Multi-scale approach

[Jalil Nourisa]

Hi,

As you know, a mechanical signal coming from a continuum model plays an important role in cell processing. This matter is usually addressed by combining ABM with finite-element analysis (FEA) to create a multi-scale model. ABM receives a mechanical stimulus calculated in FEA and takes it into account in determining cell behavior. I wonder have you considered such a multi-scale approach in developing biocellion? if yes, can you advice how biocellion addresses this need? if no, how biocellion can be expanded to meet new simulation requirements?

Best,

Jalil

[Boris Aguilar]

Hello Jalil,

Although Biocellion was designed for multi-scale modeling (It has ODEs and PDE solvers, in addition to the ABM), it does not have a FEA solver yet. So one would need to incorporate a FEA solver that would be compatible with Biocellion (multithread, C++ compatible, etc). 

I think the main challenge in adding FEA to Biocellion will be the discretization of system into elements needed for FEA, right now Biocellion just discretize the system in regular square  Voxels to solve PDEs. In summary adding FEA will require a major update to be considered in future releases.  

Best,

Boris 

  

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