PNAS Table of Contents for August 4, 2020; Vol. 117, No. 31

[Virtual Post Bioclues]

  August 4, 2020; Vol. 117, No. 31

This Week in PNAS In This Issue Editorial Scientific versus public debates: A PNAS case study Douglas S. Massey and Mary C. Waters Opinion Opinion: At a Crossroads: Reimagining science, engineering, and medicine—and its practitioners  Freeman A. Hrabowski III, J. Kathleen Tracy, and Peter H. Henderson Leading scientists discuss current issues. Inner Workings Inner Workings: A pulse of hope in the fight against Alzheimer’s  Lynne Peeples An over-the-shoulder look at scientists at work. QnAs QnAs with Hashim Al-Hashimi Brian Doctrow Commentaries Honey bee colony aggression and indirect genetic effects Marla B. Sokolowski Maladaptive response of arterial myocytes to chronic exposure to Ca2+ channel blockers Samantha C. O’Dwyer, Manuel F. Navedo, and L. F. Santana Cats as predators and early domesticates in ancient human landscapes Fiona Marshall Letters Complications and challenges for securing Mediterranean timelines Sturt W. Manning Reply to Manning: Dating of Gordion tree-ring sequence still stands within a year of 745 BC Charlotte Pearson, Matthew Salzer, Lukas Wacker, Peter Brewer, Adam Sookdeo, and Peter Kuniholm Brief Reports Discovery of the world’s highest-dwelling mammal  Jay F. Storz, Marcial Quiroga-Carmona, Juan C. Opazo, Thomas Bowen, Matthew Farson, Scott J. Steppan, and Guillermo D’Elía Inefficient V(D)J recombination underlies monogenic T cell receptor β expression  Glendon S. Wu and Craig H. Bassing Identification of GLUT12/SLC2A12 as a urate transporter that regulates the blood urate level in hyperuricemia model mice  Yu Toyoda, Tappei Takada, Hiroshi Miyata, Hirotaka Matsuo, Hidetoshi Kassai, Kazuki Nakao, Masahiro Nakatochi, Yusuke Kawamura, Seiko Shimizu, Nariyoshi Shinomiya, Kimiyoshi Ichida, Makoto Hosoyamada, Atsu Aiba, and Hiroshi Suzuki Physical Sciences Applied Mathematics Relating size and functionality in human social networks through complexity  B. J. West, G. F. Massari, G. Culbreth, R. Failla, M. Bologna, R. I. M. Dunbar, and P. Grigolini Applied Physical Sciences Plato’s cube and the natural geometry of fragmentation Gábor Domokos, Douglas J. Jerolmack, Ferenc Kun, and János Török Reconfigurable microbots folded from simple colloidal chains Tao Yang, Brennan Sprinkle, Yang Guo, Jun Qian, Daoben Hua, Aleksandar Donev, David W. M. Marr, and Ning Wu Astronomy Predicting the long-term stability of compact multiplanet systems Daniel Tamayo, Miles Cranmer, Samuel Hadden, Hanno Rein, Peter Battaglia, Alysa Obertas, Philip J. Armitage, Shirley Ho, David N. Spergel, Christian Gilbertson, Naireen Hussain, Ari Silburt, Daniel Jontof-Hutter, and Kristen Menou Biophysics and Computational Biology An influenza A hemagglutinin small-molecule fusion inhibitor identified by a new high-throughput fluorescence polarization screen  Yao Yao, Rameshwar U. Kadam, Chang-Chun David Lee, Jordan L. Woehl, Nicholas C. Wu, Xueyong Zhu, Seiya Kitamura, Ian A. Wilson, and Dennis W. Wolan Calcium-triggered fusion of lipid membranes is enabled by amphiphilic nanoparticles Mukarram A. Tahir, Zekiye P. Guven, Laura R. Arriaga, Berta Tinao, Yu-Sang Sabrina Yang, Ahmet Bekdemir, Jacob T. Martin, Alisha N. Bhanji, Darrell Irvine, Francesco Stellacci, and Alfredo Alexander-Katz Machine learning classification can reduce false positives in structure-based virtual screening  Yusuf O. Adeshina, Eric J. Deeds, and John Karanicolas A mechanism-aware and multiomic machine-learning pipeline characterizes yeast cell growth Christopher Culley, Supreeta Vijayakumar, Guido Zampieri, and Claudio Angione Chemistry Lipid sponge droplets as programmable synthetic organelles Ahanjit Bhattacharya, Henrike Niederholtmeyer, Kira A. Podolsky, Rupak Bhattacharya, Jing-Jin Song, Roberto J. Brea, Chu-Hsien Tsai, Sunil K. Sinha, and Neal K. Devaraj Two-step reaction mechanism reveals new antioxidant capability of cysteine disulfides against hydroxyl radical attack Sarju Adhikari, Ramon Crehuet, Josep M. Anglada, Joseph S. Francisco, and Yu Xia Crystallographic evidence of Watson–Crick connectivity in the base pair of anionic adenine with thymine  Manish Kumar Mishra, Steven P. Kelley, Volodymyr Smetana, David A. Dixon, Ashley S. McNeill, Anja-Verena Mudring, and Robin D. Rogers Experimental and theoretical evidence for hydrogen doping in polymer solution-processed indium gallium oxide Wei Huang, Po-Hsiu Chien, Kyle McMillen, Sawankumar Patel, Joshua Tedesco, Li Zeng, Subhrangsu Mukherjee, Binghao Wang, Yao Chen, Gang Wang, Yang Wang, Yanshan Gao, Michael J. Bedzyk, Dean M. DeLongchamp, Yan-Yan Hu, Julia E. Medvedeva, Tobin J. Marks, and Antonio Facchetti Thermodynamic energetics underlying genomic instability and whole-genome doubling in cancer Francoise Remacle, Thomas G. Graeber, and R. D. Levine Earth, Atmospheric, and Planetary Sciences Automated detection of archaeological mounds using machine-learning classification of multisensor and multitemporal satellite data  Hector A. Orengo, Francesc C. Conesa, Arnau Garcia-Molsosa, Agustín Lobo, Adam S. Green, Marco Madella, and Cameron A. Petrie Recent anthropogenic curtailing of Yellow River runoff and sediment load is unprecedented over the past 500 y Yu Liu, Huiming Song, Zhisheng An, Changfeng Sun, Valerie Trouet, Qiufang Cai, Ruoshi Liu, Steven W. Leavitt, Yi Song, Qiang Li, Congxi Fang, Weijian Zhou, Yinke Yang, Zhao Jin, Yunqiang Wang, Junyan Sun, Xingmin Mu, Ying Lei, Lu Wang, Xuxiang Li, Meng Ren, Linlin Cui, and Xueli Zeng Elevated paleomagnetic dispersion at Saint Helena suggests long-lived anomalous behavior in the South Atlantic Yael A. Engbers, Andrew J. Biggin, and Richard K. Bono Exoplanet secondary atmosphere loss and revival Edwin S. Kite and Megan N. Barnett Elevated dust depositions in West Asia linked to ocean–atmosphere shifts during North Atlantic cold events Reza Safaierad, Mahyar Mohtadi, Bernd Zolitschka, Yusuke Yokoyama, Christoph Vogt, and Enno Schefuß Soft transition between subcritical and supercritical currents through intermittent cascading interfacial instabilities Jorge Salinas, S. Balachandar, Mrugesh Shringarpure, Juan Fedele, David Hoyal, and Mariano Cantero High-pressure elastic properties of dolomite melt supporting carbonate-induced melting in deep upper mantle  Man Xu, Zhicheng Jing, Suraj K. Bajgain, Mainak Mookherjee, James A. Van Orman, Tony Yu, and Yanbin Wang Engineering Pencil–paper on-skin electronics  Yadong Xu, Ganggang Zhao, Liang Zhu, Qihui Fei, Zhe Zhang, Zanyu Chen, Fufei An, Yangyang Chen, Yun Ling, Peijun Guo, Shinghua Ding, Guoliang Huang, Pai-Yen Chen, Qing Cao, and Zheng Yan Reproductive outcomes predicted by phase imaging with computational specificity of spermatozoon ultrastructure  Mikhail E. Kandel, Marcello Rubessa, Yuchen R. He, Sierra Schreiber, Sasha Meyers, Luciana Matter Naves, Molly K. Sermersheim, G. Scott Sell, Michael J. Szewczyk, Nahil Sobh, Matthew B. Wheeler, and Gabriel Popescu Bioinspired conductive cellulose liquid-crystal hydrogels as multifunctional electrical skins Zhuohao Zhang, Zhuoyue Chen, Yu Wang, and Yuanjin Zhao Environmental Sciences Qualitative crop condition survey reveals spatiotemporal production patterns and allows early yield prediction  Santiago Beguería and Marco P. Maneta Physics Cavity molecular dynamics simulations of liquid water under vibrational ultrastrong coupling Tao E. Li, Joseph E. Subotnik, and Abraham Nitzan Link-usage asymmetry and collective patterns emerging from rich-club organization of complex networks  Paolo Moretti and Marc-Thorsten Hütt Linear resistivity and Sachdev-Ye-Kitaev (SYK) spin liquid behavior in a quantum critical metal with spin-1/2 fermions  Peter Cha, Nils Wentzell, Olivier Parcollet, Antoine Georges, and Eun-Ah Kim Sustainability Science Biocement stabilization of an experimental-scale artificial slope and the reformation of iron-rich crusts Alan Levett, Emma J. Gagen, Yitian Zhao, Paulo M. Vasconcelos, and Gordon Southam Social Sciences Anthropology Automated detection of archaeological mounds using machine-learning classification of multisensor and multitemporal satellite data  Hector A. Orengo, Francesc C. Conesa, Arnau Garcia-Molsosa, Agustín Lobo, Adam S. Green, Marco Madella, and Cameron A. Petrie Relating size and functionality in human social networks through complexity  B. J. West, G. F. Massari, G. Culbreth, R. Failla, M. Bologna, R. I. M. Dunbar, and P. Grigolini Integration of ancient DNA with transdisciplinary dataset finds strong support for Inca resettlement in the south Peruvian coast   Jacob L. Bongers, Nathan Nakatsuka, Colleen O’Shea, Thomas K. Harper, Henry Tantaleán, Charles Stanish, and Lars Fehren-Schmitz Psychological and Cognitive Sciences Robust evidence for bisexual orientation among men  Jeremy Jabbour, Luke Holmes, David Sylva, Kevin J. Hsu, Theodore L. Semon, A. M. Rosenthal, Adam Safron, Erlend Slettevold, Tuesday M. Watts-Overall, Ritch C. Savin-Williams, John Sylla, Gerulf Rieger, and J. Michael Bailey Social Sciences Lay theories of peace and their influence on policy preference during violent conflict Oded Adomi Leshem and Eran Halperin Biological Sciences Agricultural Sciences Qualitative crop condition survey reveals spatiotemporal production patterns and allows early yield prediction  Santiago Beguería and Marco P. Maneta Crop rotation mitigates impacts of corn rootworm resistance to transgenic Bt corn Yves Carrière, Zachary Brown, Serkan Aglasan, Pierre Dutilleul, Matthew Carroll, Graham Head, Bruce E. Tabashnik, Peter Søgaard Jørgensen, and Scott P. Carroll Anthropology A 1.4-million-year-old bone handaxe from Konso, Ethiopia, shows advanced tool technology in the early Acheulean Katsuhiro Sano, Yonas Beyene, Shigehiro Katoh, Daisuke Koyabu, Hideki Endo, Tomohiko Sasaki, Berhane Asfaw, and Gen Suwa Applied Biological Sciences Phosphoprotein-based biomarkers as predictors for cancer therapy Angela M. Carter, Chunfeng Tan, Karine Pozo, Rahul Telange, Roberto Molinaro, Ailan Guo, Enrica De Rosa, Jonathan O. Martinez, Shanrong Zhang, Nilesh Kumar, Masaya Takahashi, Thorsten Wiederhold, Hans K. Ghayee, Sarah C. Oltmann, Karel Pacak, Eugene A. Woltering, Kimmo J. Hatanpaa, Fiemu E. Nwariaku, Elizabeth G. Grubbs, Anthony J. Gill, Bruce Robinson, Frank Gillardon, Sushanth Reddy, Renata Jaskula-Sztul, James A. Mobley, M. Shahid Mukhtar, Ennio Tasciotti, Herbert Chen, and James A. Bibb A single-cell Raman-based platform to identify developmental stages of human pluripotent stem cell-derived neurons  Chia-Chen Hsu, Jiabao Xu, Bas Brinkhof, Hui Wang, Zhanfeng Cui, Wei E. Huang, and Hua Ye Bidirectional titration of yeast gene expression using a pooled CRISPR guide RNA approach Emily K. Bowman, Matthew Deaner, Jan-Fang Cheng, Robert Evans, Ernst Oberortner, Yasuo Yoshikuni, and Hal S. Alper Biochemistry Lipid sponge droplets as programmable synthetic organelles Ahanjit Bhattacharya, Henrike Niederholtmeyer, Kira A. Podolsky, Rupak Bhattacharya, Jing-Jin Song, Roberto J. Brea, Chu-Hsien Tsai, Sunil K. Sinha, and Neal K. Devaraj An influenza A hemagglutinin small-molecule fusion inhibitor identified by a new high-throughput fluorescence polarization screen  Yao Yao, Rameshwar U. Kadam, Chang-Chun David Lee, Jordan L. Woehl, Nicholas C. Wu, Xueyong Zhu, Seiya Kitamura, Ian A. Wilson, and Dennis W. Wolan Direct readout of heterochromatic H3K9me3 regulates DNMT1-mediated maintenance DNA methylation Wendan Ren, Huitao Fan, Sara A. Grimm, Yiran Guo, Jae Jin Kim, Jiekai Yin, Linhui Li, Christopher J. Petell, Xiao-Feng Tan, Zhi-Min Zhang, John P. Coan, Linfeng Gao, Ling Cai, Brittany Detrick, Burak Çetin, Qiang Cui, Brian D. Strahl, Or Gozani, Yinsheng Wang, Kyle M. Miller, Seán E. O’Leary, Paul A. Wade, Dinshaw J. Patel, Gang Greg Wang, and Jikui Song What ATP binding does to the Ca2+ pump and how nonproductive phosphoryl transfer is prevented in the absence of Ca2+ Yoshiki Kabashima, Haruo Ogawa, Rie Nakajima, and Chikashi Toyoshima Long-range intramolecular allostery and regulation in the dynein-like AAA protein Mdn1 Keith J. Mickolajczyk, Paul Dominic B. Olinares, Yiming Niu, Nan Chen, Sara E. Warrington, Yusuke Sasaki, Thomas Walz, Brian T. Chait, and Tarun M. Kapoor Biophysics and Computational Biology Calcium-triggered fusion of lipid membranes is enabled by amphiphilic nanoparticles Mukarram A. Tahir, Zekiye P. Guven, Laura R. Arriaga, Berta Tinao, Yu-Sang Sabrina Yang, Ahmet Bekdemir, Jacob T. Martin, Alisha N. Bhanji, Darrell Irvine, Francesco Stellacci, and Alfredo Alexander-Katz Machine learning classification can reduce false positives in structure-based virtual screening  Yusuf O. Adeshina, Eric J. Deeds, and John Karanicolas HEDGES error-correcting code for DNA storage corrects indels and allows sequence constraints  William H. Press, John A. Hawkins, Stephen K. Jones Jr, Jeffrey M. Schaub, and Ilya J. Finkelstein Cryo-EM analysis of a membrane protein embedded in the liposome Xia Yao, Xiao Fan, and Nieng Yan Calcium and hydroxyapatite binding site of human vitronectin provides insights to abnormal deposit formation Kyungsoo Shin, James E. Kent, Chandan Singh, Lynn M. Fujimoto, Jinghua Yu, Ye Tian, Wonpil Im, and Francesca M. Marassi Cell Biology Cleavage-furrow formation without F-actin in Chlamydomonas Masayuki Onishi, James G. Umen, Frederick R. Cross, and John R. Pringle Last step in the path of LDL cholesterol from lysosome to plasma membrane to ER is governed by phosphatidylserine  Michael N. Trinh, Michael S. Brown, Joseph L. Goldstein, Jaeil Han, Gonçalo Vale, Jeffrey G. McDonald, Joachim Seemann, Joshua T. Mendell, and Feiran Lu Vps13 is required for the packaging of the ER into autophagosomes during ER-phagy Shuliang Chen, Muriel Mari, Smriti Parashar, Dongmei Liu, Yixian Cui, Fulvio Reggiori, Peter J. Novick, and Susan Ferro-Novick Clusters of bacterial RNA polymerase are biomolecular condensates that assemble through liquid–liquid phase separation  Anne-Marie Ladouceur, Baljyot Singh Parmar, Stefan Biedzinski, James Wall, S. Graydon Tope, David Cohn, Albright Kim, Nicolas Soubry, Rodrigo Reyes-Lamothe, and Stephanie C. Weber Ecology Multidecadal records of intrinsic water-use efficiency in the desert shrub Encelia farinosa reveal strong responses to climate change   Avery W. Driscoll, Nicholas Q. Bitter, Darren R. Sandquist, and James R. Ehleringer High plant diversity and slow assembly of old-growth grasslands Ashish N. Nerlekar and Joseph W. Veldman Shifts in timing and duration of breeding for 73 boreal bird species over four decades  Maria H. Hällfors, Laura H. Antão, Malcolm Itter, Aleksi Lehikoinen, Tanja Lindholm, Tomas Roslin, and Marjo Saastamoinen Behavioral traits that define social dominance are the same that reduce social influence in a consensus task  Mariana Rodriguez-Santiago, Paul Nührenberg, James Derry, Oliver Deussen, Fritz A. Francisco, Linda K. Garrison, Sylvia F. Garza, Hans A. Hofmann, and Alex Jordan Environmental Sciences Biocement stabilization of an experimental-scale artificial slope and the reformation of iron-rich crusts Alan Levett, Emma J. Gagen, Yitian Zhao, Paulo M. Vasconcelos, and Gordon Southam Evolution Multiple origins of green coloration in frogs mediated by a novel biliverdin-binding serpin  Carlos Taboada, Andrés E. Brunetti, Mariana L. Lyra, Robert R. Fitak, Ana Faigón Soverna, Santiago R. Ron, María G. Lagorio, Célio F. B. Haddad, Norberto P. Lopes, Sönke Johnsen, Julián Faivovich, Lucía B. Chemes, and Sara E. Bari Evolutionary stalling and a limit on the power of natural selection to improve a cellular module  Sandeep Venkataram, Ross Monasky, Shohreh H. Sikaroodi, Sergey Kryazhimskiy, and Betul Kacar Genetics Metformin inhibits RAN translation through PKR pathway and mitigates disease in C9orf72 ALS/FTD mice   Tao Zu, Shu Guo, Olgert Bardhi, Daniel A. Ryskamp, Jian Li, Solaleh Khoramian Tusi, Avery Engelbrecht, Kelena Klippel, Paramita Chakrabarty, Lien Nguyen, Todd E. Golde, Nahum Sonenberg, and Laura P. W. Ranum Molecular characterization of a fungal gasdermin-like protein  Asen Daskalov, Patrick S. Mitchell, Andrew Sandstrom, Russell E. Vance, and N. Louise Glass Genome-wide role of Rad26 in promoting transcription-coupled nucleotide excision repair in yeast chromatin Mingrui Duan, Kathiresan Selvam, John J. Wyrick, and Peng Mao T-box transcription factor 3 governs a transcriptional program for the function of the mouse atrioventricular conduction system Rajiv A. Mohan, Fernanda M. Bosada, Jan H. van Weerd, Karel van Duijvenboden, Jianan Wang, Mathilda T. M. Mommersteeg, Ingeborg B. Hooijkaas, Vincent Wakker, Corrie de Gier-de Vries, Ruben Coronel, Gerard J. J. Boink, Jeroen Bakkers, Phil Barnett, Bas J. Boukens, and Vincent M. Christoffels Immunology and Inflammation Bacterial immunotherapy for cancer induces CD4-dependent tumor-specific immunity through tumor-intrinsic interferon-γ signaling Anthony C. Antonelli, Anna Binyamin, Tobias M. Hohl, Michael S. Glickman, and Gil Redelman-Sidi Fetal public Vγ9Vδ2 T cells expand and gain potent cytotoxic functions early after birth Maria Papadopoulou, Tanya Dimova, Muki Shey, Libby Briel, Helen Veldtsman, Nondumiso Khomba, Hadn Africa, Marcia Steyn, Willem A. Hanekom, Thomas J. Scriba, Elisa Nemes, and David Vermijlen Microbial exposure drives polyclonal expansion of innate γδ T cells immediately after birth Sarina Ravens, Alina S. Fichtner, Maike Willers, Dennis Torkornoo, Sabine Pirr, Jennifer Schöning, Malte Deseke, Inga Sandrock, Anja Bubke, Anneke Wilharm, Daniel Dodoo, Beverly Egyir, Katie L. Flanagan, Lars Steinbrück, Paul Dickinson, Peter Ghazal, Bright Adu, Dorothee Viemann, and Immo Prinz Medical Sciences Site-specific ubiquitination of pathogenic huntingtin attenuates its deleterious effects Vicky Hakim-Eshed, Ayub Boulos, Chen Cohen-Rosenzweig, Libo Yu-Taeger, Tamar Ziv, Yong Tae Kwon, Olaf Riess, Hoa Huu Phuc Nguyen, Noam E. Ziv, and Aaron Ciechanover Microbiology High-throughput discovery of phage receptors using transposon insertion sequencing of bacteria  Kaitlyn E. Kortright, Benjamin K. Chan, and Paul E. Turner Subdomain cryo-EM structure of nodaviral replication protein A crown complex provides mechanistic insights into RNA genome replication  Nuruddin Unchwaniwala, Hong Zhan, Janice Pennington, Mark Horswill, Johan A. den Boon, and Paul Ahlquist Intact proviral DNA assay analysis of large cohorts of people with HIV provides a benchmark for the frequency and composition of persistent proviral DNA Francesco R. Simonetti, Jennifer A. White, Camille Tumiotto, Kristen D. Ritter, Mian Cai, Rajesh T. Gandhi, Steven G. Deeks, Bonnie J. Howell, Luis J. Montaner, Joel N. Blankson, Albine Martin, Gregory M. Laird, Robert F. Siliciano, John W. Mellors, and Janet D. Siliciano Yin Yang 1 is a potent activator of human T lymphotropic virus type 1 LTR-driven gene expression via RNA binding Gary Z. Wang and Stephen P. Goff Molecular basis of Coxsackievirus A10 entry using the two-in-one attachment and uncoating receptor KRM1 Yingzi Cui, Ruchao Peng, Hao Song, Zhou Tong, Xiao Qu, Sheng Liu, Xin Zhao, Yan Chai, Peiyi Wang, George F. Gao, and Jianxun Qi Nanoparticles presenting clusters of CD4 expose a universal vulnerability of HIV-1 by mimicking target cells  Magnus A. G. Hoffmann, Yotam Bar-On, Zhi Yang, Harry B. Gristick, Priyanthi N. P. Gnanapragasam, Jost Vielmetter, Michel C. Nussenzweig, and Pamela J. Bjorkman Wide lag time distributions break a trade-off between reproduction and survival in bacteria Stefany Moreno-Gámez, Daniel J. Kiviet, Clément Vulin, Susan Schlegel, Kim Schlegel, G. Sander van Doorn, and Martin Ackermann The gain-of-function allele bamAE470K bypasses the essential requirement for BamD in β-barrel outer membrane protein assembly Elizabeth M. Hart, Meera Gupta, Martin Wühr, and Thomas J. Silhavy Morphological profiling of tubercle bacilli identifies drug pathways of action  Trever C. Smith II, Krista M. Pullen, Michaela C. Olson, Morgan E. McNellis, Ian Richardson, Sophia Hu, Jonah Larkins-Ford, Xin Wang, Joel S. Freundlich, D. Michael Ando, and Bree B. Aldridge Fc-mediated effector function contributes to the in vivo antiviral effect of an HIV neutralizing antibody Mangaiarkarasi Asokan, Joana Dias, Cuiping Liu, Anna Maximova, Keenan Ernste, Amarendra Pegu, Krisha McKee, Wei Shi, Xuejun Chen, Cassandra Almasri, Wanwisa Promsote, David R. Ambrozak, Lucio Gama, Jianfei Hu, Daniel C. Douek, John-Paul Todd, Jeffrey D. Lifson, Slim Fourati, Rafick P. Sekaly, Andrew R. Crowley, Margaret E. Ackerman, Sung Hee Ko, Divya Kilam, Eli A. Boritz, Laura E. Liao, Katharine Best, Alan S. Perelson, John R. Mascola, and Richard A. Koup FOXO transcription factors activate alternative major immediate early promoters to induce human cytomegalovirus reactivation Andrew E. Hale, Donna Collins-McMillen, Erik M. Lenarcic, Suzu Igarashi, Jeremy P. Kamil, Felicia Goodrum, and Nathaniel J. Moorman Human cytomegalovirus protein pUL36: A dual cell death pathway inhibitor  Alice Fletcher-Etherington, Luis Nobre, Katie Nightingale, Robin Antrobus, Jenna Nichols, Andrew J. Davison, Richard J. Stanton, and Michael P. Weekes Neuroscience A connectomics approach to understanding a retinal disease Charles L. Zucker, Paul S. Bernstein, Richard L. Schalek, Jeff W. Lichtman, and John E. Dowling Integrative structural, functional, and transcriptomic analyses of sex-biased brain organization in humans Siyuan Liu, Jakob Seidlitz, Jonathan D. Blumenthal, Liv S. Clasen, and Armin Raznahan V1 neurons encode the perceptual compensation of false torsion arising from Listing’s law Mohammad Farhan Khazali, Hamidreza Ramezanpour, and Peter Thier Redistribution of metabolic resources through astrocyte networks mitigates neurodegenerative stress  Melissa L. Cooper, Silvia Pasini, Wendi S. Lambert, Karis B. D’Alessandro, Vincent Yao, Michael L. Risner, and David J. Calkins Physiology TNNT2 mutations in the tropomyosin binding region of TNT1 disrupt its role in contractile inhibition and stimulate cardiac dysfunction Aditi Madan, Meera C. Viswanathan, Kathleen C. Woulfe, William Schmidt, Agnes Sidor, Ting Liu, Tran H. Nguyen, Bosco Trinh, Cortney Wilson, Sineej Madathil, Georg Vogler, Brian O’Rourke, Brandon J. Biesiadecki, Larry S. Tobacman, and Anthony Cammarato Plant Biology Induced proximity of a TIR signaling domain on a plant-mammalian NLR chimera activates defense in plants   Zane Duxbury, Shanshan Wang, Craig I. MacKenzie, Jeannette L. Tenthorey, Xiaoxiao Zhang, Sung Un Huh, Lanxi Hu, Lionel Hill, Pok Man Ngou, Pingtao Ding, Jian Chen, Yan Ma, Hailong Guo, Baptiste Castel, Panagiotis N. Moschou, Maud Bernoux, Peter N. Dodds, Russell E. Vance, and Jonathan D. G. Jones Light modulates the gravitropic responses through organ-specific PIFs and HY5 regulation of LAZY4 expression in Arabidopsis Panyu Yang, Qiming Wen, Renbo Yu, Xue Han, Xing Wang Deng, and Haodong Chen Tonoplast-localized Ca2+ pumps regulate Ca2+ signals during pattern-triggered immunity in Arabidopsis thaliana  Richard Hilleary, Julio Paez-Valencia, Cullen Vens, Masatsugu Toyota, Michael Palmgren, and Simon Gilroy Allosteric deactivation of PIFs and EIN3 by microproteins in light control of plant development Qingqing Wu, Kunyan Kuang, Mohan Lyu, Yan Zhao, Yue Li, Jing Li, Ying Pan, Hui Shi, and Shangwei Zhong Systems Biology A mechanism-aware and multiomic machine-learning pipeline characterizes yeast cell growth Christopher Culley, Supreeta Vijayakumar, Guido Zampieri, and Claudio Angione Thermodynamic energetics underlying genomic instability and whole-genome doubling in cancer Francoise Remacle, Thomas G. Graeber, and R. D. Levine Corrections Correction for Pearson et al., Securing timelines in the ancient Mediterranean using multiproxy annual tree-ring data Correction for Tzafetas et al., The intelligent knife (iKnife) and its intraoperative diagnostic advantage for the treatment of cervical disease SI Correction Correction to Supporting Information for Zadra et al., Inhibition of de novo lipogenesis targets androgen receptor signaling in castration-resistant prostate cancer