I have myself had instances where the palm got pressed so hard that the ring and little fingers got totally number for more than a month. Later I got to know that it is called handlebar palsy. Though they can be caused by incorrect bike setup, my opinion is that an unfit body could also be a reason.
Body weight has to be borne by three contact points - pedal (leg), saddle (bum) and handlebar (palm). In my opinion, most of the weight should be borne by a strong pair of leg muscles. It is when your legs are tired that you tend to rest too much on saddle and handlebar - both can be problematic over longer period of time.
Brevet should have a handlebar height set at somewhere between racing and touring... neither too low nor too high. In my setup, it is exactly at the same height as the saddle. You can figure out the reach to your comfort at this height.
You can set the saddle height/position like this.... keep adjusting your saddle until your legs are completely stretched out (knee locked out) when pedal is the bottom with crank arm vertically down. Now, measure the length from pedal spindle to the saddle (a point on the saddle where you would mostly rest on, can be somewhere centre area). Lets call this length as L.
Now, an ideal pedaling should bend your knees in the range of 66 to 154 degrees. Beyond this, you are bending too much or too stretched to produce power. Based on this, the crank arm length must be :
Crank arm length = L * [cos {(180 - 154) / 2} - cos{(180 - 66) / 2}] / 2
= L * (0.9744 - 0.5446) / 2
= L * 0.215
Saddle height as measured "vertically" from the bottom bracket spindle :
Vertical saddle height = L * {1 + cos(154 - 90)} / 2
= L * 1.43837 / 2
= L * 0.7199
Since we want the knee socket to be vertically above the pedal spindle when crank arm is at 3 O'clock position, saddle has to be offset behind the bottom bracket by:
Saddle offset from bottom bracket = {L * sin (154 - 90) / 2} - crank arm length
= L * 0.4494 - L * 0.215
= L * 0.2344
Saddle position/height is the most important as leg does most of the work. Above three values should give a good starting point.
Note that L could be different for left and right legs for the same individual. In such cases, take the longer leg as the measurement. Then add some height to the shorter leg in the form of thicker shoe sole or pedal rubber height.