Three-dimensional (3D) human brain tissue models derived from induced pluripotent stem cells (iPSCs) have significantly advanced the study of human neural development and neurological disease in vitro. While cerebral organoids provide high structural complexity, their large size often results in necrotic core formation, limiting reproducibility and complicating the
Type I interferons (IFNs) are essential regulators of antiviral defense, yet individual IFNα subtypes can elicit divergent immune outcomes. To systematically define these functional differences, we established an in vitro and in vivo workflow combining defined IFNα stimulations, T cell polarization assays, and viral infection models. Seven murine
Presented on: Nov 19, 2025 12:00 PM-1:00 PM ESTWatch >
Biomolecular condensates formed via liquid–liquid phase separation (LLPS) are dynamic compartments critical for spatiotemporal regulation of key cellular processes, including RNA metabolism. However, under genetic mutations or chronic cellular stress, these condensates can transition into less dynamic, gel- or solid-like structures—often associated with neurodegenerative disorders.