Farmakologija Rang Dale Pdf Download [CRACKED]
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1. Splošna farmakologija: splošni in molekularni principi v farmakodinamiki, farmakokinetični procesi in usoda zdravila v organizmu, neklinično in klinično preskušanje zdravil, škodljivo delovanje zdravil
The importance of determining the therapeutic range of a drug cannot be overstated. This is generally defined by the range between the minimum effective dose (MED) and the maximum tolerated dose (MTD). The MED is defined as the lowest dose level of a pharmaceutical product that provides a clinically significant response in average efficacy, which is also statistically significantly superior to the response provided by the placebo.[5] Similarly, the MTD is the highest possible but still tolerable dose level with respect to a pre-specified clinical limiting toxicity.[5] In general, these limits refer to the average patient population. For instances in which there is a large difference between the MED and MTD, it is stated that the drug has a large therapeutic window. Conversely, if the range is relatively small, or if the MTD is less than the MED, then the pharmaceutical product will have little to no practical value.[5]