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PeerJ
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PeerJ Content Alert
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This week's PeerJ updates (edit settings)
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Can you Publish for Free?
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Check to see if your institution has a new Annual Institutional Publishing plan with PeerJ. If it does, your publishing fees are covered.
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Find Out Now
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New peer-reviewed articles in your Subjects
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Editor note "This study addresses an ongoing need in lung squamous cell carcinoma to better stratify prognosis beyond conventional clinicopathologic factors, particularly given heterogeneous responses to immune checkpoint blockade and the biologic relevance of EMT. By deriving differentially expressed EMT-related genes from TCGA and constructing a six-gene Cox/LASSO signature, the authors provide a reproducible framework that links an EMT-anchored risk score to survival and to measurable differences in inferred immune-cell compositions and ESTIMATE scores, thereby offering a plausible connection between tumor-intrinsic programs and microenvironmental states. The additional, albeit limited, tissue-level IHC serves as a useful orthogonal check on directionality. At the same time, the impact is constrained by reliance on a single public cohort for model development, modest effect-size interpretability, nonsignificant TMB differences, and very small IHC sample size without treatment or stage-balanced validation."
Bioinformatics, Oncology
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Editor note "This review underscores the critical role of AI, machine learning, and data science in overcoming the main limitations of metagenomic shotgun sequencing—namely, the large volume of short, fragmented reads from complex microbial communities. It shows how these technologies currently enable efficient data processing by automating quality control, improving MAG assembly, enhancing next-generation and long-read sequencing, and advancing phenotype prediction models, hence providing powerful solutions until long-read technologies fully mature."
Bioinformatics, Biotechnology, Genomics, Microbiology, Data Mining and Machine Learning
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Editor note "This study isolated high-yield scopoletin from Thai Rubiaceae plants, synthesized its benzoate derivative, and evaluated its cytotoxicity on human keratinocytes (HaCaT cells). The IC50 of 182.95 μg/mL establishes safe dosage limits for the first time, providing essential safety data to support further development of scopoletin-based pain-relief drugs."
Biochemistry, Biotechnology, Plant Science
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Data Mining and Machine Learning, Data Science, Neural Networks
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Algorithms and Analysis of Algorithms, Autonomous Systems, Data Mining and Machine Learning, Natural Language and Speech, Text Mining
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More >
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Warm regards,
The PeerJ Team
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Calls for Papers
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Anthropogenic Impact on Microbe-Host Diversity in the Global South
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