Translating irregular heartbeats could lead to new insights for computer scientists and medical diagnostics, according to an international project led by a Professor of Digital Media at Queen Mary University of London (QMUL), which was presented today at the British Science Festival in Brighton (Friday 8 September).
The project takes ECG data recorded from arrhythmic hearts and represents the information using music rhythm notation, which then serves as a basis for new music compositions. When performed, the music accurately reproduces the rhythms of the irregular heartbeats, demonstrating the success of the transcription.
In addition, the performed music makes the experience of arrhythmia visceral so that people who have not experienced arrhythmia can sense what it feels like. The resulting musical representations also capture temporal structures, such as rhythmic patterns and musical form.
The team, which involves three students at Harvard, Ashwin Krishna, Daniel Soberanes, and Matthew Ybarra, used electrocardiogram recordings of two types of arrhythmia: ventricular tachycardia and atrial fibrillation.
The anonymised ECG data was collected at the Barts cardiac catheterisation laboratory with the help of Professor Pier Lambiase, consultant cardiologist at Barts and Professor of Cardiology at UCL, and Dr. Michele Orini, a bioengineering research fellow at UCL.
Existing projects linking heartbeats to music focus on normal heartbeats, which may change in rate but have little rhythmic variation. These projects are also based primarily on sonification of aggregate features such as rate or frequency.
An intermediate output is the Arrhythmia Suite, a set of piano pieces based on collaging existing music material that possess matching rhythms or similar ones that match the heartbeats with only minor modifications.
Elaine Chew, a Professor of Digital Media at Queen Mary University of London and an accomplished pianist, is analysing the heartbeat patterns of people with arrhythmia (a condition meaning the heartbeat is irregular, too fast or too slow) and turning them into classical music.
Elaine is leading an international team on the project, which will investigate whether musically representing heartbeat patterns could be used to help doctors understand irregular heartbeat conditions, and identify different subtypes of arrhythmia.
The project will take electrocardiogram data, and translate the information using musical notation software, which accurately reproduces the rhythms of individual arrhythmic heartbeats. This translation will then become the basis for new compositions.
The scientist and musician believes that once doctors and medical professionals hear these compositions (having never experienced arrhythmia themselves), they will gain a wider understanding of the condition.
Now the data they collected is packing a punch as it is being used by the state of Tennessee to create an interactive online dashboard that allows organizations and individuals to help victims of human trafficking faster and more effectively.
But to make that happen, Engage Together needs a lot of brains to help collect all that data to make the dashboards as accurate as possible. Lipscomb students got started with Post-It Notes on a projected map.
Engage Together initially had a list of about 50 organizations in the state that Engage Together knew provided services to fight or mitigate human trafficking. The Engage Together research fellows then made phone calls to confirm the information plus obtain recommendations of other organizations or individuals they worked with: from church congregations to local lawyers, from volunteer groups to government-funded agencies.
When the fellows pivoted to survey distribution, the baton was tossed to Lipscomb students, who did their own research online to identify even more service providers, paying special attention to the geography of the providers to note which counties needed extra attention.
Watson, who brings more than 20 years of experience as a social worker specializing in pregnant women with substance use disorders, is providing staff training, data analysis, program development and policy recommendations.
As part of their senior practicum hours in the field, Lipscomb students and Watson have worked together to develop capstone research projects related to these complex social problems such as best practices for working with substance exposed infants, health equity and food insecurity in minority populations and addressing systemic barriers to reporting interpersonal violence and protecting survivors.
Dr. Rachel Crouch, assistant professor of pharmacy and pharmaceutical sciences, was brought in to complete the mass spectrometry analysis and to conduct an additional study to further elucidate the metabolism pathways of masitinib.
The Dove Award-winning Profitt, whose music has been heard on 24, Quantico and The Hunger Games: Mockingjay Part 2, among other shows, created a live, staged version of his Christmas album with guest artists, a 50-person orchestra and a 100-person choir.
To arrange the original music for an orchestra, Profitt turned to Blasko, who has conducted groups such as the Nashville Symphony, Boston Symphony, the North Texas Wind Symphony and the Agora Brass Ensemble.
Northwestern came up with a model for testing the drug, called 2-hydroxylbenzamine (2HOBA), to treat arrhythmias using an animal study. Dr. Kathy Murray at Vanderbilt and Dr. Rishi Arora at Northwestern were working together to understand how 2HOBA works by studying tissues and cells from an animal model that develops the heart arrhythmia.
Carlisle, who is part of the Lipscomb-Vanderbilt Pharm.D.-to-Ph.D. pathway program, has been working with Akers on the project for a year and a half. From her experience working as the clinical research coordinator for phase one clinical trials at the University of Wisconsin Madison before coming to Lipscomb, she knew the training pathway was for her.
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