Vonnegutproposed, though, that a seed crystal of ice-9 would lower the energy barrier of that transition state. This is a pretty common phenomenon, actually. Ice-9 works the same way as mad cow disease. Prions are a protein configuration more stable than the functional form but difficult to reach. Once a small amount of the protein assumes that new configuration, though, it can catalyze the mis-folding of all the rest in your brain.
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