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We recently found that nucleosomes directly block access of CRISPR/Cas9 to DNA (Horlbeck et al., 2016). Here, we build on this observation with a comprehensive algorithm that incorporates chromatin, position, and sequence features to accurately predict highly effective single guide RNAs (sgRNAs) for targeting nuclease-dead Cas9-mediated transcriptional repression (CRISPRi) and activation (CRISPRa). We use this algorithm to design next-generation genome-scale CRISPRi and CRISPRa libraries targeting human and mouse genomes. A CRISPRi screen for essential genes in K562 cells demonstrates that the large majority of sgRNAs are highly active. We also find CRISPRi does not exhibit any detectable non-specific toxicity recently observed with CRISPR nuclease approaches. Precision-recall analysis shows that we detect over 90% of essential genes with minimal false positives using a compact 5 sgRNA/gene library. Our results establish CRISPRi and CRISPRa as premier tools for loss- or gain-of-function studies and provide a general strategy for identifying Cas9 target sites.
A little dirty, but working way is carefully sorting out what conditions are there for finding next and previous items. With id it's quite easy, since all ids are different, and Rails Guy's answer describes just that: in next for a known id pick a first entry with a larger id (if results are ordered by id, as per defaults). More than that - his answer hints to place next and previous into the model class. Do so.
If there are multiple order criteria, things get complicated. Say, we have a set of rows sorted by group parameter first (which can possibly have equal values on different rows) and then by id (which id different everywhere, guaranteed). Results are ordered by group and then by id (both ascending), so we can possibly encounter two situations of getting the next element, it's the first from the list that has elements, that (so many that):
Those fetch all next and previous entries respectively. If you need only one, use Rails' first and last (as suggested by Rails Guy) or limit(1) (and be wary of the asc/desc ordering).
In Cisco ASA Firewalls, I was using multi-context (there were two contexts, Context-A and Context-B). Context A was active on Firewall-1 and Context-B was active on Firewall-2. Once Firewall-1 goes down, Firewall-2 will be active for both Context-A and Context-B.
I have studied High Availability documentation for Palo Alto Firewalls, from what i have studied i dont think it is possible to load balance the traffic in this way. I have created two vsys, (vsys-A and vsys-B). I want vsys-A to be active on Firewall-1 and vsys-B to be active on Firewall-2. Vsys-A should get active on Firewall-2 only in case Firewall-1 goes down and once Firewall-1 gets back live again then Vsys-A should be switched to Firewall-1. Similarly for Vsys-B.
Hi everyone, I generate a report quite frequently for all active project for the next 4 weeks ahead. I currently just go through all projects and check on a column I created and them pull the data in a report, but my main data is getting too extensive and I'd like to have some functions or automations to do that. I've tried many things but haven't got to the right solution and always end doing manually.
Hi,
I am playing around with erpnext for a few days now, installed it on a ubuntu system, everything went well, now i am trying to integrate with Microsoft Active directory hosted in a windows server 2019 vm, i am able to save the settings of the ldap to erpnext but now i am unable to authenticate the user from ldap.
Basically the ldap has 3 users user1,2 and user3 and my base dn is
I am not sure about this error information, is it generated from ldap or from erpnext,
can somebody help me to sort this out.
and the installed apps are
ERPNext: v14.x.x-develop () (develop)
Okay, so maybe I'm just crazy idk. But somedays my little turkey is so active it's all day. Then the next few she's not as active but I still feel her occasionally. I have an anterior placenta so I'm sure that has something to do with it. But I can't help but get worried sometimes. Due to a previous pregnancy loss I feel it's normal to be worried. I'm 30 weeks. She just seems quiet some days. Then suddenly is a soccer player out of nowhere!
2. Create a 'Company workflow'. Call it 'open tasks / live tasks' the enrolment trigger would be 'Task status' is any of In Progress, Not Started, Waiting or Deferred then press the + for the next step. Set property value 'Property Type' Contact 'Property to Set' NAME 'NAME' Open Task. Then turn on and enrol all your contacts
Contact records do have "next activity date", which factors in future Tasks scheduled. However, Deals DO NOT have this field...sigh. So if a Rep is busy, happens to be in the Deal record, rather than the Contact record (it happens!), and adds the next Task...the Rep MUST remember to now add the Contact to this Task, while having a sandwich in one hand and a phone in the other...it's not going to happen folks.
However, these two HubSpot 'entities' do not have the same style of "next steps" functionality. Yes, they both have Tasks, but the linkage is manual and Deals doesn't capture the next Task Date, while Contacts does. We can't figure out how to keep things from falling through the cracks...too many different variables.
Yes, Firefox has a built-in setting (browser.tabs.insertRelatedAfterCurrent in about:config) to automatically open tabs next to the current tab but it only works in a very limited scenario. It only does it when you click a link inside the current tab. It will open that tab next to the current tab. But if you click the New tab button or press Ctrl+T, it will always add a new tab at the end of all the tabs. This addon will fix that.
Without the Tab Mix Plus add-on, you might have to modify a preference in about:config, but I am not sure of that because I have not researched it. You can configure TMP to open a new tab next to the current active tab.
You can only open a link in a tab next to the current tab.If you click the plus or otherwise open a new tab (e.g. middle-click a bookmark) then this tab is always opened at the end unless you would use an extension to change/override this behavior.
Thanks for that @zondermunz but neither did you or the help of this plugin answered my initial question. How to inimize active tab by simply clickin on it.Maybe I do have to get use to this add on, maybe I do have to play a little more with the settings, but the thing is that as much as I would like to, I don't have all day free to tinker with those settings. I just need specific answer, to one, two questions and that's it.So at the end of the day I won't be using this add on.Thanks for the information though:)
Does anyone know if you can use attributeSync or some other trickery to update AD pwdLastSet? Wondering if I can set this to 0 based on an identityAttribute rather than doing it in a rule, allowing me to force a password reset on next login.
I have 10 active programs and streams exactly like this that will all need the current MailChimp emails replaced with the new Marketo emails I built so I want to make sure I'm doing it the smart way. Is it simply better to just clone each entire program and turn the old one off and activate the new one?
Keep in mind that an engagement stream will send the next piece of content at the next cast from top to bottom. Meaning that if you place a new email at the very top of an engagement stream list of emails, that new email will be sent next, then proceed to the next email that has not been sent.
If the email is in the stream and active then it will be deployed to exhausted members at the next cast, so this won't work for your case then. Why don't you try to create a new stream for each new email and use transition rules to determine the new stream. For example, if they received the old Email 2 then their next email should be the new Email 3. You can create a smart campaign that will move these members to the new streams by using the smart list logic that they received Email 1 but not Email 2 or received Email 2 but not Email 3.
You could just create a nested email program for that new email and take everyone who is exhausted and add them to a static list (XYZ) so that in the nested email program your smart campaign to send the email has a Member of List not in XYZ. Once you add the nested email program to your stream, everyone will become active again, but because of your smart campaign once the next send happens, those previously exhausted people will become exhausted again and not receive the email.
In this article, we will walk through setting up a sample Navigation component and create a helper function to check the active navigation link using the usePathname hook. We will also cover handling nested URLs and the root path.
This helper function is now capable of handling the active navigation link for both simple and nested URLs while addressing the root path issue. By using the useActivePath hook in the Navigation component, developers can create a dynamic navigation experience that highlights the active link correctly.
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