significativity rate in Bimbam

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gael.even

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Jan 18, 2010, 3:47:49 AM1/18/10

to BIMBAM HELP

Hi,

I use your interesting software on a single quantitative traits, I
have generated some results and I am wondering if a score of +3 could
be significative or if I would except higher score ( > +30...) to
detect a real significativity?

Many thanks!

Gaël

Yongtao Guan

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Jan 19, 2010, 4:54:46 PM1/19/10

to gael...@gmail.com, BIMBAM HELP

Hi Gaël,

Bayes factor reflects change of odds ratio in light of data, i.e.,
posterior_odds = prior_odds x Bayes_factor.
From posterior odds, one can compute posterior probability of association.
So whether +3 or +30 or 10^3 is significant or not depends on your prior odds.
For more information, see a review paper by Stephens and Balding
(2009), http://stephenslab.uchicago.edu/MSpapers/Stephens2009.pdf

Grant

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