I have suffered this issue right this morning. Found this discussion
at Autodesk (http://discussion.autodesk.com/thread.jspa?
threadID=408832), but did not help to solve it. At least helped me to
find a better solution. I am not an expert but it appear to be a
conflict between Autocad user profile and OS User Profile. Suddenly,
it is not possible for the first to write with OS user profile
permissions. So, I found the Temporary Files directory path for
Autocad at registry and changed to another new path created specially
for Autocad use. In my case it was:
HKEY_USERS\S-1-5-21-2153880508-3726255085-1611951251-1004\Software
\Autodesk\AutoCAD\R16.0\ACAD-201:409\Profiles\<<Unnamed Profile>>
\General Configuration
You can find this two values there : "TempDirectory" and
"PlotSpoolerDirectory". I tried changing both to, for example, "C:\Temp
\" (create that directory first) and Autocad came back to life again.
After starting Autocad changed immediately all paths to temporary
files to this new directory and I am working normally since then. It
is less drastic than reinstall everything or create a new user
profile. I hope this information would be useful for anybody, had a
bad time trying to fix this.