton dispersal
Ben A. Ward, B. B. Cael, Sinead Collins, and C. Robert Young
Evolution
Deep time diversity and the early radiations of birds
Yilun Yu, Chi Zhang, and Xing Xu
Dual oxidase enables insect gut symbiosis by mediating respiratory network formation
Seonghan Jang, Peter Mergaert, Tsubasa Ohbayashi, Kota Ishigami, Shuji Shigenobu, Hideomi Itoh, and Yoshitomo Kikuchi
Adaptive evolution of hybrid bacteria by horizontal gene transfer
Jeffrey J.
Power, Fernanda Pinheiro, Simone Pompei, Viera Kovacova, Melih Yüksel,
Isabel Rathmann, Mona Förster, Michael Lässig, and Berenike Maier
Genetics
Discordant clinical features of identical hypertrophic cardiomyopathy twins
Giuliana G.
Repetti, Yuri Kim, Alexandre C. Pereira, Jodie Ingles, Mark W. Russell,
Neal K. Lakdawala, Carolyn Y. Ho, Sharlene Day, Christopher Semsarian,
Barbara McDonough, Steven R. DePalma, Daniel Quiat, Eric M. Green,
Christine E. Seidman, and J. G. Seidman
A versatile platform for locus-scale genome rewriting and verification
Ran Brosh,
Jon M. Laurent, Raquel Ordoñez, Emily Huang, Megan S. Hogan, Angela M.
Hitchcock, Leslie A. Mitchell, Sudarshan Pinglay, John A. Cadley, Raven
D. Luther, David M. Truong, Jef D. Boeke, and Matthew T. Maurano
The imprinted lncRNA Peg13 regulates sexual preference and the sex-specific brain transcriptome in mice
Maryam Keshavarz and Diethard Tautz
Up-regulation of miR-34b/c by JNK and FOXO3 protects from liver fibrosis
Pasquale
Piccolo, Rosa Ferriero, Anna Barbato, Sergio Attanasio, Marcello Monti,
Claudia Perna, Florie Borel, Patrizia Annunziata, Annamaria Carissimo,
Rossella De Cegli, Luca Quagliata, Luigi M. Terracciano, Chantal
Housset, Jeffrey H. Teckman, Christian Mueller, and Nicola
Brunetti-Pierri
Comparative
parallel analysis of RNA ends identifies mRNA substrates of a tRNA
splicing endonuclease-initiated mRNA decay pathway
Jennifer E. Hurtig, Michelle A. Steiger, Vinay K. Nagarajan, Tao Li, Ti-Chun Chao, Kuang-Lei Tsai, and Ambro van Hoof
Genome-wide shifts in climate-related variation underpin responses to selective breeding in a widespread conifer
Ian R. MacLachlan, Tegan K. McDonald, Brandon M. Lind, Loren H. Rieseberg, Sam Yeaman, and Sally N. Aitken
Immunology and Inflammation
An in vivo method for diversifying the functions of therapeutic antibodies
Ming Tian,
Hwei-Ling Cheng, Michael T. Kimble, Kelly McGovern, Peyton Waddicor,
Yiwei Chen, Elizabeth Cantor, Mengting Qiu, Marie-Elen Tuchel, Mai Dao,
and Frederick W. Alt
Sialoglycan recognition is a common connection linking acidosis, zinc, and HMGB1 in sepsis
Shoib S.
Siddiqui, Chirag Dhar, Venkatasubramaniam Sundaramurthy, Aniruddha
Sasmal, Hai Yu, Esther Bandala-Sanchez, Miaomiao Li, Xiaoxiao Zhang, Xi
Chen, Leonard C. Harrison, Ding Xu, and Ajit Varki
Pericytes regulate vascular immune homeostasis in the CNS
Orsolya
Török, Bettina Schreiner, Johanna Schaffenrath, Hsing-Chuan Tsai,
Upasana Maheshwari, Sebastian A. Stifter, Christina Welsh, Ana Amorim,
Sucheta Sridhar, Sebastian G. Utz, Wiebke Mildenberger, Sina Nassiri,
Mauro Delorenzi, Adriano Aguzzi, May H. Han, Melanie Greter, Burkhard
Becher, and Annika Keller
Targeting tumor-derived NLRP3 reduces melanoma progression by limiting MDSCs expansion
Isak W.
Tengesdal, Dinoop R. Menon, Douglas G. Osborne, Charles P. Neff,
Nicholas E. Powers, Fabia Gamboni, Adolfo G. Mauro, Angelo D’Alessandro,
Davide Stefanoni, Morkos A. Henen, Taylor S. Mills, Dennis M. De Graaf,
Tania Azam, Beat Vogeli, Brent E. Palmer, Eric M. Pietras, James
DeGregori, Aik-Choon Tan, Leo A. B. Joosten, Mayumi Fujita, Charles A.
Dinarello, and Carlo Marchetti
Local induction of bladder Th1 responses to combat urinary tract infections
Jianxuan Wu, Chunjing Bao, R. Lee Reinhardt, and Soman N. Abraham
TAp73 represses NF-κB–mediated recruitment of tumor-associated macrophages in breast cancer
Johanna
Wolfsberger, Habib A. M. Sakil, Leilei Zhou, Niek van Bree, Elena
Baldisseri, Sabrina de Souza Ferreira, Veronica Zubillaga, Marina
Stantic, Nicolas Fritz, Johan Hartman, Charlotte Rolny, and Margareta T.
Wilhelm
Host genetic control of natural killer cell diversity revealed in the Collaborative Cross
Magali S.
J. Dupont, Vincent Guillemot, Pascal Campagne, Nicolas Serafini, Solenne
Marie, Xavier Montagutelli, James P. Di Santo, and Christian A. J.
Vosshenrich
IDO1 scavenges reactive oxygen species in myeloid-derived suppressor cells to prevent graft-versus-host disease
Ji-Min Ju,
Giri Nam, Young-Kwan Lee, Minho Jung, Hanna Chang, Woojin Kim, Woo Jeong
Shon, Ji Young Lim, Joo Young Kim, Jun Chang, Chang Ki Min, Dong-Sup
Lee, Kyungho Choi, Dong-Mi Shin, and Eun Young Choi
Cysteinyl-specialized
proresolving mediators link resolution of infectious inflammation and
tissue regeneration via TRAF3 activation
Nan Chiang, Xavier de la Rosa, Stephania Libreros, Hui Pan, Jonathan M. Dreyfuss, and Charles N. Serhan
Human DNA methylation signatures differentiate persistent from resolving MRSA bacteremia
Yu-Ling
Chang, Maura Rossetti, David W. Gjertson, Liudmilla Rubbi, Michael
Thompson, Dennis J. Montoya, Marco Morselli, Felicia Ruffin, Alexander
Hoffmann, Matteo Pellegrini, Vance G. Fowler Jr, Michael R. Yeaman,
Elaine F. Reed, and with the MRSA Systems Immunology Group
Medical Sciences
Influence of a COVID-19 vaccine’s effectiveness and safety profile on vaccination acceptance
Robert M. Kaplan and Arnold Milstein
Elevated cerebrospinal fluid cytokine levels in tuberculous meningitis predict survival in response to dexamethasone
Laura J.
Whitworth, Rajan Troll, Antonio J. Pagán, Francisco J. Roca, Paul H.
Edelstein, Mark Troll, David M. Tobin, Nguyen Hoan Phu, Nguyen Duc Bang,
Guy E. Thwaites, Nguyen Thuy Thuong Thuong, Roger F. Sewell, and Lalita
Ramakrishnan
Pathogenic LRRK2 regulates ciliation probability upstream of tau tubulin kinase 2 via Rab10 and RILPL1 proteins
Yuriko Sobu, Paulina S. Wawro, Herschel S. Dhekne, Wondwossen M. Yeshaw, and Suzanne R. Pfeffer
Microbiology
Transcriptional heterogeneity and tightly regulated changes in gene expression during Plasmodium berghei sporozoite development
Haikel N.
Bogale, Tales V. Pascini, Sachie Kanatani, Juliana M. Sá, Thomas E.
Wellems, Photini Sinnis, Joel Vega-Rodríguez, and David Serre
Structural basis for a bacterial Pip system plant effector recognition protein
Shukun Luo,
Bruna G. Coutinho, Prikshat Dadhwal, Yasuhiro Oda, Jiahong Ren, Amy L.
Schaefer, E. Peter Greenberg, Caroline S. Harwood, and Liang Tong
Kaposi’s sarcoma herpesvirus is associated with osteosarcoma in Xinjiang populations
Qian Chen, Jiangtao Chen, Yuqing Li, Dawei Liu, Yan Zeng, Zheng Tian, Akbar Yunus, Yong Yang, Jie Lu, Xinghua Song, and Yan Yuan
Evaluating the potential efficacy and limitations of a phage for joint antibiotic and phage therapy of Staphylococcus aureus infections
Brandon A. Berryhill, Douglas L. Huseby, Ingrid C. McCall, Diarmaid Hughes, and Bruce R. Levin
Phytophthora sojae effector Avr1d functions as an E2 competitor and inhibits ubiquitination activity of GmPUB13 to facilitate infection
Yachun Lin,
Qinli Hu, Jia Zhou, Weixiao Yin, Deqiang Yao, Yuanyuan Shao, Yao Zhao,
Baodian Guo, Yeqiang Xia, Qian Chen, Yan Wang, Wenwu Ye, Qi Xie, Brett
M. Tyler, Weiman Xing, and Yuanchao Wang
N6-methyladenosine modification of HCV RNA genome regulates cap-independent IRES-mediated translation via YTHDC2 recognition
Geon-Woo Kim and Aleem Siddiqui
HIV-1 cores retain their integrity until minutes before uncoating in the nucleus
Chenglei Li, Ryan C. Burdick, Kunio Nagashima, Wei-Shau Hu, and Vinay K. Pathak
NF-κB–induced R-loop accumulation and DNA damage select for nucleotide excision repair deficiencies in adult T cell leukemia
Yunlong He,
Nagesh Pasupala, Huijun Zhi, Batsuhk Dorjbal, Imran Hussain, Hsiu-Ming
Shih, Sharmistha Bhattacharyya, Roopa Biswas, Milos Miljkovic, Oliver
John Semmes, Thomas A. Waldmann, Andrew L. Snow, and Chou-Zen Giam
Neuroscience
Drosophila clock cells use multiple mechanisms to transmit time-of-day signals in the brain
Annika F. Barber, Shi Yi Fong, Anna Kolesnik, Michael Fetchko, and Amita Sehgal
Monocyte markers correlate with immune and neuronal brain changes in REM sleep behavior disorder
Kristine
Farmen, Sara K. Nissen, Morten G. Stokholm, Alex Iranzo, Karen
Østergaard, Mónica Serradell, Marit Otto, Kristina B. Svendsen, Alicia
Garrido, Dolores Vilas, Per Borghammer, Joan Santamaria, Arne Møller,
Carles Gaig, David J. Brooks, Eduardo Tolosa, Nicola Pavese, and Marina
Romero-Ramos
Complexity and graded regulation of neuronal cell-type–specific alternative splicing revealed by single-cell RNA sequencing
Huijuan Feng, Daniel F. Moakley, Shuonan Chen, Melissa G. McKenzie, Vilas Menon, and Chaolin Zhang
Volitional learning promotes theta phase coding in the human hippocampus
Daniel
Pacheco Estefan, Riccardo Zucca, Xerxes Arsiwalla, Alessandro Principe,
Hui Zhang, Rodrigo Rocamora, Nikolai Axmacher, and Paul F. M. J.
Verschure
Inhibition
of neuroinflammatory nitric oxide signaling suppresses glycation and
prevents neuronal dysfunction in mouse prion disease
Julie-Myrtille
Bourgognon, Jereme G. Spiers, Sue W. Robinson, Hannah Scheiblich, Paul
Glynn, Catharine Ortori, Sophie J. Bradley, Andrew B. Tobin, and Joern
R. Steinert
Spine dynamics of PSD-95-deficient neurons in the visual cortex link silent synapses to structural cortical plasticity
Rashad Yusifov, Anja Tippmann, Jochen F. Staiger, Oliver M. Schlüter, and Siegrid Löwel
Dysregulation of myelin synthesis and actomyosin function underlies aberrant myelin in CMT4B1 neuropathy
Marta
Guerrero-Valero, Federica Grandi, Silvia Cipriani, Valeria Alberizzi,
Roberta Di Guardo, Gaetan Chicanne, Linda Sawade, Francesca Bianchi,
Ubaldo Del Carro, Ivan De Curtis, Davide Pareyson, Yesim Parman, Angelo
Schenone, Volker Haucke, Bernard Payrastre, and Alessandra Bolino
Excitatory cholecystokinin neurons of the midbrain integrate diverse temporal responses and drive auditory thalamic subdomains
Lauren J. Kreeger, Catherine J. Connelly, Preeti Mehta, Boris V. Zemelman, and Nace L. Golding
Nonthermal and reversible control of neuronal signaling and behavior by midinfrared stimulation
Xi Liu, Zhi
Qiao, Yuming Chai, Zhi Zhu, Kaijie Wu, Wenliang Ji, Daguang Li, Yujie
Xiao, Lanqun Mao, Chao Chang, Quan Wen, Bo Song, and Yousheng Shu
Physiology
A multiplier peroxiporin signal transduction pathway powers piscine spermatozoa
François
Chauvigné, Carla Ducat, Alba Ferré, Tom Hansen, Montserrat Carrascal,
Joaquín Abián, Roderick Nigel Finn, and Joan Cerdà
Plant Biology
Posttranslational regulation of multiple clock-related transcription factors triggers cold-inducible gene expression in Arabidopsis
Satoshi
Kidokoro, Kentaro Hayashi, Hiroki Haraguchi, Tomona Ishikawa, Fumiyuki
Soma, Izumi Konoura, Satomi Toda, Junya Mizoi, Takamasa Suzuki, Kazuo
Shinozaki, and Kazuko Yamaguchi-Shinozaki
Superoxide is promoted by sucrose and affects amplitude of circadian rhythms in the evening
Ángela Román, Xiang Li, Dongjing Deng, John W. Davey, Sally James, Ian A. Graham, and Michael J. Haydon
Predicting transcriptional responses to cold stress across plant species
Xiaoxi Meng, Zhikai Liang, Xiuru Dai, Yang Zhang, Samira Mahboub, Daniel W. Ngu, Rebecca L. Roston, and James C. Schnable
Negative regulation of plastidial isoprenoid pathway by herbivore-induced β-cyclocitral in Arabidopsis thaliana
Sirsha Mitra, Roger Estrada-Tejedor, Daniel C. Volke, Michael A. Phillips, Jonathan Gershenzon, and Louwrance P. Wright
SUMO enables substrate selectivity by mitogen-activated protein kinases to regulate immunity in plants
Vivek
Verma, Anjil K. Srivastava, Catherine Gough, Alberto Campanaro, Moumita
Srivastava, Rebecca Morrell, Joshua Joyce, Mark Bailey, Cunjin Zhang,
Patrick J. Krysan, and Ari Sadanandom
Evolution of Ycf54-independent chlorophyll biosynthesis in cyanobacteria
Guangyu E.
Chen, Andrew Hitchcock, Jan Mareš, Yanhai Gong, Martin Tichý, Jan Pilný,
Lucie Kovářová, Barbora Zdvihalová, Jian Xu, C. Neil Hunter, and Roman
Sobotka
Population Biology
A metapopulation model of social group dynamics and disease applied to Yellowstone wolves
Ellen E. Brandell, Andrew P. Dobson, Peter J. Hudson, Paul C. Cross, and Douglas W. Smith
Psychological and Cognitive Sciences
Aggression heuristics underlie animal dominance hierarchies and provide evidence of group-level social information
Elizabeth A. Hobson, Dan Mønster, and Simon DeDeo
Sustainability Science
Human arrival and landscape dynamics in the northern Bahamas
Patricia L. Fall, Peter J. van Hengstum, Lisa Lavold-Foote, Jeffrey P. Donnelly, Nancy A. Albury, and Anne E. Tamalavage
Systems Biology
|